central venous catheter central venous access device cvc hickman catheter gene editing therapy gene therapy newer treatments scd sickle cell anemia sickle cell disease fcm ferric carboxymaltose iron deficiency anemia anemia in malignancy rituximab in all acute lymphoblastic leukemia b cell all rituximab romiplostim thrombocytopenia sickle cell thalassemia vte testing guidelines hypercoagulable states thrombophilia testing septic shock qsofa sofa score code sepsis sepsis-3 neutropnic sepsis sepsis covid guidelines for thromboprophylaxis cac covid associated coagulopathy cvad handwash
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