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Seminar
Seminar
Seminar
Seminar
PEMERIKSAAN & INTERPRETASI
PEMERIKSAAN & INTERPRETASI
PEMERIKSAAN & INTERPRETASI
PEMERIKSAAN & INTERPRETASI
LIQUOR SEREBROSPINALIS
LIQUOR SEREBROSPINALIS
LIQUOR SEREBROSPINALIS
LIQUOR SEREBROSPINALIS
Oleh :
Oleh :
Putu Sukarini
Putu Sukarini
Pembimbing :
Pembimbing :
dr
dr.
. Dea!
Dea! K"
K" Indraari
Indraari U"ami#
U"ami#
S$.S
S$.S
1
1
Pendah%l%an
Pendah%l%an
Pendah%l%an
Pendah%l%an
•
• 
'l%me in"ra!ranial
'l%me in"ra!ranial ( )*++
( )*++ ml "dd :
ml "dd :
).
).,'l%me '"a! ( )-++ ml
,'l%me '"a! ( )-++ ml
.
.,'l%me /airan
,'l%me /airan erebr
erebr'$inal 01)2
'$inal 01)2
ml 3ra"a1ra"a )+- ml4
ml 3ra"a1ra"a )+- ml4
5.
5.darah e!i"ar )0+ ml.
darah e!i"ar )0+ ml.
•
• 6+7 dari 8aringan '"a! "erdiri dari
6+7 dari 8aringan '"a! "erdiri dari
/airan# bai! e!"rael ma%$%n in"ra
/airan# bai! e!"rael ma%$%n in"ra
el.
el.
Eri/
Eri/ R
R Kandel#
Kandel# ++2#
++2# $rin/i$le
$rin/i$le '9
'9
ne%ral /ien/e
ne%ral /ien/e
2
2

airan erebr'$inal di$r'd%!i eban;a!
airan erebr'$inal di$r'd%!i eban;a!
+#50 ml<meni" a"a% 0++ ml<hari# edang!an
+#50 ml<meni" a"a% 0++ ml<hari# edang!an
"'"al ,'l%me /airan erebr'$inal ber!iar
"'"al ,'l%me /airan erebr'$inal ber!iar
*01)0+ ml# digan"i -10 !ali<hari %n"%!
*01)0+ ml# digan"i -10 !ali<hari %n"%!
mem$er"ahan!an 8%mlah /airan
mem$er"ahan!an 8%mlah /airan
erebr
erebr'$inal "e"a$
'$inal "e"a$ .
.

Mer%$a!an %a"% !egia"an dinami# ber%$a
Mer%$a!an %a"% !egia"an dinami# ber%$a
$emben"%!an# ir!
$emben"%!an# ir!%lai dan
%lai dan ab'r$i.
ab'r$i.
Eri/ R Kandel# ++2# Prin/i$le '9 Ne%ral S/ien/e
Eri/ R Kandel# ++2# Prin/i$le '9 Ne%ral S/ien/e
3
3
P
Pemben"%
emben"%!an# Sir!%lai dan
!an# Sir!%lai dan
P
Pemben"
emben"%!an# Sir!%lai dan
%!an# Sir!%lai dan
Ab'r$i airan
Ab'r$i airan
Ab'r$i airan
Ab'r$i airan
Serebr'$inal 3SS4
Serebr'$inal 3SS4
Serebr'$inal 3SS4
Serebr'$inal 3SS4
•
• Diben"%!
Diben"%! 'leh
'leh $le!%
$le!% !h'r'ide%
!h'r'ide% :
:
$emb%l%h darah !a$iler dengan
$emb%l%h darah !a$iler dengan
9ene"ra"a di!elilingi 'leh e$i"el !%b'id
9ene"ra"a di!elilingi 'leh e$i"el !%b'id
mer%$a!an m'di=!ai dari el
mer%$a!an m'di=!ai dari el
e$endim# ;ang
e$endim# ;ang men'n8'l !e ,en"ri!
men'n8'l !e ,en"ri!el.
el.
•
• Ple!% !h'r'ide% memben"%! l'b%l1
Ple!% !h'r'ide% memben"%! l'b%l1
l'b%l dan memben"%! e$er"i da%n
l'b%l dan memben"%! e$er"i da%n
$a!i ;ang di"%"%$i 'leh mi!r',ili dan
$a!i ;ang di"%"%$i 'leh mi!r',ili dan
ilia.
ilia.
Ra;m'nd adam# )>>6# Prin/i$le '9
Ra;m'nd adam# )>>6# Prin/i$le '9
Ne%r'l'g;
Ne%r'l'g;
4
4

Sel e$i"el !%b'id berh%b%ngan a"%
Sel e$i"el !%b'id berh%b%ngan a"%
ama lain dengan "ig"h 8%n/"i'n $ada
ama lain dengan "ig"h 8%n/"i'n $ada
ii a$e!# daar el e$i"el !%b'id
ii a$e!# daar el e$i"el !%b'id
"erda$a" membran baali dengan
"erda$a" membran baali dengan
r%ang "r'ma dian"aran;a.
r%ang "r'ma dian"aran;a.
Ra;m'nd Adam# )>>6# Prin/i$le '9
Ra;m'nd Adam# )>>6# Prin/i$le '9
Ne%r'l'g;
Ne%r'l'g;
5
5
Eric
Eric R
R Kandel,
Kandel, 2006,
2006,
Eric R Kandel, 2006,
Eric R Kandel, 2006,
Principles of Neural Science
Principles of Neural Science
Principles of Neural Science
Principles of Neural Science
6
6
•
• Ada  !el'm$'! $le!% ;ang %"ama
Ada  !el'm$'! $le!% ;ang %"ama
menghail!an SS:
menghail!an SS:
).
).Daar "ia$ ,en"
Daar "ia$ ,en"ri!
ri!el la"eral :
el la"eral : $r'd ??
$r'd ??
ban;a!
ban;a!
.
.A"a$ ,en"ri!
A"a$ ,en"ri!el III
el III dan I :
dan I : $r'd @@
$r'd @@
edi!i".
edi!i".
•
• Di$er!ira!an
Di$er!ira!an SS
SS ;ang
;ang dihail!an
dihail!an
'leh
'leh ,en"ri!e
,en"ri!el
l la"eral
la"eral e!i"ar
e!i"ar >07.
>07.
Eri/ r Kandel# ++2# Prin/i$le '9 Ne%ral
Eri/ r Kandel# ++2# Prin/i$le '9 Ne%ral
S/ien/e
S/ien/e
7
7
David
David L
L Felten,
Felten, 2010,
2010,
David L Felten, 2010,
David L Felten, 2010,
Nettes !tlas of Neuroscience
Nettes !tlas of Neuroscience
Nettes !tlas of Neuroscience
Nettes !tlas of Neuroscience
8
8
8
8
Sir!%lai
Sir!%lai
Sir!%lai
Sir!%lai
•
• SS dari ,en"ri!el la"eral melal%i
SS dari ,en"ri!el la"eral melal%i
9'ramen in"er,en"ri!%lar m'nr'e
9'ramen in"er,en"ri!%lar m'nr'e 

en"ri!el III# melal%i a%ad%/"% ;l,ii
en"ri!el III# melal%i a%ad%/"% ;l,ii

 ,en"ri!el I.
,en"ri!el I.
•
• T
Tiga
iga b%ah
b%ah l%bang
l%bang dalam
dalam ,en"ri!e
,en"ri!el
l I
I
;ang "erdiri dari  9'ramen ,en"ri!el
;ang "erdiri dari  9'ramen ,en"ri!el
la"eral 39'ramen l%/h!a4 dan 9'ramen
la"eral 39'ramen l%/h!a4 dan 9'ramen
,en"ri!%ler medial 39'ramen magendi4
,en"ri!%ler medial 39'ramen magendi4

 mem%ng!in!an SS !el%ar dari
mem%ng!in!an SS !el%ar dari
i"em ,en"ri!el ma%! !e dalam
i"em ,en"ri!el ma%! !e dalam
r'ngga %bara!hn'id.
r'ngga %bara!hn'id.
Eri/
Eri/ R
R Kandel#
Kandel# ++2#
++2# Prin/i$le
Prin/i$le '9
'9 Ne%ral
Ne%ral
S/ien/e
S/ien/e
9
9

SS mengii r'ngga %bara!hn'id
SS mengii r'ngga %bara!hn'id
mengelilingi med%la $inali
mengelilingi med%la $inali
am$ai ba"a e!i"ar S# 8%ga
am$ai ba"a e!i"ar S# 8%ga
mengii !eliling 8aringan '"a!.
mengii !eliling 8aringan '"a!.
Eri/
Eri/ R
R Kandel#
Kandel# ++2#
++2#
Prin/i$le '9 Ne%ral S/ien/e
Prin/i$le '9 Ne%ral S/ien/e
10
10
Ab'rbi
Ab'rbi
Ab'rbi
Ab'rbi

SS mengalir $erlahan men%8% i"erna
SS mengalir $erlahan men%8% i"erna
baali# i"erna ambien# melal%i
baali# i"erna ambien# melal%i
a$er"%ra "en"'rial dan bera!hir
a$er"%ra "en"'rial dan bera!hir
di$erm%!aan a"a dan am$ing erebri
di$erm%!aan a"a dan am$ing erebri
dimana ebagian bear SS a!an
dimana ebagian bear SS a!an
diab'r$i melal%i ,illi ara!hn'id
diab'r$i melal%i ,illi ara!hn'id
3gran%la Pa//hi'ni4 $ada dinding in%
3gran%la Pa//hi'ni4 $ada dinding in%
agi"ali %$eri'r ma%! !e dalam
agi"ali %$eri'r ma%! !e dalam
aliran darah ,ena dalam in%.
aliran darah ,ena dalam in%.
Eri/
Eri/ R
R Kandel#
Kandel# ++2#
++2# Prin/i$le
Prin/i$le '9
'9 Ne%ral
Ne%ral
S/ien/e
S/ien/e
11
11

SS 8%ga diera$ di r'ngga
SS 8%ga diera$ di r'ngga
%bra!hn'id ;ang mengelilingi ba"ang
%bra!hn'id ;ang mengelilingi ba"ang
'"a! dan med%la $inali 'leh
'"a! dan med%la $inali 'leh
$emb%l%h darah ;ang "erda$a" $ada
$emb%l%h darah ;ang "erda$a" $ada
ar%ng<ela$%" ara9 !ranial dan $inal.
ar%ng<ela$%" ara9 !ranial dan $inal.


ang
ang mem$eng
mem$engar%hi
ar%hi alirann;a
alirann;a adalah:
adalah:
me"ab'lime '"a!# !e!%a"an
me"ab'lime '"a!# !e!%a"an
hidr'dinami! aliran darah dan
hidr'dinami! aliran darah dan
$er%bahan dalam "e!anan 'm'"i!
$er%bahan dalam "e!anan 'm'"i!
darah.
darah.
Eri/
Eri/ R
R Kandel#
Kandel# ++2#
++2# Prin/i$le
Prin/i$le '9
'9 Ne%ral
Ne%ral
S/ien/e
S/ien/e
12
12
Ko"posisi dan fun#si
Ko"posisi dan fun#si
Ko"posisi dan fun#si
Ko"posisi dan fun#si
cairan sere$rospinal
cairan sere$rospinal
cairan sere$rospinal
cairan sere$rospinal
%&SS'
%&SS'
%&SS'
%&SS'

SS ham$ir me;er%$ai %l"ra=l"rai
SS ham$ir me;er%$ai %l"ra=l"rai
dari $lama darah "a$i berii
dari $lama darah "a$i berii
!'nen"rai Na# K# bi!arb'na"# $r'"ein#
!'nen"rai Na# K# bi!arb'na"# $r'"ein#
gl%!'a ;ang lebih !e/il dan
gl%!'a ;ang lebih !e/il dan
!'nen"rai Mg dan !l'rida ;ang lebih
!'nen"rai Mg dan !l'rida ;ang lebih
"inggi. Ph SS lebih rendah dari darah.
"inggi. Ph SS lebih rendah dari darah.
Eri/ R Kandel# ++2# Prin/i$le '9 Ne%ral
Eri/ R Kandel# ++2# Prin/i$le '9 Ne%ral
S/iene/e
S/iene/e
13
13
Fun#si (
Fun#si (
Fun#si (
Fun#si (
).
). SS men;edia!an !eeimbangan
SS men;edia!an !eeimbangan
an"ara el1el dalam i"em ara9
an"ara el1el dalam i"em ara9
dengan !'ndii i"emi!.
dengan !'ndii i"emi!.
.
. A!an meng%rangi bera" '"a! dalam
A!an meng%rangi bera" '"a! dalam
"eng!'ra! dan men;edia!an ban"alan
"eng!'ra! dan men;edia!an ban"alan
me!ani! %n"%! melind%ngi '"a! dari
me!ani! %n"%! melind%ngi '"a! dari
"ra%ma ;ang mengenai "%lang
"ra%ma ;ang mengenai "%lang
"eng!'ra!.
"eng!'ra!.
Eri/
Eri/ R
R Kandel#
Kandel# ++2#
++2# Prin/i$le
Prin/i$le '9
'9 Ne%ral
Ne%ral
S/ien/e
S/ien/e
14
14
5.
5. Mengalir!an
Mengalir!an Cam$ah
Cam$ah
 e$er"i
e$er"i
O#la!"a"# dan i'n idr'gen 3'"a!
O#la!"a"# dan i'n idr'gen 3'"a!
han;a edi!i" i"em lim9a"i!4# dan
han;a edi!i" i"em lim9a"i!4# dan
"ran$'r $r'd%! 3darah# ba!"eri# ma"eri
"ran$'r $r'd%! 3darah# ba!"eri# ma"eri
$%r%len<ne!r'"i!4 ;ang a!an diirigai
$%r%len<ne!r'"i!4 ;ang a!an diirigai
dan di!el%ar!an melal%i ,illi ara!hn'id.
dan di!el%ar!an melal%i ,illi ara!hn'id.
-. Sal%ran "ran$'r" in"raerebral
-. Sal%ran "ran$'r" in"raerebral
3'rm'n
3'rm'n dari
dari hi$'=e#
hi$'=e# hi$'"halam%4
hi$'"halam%4
da$a" di!el%ar!an !e SS dan
da$a" di!el%ar!an !e SS dan
"ran$'r"ai !e ii lain melal%i
"ran$'r"ai !e ii lain melal%i
"ran$'r" in"raerebral.
"ran$'r" in"raerebral.
Eri/
Eri/ R
R Kandel#
Kandel# ++2#
++2# Prin/i$le
Prin/i$le '9
'9 Ne%ral
Ne%ral
S/ien/e
S/ien/e
15
15
Fun#si (
Fun#si (
Fun#si (
Fun#si (
0.
0. Mem$er"ahan!an "e!anan
Mem$er"ahan!an "e!anan
in"ra!ranial 3$eng%rangan SS4
in"ra!ranial 3$eng%rangan SS4 

mengalir!ann;a !e l%ar r'ngga
mengalir!ann;a !e l%ar r'ngga
"eng!'ra!# mem$er/e$a"
"eng!'ra!# mem$er/e$a"
$engalirann;a melal%i berbagai
$engalirann;a melal%i berbagai
9'ramina# hingga men/a$ai in%
9'ramina# hingga men/a$ai in%
,en'%# a"a% ma%! !e dalam
,en'%# a"a% ma%! !e dalam
r'ngga %bara!hn'id l%mbal.
r'ngga %bara!hn'id l%mbal.
Eri/
Eri/ R
R Kandel#
Kandel# Prin/i$le
Prin/i$le '9
'9 Ne%ral
Ne%ral
S/ien/e
S/ien/e
16
16
PEN)!*+L!N &!R!N
PEN)!*+L!N &!R!N
PEN)!*+L!N &!R!N
PEN)!*+L!N &!R!N
SERE+R-SPN!L
SERE+R-SPN!L
SERE+R-SPN!L
SERE+R-SPN!L

Dengan /ara L%mbal P%n!i# Si"ernal
Dengan /ara L%mbal P%n!i# Si"ernal
P%n!i a"a% La"eral er,i/al
P%n!i a"a% La"eral er,i/al P%n!i.
P%n!i.

L%mbal P%n!i mer%$a!an $r'ed%re
L%mbal P%n!i mer%$a!an $r'ed%re
ne%r' diagn'"i! ;ang $aling ering
ne%r' diagn'"i! ;ang $aling ering
dila!%!an# edang!an i"ernal
dila!%!an# edang!an i"ernal
$%n!i dan la"eral han;a dila!%!an
$%n!i dan la"eral han;a dila!%!an
'leh 'rang
'leh 'rang ;ang benar
;ang benar1benar ahli.
1benar ahli.
Eri/
Eri/ R
R Kandel#
Kandel# ++2#
++2# Prin/i$le
Prin/i$le '9
'9 Ne%ral
Ne%ral
/ien/e
/ien/e
17
17
PEMERI
PEMERIKSA
KSAAN LS
AN LS
PEMER
PEMERIKSAAN
IKSAAN LS
LS
T
T%8%an LP :
%8%an LP :
). Diagn'"i! F -
). Diagn'"i! F - !a"ag'ri ma;'r $en;a!i"
!a"ag'ri ma;'r $en;a!i"
1 Meningi"i
1 Meningi"i
1 Per
1 Perdarahan
darahan %bara!n'id
%bara!n'id
1 Pr'e !
1 Pr'e !eganaan 3menin
eganaan 3meningeal a#
geal a#
T
T%.Me"a"ai4
%.Me"a"ai4
1 Gangg%an a%"'im%n
1 Gangg%an a%"'im%n
. Menge"ah%i Te!anan LS Fadan;a
. Menge"ah%i Te!anan LS Fadan;a
gangg%an aliran LS
gangg%an aliran LS
Barne"
Barne" R
R Na"han#
Na"han# ++)#
++)# lini/al
lini/al
Lab'ra"'r; Medi/ine
Lab'ra"'r; Medi/ine 18
18
.
..
. Mengiden"i=!ai Pen;. berh%b. dengan
Mengiden"i=!ai Pen;. berh%b. dengan
im%n'gl'b%lin
im%n'gl'b%lin 3
3 IgG#
IgG# IgA#
IgA# IgM4F
IgM4F
1ne%r' TB
1ne%r' TB
1ne%r'b'rreli'i
1ne%r'b'rreli'i
1in9e!i '$'
1in9e!i '$'r"%ni"
r"%ni"i!
i!
-. Un"%! mema%!!an ane"ei#'ba"#media
-. Un"%! mema%!!an ane"ei#'ba"#media
!'n"ra $d PH Radi'l'gi
!'n"ra $d PH Radi'l'gi
0.
0. Menge"ah%i
Menge"ah%i inde!
inde! an"ib'di
an"ib'di IgG
IgG $d
$d re$'n
re$'n
im%ne dlm NS
im%ne dlm NS
2. Mengiden"i=!ai $r'"ein ;g beraal dari '"a!
2. Mengiden"i=!ai $r'"ein ;g beraal dari '"a!
3adan;a ne%r'n $ei=!1en'lae e"elah
3adan;a ne%r'n $ei=!1en'lae e"elah
"ra%ma erebral4
"ra%ma erebral4 Barne" R Na"han# ++)# lini/al Lab'ra"'r; Medi/ine
Barne" R Na"han# ++)# lini/al Lab'ra"'r; Medi/ine
19
19
Pemeri!aan LS
Pemeri!aan LS
Pemeri!aan LS
Pemeri!aan LS
meli$%"i :
meli$%"i :
meli$%"i :
meli$%"i :
) Peng%!%ran "e!anan LS
) Peng%!%ran "e!anan LS
 P Ma!r'!'$i!3Penam$a!an %m%m4
 P Ma!r'!'$i!3Penam$a!an %m%m4
!e!er%han# $#BJ#arna#edimen#$eli!el
!e!er%han# $#BJ#arna#edimen#$eli!el
5 PH Mi!r'!'$i!
5 PH Mi!r'!'$i!
8%mlah el & hi"%ng el
8%mlah el & hi"%ng el
ba!"eri'l'gi
ba!"eri'l'gi
- PH Kimiai
- PH Kimiai
$r'"ein #gl%!'a# !l'rida LS
$r'"ein #gl%!'a# !l'rida LS
0 PH er'l'gi
0 PH er'l'gi
2 PH $e"anda "%m'r $d LS
2 PH $e"anda "%m'r $d LS
Barne"
Barne" R
R Na"han#
Na"han# ++)#
++)# lini/al
lini/al
Lab'ra"'r; Medi/ine
Lab'ra"'r; Medi/ine
20
20
21
21
Barne"
Barne" R
R Na"han#
Na"han# ++)#
++)# lini/al
lini/al Lab'ra"'r;
Lab'ra"'r;
Med'/ine
Med'/ine
Karakteristik L&S de/asa nor"al
Karakteristik L&S de/asa nor"al
Karakteristik L&S de/asa nor"al
Karakteristik L&S de/asa nor"al
K
Ka
ad
da
ar
r L
LC
CS
S R
Re
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la
at
ti
if
f t
t/
/ p
pl
la
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a
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Te
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75
5!
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0 m
mm
m"
"2
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#
p
p"
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7$
$3
32
2!
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7$
$3
35
5 S
Sd
dk
kt
t l
l%
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& r
re
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da
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te
ei
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 t
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(t
ta
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l 1
15
5!
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45
5 m
m)
)/
/d
dL
L 0
0$
$2
2!
!0
0$
$5
5 *
*
+
+m
m,
,
(
()
)l
l(
(%
%,
,l
li
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0$
$7
75
5!
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3$
$5
5 m
m)
)/
/d
dL
L -
- 0
0$
$1
1 *
*
.l%/)l(%,li
.l%/)l(%,li 81
81 3!4  l%& ti))i
3!4  l%& ti))i

l
l,
,k
k(
(s
sa
a 4
40
0!
!8
80
0 m
m)
)/
/d
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L 5
50
0!
!8
80
0*
* k
kd
dr
r d
dl
lm
m d
dr
r&
&
30!60mt
30!60mt
L
La
ak
kt
ta
at
t 1
10
0!
!2
20
0 m
m)
)/
/d
dL
L "
"a
am
mp
pi
ir
r s
sa
am
ma
a

r
re
ea
a 1
10
0!
!1
15
5 m
m)
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dL
L "
"a
am
mp
pi
ir
r s
sa
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- 2
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L "
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mp
pi
ir
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sa
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ma
a
Barne"
Barne" R
R Na"han#
Na"han# ++)#
++)# lini/al
lini/al Lab'ra"'r;
Lab'ra"'r;
22
22
Medi/ine
Medi/ine
Pen#ukuran tekanan L&S
Pen#ukuran tekanan L&S
Pen#ukuran tekanan L&S
Pen#ukuran tekanan L&S


T
Te!. LS :
e!. LS : N'rmal : 6+1)6+ mmO<6  )- mmg
N'rmal : 6+1)6+ mmO<6  )- mmg
B'rderline : )6+1++ mmO
B'rderline : )6+1++ mmO
Tinggi
Tinggi :
: ?
? ++
++ mmO
mmO a"a%
a"a% ?
? 0+
0+ mmO
mmO 3'bee4
3'bee4
++15++ 3ringan4
++15++ 3ringan4
5++1-++ 3edang4
5++1-++ 3edang4
? -++ 3anga" "inggi4F KI m%"la! %< LP
? -++ 3anga" "inggi4F KI m%"la! %< LP

 Man'me"er men/a"a" TIK ra"a1ra"a
Man'me"er men/a"a" TIK ra"a1ra"a
dier"ai dgn $%lai ar"eri F10 mm O
dier"ai dgn $%lai ar"eri F10 mm O
re$irai F -1)+ mm O
re$irai F -1)+ mm O

 Initial Pressure :
Initial Pressure : "er/a$ai dlm ) mn" #bila $aien "d! bergera! F N : 2+1++
"er/a$ai dlm ) mn" #bila $aien "d! bergera! F N : 2+1++
mm O
mm O

 Jugular compression
Jugular compression test
test :
:
Queckenstedt’s test/bilateral jugular test
Queckenstedt’s test/bilateral jugular test
dig%na!an %"! menen"%!an adan;a bl'! $inal
dig%na!an %"! menen"%!an adan;a bl'! $inal
T
Tobey -Ayer test/ uni
obey -Ayer test/ unilateral jugul
lateral jugular compression
ar compression
%n"! membanding!an $a"eni in% ,en'% dari la"eral d%ra !anan & !iri
%n"! membanding!an $a"eni in% ,en'% dari la"eral d%ra !anan & !iri
$d !e/%rigaan "r'mb'ebi"i
$d !e/%rigaan "r'mb'ebi"i
Bernar
Bernard
d J
J enr;#
enr;# ++2#
++2# lini/al
lini/al Diagn'i
Diagn'i and
and Managemen"
Managemen" b;
b;
Lab'ra"'r; Me"h'd
Lab'ra"'r; Me"h'd
23
23

 Clossing pressure :
Clossing pressure :
$en%r%nan rela"i9 "e!. LS e"elah $engambilan am$el F
$en%r%nan rela"i9 "e!. LS e"elah $engambilan am$el F
menanda!an
menanda!an ban;a!n;a
ban;a!n;a reer,'ir
reer,'ir LS
LS
Nor"al
Nor"al: e"ia$ $engambilan ) ml
: e"ia$ $engambilan ) ml LS # "e!anan a!an
LS # "e!anan a!an
"%r%n ebear ) /m
"%r%n ebear ) /m
Pada spinal $lok ko"plit
Pada spinal $lok ko"plit
a!an di da$a" mialn;a : ini"ia
a!an di da$a" mialn;a : ini"ial $re%re: 6+ mm
l $re%re: 6+ mm
!md diambil ) ml LS F
!md diambil ) ml LS F di%!%r lagi F + mm
di%!%r lagi F + mm
F menanda!an reer,'ir @@
F menanda!an reer,'ir @@
Pada idrosefalus
Pada idrosefalus d$" "er8adi : ini"ial
d$" "er8adi : ini"ial $re%r
$re%re : )6+ mm
e : )6+ mm
!md diambil )+ ml F di%!%r lagi F )2+ mm
!md diambil )+ ml F di%!%r lagi F )2+ mm
F menanda!an reer,'ir ??
F menanda!an reer,'ir ??
Bernard
Bernard J
J enr;#
enr;# ++2#
++2# lini/al
lini/al Diagn'i
Diagn'i and
and Managemen"
Managemen" b;
b;
Lab'ra"'r; Me"h'd
Lab'ra"'r; Me"h'd
24
24

 A
A;ala
;ala IndeH :
IndeH :
)+ //  $ 3/l'ing $re%re4
)+ //  $ 3/l'ing $re%re4
I.$
I.$ 3ini"ia
3ini"ial
l $re%re4
$re%re4
N'rmal : 0#0 12#0
N'rmal : 0#0 12#0
@ 0
@ 0 F $inal
F $inal bl'!#
bl'!# maa
maa dir%ang 
dir%ang %bara!n'id
%bara!n'id
? *
? * F a"r'= erebri# hidr'e9al%#$e%d'"%m'r erebri
F a"r'= erebri# hidr'e9al%#$e%d'"%m'r erebri
Bernard
Bernard R
R Na"han#
Na"han# ++)#
++)# lini/al
lini/al
Lab'ra"'r; Medi/ine
Lab'ra"'r; Medi/ine
25
25
In"er$re"ai !lini! "e!anan LS
In"er$re"ai !lini! "e!anan LS
In"er$re"ai !lini! "e!anan LS
In"er$re"ai !lini! "e!anan LS
Penin#katan tekanan
Penin#katan tekanan
L&S
L&S

 T
T%m'r in"ra!ranial
%m'r in"ra!ranial

 Meningi"i
Meningi"i

 i$''m'la"i"a '!
i$''m'la"i"a '!
hem'dialii
hem'dialii

 ena /ana %$. S;ndr
ena /ana %$. S;ndr

 Perdarahan
Perdarahan
%bara!n'id
%bara!n'id

 Edema erebri
Edema erebri

 T
Tr'mb'i 
r'mb'i in%
in%
,en'%
,en'%


Gang%an abr'$i SS
Gang%an abr'$i SS
Penurunan tekanan
Penurunan tekanan
L&S
L&S

 Ggn ir!%lai 3!'la$4
Ggn ir!%lai 3!'la$4

 Dehidrai bera"
Dehidrai bera"

 i$er'm'lali"a
i$er'm'lali"a

 Keb'/'ran SS
Keb'/'ran SS

 Bl'! $d %bara!n'id
Bl'! $d %bara!n'id
$inal
$inal
Barne"
Barne" R
R Na"han#
Na"han# ++)#
++)# lini/al
lini/al Lab'ra"'r;
Lab'ra"'r;
Medi/ine
Medi/ine
26
26
In"er$re"ai Klini! PH
In"er$re"ai Klini! PH
In"er$re"ai Klini! PH
In"er$re"ai Klini! PH
ma!r'!'$i!
ma!r'!'$i!
ma!r'!'$i!
ma!r'!'$i!
Pemeri!aan ma!r'!'$i! meli$%"i
Pemeri!aan ma!r'!'$i! meli$%"i
1 !e!er%han
1 !e!er%han
1 $
1 $
1 B8
1 B8
1 arna
1 arna
1 edimen
1 edimen
1 $eli!el
1 $eli!el
N'rmal : 8ernih dan "ida! berarna
N'rmal : 8ernih dan "ida! berarna
Barne"
Barne" r
r Kandel#
Kandel# ++)#
++)# lini/al
lini/al Lab'ra"'r;
Lab'ra"'r; Medi/ine
Medi/ine
BernardRNa"han#++)#
BernardRNa"han#++)#lini/alLab'ra"'r;
lini/alLab'ra"'r;
Medi/ine
Medi/ine
27
27
Ke!er%han
Ke!er%han
Ke!er%han da$a" diebab!an 'leh:
Ke!er%han da$a" diebab!an 'leh:

 Le!
Le!'i"
'i" 3$lei'i"'i4
3$lei'i"'i4

 Eri"r'i"
Eri"r'i"


Mi!r''r
Mi!r''rganime 38am%r #
ganime 38am%r # am%ba4
am%ba4

 Pr'"ein
Pr'"ein

 A$irai lema! e$id%ral
A$irai lema! e$id%ral


Media !'n"ra
Media !'n"ra
Barne"
Barne" R
R Na"han#
Na"han# ++)#
++)# lini/al
lini/al
Lab'ra"'r; medi/ine
Lab'ra"'r; medi/ine
28
28

 Ke!er%han m%lai "am$a! $ada
Ke!er%han m%lai "am$a! $ada
$leii"'i
$leii"'i B
B ?
? ++
++ el<mm
el<mm
5
5
RB ? -++ el<mm
RB ? -++ el<mm5
5

 ndall efect
ndall efect : %n"%! mende"e!i !e!er%han dibaah
: %n"%! mende"e!i !e!er%han dibaah
8%mlah el dia"a
8%mlah el dia"a dengan /ara
dengan /ara
LS
LS di!'/'!
di!'/'! dalam
dalam b'"'l !
b'"'l !em%dian diliha"
em%dian diliha" lang%n
lang%ng
g
dibaah inar ma"ahari
dibaah inar ma"ahari
"ida! da$a" membeda!an B dan RB #han;a
"ida! da$a" membeda!an B dan RB #han;a
menanda!
menanda!an
an $lei'i"'i
$lei'i"'i
Barne"
Barne" R
R Na"han#
Na"han# ++)#
++)# lini/al
lini/al
Lab'ra"'r; Medi/ine
Lab'ra"'r; Medi/ine
29
29

 i/'% %id : LS ;ang !en"al e$er"i ir%$ $ada
i/'% %id : LS ;ang !en"al e$er"i ir%$ $ada
1 me"a"ae m%/in'% aden' a 'l'n $d
1 me"a"ae m%/in'% aden' a 'l'n $d meningen
meningen
1 in9e!i 8am%r !ri$"'!'!'i
1 in9e!i 8am%r !ri$"'!'!'i
Pelikel3$ekuan alus
Pelikel3$ekuan alus
N'rmal : LS didiam!an elama - 8am a!an "erben"%! $eli!el
N'rmal : LS didiam!an elama - 8am a!an "erben"%! $eli!el
hal% da$a" diliha"
hal% da$a" diliha"
Abn'rmal :
Abn'rmal :
1 M.$%r%len"a
1 M.$%r%len"a : /e$a" "erben"
: /e$a" "erben"%! 3meni"1
%! 3meni"1 )8am4 bear d
)8am4 bear dan
an !aar
!aar
1 M.TB : "erben"%! )1- 8am#men;er%$ai arang laba1 laba
1 M.TB : "erben"%! )1- 8am#men;er%$ai arang laba1 laba
Barne"
Barne" R
R Na"han#
Na"han# ++)#
++)# lini/al
lini/al Lab'ra"'r;
Lab'ra"'r; medi/ine
medi/ine
30
30
4arna L&S
4arna L&S
n'rmal :"ida! berarna
n'rmal :"ida! berarna
15
15 Santroko"
Santroko"
Da$a" diebab!an 'leh:
Da$a" diebab!an 'leh:

 O!ihemagl'bin ;g beraal dari lii el darah merah
O!ihemagl'bin ;g beraal dari lii el darah merah
$d LS ebel%m LP
$d LS ebel%m LP

 Me"hem'gl'bin
Me"hem'gl'bin

 Bilir%bin 3?2mg<dL4
Bilir%bin 3?2mg<dL4

 Pening!a"an $r'"ein3?)0+ mg<dL4
Pening!a"an $r'"ein3?)0+ mg<dL4

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Kar'"en 3i"emi! !ar'"enemia4
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lab'ra"'r; Medi/ine
31
31
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32
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Dengan /ara en"ri9%gai da$a" dibeda!an an"ara
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34
34
lab'ra"'r; medi/ine
lab'ra"'r; medi/ine
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35
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Barne"
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lab'ra"'r; medi/ine
lab'ra"'r; medi/ine
lab'ra"'r; medi/ine
36
36
Per%bahan arna $ada LS ;ang berh%b.dgn !em%ng!inan
Per%bahan arna $ada LS ;ang berh%b.dgn !em%ng!inan
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Barne" R N
Barne" R Na"han# ++)# lini/al la
a"han# ++)# lini/al lab'ra"'r;
b'ra"'r; Medi/ine
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5 Pada $erm%laan meningi"i "%ber!%l'a
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++)# lini/al
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Lab'ra"'r; Medi/ine
38
38
Re!'mendai in"er,al Chi"%ng el
Re!'mendai in"er,al Chi"%ng el
Re!'mendai in"er,al Chi"%ng el
Re!'mendai in"er,al Chi"%ng el
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Barne" R Na"han## ++)# lini/al Lab'ra"'r; Medi/ine
Lab'ra"'r; Medi/ine
39
39

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arne" R Na"han# ++)# lini/al
Lab'ra"'r;Medi/ine
Lab'ra"'r;Medi/ine
40
40

 B 5++10++<L 3 d'minan lim$'i"4da$a"
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◦
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Meningi"i ,ir%
Meningi"i ,ir%
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Si=li SSP3mening'ene9ali"i4
◦
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In9e"ai $arai" $d SSP
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◦ Meningi"i ba!"eri '! 8eni ;g 8arang 3li"eria 4
Meningi"i ba!"eri '! 8eni ;g 8arang 3li"eria 4
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Ene9al'$a"i '! dr%g ab%e
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Sar!'id'i $d meningen
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41
41

 B dng ? -+ 7 3m'n'i"4 "er8adi $ada
B dng ? -+ 7 3m'n'i"4 "er8adi $ada
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Medi/ine
42
42
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 Ma!r'9ag el da$a" di"em%!an $ada meningi"i TB &
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E'in'=l da$a" di"em%!an $ada
1 in9e!i $arai"
1 in9e!i $arai"
1 in9e!i 8am%r
1 in9e!i 8am%r
1 in9e!i
1 in9e!i ri!e"
ri!e"ia
ia
1 ar!'id'i
1 ar!'id'i
Barne"
Barne" R
R Na"han#
Na"han# ++)#
++)# lini/al
lini/al lab'ra"'r;
lab'ra"'r;
Medi/ine
Medi/ine
43
43
ara Pem
ara Pemeri!aan i"%ng 8eni
eri!aan i"%ng 8eni el 3di
el 3di
ara Pe
ara Pemeri!aan i"%ng 8eni
meri!aan i"%ng 8eni el 3di
el 3di
/'%n"4
/'%n"4
/'%n"4
/'%n"4

 LS dien"ri9%gai !e/.++
LS dien"ri9%gai !e/.+++ r$m
+ r$m elama )+
elama )+ mn"
mn"

 S%$erna
S%$erna"an dib%ang# edimen
"an dib%ang# edimen dib%a" ha$%an
dib%a" ha$%an

 Pearnaan righ"< bir% me"ilin
Pearnaan righ"< bir% me"ilin


i"%ng )++ el3le!'i"4 dan hailn;a dalam 7
i"%ng )++ el3le!'i"4 dan hailn;a dalam 7
◦
◦ PMN  
PMN   7
7 # MN 
# MN  3)++1 H 4
3)++1 H 4 7
7
Barne"
Barne" R
R Na"han#
Na"han# ++)#
++)# lini/al
lini/al Lab'ra"'r;
Lab'ra"'r;
Medi/ine
Medi/ine
44
44
P
Pemeri!aan
emeri!aan gl%!
gl%!'a
'a
Pemeri!aan gl%!'a
Pemeri!aan gl%!'a

 
ang $erl% di$erha"i!an :
ang $erl% di$erha"i!an :
1 $emeri!aan egera dila!%!an 3 LS egar4
1 $emeri!aan egera dila!%!an 3 LS egar4
1 $enderi"a dalam !'ndii $%aa 3 5 8am $'" $randial4
1 $enderi"a dalam !'ndii $%aa 3 5 8am $'" $randial4
1 ebai!n;a di!er8a!an $emeri!aan gl%!'a darah %n"%!
1 ebai!n;a di!er8a!an $emeri!aan gl%!'a darah %n"%!
$embanding
$embanding

 
a!"'r1 9a!"'r ;ang
a!"'r1 9a!"'r ;ang mem$engar%hi !adar
mem$engar%hi !adar gl%!'a LS
gl%!'a LS
1 !adar gl%!'a darah
1 !adar gl%!'a darah
1 $ermiabili"a !a$iler dan e$i"el $le!% !'r'ide% er"a
1 $ermiabili"a !a$iler dan e$i"el $le!% !'r'ide% er"a
e$endim ,en"ri!el
e$endim ,en"ri!el
1 dera8a" gli!'lii
1 dera8a" gli!'lii
Barne"
Barne" R
R Na"han#
Na"han# ++)#
++)# lini/al
lini/al Lab'ra"'r;
Lab'ra"'r;
medi/ine
medi/ine
45
45
In"er$re"ai !lini! $emeri!aan
In"er$re"ai !lini! $emeri!aan
In"er$re"ai !lini! $emeri!aan
In"er$re"ai !lini! $emeri!aan
gl%!'a LS
gl%!'a LS
gl%!'a LS
gl%!'a LS

 Pen%r%nan !adar gl%!'a d$" "er8adi $ada
Pen%r%nan !adar gl%!'a d$" "er8adi $ada
1 meningi"i ba!"eri a!%"
1 meningi"i ba!"eri a!%"
1 meningi"i TB# 8am%r dan am%ba
1 meningi"i TB# 8am%r dan am%ba
1 hi$'gli!emi i"emi!
1 hi$'gli!emi i"emi!
1 $erdarahan %bara!n'id
1 $erdarahan %bara!n'id

 Kadar gl%!'a SS 8arang men%r%n $d:
Kadar gl%!'a SS 8arang men%r%n $d:
1 "%m'r '"a!
1 "%m'r '"a!
1 meningi"i i=li a!%"
1 meningi"i i=li a!%"
1meningi"i n'n ba!"eri
1meningi"i n'n ba!"eri


Pening!a"an gl%!'a "er8adi $ada i$ergli!emia 3DM4
Pening!a"an gl%!'a "er8adi $ada i$ergli!emia 3DM4
$ening!a"an gl%!'a elal% berh%b%ngan dengan
$ening!a"an gl%!'a elal% berh%b%ngan dengan !adar gl%!'a
!adar gl%!'a
$lama
$lama
Barne"
Barne" R
R Na"han#
Na"han# ++)#
++)# lini/al
lini/al Lab'ra"'r;
Lab'ra"'r; Medi/ine
Medi/ine
46
46
P
Pemeri!aan
emeri!aan $r
$r'"ein
'"ein
P
Pemeri!aan
emeri!aan $r'"ein
$r'"ein

 P
Pemeri!aan e/.
emeri!aan e/. !%ali"a"i9 & !%an"i"a"i9
!%ali"a"i9 & !%an"i"a"i9

 Pada !eadaan $a"'l'gi! 9ra!i $r'"ein ;g mening!a"
Pada !eadaan $a"'l'gi! 9ra!i $r'"ein ;g mening!a"
Fgl'b%lin hg "e
Fgl'b%lin hg "e !%ali"a"i9 berdaar!
!%ali"a"i9 berdaar!an !adar
an !adar
gl'b%lin
gl'b%lin

 N'rmal : )0 1 -0 mg
N'rmal : )0 1 -0 mg
$ening!a"an
$ening!a"an ringan
ringan :
: -*1*0
-*1*0 mg
mg
edang
edang :
: *01)++
*01)++ mg
mg
bera"
bera" :
: )++10++
)++10++ mg
mg
anga"
anga" bera"
bera" :
: 0++152++
0++152++ mg
mg
Barne"
Barne" R
R Na"han#
Na"han# ++)#
++)# lini/al
lini/al Lab'ra"'r;
Lab'ra"'r;
Medi/ine
Medi/ine
47
47
Keadaan ;ang men;ebab!an
Keadaan ;ang men;ebab!an
Keadaan ;ang men;ebab!an
Keadaan ;ang men;ebab!an
$r'"ein mening!a"
$r'"ein mening!a"
$r'"ein mening!a"
$r'"ein mening!a"

Ker%a!an BBB
Ker%a!an BBB

Re'r$i LS men%r%n
Re'r$i LS men%r%n

Ob"r%!i aliran LS
Ob"r%!i aliran LS

Sin"ea Imm%n'gl'b%lin ;ang
Sin"ea Imm%n'gl'b%lin ;ang
mening!a"
mening!a"
Barne"
Barne" R
R Na"han#
Na"han# ++)#
++)# lini/al
lini/al Lab'ra"'r;
Lab'ra"'r;
Medi/ine
Medi/ine
48
48
In"er$re"ai !lini! $emeri!aan
In"er$re"ai !lini! $emeri!aan
In"er$re"ai !lini! $emeri!aan
In"er$re"ai !lini! $emeri!aan
$r'"ein
$r'"ein
$r'"ein
$r'"ein

 Pe
Pening!a"an $r'"ein LS d$"
ning!a"an $r'"ein LS d$" "er8adi $ada
"er8adi $ada
).
). LP "ra%ma"i!
LP "ra%ma"i!
.
. BBB ;ang
BBB ;ang mening!a
mening!a"
"
Ara!n'idi"i
Ara!n'idi"i
Meni
Meningi
ngi"i
"i ba!
ba!"er
"eri
i F
F dgn
dgn gra
gram
m 

"%ber!%l'i
"%ber!%l'i F
F 0+15++
0+15++ mg
mg <dl
<dl dgn
dgn miHed
miHed
el%lar
el%lar
8am%r
8am%r F3
F3 0+15++
0+15++ mg<dl4
mg<dl4
,
,i
ir
r%
%
 F
F 3
3@
@
+
++
+ m
mg
g<
<d
dl
l4
4
SA
SA
Gg
Gg me"ab'li!
me"ab'li!
Kera/%nan
Kera/%nan 'ba"
'ba"
5
5 Gangg%an 
Gangg%an ir!%
ir!%lai
lai
Ob"r%!i m
Ob"r%!i me!ani!
e!ani! 3"%m'r# abe#
3"%m'r# abe# erniai
erniai di!%4
di!%4
Barne
Barne" R
" R Na"han# ++)# lini/al Lab'ra"'r;
Na"han# ++)# lini/al Lab'ra"'r;
Medi/ine
Medi/ine
49
49
-.
-. P
Pening!a"an in"ea imm%n'gl'
ening!a"an in"ea imm%n'gl'b%lin
b%lin
Ne%r'i$hili# M%l"i$le S!ler'i
Ne%r'i$hili# M%l"i$le S!ler'i
0.
0. P
Pening!a"an in"ea imm%n'gl'b%lin
ening!a"an in"ea imm%n'gl'b%lin dan gg.
dan gg.
BBB
BBB
GBS# 'lagen ,a/%lar d 3l%$%# $eriar"ri"i4
GBS# 'lagen ,a/%lar d 3l%$%# $eriar"ri"i4
Barne"
Barne" R
R Na"han#
Na"han# ++)#
++)# lini/al
lini/al Lab'ra"'r;
Lab'ra"'r;
medi/ine
medi/ine
50
50

 Pen%r%nan $r'"ein da$a" "er8adi :
Pen%r%nan $r'"ein da$a" "er8adi :
1 Keb'/'ran LS '! "ra%ma
1 Keb'/'ran LS '! "ra%ma
1
1 Pengambilan
Pengambilan LS
LS dalam
dalam 8%mlah
8%mlah ban;a!
ban;a!
1 TIK 
1 TIK 
1 i$er"ir'id
1 i$er"ir'id
1 Ana!1ana! 2 bln1 "hn
1 Ana!1ana! 2 bln1 "hn
Barne"
Barne" R
R Na"han#
Na"han# ++)#
++)# lini/al
lini/al
Lab'ra"'r; Medi/ine
Lab'ra"'r; Medi/ine
51
51
ara
ara Pemeri!aan
Pemeri!aan Pr
Pr'"ein
'"ein
ara
ara Pemeri!aan
Pemeri!aan Pr
Pr'"ein
'"ein
3K%ali"a"i94
3K%ali"a"i94
3K%ali"a"i94
3K%ali"a"i94

 T
Te berdaar!
e berdaar!an $ening!a"an !ada
an $ening!a"an !adar gl'b%lin
r gl'b%lin

 T
Te B%a
e B%a
◦
◦ N : LS
N : LS bila di!
bila di!'/'! F b%a 34 !md
'/'! F b%a 34 !md menghilang )1 mn" "lh d
menghilang )1 mn" "lh di
i
"enang!an
"enang!an
◦
◦
Pr'"ein mening!a" F b%a menghilang ? 0mn"
Pr'"ein mening!a" F b%a menghilang ? 0mn"

 T
Te N'nne P
e N'nne Pand; < N'nne1 A$el" < R
and; < N'nne1 A$el" < R'e  J'ne
'e  J'ne
1 gl'b%lin mengenda$ dl
1 gl'b%lin mengenda$ dlm lar
m lar. Jen%h Am'ni%m %l9a"
. Jen%h Am'ni%m %l9a" 3N-4
3N-4
SO-
SO-
1 $r'ed%r !er8a :
1 $r'ed%r !er8a :
ma%!!an
ma%!!an +#0 // LS
+#0 // LS  ) // lar
 ) // lar. 3N-4 SO-
. 3N-4 SO-
"%ngg% 5 meni" F "erben"%! 
"%ngg% 5 meni" F "erben"%!  la$ian F $erha"i!an /in/in
la$ian F $erha"i!an /in/in
$%"ih
$%"ih $d
$d $erba"aan
$erba"aan
Barne"
Barne" R
R Na"han#
Na"han# ++)#
++)# lini/al
lini/al Lab'ra"'r;
Lab'ra"'r; Medi/ine
Medi/ine
@
@
52
52

 In"er$re"
In"er$re"ai
ai N'nne:
N'nne:
31
314
4 :
: "d
"d!
! "e
"erb
rben
en"%
"%!
! /i
/in/
n/in
in $%
$%"i
"ih
h

 : /i
: /in/i
n/in $
n $%"i
%"ih 3
h 34 a
4 anga
nga" "i
" "i$i
$i han
han;a d
;a d$"
$" dil
dilih
iha" d
a" dgn
gn LB
LB
hi"am
hi"am

 : /
: /in/in
in/in "am$a!
"am$a! aga!
aga! 8ela#
8ela# bila
bila di!
di!'/'!
'/'! /airan
/airan '$aleen
'$aleen



 : /
: /i
in
n/
/i
in "
n "a
am
m$
$a
a! 8
! 8e
el
la
a
# d
# di
i!
!'
'/
/'
'! /
! /a
ai
ir
ra
an !
n !e
er
r%
%h
h
 : /in/in anga" 8ela# bila di!'/'! /airan anga" !er%h
 : /in/in anga" 8ela# bila di!'/'! /airan anga" !er%h
Barne"
Barne" R
R Na"han#
Na"han# ++)#
++)# /lini/al
/lini/al lab'ra"'r;
lab'ra"'r;
medi/ine
medi/ine
53
53

 T
Te P
e Pand;
and;
1 %n"%! menge"ah%i !enai!an !adar gl'b%lin & alb%min
1 %n"%! menge"ah%i !enai!an !adar gl'b%lin & alb%min
1 $r'"ein a!an mengenda$ dlm lar
1 $r'"ein a!an mengenda$ dlm lar. Phen'l 8
. Phen'l 8en%h dlm a
en%h dlm air
ir
1 $r
1 $r'ed%r
'ed%r !er8a :
!er8a : ma%!!an )// lar
ma%!!an )// lar. P
. Pand; )// LS
and; )// LS
1 in"er$re"ai :
1 in"er$re"ai :
3
31
14
4 :
: !
!e
e!
!er
er%
%h
ha
an3
n3 
4
4
34
34 : '$
: '$ale
aleen 30
en 30+1)+
+1)++ mg 7
+ mg 74
4
3
3

4
4 :
: !
!e
er
r%
%h
h 3
3)
)+
++
+1
15
5+
++
+ m
mg
g 7
74
4
3
3


4
4 :
: 
a
an
ng
ga
a"
" !
!e
er
r%
%h
h 3
35
5+
++
+1
10
0+
++
+ m
mg
g 7
74
4
34 : !er%h $" %% 3?0++ mg74
34 : !er%h $" %% 3?0++ mg74
Barne"
Barne" R
R Na"han#
Na"han# ++)#
++)# lini/al
lini/al Lab'ra"'r;
Lab'ra"'r;
Medi/ine
Medi/ine
54
54
Kada
Kadar Alb%min &
r Alb%min & Im%n'gl'b%lin G 3IgG4
Im%n'gl'b%lin G 3IgG4
Kad
Kadar Alb%min &
ar Alb%min & Im%n'gl'b%lin G 3IgG4
Im%n'gl'b%lin G 3IgG4

 Ig
Ig G
G &
& Alb%min
Alb%min Fn'rmal
Fn'rmal 34
34 dlm
dlm LS
LS ;g
;g beraal
beraal dari
dari er%m
er%m

 Sehingga $e Alb%min & Ig G menanda!an adan;a !er%a!an
Sehingga $e Alb%min & Ig G menanda!an adan;a !er%a!an
dari bl''d brain barrier
dari bl''d brain barrier

 Alb%min
Alb%min indeH
indeH 
 Alb
Alb S
S 3mg<dL4
3mg<dL4
Alb
Alb er%m
er%m g<dL
g<dL
In"er$re"ai
In"er$re"ai :
: @
@ >
> BBB
BBB in"a!
in"a!
>1)-
>1)- R%
R%a!
a! ringan
ringan
)
)-
-1
15
5+
+ K
Ke
er
r%
%
a
a!
!a
an
n m
m'
'd
de
er
ra
a"
"
5
5+
+1
1)
)+
++
+ R
R%
%
a
a!
! b
be
er
ra
a"
"

 Ig G indeH 
Ig G indeH 
IgG
IgG &SF %"#3dl'
&SF %"#3dl' Alb S
Alb S 3mg<dL4
3mg<dL4 9
9 IgG LS  er%m alb%min
IgG LS  er%m alb%min
IgG
IgG er3mg<dL4
er3mg<dL4 Alb S
Alb S 3mg<dL4
3mg<dL4 Alb%min
Alb%min LS
LS 
 er%m
er%m Ig
Ig G
G
N'rmal : indeH @ +#2+
N'rmal : indeH @ +#2+
MS : indeH ? +#**
MS : indeH ? +#**
Barne" R Na"han# ++)# /lini/al Lab'ra"'r; Medi/ine
Barne" R Na"han# ++)# /lini/al Lab'ra"'r; Medi/ine
55
55

 Pening!a"an
Pening!a"an Alb%min V
Alb%min V Pening!a"an
Pening!a"an "'"al
"'"al $r'"ein
$r'"ein
1 M. ba!"eri
1 M. ba!"eri
1 GBS
1 GBS
1 ne'$lama malignan SSP
1 ne'$lama malignan SSP
1
1 $en;a!i"
$en;a!i" in9e!i
in9e!i lain
lain

 Pening!a"an Ig G dgn Alb%min n'rmal
Pening!a"an Ig G dgn Alb%min n'rmal
1 MS
1 MS
1 S%ba!%" !ler'ing $anen/e$hali"i
1 S%ba!%" !ler'ing $anen/e$hali"i
1 ne%r'i=li
1 ne%r'i=li
1 in9e!i SSP !r'ni!
1 in9e!i SSP !r'ni!
Barne"
Barne" R
R Na"han#
Na"han# ++)#
++)# lini/al
lini/al
lab'ra"'r; Medi/ine
lab'ra"'r; Medi/ine
56
56

 Pening!a"an alb%min indeH d$" "er8adi $d
Pening!a"an alb%min indeH d$" "er8adi $d
1 ggn ir!%lai
1 ggn ir!%lai
1 ggn bl''d brain barrier
1 ggn bl''d brain barrier
1 DM
1 DM
1 SLE $d SSP
1 SLE $d SSP
1 $'line%r'$a"i
1 $'line%r'$a"i
1 er,i!al $'ndil'i
1 er,i!al $'ndil'i
Barne"
Barne" R
R Na"han#
Na"han# ++)#
++)# lini/al
lini/al
Lab'ra"'r; Medi/ine
Lab'ra"'r; Medi/ine
57
57
Pr'"ein ele!"r'9'rei# 'lig'!l'nal band
Pr'"ein ele!"r'9'rei# 'lig'!l'nal band
Pr'"ein ele!"r'9'rei# 'lig'!l'nal band
Pr'"ein ele!"r'9'rei# 'lig'!l'nal band

 Un"%! mende"e!i 'lig'!l'nal band mengg%na!an agar'e gel
Un"%! mende"e!i 'lig'!l'nal band mengg%na!an agar'e gel
ele!"r'9erei
ele!"r'9erei

 Ele!"r'9'rei da$a" dig%na!an %n"%!
Ele!"r'9'rei da$a" dig%na!an %n"%!
mende"e!i
mende"e!i 3e,al%ai4
3e,al%ai4 1
1 in9e!i
in9e!i ,ir%
,ir% &
& ba!"eri
ba!"eri
1 "%m'r SSP
1 "%m'r SSP
1 diagn'i MS
1 diagn'i MS

 Olig'!l'nal band :Im%n'gl'b%lin abn'rm
Olig'!l'nal band :Im%n'gl'b%lin abn'rmal # gel
al # gel "a8am
"a8am
F ering di"em%!an $ada $aien dgn ggn i"em
F ering di"em%!an $ada $aien dgn ggn i"em im%n "erma%!
im%n "erma%!
I
I

 Penin
Pening!a"an gamma gl'b%lin &
g!a"an gamma gl'b%lin & 'lig'!l'nal band
'lig'!l'nal band
1
1 M
MS
S 1
1 b
b%
%r
r!
!i
i"
" l
li
im
m9
9'
'm
ma
a
1 n
1 ne
e%
%r
r'
'
i
i=
=l
li
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 1
1 
%
%b
ba
a!
!%
%" 
" !
!l
le
er
r'
'
i
in
ng
g $
$a
an
ne
en
n
e
e9
9a
al
li
i"
"i
i

1
1 G
GB
BS
S 1
1 m
me
en
ni
in
ng
gi
i"
"i
i
 b
ba
a!
!"
"e
er
ri
i &
& ,
,i
ir
r%
%

1 AIDS
1 AIDS
Barne" R na"han# ++)# lini/al Lab'ra"'r;
Barne" R na"han# ++)# lini/al Lab'ra"'r;
Medi/ine
Medi/ine
58
58
'nnie R mah'n# ++2# Diagn'"i/
'nnie R mah'n# ++2# Diagn'"i/
Mi/r'bi'l'g;
Mi/r'bi'l'g;
59
59
Pemeri!aan !l'rida
Pemeri!aan !l'rida
Pemeri!aan !l'rida
Pemeri!aan !l'rida

 Kadar $d LS di$engar%hi 'leh !adar dlm darah
Kadar $d LS di$engar%hi 'leh !adar dlm darah

 P
Pemeri!aan ini anga" b
emeri!aan ini anga" berman9aa" bg $en%n8ang
erman9aa" bg $en%n8ang
dH. Meningi"i
dH. Meningi"i
1 M. A!%" F !adar l W 3@ 26+ mg 74
1 M. A!%" F !adar l W 3@ 26+ mg 74
1 M. TB F !adar l W 3@ 2++ mg 74
1 M. TB F !adar l W 3@ 2++ mg 74

 Kadar l n'rmal di"em%!an $ada :
Kadar l n'rmal di"em%!an $ada :
1$eradangan e"em$a"
1$eradangan e"em$a"
1n'n ba!"eri
1n'n ba!"eri
1$'li'mieli"i
1$'li'mieli"i
1ne%r'l%e
1ne%r'l%e
1"%m'r '"a!
1"%m'r '"a!
Barne"
Barne" R
R Na"han#
Na"han# ++)#
++)# lini/al
lini/al
Lab'ra"'r; Medi/ine
Lab'ra"'r; Medi/ine
60
60
P
Pemeri!aan
emeri!aan Gl%"amin
Gl%"amin
P
Pemeri!aan
emeri!aan Gl%"amin
Gl%"amin

 Gl%"amin diin"ea dari am'nia & X !e"' gl%"ara"
Gl%"amin diin"ea dari am'nia & X !e"' gl%"ara"

 Gl%"amin 34  menanda!an adan;a %a"%
Gl%"amin 34  menanda!an adan;a %a"%
me!anime %n"%! men;ing!ir!an am'nia
me!anime %n"%! men;ing!ir!an am'nia
3 $r'd%! ia me"ab'li! ;g "'!i!4
3 $r'd%! ia me"ab'li! ;g "'!i!4

 Pening!
Pening!a"an gl%"amin $ada
a"an gl%"amin $ada :
:
◦
◦ e$a"i! ene9al'$a"i
e$a"i! ene9al'$a"i
◦
◦ Sindr'm Re;eY
Sindr'm Re;eY

 Kadar ? 50mg<dl da$a" menimb%l!an ggn
Kadar ? 50mg<dl da$a" menimb%l!an ggn
!eadaran
!eadaran
Barne"
Barne" R
R Na"han#
Na"han# ++2#
++2# lini/al
lini/al Lab'ra"'r;
Lab'ra"'r;
Medi/ine
Medi/ine
61
61
P
Pemeri!aan Aam
emeri!aan Aam la!"a"
la!"a"
P
Pemeri!aan Aam
emeri!aan Aam la!"a"
la!"a"

 Aam la!"a" ber%mber dari me"ab'lime anaer'b SSP
Aam la!"a" ber%mber dari me"ab'lime anaer'b SSP

 Ker%a!an 8aringan $d SSPF ggn '!igenai F
Ker%a!an 8aringan $d SSPF ggn '!igenai F
$e  aam la!"a"
$e  aam la!"a"


Pening!a"an aam la!"a" da$a" "er8adi $d
Pening!a"an aam la!"a" da$a" "er8adi $d
1 M. ba!"eri
1 M. ba!"eri
1 T%m'r<abe
1 T%m'r<abe
1 in9ar!<i!emi!
1 in9ar!<i!emi!
1 "ra%ma erebri
1 "ra%ma erebri F $r'gn'
F $r'gn'e 8ele!
e 8ele!
1 !e8ang
1 !e8ang
Bernard
Bernard J
J enr;#
enr;# ++2#
++2# lini/al
lini/al Diagn'i
Diagn'i
 and
and Managemen"
Managemen" b;
b;
Lab'ra"'r; Me"h'd
Lab'ra"'r; Me"h'd
62
62
P
Pemeri!aan
emeri!aan LD
LD
P
Pemeri!aan
emeri!aan LD
LD
3La!"a" dehidr'genae i'en;m4
3La!"a" dehidr'genae i'en;m4
3La!"a" dehidr'genae i'en;m4
3La!"a" dehidr'genae i'en;m4

 LD beraal dari
LD beraal dari
1 di9%i mll bl''d brain
1 di9%i mll bl''d brain barrier3BBB4
barrier3BBB4
1 a!"i="a el 3
1 a!"i="a el 3 le!'
le!'i"# ba!"eri# "%m'r4
i"# ba!"eri# "%m'r4

 Pe LD a!iba" dari !er%a!an BBB
Pe LD a!iba" dari !er%a!an BBB
di"em%!an $ada
di"em%!an $ada
1 M.ba!"eri
1 M.ba!"eri
1 M. ,ir% F elal% dii!%"i 'l. Ene9ali"i F$r'gn'e
1 M. ,ir% F elal% dii!%"i 'l. Ene9ali"i F$r'gn'e
8ele!
8ele!
1 mai9 /erebr',a!%lar a//iden"
1 mai9 /erebr',a!%lar a//iden"
1
1 le%!em
le%!emia<lim9'ma
ia<lim9'ma
1 me"a"a"i! a
1 me"a"a"i! a
'nnie
'nnie R
R Mah'n#
Mah'n# ++2#
++2# Diagn'"i/
Diagn'"i/
Mi/r'bi'l'g;
Mi/r'bi'l'g;
63
63
Pe"anda "%m'r $ada SS
Pe"anda "%m'r $ada SS
Pe"anda "%m'r $ada SS
Pe"anda "%m'r $ada SS
=
=e
e
i
is
s '
'
 B
Bi
ia
a)
)
(
(s
si
is
s 
i
il
la
ai
i 
(
(r
rm
ma
al
l
.D'
.D'
alfa fet(pr(tei:
alfa fet(pr(tei:
Bis)ermi(ma$
Bis)ermi(ma$
mei)eal Ca
mei)eal Ca
- 1$5 m)/mL
- 1$5 m)/mL
>
>e
et
ta )
a )l,
l,
,r
,r(
(
i
id
das
ase
e !
!A
Ae
e
i
i)
)ea
eal
l
ade(karsi(ma
ade(karsi(ma
!mel(%lastik
!mel(%lastik
le,kemia ak,t
le,kemia ak,t
- 49 m/L
- 49 m/L
- 70 m/L
- 70 m/L
Cari(em%r(ik
Cari(em%r(ik
.) C?.:
.) C?.:
Aei)eal
Aei)eal
ari(mat(sis
ari(mat(sis
-0$6 m)/ml
-0$6 m)/ml
"C Aem%edaka
"C Aem%edaka
dis)ermi(ma/mars
dis)ermi(ma/mars
i(ma
i(ma
-0$21/L
-0$21/L
64
64
Barne" R Na"han# ++)# lini/al Lab'ra"'r; Medi/ine
Barne" R Na"han# ++)# lini/al Lab'ra"'r; Medi/ine
P
Pemeri!aan
emeri!aan Ba!"eri'l'gi
Ba!"eri'l'gi
P
Pemeri!aan
emeri!aan Ba!"eri'l'gi
Ba!"eri'l'gi

 P
Penge/a"an gram # TT# Z
enge/a"an gram # TT# Zeihl NeelenF
eihl NeelenF dilan8%"!an
dilan8%"!an
dgn K%l"%r LS
dgn K%l"%r LS

 P
Pemeri!aan Ag $ei=! %n
emeri!aan Ag $ei=! %n"%! ba!"eri
"%! ba!"eri
Ag e%ai "i$e
Ag e%ai "i$e !%man
!%man
1IE 3/'%n"erim%ne
1IE 3/'%n"erim%ne ele!"'9'rei
ele!"'9'rei4
4
1 la"eH agl%"ina"i'n 3lebih eni"i9 dr IE4
1 la"eH agl%"ina"i'n 3lebih eni"i9 dr IE4

 Lim%l% l;a"e :
Lim%l% l;a"e :
%n"%! mende"e!i end'"'!in ba!"eri dgn
%n"%! mende"e!i end'"'!in ba!"eri dgn
mengg%na!an lia" dr !e$i"ing Fend'"'!in 34 F
mengg%na!an lia" dr !e$i"ing Fend'"'!in 34 F
a!an memben"%! gel
a!an memben"%! gel
"er%"ama %n. Ba!"eri gram 314
"er%"ama %n. Ba!"eri gram 314
3)++ 7 eni"i94
3)++ 7 eni"i94
Barne"
Barne" R
R Na"han#
Na"han# ++)#
++)# lini/al
lini/al
Lab'ra"'r; Medi/ine
Lab'ra"'r; Medi/ine
65
65
PR 3$'limerae /hain rea/"i'n< DNA am$li=/a"i'n4
PR 3$'limerae /hain rea/"i'n< DNA am$li=/a"i'n4

 Sanga" eni"i9 dan $ei=! %n"! mende"e!i DNA dari
Sanga" eni"i9 dan $ei=! %n"! mende"e!i DNA dari
ba!"eri #!%man TB dan ,ir%
ba!"eri #!%man TB dan ,ir%

 P
Pemeri!an menda$a"!an hail dlm
emeri!an menda$a"!an hail dlm a!"% ing!a"
a!"% ing!a"

 Mende"e!i an"ib'di # gen'm mi!r'ba dan "'!in $ei=!
Mende"e!i an"ib'di # gen'm mi!r'ba dan "'!in $ei=!

 Memerl%!an 8%mlah LS 8a%h
Memerl%!an 8%mlah LS 8a%h lebih edi!i" dibanding!an
lebih edi!i" dibanding!an
!%l"%r
!%l"%r
Barne" R Na"han# ++)# lini/al Lab'ra"'r;
Barne" R Na"han# ++)# lini/al Lab'ra"'r;
Medi/ine
Medi/ine
66
66
P
Pemeri!aan
emeri!aan Jam%r
Jam%r
P
Pemeri!aan
emeri!aan Jam%r
Jam%r

 India In! "ain
India In! "ain
1 %n"%! membeda!an 8am%r /r;$"'/'//% den el
1 %n"%! membeda!an 8am%r /r;$"'/'//% den el
m'n'n%!lear
m'n'n%!lear
1 8am%r "am$a! berhal'
1 8am%r "am$a! berhal'
1 eni"i="a 0+1*+ 7
1 eni"i="a 0+1*+ 7

 r;$"'/'//al An"igen aa; 3RAG4
r;$"'/'//al An"igen aa; 3RAG4
1 lebih eni"i9 dari
1 lebih eni"i9 dari India In! "ain # nam%n lebih lama
India In! "ain # nam%n lebih lama
1
1 mende"e!i
mende"e!i "i"er
"i"er "hd
"hd Ag
Ag /r;$"'/'//%
/r;$"'/'//%
1 "i"er ): 6 3
1 "i"er ): 6 3 %$e/"ed /ae4
%$e/"ed /ae4
1 AIDS 3"i"er ):)+- <d ):)+.+++4
1 AIDS 3"i"er ):)+- <d ):)+.+++4
Bernard
Bernard J
J enr;#
enr;# ++2#
++2# lini/al
lini/al Diagn'i
Diagn'i and
and Managemen"
Managemen" b;
b;
Lab'ra"'r; Me"h'd
Lab'ra"'r; Me"h'd
67
67
P
Pemeri!aan
emeri!aan er'l'gi i=li
er'l'gi i=li
Pemeri!aan er'l'gi i=li
Pemeri!aan er'l'gi i=li

T
Te er'l'gi
e er'l'gi
1 n'n $ei=! 3DRL4
1 n'n $ei=! 3DRL4
1 $ei=! "re$'nema an"ib'di 3 TPA# T1ABS4
1 $ei=! "re$'nema an"ib'di 3 TPA# T1ABS4

T
Te DRL $d LS di!
e DRL $d LS di!er8a!an bila DRL er%m 34
er8a!an bila DRL er%m 34

DRL "ida! dig%na!an %n"%! 9'll' %$ "era$i
DRL "ida! dig%na!an %n"%! 9'll' %$ "era$i

ale 34 a!%" : 1 in9e!i a!%" ba!"eri & ,ir%
ale 34 a!%" : 1 in9e!i a!%" ba!"eri & ,ir%


ale 34
ale 34 !r'ni! : SLE# "ir'idi"i# hem'li"i!
!r'ni! : SLE# "ir'idi"i# hem'li"i! anemia
anemia
'nnie
'nnie R
R Mah'n#
Mah'n# ++2#
++2# Diagn'"i/
Diagn'"i/ Mi/r'bi'l'g;
Mi/r'bi'l'g;
68
68
69
69
.eni!armila.bl'g$'"./'m
.eni!armila.bl'g$'"./'m
.eni!armila.bl'g$'"./'m
.eni!armila.bl'g$'"./'m
70
70
DAT
DATAR
AR PU
PUST
STAKA
AKA
DATAR PUSTAKA
DATAR PUSTAKA

 Bernar
Bernard
d J
J enr;#
enr;# ++2#
++2# lini/al
lini/al Diagn'i
Diagn'i and
and
Managemen"
Managemen" b;
b; Lab'ra"'r;
Lab'ra"'r; Me"h'd
Me"h'd 6
6"h
"h edi"i'n #
edi"i'n #
ha$"er )> $age.-+51-)0.
ha$"er )> $age.-+51-)0.

 Barne" R
Barne" R. Na"han# ++)#
. Na"han# ++)# lini/al Lab'ra"'r; Medi/ine
lini/al Lab'ra"'r; Medi/ine
L. ha$"er 2# $age 0))10>.
L. ha$"er 2# $age 0))10>.

 'nnei R Mah'n# ++2# TeHb''! '9 Diagn'"i/
'nnei R Mah'n# ++2# TeHb''! '9 Diagn'"i/
Mi/r'bi'l'g;
Mi/r'bi'l'g;#"hird edi"i'n# /
#"hird edi"i'n# /ha$"er 50#$age >6+1>>-.
ha$"er 50#$age >6+1>>-.

 Da,id L 9el"en# +)+# Ne""erY A"la '9 Ne%r'/ien/e
Da,id L 9el"en# +)+# Ne""erY A"la '9 Ne%r'/ien/e
nd Edi"i'n# anada
nd Edi"i'n# anada

 Eri/ R Kandel# ++2# Prin/i$le '9 Ne%ral S/ien/e#
Eri/ R Kandel# ++2# Prin/i$le '9 Ne%ral S/ien/e#
9'%r"h Ed"i'n. M/ Gra ill# $age )661)5++.
9'%r"h Ed"i'n. M/ Gra ill# $age )661)5++.

 Ra;m'nd Adam# )>>6# Prin/i$le '9 ne%r'l'g;# iH"h
Ra;m'nd Adam# )>>6# Prin/i$le '9 ne%r'l'g;# iH"h
Edi"i'n# /ha$"er # $age )1)*.
Edi"i'n# /ha$"er # $age )1)*.
TERIMA K
TERIMA KASI
ASI
72
72
K
K're!
're!i
i B
B 

B 'b B added
B 'b B added
B added 
B added 
 bld H RB /9
 bld H RB /9
RB
RB bld
bld
73
73
74
74
75
75
76
76
77
77

Ser'l'gi & mi!r'bi'l'gi3n'rmal SS4
Ser'l'gi & mi!r'bi'l'gi3n'rmal SS4
DRL
DRL :
: nega"i9
nega"i9
B
Ba
a!
!"
"e
er
ri
i :
: "
"i
id
da
a!
! a
ad
da
a

i
ir
r%
%
 :
: "
"i
id
da
a!
! a
ad
da
a
I
In
nd
de
e!
!
 a
an
n"
"i
ib
b'
'd
di
i :
: ?
?)
)#
#0
0 3
3$
$r
r'
'
e
e

inammai !r'ni!4
inammai !r'ni!4
@
@ +#-
+#- 3m%ng!in
3m%ng!in b%!an
b%!an
$r'e inamai
$r'e inamai
a!%"4
a!%"4
78
78
ara Pemeri!aan Mi!r'!'$i!
ara Pemeri!aan Mi!r'!'$i!
ara Pemeri!aan Mi!r'!'$i!
ara Pemeri!aan Mi!r'!'$i!

 Pemeri!aan dila!%!an egera 3#5+ meni"4'!
Pemeri!aan dila!%!an egera 3#5+ meni"4'!
1
1 D$" menimb%l!an i"'lii
D$" menimb%l!an i"'lii
1
1 Sel mengenda$ hg %li" %n"%! menda$a" LS
Sel mengenda$ hg %li" %n"%! menda$a" LS
h'm'gen
h'm'gen
1
1 Sel "er$erang!a$ dlm $eli!el
Sel "er$erang!a$ dlm $eli!el
1
1 Sel mengalami $er%bahan ben"%!
Sel mengalami $er%bahan ben"%!

 Ala" & reagen
Ala" & reagen
) $i$e" $engen/er "h'ma
) $i$e" $engen/er "h'ma

 reagen
reagen :
: "%r!
"%r! r'en"hal
r'en"hal
5 !amar hi"%ng : %/h1 r'en"hal
5 !amar hi"%ng : %/h1 r'en"hal
Im$r',eed
Im$r',eed Ne%ba%er
Ne%ba%er
79
79

 Pr'ed%r !er8a
Pr'ed%r !er8a
LS di!'/'!F h'm'gen
LS di!'/'!F h'm'gen
ia$ reagen F !md hia$ LS F$engen/eran )+<>
ia$ reagen F !md hia$ LS F$engen/eran )+<>
!'/'!
!'/'! lm
lm 5mn"
5mn" F
F "ega! l%r%
"ega! l%r% %mb%
%mb% $i$e"
$i$e"
"iga "e"e $er"ama dib%ang '! "di i!%" $engen/eran
"iga "e"e $er"ama dib%ang '! "di i!%" $engen/eran
"e"e!an dalam !amar hi"%ng Fbiar!an 0 mn"
"e"e!an dalam !amar hi"%ng Fbiar!an 0 mn"
hi"%ng el
hi"%ng el
r%m% : )<5 N el <mm5 3R4
r%m% : )<5 N el <mm5 3R4
0<-
0<- N
N el<mm5
el<mm5 3IN4
3IN4
80
80
Collooidal Gold Reaction
Collooidal Gold Reaction
Collooidal Gold Reaction
Collooidal Gold Reaction

 Berdaar!
Berdaar!an "e $rei$i"ai %$eni
an "e $rei$i"ai %$eni dgn g'ld /'l'idal
dgn g'ld /'l'idal
$ada )+ erial $engen/eran 3del%"i'n4
$ada )+ erial $engen/eran 3del%"i'n4
):+ am$ai ):0.)+
):+ am$ai ):0.)+

 In"er$re"ai :
In"er$re"ai :
◦
◦ + : "d! ada $er%b.arna
+ : "d! ada $er%b.arna
◦
◦ )
) : $
: $er%
er%b.
b.d!"
d!" 3me
3merah
rah gel
gela$4
a$4
◦
◦

 :
: L
Li
il
la
a/
/
◦
◦ 5
5 :
: B
Bi
ir
r%
%
◦
◦ -
- : Bi
: Bir%
r% $
$r
re
ei$
i$i"a
i"ai
i
◦
◦ 0
0 : 8er
: 8ernih  !
nih  !'m$
'm$li" $r
li" $rei
ei$i"a
$i"ai
i

 Pr
Prei$i"ai "g"
ei$i"ai "g" 8ml gl'b%lin dan alb%min
8ml gl'b%lin dan alb%min
81
81

 In"er$re"ai :
In"er$re"ai :
N'rmal : "ida! ada $er%bahan arna
N'rmal : "ida! ada $er%bahan arna
!%r,a
!%r,a :
: da"ar
da"ar 3++++++++++4
3++++++++++4
Abn'rmal !%r,a
Abn'rmal !%r,a
I : $rei$i"ai ma!imal "8d $ada "ab%ng $er"ama
I : $rei$i"ai ma!imal "8d $ada "ab%ng $er"ama
mi. 0000--5)+
mi. 0000--5)+
II : $rei$i"ai ma!imal $ada "ab%ng "engah
II : $rei$i"ai ma!imal $ada "ab%ng "engah
mi. +)5-0-5+
mi. +)5-0-5+
III : $rei$i"ai ma!imal $ada "ab%ng dgn
III : $rei$i"ai ma!imal $ada "ab%ng dgn
$engen/era
$engen/eran
n "era!hir
"era!hir
mi. ++++))5-0
mi. ++++))5-0
82
82

 In"er$re"ai !%r,a /'l'idal g'ld
In"er$re"ai !%r,a /'l'idal g'ld
I
I :
: $
$e
e 
 
 g
ga
am
mm
ma
a g
gl'
l'b
b%l
%lin
in $
$a
ad
da
a N
Ne
e%r
%r'
'i
i=
=li
li#
# MS
MS#
#
S%ba/%"e $anene9ali"i
S%ba/%"e $anene9ali"i
II
II :
: $e
$e 
 gamma
gamma gl'b%lin
gl'b%lin
III
III :
: $e
$e 
 $r'"ein
$r'"ein 3alb%min?
3alb%min? gl'b%lin4
gl'b%lin4
3!%r,a meningi"i4
3!%r,a meningi"i4
da$a"
da$a" "er8adi $ada:
"er8adi $ada: m.$%r%len
m.$%r%len a!%"#
a!%"# bl'!
bl'! $inal #
$inal #
$erdrhan %bara!n'id
$erdrhan %bara!n'id
83
83
ara Pemeri!aan Pr'"ein
ara Pemeri!aan Pr'"ein
ara Pemeri!aan Pr'"ein
ara Pemeri!aan Pr'"ein
3"'"al $r'"ein<!%an"i"a"i94
3"'"al $r'"ein<!%an"i"a"i94
3"'"al $r'"ein<!%an"i"a"i94
3"'"al $r'"ein<!%an"i"a"i94

 Pr'ed%r !
Pr'ed%r !er8a
er8a :
:
ma%!!an )1 // LS +#6 di"iled a"er //
ma%!!an )1 // LS +#6 di"iled a"er //
SSA 0 7
SSA 0 7
biar!an "ega! elama 0 mn"
biar!an "ega! elama 0 mn"
ba/a dgn !al'rime"er "hd "andar %$. Pr'"ein
ba/a dgn !al'rime"er "hd "andar %$. Pr'"ein
;g "elah di!e"ah%i
;g "elah di!e"ah%i
Bila !adar $r'" "inggi dila!%!an $engen/eran
Bila !adar $r'" "inggi dila!%!an $engen/eran
Perhi"%ngan:
Perhi"%ngan:
mm "andar<mm 3%n!n'n4H 0+  [. Mg
mm "andar<mm 3%n!n'n4H 0+  [. Mg
$r'"<)++// L/
$r'"<)++// L/
84
84
ara Pemeri!aan Gl%!'a
ara Pemeri!aan Gl%!'a
ara Pemeri!aan Gl%!'a
ara Pemeri!aan Gl%!'a

 Pr'ed%r !er8a:
Pr'ed%r !er8a:
1 //
1 // LS
LS egar 
egar  ) ""
) "" 9'rmaldeh;de
9'rmaldeh;de )+ 7
)+ 7
1 im$an dlm re9rigera"'r
1 im$an dlm re9rigera"'r
1 lima
1 lima "ab%ng !e/il#maing1ma
"ab%ng !e/il#maing1maing dii
ing dii lar
lar. Benedi/"
. Benedi/" )//
)//
1 $ana!an 0 mn" F
1 $ana!an 0 mn" F liha" red%!i
liha" red%!i
1 In"er$re"ai:
1 In"er$re"ai:
!elima
!elima "ab%ng 34
"ab%ng 34 :
: 0+
0+ mg7
mg7
"b.
"b. 10 3
10 34
4 :-+10
:-+10+ mg 7
+ mg 7
"a
"ab 5
b 510
10 3
34
4 :5
:5+1
+1-+
-+ mg
mg 7
7
"a
"ab -
b -10
10 3
34
4 : 
: +1
+15+
5+ mg
mg 7
7
"
"a
ab
b 0
0 3
3
4
4 :
: )
)+
+1
1
+
+ m
mg
g 7
7
3
31
14
4 :
: +
+1
1)
)+
+ m
mg
g 7
7
85
85
Pne%m'ene9al'gra= &
Pne%m'ene9al'gra= &
Pne%m'ene9al'gra= &
Pne%m'ene9al'gra= &
en"ri!%l'gra=
en"ri!%l'gra=
en"ri!%l'gra=
en"ri!%l'gra=

 Udara dima%!!an !e dalam r.%bara!n'id dan !e dlm
Udara dima%!!an !e dalam r.%bara!n'id dan !e dlm
%%nan
%%nan ,en"ri!
,en"ri!el
el melal%i
melal%i $%ngi
$%ngi

 Pne%m'ene9al'gra= : !'n"raindi!
Pne%m'ene9al'gra= : !'n"raindi!ai $d
ai $d TIK
TIK 


 T
Te!ni! Pne%m'ene9al'gra=:
e!ni! Pne%m'ene9al'gra=:
1 LP
1 LP F !md
F !md $H d%d%!#
$H d%d%!# !e$ala
!e$ala d!" e!i
d!" e!i Fma%!!an
Fma%!!an
%dara
%dara !e
!e r
r.%bar
.%bara!n'id
a!n'id
1 b%a"
1 b%a" 9'"' !e$ala3AP<La"4
9'"' !e$ala3AP<La"4
1 bila
1 bila "ern;a"a
"ern;a"a ,en"ri!el
,en"ri!el "erii %dara
"erii %dara F biar!
F biar!an LS
an LS
mene"e !el%ar
mene"e !el%ar
1 e"ia$ )+ // LS F ma%!!an )+ // %dara# e
1 e"ia$ )+ // LS F ma%!!an )+ // %dara# el%r%hn;a
l%r%hn;a
+15+ //
+15+ //
1 bila "ern;a"a ,en" %dara
1 bila "ern;a"a ,en" %dara 314 F!e$ala di%bah
314 F!e$ala di%bah
e!i<e!"eni
e!i<e!"eni Fma%!!an
Fma%!!an %dara
%dara )+
)+ //
// F
F b%a"
b%a" 9'"'
9'"'
86
86

 en"ri!%l'gra=
en"ri!%l'gra=
di!er8
di!er8a!an
a!an %n"%!
%n"%! mende"e!i
mende"e!i "%m'r i
"%m'r in"ra!ranial
n"ra!ranial

 T
Te!ni! :
e!ni! :
b%a" e$aang l%bang di daerah $arie"''!i$i"al
b%a" e$aang l%bang di daerah $arie"''!i$i"al
ma%!!an 8ar%m am$ai di
ma%!!an 8ar%m am$ai di !'r
!'rn% '!i$i"al ,en"
n% '!i$i"al ,en" la" !i<!a
la" !i<!a
ma%!!an
ma%!!an )+ //
)+ // %dara mll
%dara mll ,en" !
,en" !anan F LS me
anan F LS mene"e
ne"e
!md ma%!!an )+ // %dara $d ,en" !iri
!md ma%!!an )+ // %dara $d ,en" !iri
el%r%hn;a +15+ // %dara
el%r%hn;a +15+ // %dara

 Penilaian :
Penilaian :
elal% "am$a! ,en"ri!el "erii %dara &
elal% "am$a! ,en"ri!el "erii %dara & li!
li!%'r
%'r
%dara diebelah a"a#li!%'r bag. Baah
%dara diebelah a"a#li!%'r bag. Baah
$r';e!i
$r';e!i APF
APF !%$%1!%$%
!%$%1!%$%
$r';e!i PA F b%r%ng "erbang
$r';e!i PA F b%r%ng "erbang
$r';e!i h'ri'n"al F "am$a!gari h'ri'n"al
$r';e!i h'ri'n"al F "am$a!gari h'ri'n"al
$r';e!i
$r';e!i la"
la" DS<SD
DS<SD F
F "am$a!
"am$a! ,en"ri!el
,en"ri!el
87
87
88
88
89
89
90
90
91
91
T
Te Q%e/!
e Q%e/!en"ed"
en"ed"
T
Te Q%e/!
e Q%e/!en"ed"
en"ed"
92
92
.heal"h/en"er./'m
.heal"h/en"er./'m
P%ngi ,en"ri!el
P%ngi ,en"ri!el
P%ngi ,en"ri!el
P%ngi ,en"ri!el
93
93
.heal"h/en"er./'m
.heal"h/en"er./'m
P%ngi %b'!i$i"al
P%ngi %b'!i$i"al
P%ngi %b'!i$i"al
P%ngi %b'!i$i"al
94
94
.heal"h/en"er./'m
.heal"h/en"er./'m
Da,id
Da,id L
L 
al"en#
al"en# +)+#
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Ne""erY A"la
A"la '9
'9
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Da,id L al"en# +)+# Ne""erY A"la '9
Ne%r'/ien/e
Ne%r'/ien/e
Ne%r'/ien/e
Ne%r'/ien/e
95
95
96
96
S%b'//i$i"al P%n!i
S%b'//i$i"al P%n!i
S%b'//i$i"al P%n!i
S%b'//i$i"al P%n!i

Ma%!!an 8ar%m !edalam /i"erna
Ma%!!an 8ar%m !edalam /i"erna
magna dgn men%%!!an 8ar%m di
magna dgn men%%!!an 8ar%m di
an"ara  ) & ' '//i$i"al
an"ara  ) & ' '//i$i"al

Ki"a la!%!
Ki"a la!%!an $ada
an $ada miel'gra$h;
miel'gra$h;
dgn mengg%na!an /airan !'n"ra
dgn mengg%na!an /airan !'n"ra
;ang lebih bera".
;ang lebih bera".
arne" R Na"han# lini/al
arne" R Na"han# lini/al
Lab'ra"'r;Medi/in
Lab'ra"'r;Medi/in
97
97
en"ri/%lar P%n!i
en"ri/%lar P%n!i
en"ri/%lar P%n!i
en"ri/%lar P%n!i

Sanga" 8arang# "a$i da$a" diindi!ai!an
Sanga" 8arang# "a$i da$a" diindi!ai!an
$ada $H dgn herniai '"a!. Dila!%!an di
$ada $H dgn herniai '"a!. Dila!%!an di
OK. L%bang diben"%! dgn
OK. L%bang diben"%! dgn memb'r
memb'r
/al,aria & 8ar%m lang%ng dima%!!an
/al,aria & 8ar%m lang%ng dima%!!an
!e dalam ,en"ri/le.
!e dalam ,en"ri/le.

Pr'ed%r $eng%m$%lan S e$er"i
Pr'ed%r $eng%m$%lan S e$er"i
$ada $r'ed%re $emaangan P 1
$ada $r'ed%re $emaangan P 1
Sh%n".
Sh%n".
Ra;m'nd Adam# )>>6# Prin/i$le '9
Ra;m'nd Adam# )>>6# Prin/i$le '9
Ne%r'l'g;
Ne%r'l'g;
98
98
ndikasi Lu"$al Punksi(
ndikasi Lu"$al Punksi(
ndikasi Lu"$al Punksi(
ndikasi Lu"$al Punksi(
•
• Un"%! menge"ah%i "e!anan dan
Un"%! menge"ah%i "e!anan dan
mengambil am$el %n"%! $emeri!an
mengambil am$el %n"%! $emeri!an
el# !imia dan ba!"eri'l'gi
el# !imia dan ba!"eri'l'gi
•
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Un"%! memban"% $eng'ba"an melal%i
$inal# $emberian an"ibi'"i!a# an"i
$inal# $emberian an"ibi'"i!a# an"i
"%m'r dan $inal ana"ei
"%m'r dan $inal ana"ei
•
• Un"%! memban"% diagn'a
Un"%! memban"% diagn'a dengan
dengan
$en;%n"i!an %dara $ada
$en;%n"i!an %dara $ada
$ne%m'en/e$hal'gra=# dan a"
$ne%m'en/e$hal'gra=# dan a"
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!'n"ra $ada m;el'gra=
Eri/
Eri/ R
R Kandel#
Kandel# ++2#
++2# Prin/i$le
Prin/i$le '9
'9 Ne%ral
Ne%ral
S/ien/e
S/ien/e
99
99
Kontra ndikasi Lu"$al
Kontra ndikasi Lu"$al
Kontra ndikasi Lu"$al
Kontra ndikasi Lu"$al
Punski(
Punski(
Punski(
Punski(
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Adan;a $eninggian "e!anan in"ra
Adan;a $eninggian "e!anan in"ra
!ranial dengan "anda1"anda n;eri
!ranial dengan "anda1"anda n;eri
!e$ala# m%n"ah dan $a$il edema
!e$ala# m%n"ah dan $a$il edema

Pen;a!i" ggn 9aal hem'"a"i! ;ang
Pen;a!i" ggn 9aal hem'"a"i! ;ang
bera"
bera"
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Ada in9e!i l'!al $ada "em$a" L%mbal
Ada in9e!i l'!al $ada "em$a" L%mbal
P%n!i
P%n!i
Eri/ R Kandel# ++2# Prin/i$le '9
Eri/ R Kandel# ++2# Prin/i$le '9 Ne%ral
Ne%ral
S/ien/e
S/ien/e
100
100
eknik Lu"$al Punksi(
eknik Lu"$al Punksi(
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ekni
eknik
k Lu"$
Lu"$al
al Punk
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Paien $ada $inggir "em$a" "id%r#
dalam $'ii la"eral de/%bi"%
dalam $'ii la"eral de/%bi"% 
 leher#
leher#
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$%ngg%ng# $ingg%l dan "%mi" lema.
•
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P%ngi $ada /elah !'l%mna ,e"ebrali
e"inggi L 51- 3/ri"a ilia/a4.
e"inggi L 51- 3/ri"a ilia/a4. 
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"ida!
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berhail di/'ba !e a"a a"a% !e baah.
Pada ba;i dan ana! e"inggi
Pada ba;i dan ana! e"inggi
in"er,er"ebrale L-10
in"er,er"ebrale L-10
Eri/
Eri/ R
R Kandel#
Kandel# ++2#
++2# Prin/i$le
Prin/i$le '9
'9 Ne%ral
Ne%ral
S/ien/e
S/ien/e
101
101
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Berih!an dengan ;'di%m dan
Berih!an dengan ;'di%m dan
al!
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;ang a!an di$%ngi#
ana"hei l'!al lid'/ain L
ana"hei l'!al lid'/ain L
•
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"angan# 8ar%m
8ar%m "eril
"eril 
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la!
la!%!an $%n!i#
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ma%!!an 8ar%m
"ega! l%r% arah %mbili!%
"ega! l%r% arah %mbili!%
•
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Bila "elah menemb% 8aringan
meningen $en%%!an dihen"i!an.
meningen $en%%!an dihen"i!an.
Eri/ R Kandel# ++2# Prin/i$le '9
Eri/ R Kandel# ++2# Prin/i$le '9
Ne%ral S/ien/e
Ne%ral S/ien/e
102
102
•
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Bila di$erl%!an da$a" dila!%!an
$emeri!aan "e!anan dengan
$emeri!aan "e!anan dengan
man'me"er 3"e" Q%e/!en"ed"4
man'me"er 3"e" Q%e/!en"ed"4
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Kem%dian ambil am$el %n"%!
$emeri!aan 8%mlah dan 8eni el#
$emeri!aan 8%mlah dan 8eni el#
!adar g%la# $r'"ein# !%l"%r ba!"eri
!adar g%la# $r'"ein# !%l"%r ba!"eri
dan ebagain;a.
dan ebagain;a.
Eri/
Eri/ R
R Kandel#
Kandel# ++2#
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103
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pdf-pemeriksaan-amp-interpretasi-lcs_compress.pdf

  • 1. Seminar Seminar Seminar Seminar PEMERIKSAAN & INTERPRETASI PEMERIKSAAN & INTERPRETASI PEMERIKSAAN & INTERPRETASI PEMERIKSAAN & INTERPRETASI LIQUOR SEREBROSPINALIS LIQUOR SEREBROSPINALIS LIQUOR SEREBROSPINALIS LIQUOR SEREBROSPINALIS Oleh : Oleh : Putu Sukarini Putu Sukarini Pembimbing : Pembimbing : dr dr. . Dea! Dea! K" K" Indraari Indraari U"ami# U"ami# S$.S S$.S 1 1
  • 2. Pendah%l%an Pendah%l%an Pendah%l%an Pendah%l%an • •  'l%me in"ra!ranial 'l%me in"ra!ranial ( )*++ ( )*++ ml "dd : ml "dd : ). ).,'l%me '"a! ( )-++ ml ,'l%me '"a! ( )-++ ml . .,'l%me /airan ,'l%me /airan erebr erebr'$inal 01)2 '$inal 01)2 ml 3ra"a1ra"a )+- ml4 ml 3ra"a1ra"a )+- ml4 5. 5.darah e!i"ar )0+ ml. darah e!i"ar )0+ ml. • • 6+7 dari 8aringan '"a! "erdiri dari 6+7 dari 8aringan '"a! "erdiri dari /airan# bai! e!"rael ma%$%n in"ra /airan# bai! e!"rael ma%$%n in"ra el. el. Eri/ Eri/ R R Kandel# Kandel# ++2# ++2# $rin/i$le $rin/i$le '9 '9 ne%ral /ien/e ne%ral /ien/e 2 2
  • 3.  airan erebr'$inal di$r'd%!i eban;a! airan erebr'$inal di$r'd%!i eban;a! +#50 ml<meni" a"a% 0++ ml<hari# edang!an +#50 ml<meni" a"a% 0++ ml<hari# edang!an "'"al ,'l%me /airan erebr'$inal ber!iar "'"al ,'l%me /airan erebr'$inal ber!iar *01)0+ ml# digan"i -10 !ali<hari %n"%! *01)0+ ml# digan"i -10 !ali<hari %n"%! mem$er"ahan!an 8%mlah /airan mem$er"ahan!an 8%mlah /airan erebr erebr'$inal "e"a$ '$inal "e"a$ . .  Mer%$a!an %a"% !egia"an dinami# ber%$a Mer%$a!an %a"% !egia"an dinami# ber%$a $emben"%!an# ir! $emben"%!an# ir!%lai dan %lai dan ab'r$i. ab'r$i. Eri/ R Kandel# ++2# Prin/i$le '9 Ne%ral S/ien/e Eri/ R Kandel# ++2# Prin/i$le '9 Ne%ral S/ien/e 3 3
  • 4. P Pemben"% emben"%!an# Sir!%lai dan !an# Sir!%lai dan P Pemben" emben"%!an# Sir!%lai dan %!an# Sir!%lai dan Ab'r$i airan Ab'r$i airan Ab'r$i airan Ab'r$i airan Serebr'$inal 3SS4 Serebr'$inal 3SS4 Serebr'$inal 3SS4 Serebr'$inal 3SS4 • • Diben"%! Diben"%! 'leh 'leh $le!% $le!% !h'r'ide% !h'r'ide% : : $emb%l%h darah !a$iler dengan $emb%l%h darah !a$iler dengan 9ene"ra"a di!elilingi 'leh e$i"el !%b'id 9ene"ra"a di!elilingi 'leh e$i"el !%b'id mer%$a!an m'di=!ai dari el mer%$a!an m'di=!ai dari el e$endim# ;ang e$endim# ;ang men'n8'l !e ,en"ri! men'n8'l !e ,en"ri!el. el. • • Ple!% !h'r'ide% memben"%! l'b%l1 Ple!% !h'r'ide% memben"%! l'b%l1 l'b%l dan memben"%! e$er"i da%n l'b%l dan memben"%! e$er"i da%n $a!i ;ang di"%"%$i 'leh mi!r',ili dan $a!i ;ang di"%"%$i 'leh mi!r',ili dan ilia. ilia. Ra;m'nd adam# )>>6# Prin/i$le '9 Ra;m'nd adam# )>>6# Prin/i$le '9 Ne%r'l'g; Ne%r'l'g; 4 4
  • 5.  Sel e$i"el !%b'id berh%b%ngan a"% Sel e$i"el !%b'id berh%b%ngan a"% ama lain dengan "ig"h 8%n/"i'n $ada ama lain dengan "ig"h 8%n/"i'n $ada ii a$e!# daar el e$i"el !%b'id ii a$e!# daar el e$i"el !%b'id "erda$a" membran baali dengan "erda$a" membran baali dengan r%ang "r'ma dian"aran;a. r%ang "r'ma dian"aran;a. Ra;m'nd Adam# )>>6# Prin/i$le '9 Ra;m'nd Adam# )>>6# Prin/i$le '9 Ne%r'l'g; Ne%r'l'g; 5 5
  • 6. Eric Eric R R Kandel, Kandel, 2006, 2006, Eric R Kandel, 2006, Eric R Kandel, 2006, Principles of Neural Science Principles of Neural Science Principles of Neural Science Principles of Neural Science 6 6
  • 7. • • Ada  !el'm$'! $le!% ;ang %"ama Ada  !el'm$'! $le!% ;ang %"ama menghail!an SS: menghail!an SS: ). ).Daar "ia$ ,en" Daar "ia$ ,en"ri! ri!el la"eral : el la"eral : $r'd ?? $r'd ?? ban;a! ban;a! . .A"a$ ,en"ri! A"a$ ,en"ri!el III el III dan I : dan I : $r'd @@ $r'd @@ edi!i". edi!i". • • Di$er!ira!an Di$er!ira!an SS SS ;ang ;ang dihail!an dihail!an 'leh 'leh ,en"ri!e ,en"ri!el l la"eral la"eral e!i"ar e!i"ar >07. >07. Eri/ r Kandel# ++2# Prin/i$le '9 Ne%ral Eri/ r Kandel# ++2# Prin/i$le '9 Ne%ral S/ien/e S/ien/e 7 7
  • 8. David David L L Felten, Felten, 2010, 2010, David L Felten, 2010, David L Felten, 2010, Nettes !tlas of Neuroscience Nettes !tlas of Neuroscience Nettes !tlas of Neuroscience Nettes !tlas of Neuroscience 8 8
  • 9. 8 8 Sir!%lai Sir!%lai Sir!%lai Sir!%lai • • SS dari ,en"ri!el la"eral melal%i SS dari ,en"ri!el la"eral melal%i 9'ramen in"er,en"ri!%lar m'nr'e 9'ramen in"er,en"ri!%lar m'nr'e   en"ri!el III# melal%i a%ad%/"% ;l,ii en"ri!el III# melal%i a%ad%/"% ;l,ii   ,en"ri!el I. ,en"ri!el I. • • T Tiga iga b%ah b%ah l%bang l%bang dalam dalam ,en"ri!e ,en"ri!el l I I ;ang "erdiri dari  9'ramen ,en"ri!el ;ang "erdiri dari  9'ramen ,en"ri!el la"eral 39'ramen l%/h!a4 dan 9'ramen la"eral 39'ramen l%/h!a4 dan 9'ramen ,en"ri!%ler medial 39'ramen magendi4 ,en"ri!%ler medial 39'ramen magendi4   mem%ng!in!an SS !el%ar dari mem%ng!in!an SS !el%ar dari i"em ,en"ri!el ma%! !e dalam i"em ,en"ri!el ma%! !e dalam r'ngga %bara!hn'id. r'ngga %bara!hn'id. Eri/ Eri/ R R Kandel# Kandel# ++2# ++2# Prin/i$le Prin/i$le '9 '9 Ne%ral Ne%ral S/ien/e S/ien/e
  • 10. 9 9  SS mengii r'ngga %bara!hn'id SS mengii r'ngga %bara!hn'id mengelilingi med%la $inali mengelilingi med%la $inali am$ai ba"a e!i"ar S# 8%ga am$ai ba"a e!i"ar S# 8%ga mengii !eliling 8aringan '"a!. mengii !eliling 8aringan '"a!. Eri/ Eri/ R R Kandel# Kandel# ++2# ++2# Prin/i$le '9 Ne%ral S/ien/e Prin/i$le '9 Ne%ral S/ien/e
  • 11. 10 10 Ab'rbi Ab'rbi Ab'rbi Ab'rbi  SS mengalir $erlahan men%8% i"erna SS mengalir $erlahan men%8% i"erna baali# i"erna ambien# melal%i baali# i"erna ambien# melal%i a$er"%ra "en"'rial dan bera!hir a$er"%ra "en"'rial dan bera!hir di$erm%!aan a"a dan am$ing erebri di$erm%!aan a"a dan am$ing erebri dimana ebagian bear SS a!an dimana ebagian bear SS a!an diab'r$i melal%i ,illi ara!hn'id diab'r$i melal%i ,illi ara!hn'id 3gran%la Pa//hi'ni4 $ada dinding in% 3gran%la Pa//hi'ni4 $ada dinding in% agi"ali %$eri'r ma%! !e dalam agi"ali %$eri'r ma%! !e dalam aliran darah ,ena dalam in%. aliran darah ,ena dalam in%. Eri/ Eri/ R R Kandel# Kandel# ++2# ++2# Prin/i$le Prin/i$le '9 '9 Ne%ral Ne%ral S/ien/e S/ien/e
  • 12. 11 11  SS 8%ga diera$ di r'ngga SS 8%ga diera$ di r'ngga %bra!hn'id ;ang mengelilingi ba"ang %bra!hn'id ;ang mengelilingi ba"ang '"a! dan med%la $inali 'leh '"a! dan med%la $inali 'leh $emb%l%h darah ;ang "erda$a" $ada $emb%l%h darah ;ang "erda$a" $ada ar%ng<ela$%" ara9 !ranial dan $inal. ar%ng<ela$%" ara9 !ranial dan $inal.   ang ang mem$eng mem$engar%hi ar%hi alirann;a alirann;a adalah: adalah: me"ab'lime '"a!# !e!%a"an me"ab'lime '"a!# !e!%a"an hidr'dinami! aliran darah dan hidr'dinami! aliran darah dan $er%bahan dalam "e!anan 'm'"i! $er%bahan dalam "e!anan 'm'"i! darah. darah. Eri/ Eri/ R R Kandel# Kandel# ++2# ++2# Prin/i$le Prin/i$le '9 '9 Ne%ral Ne%ral S/ien/e S/ien/e
  • 13. 12 12 Ko"posisi dan fun#si Ko"posisi dan fun#si Ko"posisi dan fun#si Ko"posisi dan fun#si cairan sere$rospinal cairan sere$rospinal cairan sere$rospinal cairan sere$rospinal %&SS' %&SS' %&SS' %&SS'  SS ham$ir me;er%$ai %l"ra=l"rai SS ham$ir me;er%$ai %l"ra=l"rai dari $lama darah "a$i berii dari $lama darah "a$i berii !'nen"rai Na# K# bi!arb'na"# $r'"ein# !'nen"rai Na# K# bi!arb'na"# $r'"ein# gl%!'a ;ang lebih !e/il dan gl%!'a ;ang lebih !e/il dan !'nen"rai Mg dan !l'rida ;ang lebih !'nen"rai Mg dan !l'rida ;ang lebih "inggi. Ph SS lebih rendah dari darah. "inggi. Ph SS lebih rendah dari darah. Eri/ R Kandel# ++2# Prin/i$le '9 Ne%ral Eri/ R Kandel# ++2# Prin/i$le '9 Ne%ral S/iene/e S/iene/e
  • 14. 13 13 Fun#si ( Fun#si ( Fun#si ( Fun#si ( ). ). SS men;edia!an !eeimbangan SS men;edia!an !eeimbangan an"ara el1el dalam i"em ara9 an"ara el1el dalam i"em ara9 dengan !'ndii i"emi!. dengan !'ndii i"emi!. . . A!an meng%rangi bera" '"a! dalam A!an meng%rangi bera" '"a! dalam "eng!'ra! dan men;edia!an ban"alan "eng!'ra! dan men;edia!an ban"alan me!ani! %n"%! melind%ngi '"a! dari me!ani! %n"%! melind%ngi '"a! dari "ra%ma ;ang mengenai "%lang "ra%ma ;ang mengenai "%lang "eng!'ra!. "eng!'ra!. Eri/ Eri/ R R Kandel# Kandel# ++2# ++2# Prin/i$le Prin/i$le '9 '9 Ne%ral Ne%ral S/ien/e S/ien/e
  • 15. 14 14 5. 5. Mengalir!an Mengalir!an Cam$ah Cam$ah  e$er"i e$er"i O#la!"a"# dan i'n idr'gen 3'"a! O#la!"a"# dan i'n idr'gen 3'"a! han;a edi!i" i"em lim9a"i!4# dan han;a edi!i" i"em lim9a"i!4# dan "ran$'r $r'd%! 3darah# ba!"eri# ma"eri "ran$'r $r'd%! 3darah# ba!"eri# ma"eri $%r%len<ne!r'"i!4 ;ang a!an diirigai $%r%len<ne!r'"i!4 ;ang a!an diirigai dan di!el%ar!an melal%i ,illi ara!hn'id. dan di!el%ar!an melal%i ,illi ara!hn'id. -. Sal%ran "ran$'r" in"raerebral -. Sal%ran "ran$'r" in"raerebral 3'rm'n 3'rm'n dari dari hi$'=e# hi$'=e# hi$'"halam%4 hi$'"halam%4 da$a" di!el%ar!an !e SS dan da$a" di!el%ar!an !e SS dan "ran$'r"ai !e ii lain melal%i "ran$'r"ai !e ii lain melal%i "ran$'r" in"raerebral. "ran$'r" in"raerebral. Eri/ Eri/ R R Kandel# Kandel# ++2# ++2# Prin/i$le Prin/i$le '9 '9 Ne%ral Ne%ral S/ien/e S/ien/e
  • 16. 15 15 Fun#si ( Fun#si ( Fun#si ( Fun#si ( 0. 0. Mem$er"ahan!an "e!anan Mem$er"ahan!an "e!anan in"ra!ranial 3$eng%rangan SS4 in"ra!ranial 3$eng%rangan SS4   mengalir!ann;a !e l%ar r'ngga mengalir!ann;a !e l%ar r'ngga "eng!'ra!# mem$er/e$a" "eng!'ra!# mem$er/e$a" $engalirann;a melal%i berbagai $engalirann;a melal%i berbagai 9'ramina# hingga men/a$ai in% 9'ramina# hingga men/a$ai in% ,en'%# a"a% ma%! !e dalam ,en'%# a"a% ma%! !e dalam r'ngga %bara!hn'id l%mbal. r'ngga %bara!hn'id l%mbal. Eri/ Eri/ R R Kandel# Kandel# Prin/i$le Prin/i$le '9 '9 Ne%ral Ne%ral S/ien/e S/ien/e
  • 17. 16 16 PEN)!*+L!N &!R!N PEN)!*+L!N &!R!N PEN)!*+L!N &!R!N PEN)!*+L!N &!R!N SERE+R-SPN!L SERE+R-SPN!L SERE+R-SPN!L SERE+R-SPN!L  Dengan /ara L%mbal P%n!i# Si"ernal Dengan /ara L%mbal P%n!i# Si"ernal P%n!i a"a% La"eral er,i/al P%n!i a"a% La"eral er,i/al P%n!i. P%n!i.  L%mbal P%n!i mer%$a!an $r'ed%re L%mbal P%n!i mer%$a!an $r'ed%re ne%r' diagn'"i! ;ang $aling ering ne%r' diagn'"i! ;ang $aling ering dila!%!an# edang!an i"ernal dila!%!an# edang!an i"ernal $%n!i dan la"eral han;a dila!%!an $%n!i dan la"eral han;a dila!%!an 'leh 'rang 'leh 'rang ;ang benar ;ang benar1benar ahli. 1benar ahli. Eri/ Eri/ R R Kandel# Kandel# ++2# ++2# Prin/i$le Prin/i$le '9 '9 Ne%ral Ne%ral /ien/e /ien/e
  • 18. 17 17 PEMERI PEMERIKSA KSAAN LS AN LS PEMER PEMERIKSAAN IKSAAN LS LS T T%8%an LP : %8%an LP : ). Diagn'"i! F - ). Diagn'"i! F - !a"ag'ri ma;'r $en;a!i" !a"ag'ri ma;'r $en;a!i" 1 Meningi"i 1 Meningi"i 1 Per 1 Perdarahan darahan %bara!n'id %bara!n'id 1 Pr'e ! 1 Pr'e !eganaan 3menin eganaan 3meningeal a# geal a# T T%.Me"a"ai4 %.Me"a"ai4 1 Gangg%an a%"'im%n 1 Gangg%an a%"'im%n . Menge"ah%i Te!anan LS Fadan;a . Menge"ah%i Te!anan LS Fadan;a gangg%an aliran LS gangg%an aliran LS Barne" Barne" R R Na"han# Na"han# ++)# ++)# lini/al lini/al
  • 19. Lab'ra"'r; Medi/ine Lab'ra"'r; Medi/ine 18 18 . .. . Mengiden"i=!ai Pen;. berh%b. dengan Mengiden"i=!ai Pen;. berh%b. dengan im%n'gl'b%lin im%n'gl'b%lin 3 3 IgG# IgG# IgA# IgA# IgM4F IgM4F 1ne%r' TB 1ne%r' TB 1ne%r'b'rreli'i 1ne%r'b'rreli'i 1in9e!i '$' 1in9e!i '$'r"%ni" r"%ni"i! i! -. Un"%! mema%!!an ane"ei#'ba"#media -. Un"%! mema%!!an ane"ei#'ba"#media !'n"ra $d PH Radi'l'gi !'n"ra $d PH Radi'l'gi 0. 0. Menge"ah%i Menge"ah%i inde! inde! an"ib'di an"ib'di IgG IgG $d $d re$'n re$'n im%ne dlm NS im%ne dlm NS 2. Mengiden"i=!ai $r'"ein ;g beraal dari '"a! 2. Mengiden"i=!ai $r'"ein ;g beraal dari '"a! 3adan;a ne%r'n $ei=!1en'lae e"elah 3adan;a ne%r'n $ei=!1en'lae e"elah "ra%ma erebral4 "ra%ma erebral4 Barne" R Na"han# ++)# lini/al Lab'ra"'r; Medi/ine Barne" R Na"han# ++)# lini/al Lab'ra"'r; Medi/ine
  • 20. 19 19 Pemeri!aan LS Pemeri!aan LS Pemeri!aan LS Pemeri!aan LS meli$%"i : meli$%"i : meli$%"i : meli$%"i : ) Peng%!%ran "e!anan LS ) Peng%!%ran "e!anan LS  P Ma!r'!'$i!3Penam$a!an %m%m4  P Ma!r'!'$i!3Penam$a!an %m%m4 !e!er%han# $#BJ#arna#edimen#$eli!el !e!er%han# $#BJ#arna#edimen#$eli!el 5 PH Mi!r'!'$i! 5 PH Mi!r'!'$i! 8%mlah el & hi"%ng el 8%mlah el & hi"%ng el ba!"eri'l'gi ba!"eri'l'gi - PH Kimiai - PH Kimiai $r'"ein #gl%!'a# !l'rida LS $r'"ein #gl%!'a# !l'rida LS 0 PH er'l'gi 0 PH er'l'gi 2 PH $e"anda "%m'r $d LS 2 PH $e"anda "%m'r $d LS Barne" Barne" R R Na"han# Na"han# ++)# ++)# lini/al lini/al Lab'ra"'r; Medi/ine Lab'ra"'r; Medi/ine
  • 21. 20 20
  • 22. 21 21 Barne" Barne" R R Na"han# Na"han# ++)# ++)# lini/al lini/al Lab'ra"'r; Lab'ra"'r; Med'/ine Med'/ine Karakteristik L&S de/asa nor"al Karakteristik L&S de/asa nor"al Karakteristik L&S de/asa nor"al Karakteristik L&S de/asa nor"al K Ka ad da ar r L LC CS S R Re el la at ti if f t t/ / p pl la as sm ma a T Te ek ka a a a  7 75 5! !2 20 00 0 m mm m" "2 2# # p p" " 7 7$ $3 32 2! !7 7$ $3 35 5 S Sd dk kt t l l% %& & r re e d da a& & ' 'r r( (t te ei i  t t( (t ta al l 1 15 5! !4 45 5 m m) )/ /d dL L 0 0$ $2 2! !0 0$ $5 5 * * + +m m, , ( () )l l( (% %, ,l li i  0 0$ $7 75 5! !3 3$ $5 5 m m) )/ /d dL L - - 0 0$ $1 1 * * .l%/)l(%,li .l%/)l(%,li 81 81 3!4  l%& ti))i 3!4  l%& ti))i  l l, ,k k( (s sa a 4 40 0! !8 80 0 m m) )/ /d dL L 5 50 0! !8 80 0* * k kd dr r d dl lm m d dr r& & 30!60mt 30!60mt L La ak kt ta at t 1 10 0! !2 20 0 m m) )/ /d dL L " "a am mp pi ir r s sa am ma a  r re ea a 1 10 0! !1 15 5 m m) )/ /d dL L " "a am mp pi ir r s sa am ma a  l l, ,t ta am mi i  - - 2 20 0 m m) )/ /d dL L " "a am mp pi ir r s sa am ma a Barne" Barne" R R Na"han# Na"han# ++)# ++)# lini/al lini/al Lab'ra"'r; Lab'ra"'r;
  • 23. 22 22 Medi/ine Medi/ine Pen#ukuran tekanan L&S Pen#ukuran tekanan L&S Pen#ukuran tekanan L&S Pen#ukuran tekanan L&S   T Te!. LS : e!. LS : N'rmal : 6+1)6+ mmO<6  )- mmg N'rmal : 6+1)6+ mmO<6  )- mmg B'rderline : )6+1++ mmO B'rderline : )6+1++ mmO Tinggi Tinggi : : ? ? ++ ++ mmO mmO a"a% a"a% ? ? 0+ 0+ mmO mmO 3'bee4 3'bee4 ++15++ 3ringan4 ++15++ 3ringan4 5++1-++ 3edang4 5++1-++ 3edang4 ? -++ 3anga" "inggi4F KI m%"la! %< LP ? -++ 3anga" "inggi4F KI m%"la! %< LP   Man'me"er men/a"a" TIK ra"a1ra"a Man'me"er men/a"a" TIK ra"a1ra"a dier"ai dgn $%lai ar"eri F10 mm O dier"ai dgn $%lai ar"eri F10 mm O re$irai F -1)+ mm O re$irai F -1)+ mm O   Initial Pressure : Initial Pressure : "er/a$ai dlm ) mn" #bila $aien "d! bergera! F N : 2+1++ "er/a$ai dlm ) mn" #bila $aien "d! bergera! F N : 2+1++ mm O mm O   Jugular compression Jugular compression test test : : Queckenstedt’s test/bilateral jugular test Queckenstedt’s test/bilateral jugular test dig%na!an %"! menen"%!an adan;a bl'! $inal dig%na!an %"! menen"%!an adan;a bl'! $inal T Tobey -Ayer test/ uni obey -Ayer test/ unilateral jugul lateral jugular compression ar compression %n"! membanding!an $a"eni in% ,en'% dari la"eral d%ra !anan & !iri %n"! membanding!an $a"eni in% ,en'% dari la"eral d%ra !anan & !iri $d !e/%rigaan "r'mb'ebi"i $d !e/%rigaan "r'mb'ebi"i Bernar Bernard d J J enr;# enr;# ++2# ++2# lini/al lini/al Diagn'i Diagn'i and and Managemen" Managemen" b; b; Lab'ra"'r; Me"h'd Lab'ra"'r; Me"h'd
  • 24. 23 23   Clossing pressure : Clossing pressure : $en%r%nan rela"i9 "e!. LS e"elah $engambilan am$el F $en%r%nan rela"i9 "e!. LS e"elah $engambilan am$el F menanda!an menanda!an ban;a!n;a ban;a!n;a reer,'ir reer,'ir LS LS Nor"al Nor"al: e"ia$ $engambilan ) ml : e"ia$ $engambilan ) ml LS # "e!anan a!an LS # "e!anan a!an "%r%n ebear ) /m "%r%n ebear ) /m Pada spinal $lok ko"plit Pada spinal $lok ko"plit a!an di da$a" mialn;a : ini"ia a!an di da$a" mialn;a : ini"ial $re%re: 6+ mm l $re%re: 6+ mm !md diambil ) ml LS F !md diambil ) ml LS F di%!%r lagi F + mm di%!%r lagi F + mm F menanda!an reer,'ir @@ F menanda!an reer,'ir @@ Pada idrosefalus Pada idrosefalus d$" "er8adi : ini"ial d$" "er8adi : ini"ial $re%r $re%re : )6+ mm e : )6+ mm !md diambil )+ ml F di%!%r lagi F )2+ mm !md diambil )+ ml F di%!%r lagi F )2+ mm F menanda!an reer,'ir ?? F menanda!an reer,'ir ?? Bernard Bernard J J enr;# enr;# ++2# ++2# lini/al lini/al Diagn'i Diagn'i and and Managemen" Managemen" b; b; Lab'ra"'r; Me"h'd Lab'ra"'r; Me"h'd
  • 25. 24 24   A A;ala ;ala IndeH : IndeH : )+ //  $ 3/l'ing $re%re4 )+ //  $ 3/l'ing $re%re4 I.$ I.$ 3ini"ia 3ini"ial l $re%re4 $re%re4 N'rmal : 0#0 12#0 N'rmal : 0#0 12#0 @ 0 @ 0 F $inal F $inal bl'!# bl'!# maa maa dir%ang  dir%ang %bara!n'id %bara!n'id ? * ? * F a"r'= erebri# hidr'e9al%#$e%d'"%m'r erebri F a"r'= erebri# hidr'e9al%#$e%d'"%m'r erebri Bernard Bernard R R Na"han# Na"han# ++)# ++)# lini/al lini/al Lab'ra"'r; Medi/ine Lab'ra"'r; Medi/ine
  • 26. 25 25 In"er$re"ai !lini! "e!anan LS In"er$re"ai !lini! "e!anan LS In"er$re"ai !lini! "e!anan LS In"er$re"ai !lini! "e!anan LS Penin#katan tekanan Penin#katan tekanan L&S L&S   T T%m'r in"ra!ranial %m'r in"ra!ranial   Meningi"i Meningi"i   i$''m'la"i"a '! i$''m'la"i"a '! hem'dialii hem'dialii   ena /ana %$. S;ndr ena /ana %$. S;ndr   Perdarahan Perdarahan %bara!n'id %bara!n'id   Edema erebri Edema erebri   T Tr'mb'i  r'mb'i in% in% ,en'% ,en'%   Gang%an abr'$i SS Gang%an abr'$i SS Penurunan tekanan Penurunan tekanan L&S L&S   Ggn ir!%lai 3!'la$4 Ggn ir!%lai 3!'la$4   Dehidrai bera" Dehidrai bera"   i$er'm'lali"a i$er'm'lali"a   Keb'/'ran SS Keb'/'ran SS   Bl'! $d %bara!n'id Bl'! $d %bara!n'id $inal $inal Barne" Barne" R R Na"han# Na"han# ++)# ++)# lini/al lini/al Lab'ra"'r; Lab'ra"'r; Medi/ine Medi/ine
  • 27. 26 26 In"er$re"ai Klini! PH In"er$re"ai Klini! PH In"er$re"ai Klini! PH In"er$re"ai Klini! PH ma!r'!'$i! ma!r'!'$i! ma!r'!'$i! ma!r'!'$i! Pemeri!aan ma!r'!'$i! meli$%"i Pemeri!aan ma!r'!'$i! meli$%"i 1 !e!er%han 1 !e!er%han 1 $ 1 $ 1 B8 1 B8 1 arna 1 arna 1 edimen 1 edimen 1 $eli!el 1 $eli!el N'rmal : 8ernih dan "ida! berarna N'rmal : 8ernih dan "ida! berarna Barne" Barne" r r Kandel# Kandel# ++)# ++)# lini/al lini/al Lab'ra"'r; Lab'ra"'r; Medi/ine Medi/ine BernardRNa"han#++)# BernardRNa"han#++)#lini/alLab'ra"'r; lini/alLab'ra"'r; Medi/ine Medi/ine
  • 28. 27 27 Ke!er%han Ke!er%han Ke!er%han da$a" diebab!an 'leh: Ke!er%han da$a" diebab!an 'leh:   Le! Le!'i" 'i" 3$lei'i"'i4 3$lei'i"'i4   Eri"r'i" Eri"r'i"   Mi!r''r Mi!r''rganime 38am%r # ganime 38am%r # am%ba4 am%ba4   Pr'"ein Pr'"ein   A$irai lema! e$id%ral A$irai lema! e$id%ral   Media !'n"ra Media !'n"ra Barne" Barne" R R Na"han# Na"han# ++)# ++)# lini/al lini/al Lab'ra"'r; medi/ine Lab'ra"'r; medi/ine
  • 29. 28 28   Ke!er%han m%lai "am$a! $ada Ke!er%han m%lai "am$a! $ada $leii"'i $leii"'i B B ? ? ++ ++ el<mm el<mm 5 5 RB ? -++ el<mm RB ? -++ el<mm5 5   ndall efect ndall efect : %n"%! mende"e!i !e!er%han dibaah : %n"%! mende"e!i !e!er%han dibaah 8%mlah el dia"a 8%mlah el dia"a dengan /ara dengan /ara LS LS di!'/'! di!'/'! dalam dalam b'"'l ! b'"'l !em%dian diliha" em%dian diliha" lang%n lang%ng g dibaah inar ma"ahari dibaah inar ma"ahari "ida! da$a" membeda!an B dan RB #han;a "ida! da$a" membeda!an B dan RB #han;a menanda! menanda!an an $lei'i"'i $lei'i"'i Barne" Barne" R R Na"han# Na"han# ++)# ++)# lini/al lini/al Lab'ra"'r; Medi/ine Lab'ra"'r; Medi/ine
  • 30. 29 29   i/'% %id : LS ;ang !en"al e$er"i ir%$ $ada i/'% %id : LS ;ang !en"al e$er"i ir%$ $ada 1 me"a"ae m%/in'% aden' a 'l'n $d 1 me"a"ae m%/in'% aden' a 'l'n $d meningen meningen 1 in9e!i 8am%r !ri$"'!'!'i 1 in9e!i 8am%r !ri$"'!'!'i Pelikel3$ekuan alus Pelikel3$ekuan alus N'rmal : LS didiam!an elama - 8am a!an "erben"%! $eli!el N'rmal : LS didiam!an elama - 8am a!an "erben"%! $eli!el hal% da$a" diliha" hal% da$a" diliha" Abn'rmal : Abn'rmal : 1 M.$%r%len"a 1 M.$%r%len"a : /e$a" "erben" : /e$a" "erben"%! 3meni"1 %! 3meni"1 )8am4 bear d )8am4 bear dan an !aar !aar 1 M.TB : "erben"%! )1- 8am#men;er%$ai arang laba1 laba 1 M.TB : "erben"%! )1- 8am#men;er%$ai arang laba1 laba Barne" Barne" R R Na"han# Na"han# ++)# ++)# lini/al lini/al Lab'ra"'r; Lab'ra"'r; medi/ine medi/ine
  • 31. 30 30 4arna L&S 4arna L&S n'rmal :"ida! berarna n'rmal :"ida! berarna 15 15 Santroko" Santroko" Da$a" diebab!an 'leh: Da$a" diebab!an 'leh:   O!ihemagl'bin ;g beraal dari lii el darah merah O!ihemagl'bin ;g beraal dari lii el darah merah $d LS ebel%m LP $d LS ebel%m LP   Me"hem'gl'bin Me"hem'gl'bin   Bilir%bin 3?2mg<dL4 Bilir%bin 3?2mg<dL4   Pening!a"an $r'"ein3?)0+ mg<dL4 Pening!a"an $r'"ein3?)0+ mg<dL4   Melanin 3meningeal melan'/arin'ma4 Melanin 3meningeal melan'/arin'ma4   Kar'"en 3i"emi! !ar'"enemia4 Kar'"en 3i"emi! !ar'"enemia4 Barne" Barne" R R Na"han# Na"han# ++)# ++)# lini/al lini/al lab'ra"'r; Medi/ine lab'ra"'r; Medi/ine
  • 32. 31 31 25*era %dara' 25*era %dara' O! O! 1 1 $erd $erdaraha arahan n ar"i= ar"i=ial ial a!ib a!iba" a" ! !'m$l 'm$li!a i!ai i LP LP 3"ra% 3"ra%ma"i! ma"i! LP4 LP4 1 $erdarahan %bara!n'id 1 $erdarahan %bara!n'id Un"%! membeda!an;a dengan /ara : "e Un"%! membeda!an;a dengan /ara : "e "iga "ab%ng "iga "ab%ng en"ri9%gai en"ri9%gai Barne" Barne" R R Na"han# Na"han# ++)# ++)# lini/al lini/al Lab'ra"'r; Lab'ra"'r; Medi/ine Medi/ine
  • 33. 32 32 Perbedaan $erdarahan %bara!n'id dgn Perbedaan $erdarahan %bara!n'id dgn Perbedaan $erdarahan %bara!n'id dgn Perbedaan $erdarahan %bara!n'id dgn "ra%ma"i! LP "ra%ma"i! LP "ra%ma"i! LP "ra%ma"i! LP L LC CS S ' 'd dr r& & S S, ,% %a ar ra ak k ( (i id d T Tr ra a, ,m ma at ti ik k L L' ' T Te ek k  L LC CS S S Se er ri i ) ) m me e i i ) )k ka at t  ( (r rm ma al l T Te es s 3 3 t ta a% %, , ) ) S Sa am ma a p pd d s se em m, ,a a t t% % T T% % 1 1 l le e% %i i& & % %e er rd dr r& & di%adi)ka ) di%adi)ka ) lai lai L LC CS S C Cl l( (t t   ! !  a a t t& &( ( & &r r( (m mi ia a   : : % %i il la a d di ia am m% %i il l 8 8! !1 12 2 ;am stl perdr& ;am stl perdr& ! ! L L' ' , ,l la a ) ) S Sa am ma a d d) )  L L' ' a a< <a al l = =e er r i i& &  ; ;i ik ka a atra,matik: atra,matik:
  • 34. Bane" R Na"han# ++)# lini/al Lab'ra"'r; Medi/ine Bane" R Na"han# ++)# lini/al Lab'ra"'r; Medi/ine Dengan /ara en"ri9%gai da$a" dibeda!an an"ara Dengan /ara en"ri9%gai da$a" dibeda!an an"ara Dengan /ara en"ri9%gai da$a" dibeda!an an"ara Dengan /ara en"ri9%gai da$a" dibeda!an an"ara $rdarahan lama dan bar% $rdarahan lama dan bar% $rdarahan lama dan bar% $rdarahan lama dan bar% > >a ar r, , L La am ma a s s, ,p pe er r a at ta a  = =e er r i i& &$ $ m me er ra a& & m,da m,da sat(kr(m sat(kr(m e e d da ap pa a  ? ?r ri it tr r( (s si it t :$le,k(sit: :$le,k(sit: d) m(rf(l()i d) m(rf(l()i sel %aik sel %aik ?ritr(sit :$ ?ritr(sit :$ m(rf(l()i sel m(rf(l()i sel %er,%a&@ %er,%a&@ kreasi kreasi Barne" R na"han# ++)# /lini/al Barne" R na"han# ++)# /lini/al
  • 35. 34 34 lab'ra"'r; medi/ine lab'ra"'r; medi/ine  Eri"r'i" 3RB4 F"erde"e Eri"r'i" 3RB4 F"erde"e!i maH !i maH - 8am - 8am menghilang menghilang *1)+ *1)+ hr hr <lebih <lebih "g" "g" 8ml 8ml $erdarahan $erdarahan  em'gl'bin 3b4 F "erde"e!i -1)+ 8am "l $erdrh em'gl'bin 3b4 F "erde"e!i -1)+ 8am "l $erdrh berarna berarna merah merah m%da#maH m%da#maH -1-6 -1-6 8am 8am !md !md $elan1$elan menghilang $elan1$elan menghilang  Bilir%bin Bilir%bin F F "erde"e!i "erde"e!i >1)0 >1)0 8am 8am "l "l $erdarahan $erdarahan arna arna !%n !%ning ing #menghilang #menghilang $elan $elan "h "h )+1)- hr )+1)- hr Barne" Barne" R R Na"han# Na"han# ++)# ++)# lini/al lini/al Lab'ra"'r; Lab'ra"'r; Medi/ine Medi/ine
  • 36. 35 35 Barne" Barne" R R na"han# na"han# ++)# ++)# /lini/al /lini/al Barne" R na"han# ++)# /lini/al Barne" R na"han# ++)# /lini/al lab'ra"'r; medi/ine lab'ra"'r; medi/ine lab'ra"'r; medi/ine lab'ra"'r; medi/ine
  • 37. 36 36 Per%bahan arna $ada LS ;ang berh%b.dgn !em%ng!inan Per%bahan arna $ada LS ;ang berh%b.dgn !em%ng!inan Per%bahan arna $ada LS ;ang berh%b.dgn !em%ng!inan Per%bahan arna $ada LS ;ang berh%b.dgn !em%ng!inan $en;a!i" $en;a!i" $en;a!i" $en;a!i" ' 'e er r, ,% % < <a ar r a a K Ke em m, , ) )k ki i a a  p pe e  a ak ki it t >er >erka% ka%,t$ ,t$kek, kek,i i)a )a d) sedi  d) sedikit l(t kit l(t Ae Aei i)it )itis t,%e is t,%erk, rk,l(s l(sa a >erka%,t$ k,i) ke&i;a,a >erka%,t$ k,i) ke&i;a,a p,r,le$%a p,r,le$%aak ak l(t l(t Aei)itis pi()eik ak,t Aei)itis pi()eik ak,t Kek,i)a$;eri& Kek,i)a$;eri&/ sdkt / sdkt %erka%,t$sdkt l(t %erka%,t$sdkt l(t '(li(melitis ak,t '(li(melitis ak,t B Ba ar ra a& &$ $ p p, ,r r, ,l le e $ $k ke er r, ,& & A Ae e i i ) )( (e e s se ef fa al li it ti is s a am m, ,% %a a p pr ri im me er r = =e er r i i& &$ $m m, , ) )k ki i  s sa a t t( (k kr r( (m m T T, ,m m( (r r ( (t ta ak k/ /s sp pi i a al l S Sa a t t( (k kr r( (m m T T( ( ( (p pl la as sm m( (s si is s  i is s ( (, ,s s A Ae et ta as st ta as se eC Ca aC C( (l l( ( $ $A Ae e i i ) )i it ti is s  ) ) % %e er ra at t$ $ ript(k(k(sis$ tra,ma ript(k(k(sis$ tra,ma
  • 38. 37 37 Barne" R N Barne" R Na"han# ++)# lini/al la a"han# ++)# lini/al lab'ra"'r; b'ra"'r; Medi/ine Medi/ine In"er$re"ai !lini! PH.Mi!r'!'$i! In"er$re"ai !lini! PH.Mi!r'!'$i! In"er$re"ai !lini! PH.Mi!r'!'$i! In"er$re"ai !lini! PH.Mi!r'!'$i!   i"%ng el mer%$a!an $e"anda ;ang anga" eni"i9 i"%ng el mer%$a!an $e"anda ;ang anga" eni"i9 $ada $ada inamai NS ;ang a!%" inamai NS ;ang a!%"   4+& 70038L 4+& 70038L 3"er%"ama gran%l'i" $" ne%"r'=l4 3"er%"ama gran%l'i" $" ne%"r'=l4 biaan;a '!.in9e!i $%r%len# bah!an meningi"i '! biaan;a '!.in9e!i $%r%len# bah!an meningi"i '! !%man $i'geni! B1n;a d$" men/a$ai )+++1 !%man $i'geni! B1n;a d$" men/a$ai )+++1 +.+++<L +.+++<L Pening! Pening!a"an a"an Ne%"r'=l Ne%"r'=l da$a" da$a" diebab!an diebab!an 'leh: 'leh: ) Meningi"i ba!"eri ) Meningi"i ba!"eri  Pada $erm%laan meningi"i ,ir%  Pada $erm%laan meningi"i ,ir% 5 Pada $erm%laan meningi"i "%ber!%l'a 5 Pada $erm%laan meningi"i "%ber!%l'a - En/e$hal'm;eli"i am%ba - En/e$hal'm;eli"i am%ba 0 0 Per Perm%laan m%laan %a"% %a"% abe abe erebri erebri Barne" Barne" R R Na"han# Na"han# ++)# ++)# lini/al lini/al Lab'ra"'r; Medi/ine Lab'ra"'r; Medi/ine
  • 39. 38 38 Re!'mendai in"er,al Chi"%ng el Re!'mendai in"er,al Chi"%ng el Re!'mendai in"er,al Chi"%ng el Re!'mendai in"er,al Chi"%ng el di9er di9eren"ial LS dengan en"ial LS dengan i"'en"ri9%ge i"'en"ri9%ge di9er di9eren"ial LS en"ial LS dengan i"'en"ri9%ge dengan i"'en"ri9%ge  i ip pe e s se el l D De e/ /a as sa a N Ne eo on na at tu us s L Li im m9 9' ' i i" " 2 2    5 5- -  + +   ) )6 6 M M' 'n n' ' i i" " 5 52 2    + + * *       N Ne e% %" "r r' '= =l l     0 0 5 5   0 0 i"i'i" i"i'i" Jarang Jarang 0 0   - - E E9 9e en nd di im m J Ja ar ra an ng g J Ja ar ra an ng g E%in'=l E%in'=l Jarang Jarang Jarang Jarang Barne" R Na"han## ++)# lini/al Barne" R Na"han## ++)# lini/al Lab'ra"'r; Medi/ine Lab'ra"'r; Medi/ine
  • 40. 39 39   Ne%"r'=lia 3$e Ne%"r'=l4 da$a" 8%ga "er8adi $ada Ne%"r'=lia 3$e Ne%"r'=l4 da$a" 8%ga "er8adi $ada ! !'ndii n'n in9e!i a.l 'ndii n'n in9e!i a.l : : ◦ ◦ R Rea!i ea!i $ada $ada $erdarahan $erdarahan erebral erebral ◦ ◦ In8e!i %a"% a" !e r%ang %bara!n'id 3bhn In8e!i %a"% a" !e r%ang %bara!n'id 3bhn !'n"ra# 'ba" an"i !an!er4 !'n"ra# 'ba" an"i !an!er4 ◦ ◦ In9ar! erebri In9ar! erebri ◦ ◦ T T%m'r me"a"ae ! %m'r me"a"ae !'n"a! dgn LS 'n"a! dgn LS ◦ ◦ R Rea!i dari "inda!an LP ea!i dari "inda!an LP ber%lang ber%lang arne" R Na"han# ++)# lini/al arne" R Na"han# ++)# lini/al Lab'ra"'r;Medi/ine Lab'ra"'r;Medi/ine
  • 41. 40 40   B 5++10++<L 3 d'minan lim$'i"4da$a" B 5++10++<L 3 d'minan lim$'i"4da$a" di"em%!an $ada : di"em%!an $ada : ◦ ◦ Meningi"i ,ir% Meningi"i ,ir% ◦ ◦ Si=li SSP3mening'ene9ali"i4 Si=li SSP3mening'ene9ali"i4 ◦ ◦ In9e"ai $arai" $d SSP In9e"ai $arai" $d SSP ◦ ◦ Meningi"i ba!"eri '! 8eni ;g 8arang 3li"eria 4 Meningi"i ba!"eri '! 8eni ;g 8arang 3li"eria 4 ◦ ◦ M%l"i$le !ler'i M%l"i$le !ler'i ◦ ◦ Ene9al'$a"i '! dr%g ab%e Ene9al'$a"i '! dr%g ab%e ◦ ◦ GBS GBS ◦ ◦ Sar!'id'i $d meningen Sar!'id'i $d meningen ◦ ◦ I I ◦ ◦ Meningi"i 9%ngi Meningi"i 9%ngi ◦ ◦ P'l;ne%ri"i P'l;ne%ri"i Barne Barne" " R R Na"han# Na"han# ++)# ++)# /lini/al /lini/al Lab'ra"'r; Lab'ra"'r; medi/ine medi/ine
  • 42. 41 41   B dng ? -+ 7 3m'n'i"4 "er8adi $ada B dng ? -+ 7 3m'n'i"4 "er8adi $ada 1 meningi"i ba!"eri !r'ni! 1 meningi"i ba!"eri !r'ni! 1 meningi"i '! "'!'$lama# am%ba 1 meningi"i '! "'!'$lama# am%ba 1 "%m'r '"a! ;g r%$"%r 1 "%m'r '"a! ;g r%$"%r   Sel malignan 3lim$'i"<hi"i'i"4 da$a" di"em%!an $ada "%m'r Sel malignan 3lim$'i"<hi"i'i"4 da$a" di"em%!an $ada "%m'r $rimer a"a% me"a"ae $rimer a"a% me"a"ae   Pening! Pening!a"an a"an el $lama el $lama da$a" "er8 da$a" "er8adi adi $ada $ada 1 in9e!i ,ir% 1 in9e!i ,ir% a!%" a!%" 1 MS 1 MS 1 Sar!'id'i 1 Sar!'id'i 1 mening'ene9ali"i i=li 1 mening'ene9ali"i i=li 1 meningi"i 1 meningi"i "%ber!%l "%ber!%l'a 'a 1 In9e!i $arai" $d SSP 1 In9e!i $arai" $d SSP 1 GBS 1 GBS Barne" Barne" R R Na"han# Na"han# ++)# ++)# lini/al lini/al Lab'ra"'r; Lab'ra"'r; Medi/ine Medi/ine
  • 43. 42 42   Ma!r'9ag el da$a" di"em%!an $ada meningi"i TB & Ma!r'9ag el da$a" di"em%!an $ada meningi"i TB & ,ir% ,ir%   E'in'=l da$a" di"em%!an $ada E'in'=l da$a" di"em%!an $ada 1 in9e!i $arai" 1 in9e!i $arai" 1 in9e!i 8am%r 1 in9e!i 8am%r 1 in9e!i 1 in9e!i ri!e" ri!e"ia ia 1 ar!'id'i 1 ar!'id'i Barne" Barne" R R Na"han# Na"han# ++)# ++)# lini/al lini/al lab'ra"'r; lab'ra"'r; Medi/ine Medi/ine
  • 44. 43 43 ara Pem ara Pemeri!aan i"%ng 8eni eri!aan i"%ng 8eni el 3di el 3di ara Pe ara Pemeri!aan i"%ng 8eni meri!aan i"%ng 8eni el 3di el 3di /'%n"4 /'%n"4 /'%n"4 /'%n"4   LS dien"ri9%gai !e/.++ LS dien"ri9%gai !e/.+++ r$m + r$m elama )+ elama )+ mn" mn"   S%$erna S%$erna"an dib%ang# edimen "an dib%ang# edimen dib%a" ha$%an dib%a" ha$%an   Pearnaan righ"< bir% me"ilin Pearnaan righ"< bir% me"ilin   i"%ng )++ el3le!'i"4 dan hailn;a dalam 7 i"%ng )++ el3le!'i"4 dan hailn;a dalam 7 ◦ ◦ PMN   PMN   7 7 # MN  # MN  3)++1 H 4 3)++1 H 4 7 7 Barne" Barne" R R Na"han# Na"han# ++)# ++)# lini/al lini/al Lab'ra"'r; Lab'ra"'r; Medi/ine Medi/ine
  • 45. 44 44 P Pemeri!aan emeri!aan gl%! gl%!'a 'a Pemeri!aan gl%!'a Pemeri!aan gl%!'a    ang $erl% di$erha"i!an : ang $erl% di$erha"i!an : 1 $emeri!aan egera dila!%!an 3 LS egar4 1 $emeri!aan egera dila!%!an 3 LS egar4 1 $enderi"a dalam !'ndii $%aa 3 5 8am $'" $randial4 1 $enderi"a dalam !'ndii $%aa 3 5 8am $'" $randial4 1 ebai!n;a di!er8a!an $emeri!aan gl%!'a darah %n"%! 1 ebai!n;a di!er8a!an $emeri!aan gl%!'a darah %n"%! $embanding $embanding    a!"'r1 9a!"'r ;ang a!"'r1 9a!"'r ;ang mem$engar%hi !adar mem$engar%hi !adar gl%!'a LS gl%!'a LS 1 !adar gl%!'a darah 1 !adar gl%!'a darah 1 $ermiabili"a !a$iler dan e$i"el $le!% !'r'ide% er"a 1 $ermiabili"a !a$iler dan e$i"el $le!% !'r'ide% er"a e$endim ,en"ri!el e$endim ,en"ri!el 1 dera8a" gli!'lii 1 dera8a" gli!'lii Barne" Barne" R R Na"han# Na"han# ++)# ++)# lini/al lini/al Lab'ra"'r; Lab'ra"'r; medi/ine medi/ine
  • 46. 45 45 In"er$re"ai !lini! $emeri!aan In"er$re"ai !lini! $emeri!aan In"er$re"ai !lini! $emeri!aan In"er$re"ai !lini! $emeri!aan gl%!'a LS gl%!'a LS gl%!'a LS gl%!'a LS   Pen%r%nan !adar gl%!'a d$" "er8adi $ada Pen%r%nan !adar gl%!'a d$" "er8adi $ada 1 meningi"i ba!"eri a!%" 1 meningi"i ba!"eri a!%" 1 meningi"i TB# 8am%r dan am%ba 1 meningi"i TB# 8am%r dan am%ba 1 hi$'gli!emi i"emi! 1 hi$'gli!emi i"emi! 1 $erdarahan %bara!n'id 1 $erdarahan %bara!n'id   Kadar gl%!'a SS 8arang men%r%n $d: Kadar gl%!'a SS 8arang men%r%n $d: 1 "%m'r '"a! 1 "%m'r '"a! 1 meningi"i i=li a!%" 1 meningi"i i=li a!%" 1meningi"i n'n ba!"eri 1meningi"i n'n ba!"eri   Pening!a"an gl%!'a "er8adi $ada i$ergli!emia 3DM4 Pening!a"an gl%!'a "er8adi $ada i$ergli!emia 3DM4 $ening!a"an gl%!'a elal% berh%b%ngan dengan $ening!a"an gl%!'a elal% berh%b%ngan dengan !adar gl%!'a !adar gl%!'a $lama $lama Barne" Barne" R R Na"han# Na"han# ++)# ++)# lini/al lini/al Lab'ra"'r; Lab'ra"'r; Medi/ine Medi/ine
  • 47. 46 46 P Pemeri!aan emeri!aan $r $r'"ein '"ein P Pemeri!aan emeri!aan $r'"ein $r'"ein   P Pemeri!aan e/. emeri!aan e/. !%ali"a"i9 & !%an"i"a"i9 !%ali"a"i9 & !%an"i"a"i9   Pada !eadaan $a"'l'gi! 9ra!i $r'"ein ;g mening!a" Pada !eadaan $a"'l'gi! 9ra!i $r'"ein ;g mening!a" Fgl'b%lin hg "e Fgl'b%lin hg "e !%ali"a"i9 berdaar! !%ali"a"i9 berdaar!an !adar an !adar gl'b%lin gl'b%lin   N'rmal : )0 1 -0 mg N'rmal : )0 1 -0 mg $ening!a"an $ening!a"an ringan ringan : : -*1*0 -*1*0 mg mg edang edang : : *01)++ *01)++ mg mg bera" bera" : : )++10++ )++10++ mg mg anga" anga" bera" bera" : : 0++152++ 0++152++ mg mg Barne" Barne" R R Na"han# Na"han# ++)# ++)# lini/al lini/al Lab'ra"'r; Lab'ra"'r; Medi/ine Medi/ine
  • 48. 47 47 Keadaan ;ang men;ebab!an Keadaan ;ang men;ebab!an Keadaan ;ang men;ebab!an Keadaan ;ang men;ebab!an $r'"ein mening!a" $r'"ein mening!a" $r'"ein mening!a" $r'"ein mening!a"  Ker%a!an BBB Ker%a!an BBB  Re'r$i LS men%r%n Re'r$i LS men%r%n  Ob"r%!i aliran LS Ob"r%!i aliran LS  Sin"ea Imm%n'gl'b%lin ;ang Sin"ea Imm%n'gl'b%lin ;ang mening!a" mening!a" Barne" Barne" R R Na"han# Na"han# ++)# ++)# lini/al lini/al Lab'ra"'r; Lab'ra"'r; Medi/ine Medi/ine
  • 49. 48 48 In"er$re"ai !lini! $emeri!aan In"er$re"ai !lini! $emeri!aan In"er$re"ai !lini! $emeri!aan In"er$re"ai !lini! $emeri!aan $r'"ein $r'"ein $r'"ein $r'"ein   Pe Pening!a"an $r'"ein LS d$" ning!a"an $r'"ein LS d$" "er8adi $ada "er8adi $ada ). ). LP "ra%ma"i! LP "ra%ma"i! . . BBB ;ang BBB ;ang mening!a mening!a" " Ara!n'idi"i Ara!n'idi"i Meni Meningi ngi"i "i ba! ba!"er "eri i F F dgn dgn gra gram m   "%ber!%l'i "%ber!%l'i F F 0+15++ 0+15++ mg mg <dl <dl dgn dgn miHed miHed el%lar el%lar 8am%r 8am%r F3 F3 0+15++ 0+15++ mg<dl4 mg<dl4 , ,i ir r% %  F F 3 3@ @ + ++ + m mg g< <d dl l4 4 SA SA Gg Gg me"ab'li! me"ab'li! Kera/%nan Kera/%nan 'ba" 'ba" 5 5 Gangg%an  Gangg%an ir!% ir!%lai lai Ob"r%!i m Ob"r%!i me!ani! e!ani! 3"%m'r# abe# 3"%m'r# abe# erniai erniai di!%4 di!%4 Barne Barne" R " R Na"han# ++)# lini/al Lab'ra"'r; Na"han# ++)# lini/al Lab'ra"'r; Medi/ine Medi/ine
  • 50. 49 49 -. -. P Pening!a"an in"ea imm%n'gl' ening!a"an in"ea imm%n'gl'b%lin b%lin Ne%r'i$hili# M%l"i$le S!ler'i Ne%r'i$hili# M%l"i$le S!ler'i 0. 0. P Pening!a"an in"ea imm%n'gl'b%lin ening!a"an in"ea imm%n'gl'b%lin dan gg. dan gg. BBB BBB GBS# 'lagen ,a/%lar d 3l%$%# $eriar"ri"i4 GBS# 'lagen ,a/%lar d 3l%$%# $eriar"ri"i4 Barne" Barne" R R Na"han# Na"han# ++)# ++)# lini/al lini/al Lab'ra"'r; Lab'ra"'r; medi/ine medi/ine
  • 51. 50 50   Pen%r%nan $r'"ein da$a" "er8adi : Pen%r%nan $r'"ein da$a" "er8adi : 1 Keb'/'ran LS '! "ra%ma 1 Keb'/'ran LS '! "ra%ma 1 1 Pengambilan Pengambilan LS LS dalam dalam 8%mlah 8%mlah ban;a! ban;a! 1 TIK  1 TIK  1 i$er"ir'id 1 i$er"ir'id 1 Ana!1ana! 2 bln1 "hn 1 Ana!1ana! 2 bln1 "hn Barne" Barne" R R Na"han# Na"han# ++)# ++)# lini/al lini/al Lab'ra"'r; Medi/ine Lab'ra"'r; Medi/ine
  • 52. 51 51 ara ara Pemeri!aan Pemeri!aan Pr Pr'"ein '"ein ara ara Pemeri!aan Pemeri!aan Pr Pr'"ein '"ein 3K%ali"a"i94 3K%ali"a"i94 3K%ali"a"i94 3K%ali"a"i94   T Te berdaar! e berdaar!an $ening!a"an !ada an $ening!a"an !adar gl'b%lin r gl'b%lin   T Te B%a e B%a ◦ ◦ N : LS N : LS bila di! bila di!'/'! F b%a 34 !md '/'! F b%a 34 !md menghilang )1 mn" "lh d menghilang )1 mn" "lh di i "enang!an "enang!an ◦ ◦ Pr'"ein mening!a" F b%a menghilang ? 0mn" Pr'"ein mening!a" F b%a menghilang ? 0mn"   T Te N'nne P e N'nne Pand; < N'nne1 A$el" < R and; < N'nne1 A$el" < R'e  J'ne 'e  J'ne 1 gl'b%lin mengenda$ dl 1 gl'b%lin mengenda$ dlm lar m lar. Jen%h Am'ni%m %l9a" . Jen%h Am'ni%m %l9a" 3N-4 3N-4 SO- SO- 1 $r'ed%r !er8a : 1 $r'ed%r !er8a : ma%!!an ma%!!an +#0 // LS +#0 // LS  ) // lar  ) // lar. 3N-4 SO- . 3N-4 SO- "%ngg% 5 meni" F "erben"%!  "%ngg% 5 meni" F "erben"%!  la$ian F $erha"i!an /in/in la$ian F $erha"i!an /in/in $%"ih $%"ih $d $d $erba"aan $erba"aan Barne" Barne" R R Na"han# Na"han# ++)# ++)# lini/al lini/al Lab'ra"'r; Lab'ra"'r; Medi/ine Medi/ine @ @
  • 53. 52 52   In"er$re" In"er$re"ai ai N'nne: N'nne: 31 314 4 : : "d "d! ! "e "erb rben en"% "%! ! /i /in/ n/in in $% $%"i "ih h   : /i : /in/i n/in $ n $%"i %"ih 3 h 34 a 4 anga nga" "i " "i$i $i han han;a d ;a d$" $" dil dilih iha" d a" dgn gn LB LB hi"am hi"am   : / : /in/in in/in "am$a! "am$a! aga! aga! 8ela# 8ela# bila bila di! di!'/'! '/'! /airan /airan '$aleen '$aleen     : / : /i in n/ /i in " n "a am m$ $a a! 8 ! 8e el la a # d # di i! !' '/ /' '! / ! /a ai ir ra an ! n !e er r% %h h  : /in/in anga" 8ela# bila di!'/'! /airan anga" !er%h  : /in/in anga" 8ela# bila di!'/'! /airan anga" !er%h Barne" Barne" R R Na"han# Na"han# ++)# ++)# /lini/al /lini/al lab'ra"'r; lab'ra"'r; medi/ine medi/ine
  • 54. 53 53   T Te P e Pand; and; 1 %n"%! menge"ah%i !enai!an !adar gl'b%lin & alb%min 1 %n"%! menge"ah%i !enai!an !adar gl'b%lin & alb%min 1 $r'"ein a!an mengenda$ dlm lar 1 $r'"ein a!an mengenda$ dlm lar. Phen'l 8 . Phen'l 8en%h dlm a en%h dlm air ir 1 $r 1 $r'ed%r 'ed%r !er8a : !er8a : ma%!!an )// lar ma%!!an )// lar. P . Pand; )// LS and; )// LS 1 in"er$re"ai : 1 in"er$re"ai : 3 31 14 4 : : ! !e e! !er er% %h ha an3 n3  4 4 34 34 : '$ : '$ale aleen 30 en 30+1)+ +1)++ mg 7 + mg 74 4 3 3  4 4 : : ! !e er r% %h h 3 3) )+ ++ +1 15 5+ ++ + m mg g 7 74 4 3 3   4 4 : :  a an ng ga a" " ! !e er r% %h h 3 35 5+ ++ +1 10 0+ ++ + m mg g 7 74 4 34 : !er%h $" %% 3?0++ mg74 34 : !er%h $" %% 3?0++ mg74 Barne" Barne" R R Na"han# Na"han# ++)# ++)# lini/al lini/al Lab'ra"'r; Lab'ra"'r; Medi/ine Medi/ine
  • 55. 54 54 Kada Kadar Alb%min & r Alb%min & Im%n'gl'b%lin G 3IgG4 Im%n'gl'b%lin G 3IgG4 Kad Kadar Alb%min & ar Alb%min & Im%n'gl'b%lin G 3IgG4 Im%n'gl'b%lin G 3IgG4   Ig Ig G G & & Alb%min Alb%min Fn'rmal Fn'rmal 34 34 dlm dlm LS LS ;g ;g beraal beraal dari dari er%m er%m   Sehingga $e Alb%min & Ig G menanda!an adan;a !er%a!an Sehingga $e Alb%min & Ig G menanda!an adan;a !er%a!an dari bl''d brain barrier dari bl''d brain barrier   Alb%min Alb%min indeH indeH   Alb Alb S S 3mg<dL4 3mg<dL4 Alb Alb er%m er%m g<dL g<dL In"er$re"ai In"er$re"ai : : @ @ > > BBB BBB in"a! in"a! >1)- >1)- R% R%a! a! ringan ringan ) )- -1 15 5+ + K Ke er r% % a a! !a an n m m' 'd de er ra a" " 5 5+ +1 1) )+ ++ + R R% % a a! ! b be er ra a" "   Ig G indeH  Ig G indeH  IgG IgG &SF %"#3dl' &SF %"#3dl' Alb S Alb S 3mg<dL4 3mg<dL4 9 9 IgG LS  er%m alb%min IgG LS  er%m alb%min IgG IgG er3mg<dL4 er3mg<dL4 Alb S Alb S 3mg<dL4 3mg<dL4 Alb%min Alb%min LS LS   er%m er%m Ig Ig G G N'rmal : indeH @ +#2+ N'rmal : indeH @ +#2+ MS : indeH ? +#** MS : indeH ? +#** Barne" R Na"han# ++)# /lini/al Lab'ra"'r; Medi/ine Barne" R Na"han# ++)# /lini/al Lab'ra"'r; Medi/ine
  • 56. 55 55   Pening!a"an Pening!a"an Alb%min V Alb%min V Pening!a"an Pening!a"an "'"al "'"al $r'"ein $r'"ein 1 M. ba!"eri 1 M. ba!"eri 1 GBS 1 GBS 1 ne'$lama malignan SSP 1 ne'$lama malignan SSP 1 1 $en;a!i" $en;a!i" in9e!i in9e!i lain lain   Pening!a"an Ig G dgn Alb%min n'rmal Pening!a"an Ig G dgn Alb%min n'rmal 1 MS 1 MS 1 S%ba!%" !ler'ing $anen/e$hali"i 1 S%ba!%" !ler'ing $anen/e$hali"i 1 ne%r'i=li 1 ne%r'i=li 1 in9e!i SSP !r'ni! 1 in9e!i SSP !r'ni! Barne" Barne" R R Na"han# Na"han# ++)# ++)# lini/al lini/al lab'ra"'r; Medi/ine lab'ra"'r; Medi/ine
  • 57. 56 56   Pening!a"an alb%min indeH d$" "er8adi $d Pening!a"an alb%min indeH d$" "er8adi $d 1 ggn ir!%lai 1 ggn ir!%lai 1 ggn bl''d brain barrier 1 ggn bl''d brain barrier 1 DM 1 DM 1 SLE $d SSP 1 SLE $d SSP 1 $'line%r'$a"i 1 $'line%r'$a"i 1 er,i!al $'ndil'i 1 er,i!al $'ndil'i Barne" Barne" R R Na"han# Na"han# ++)# ++)# lini/al lini/al Lab'ra"'r; Medi/ine Lab'ra"'r; Medi/ine
  • 58. 57 57 Pr'"ein ele!"r'9'rei# 'lig'!l'nal band Pr'"ein ele!"r'9'rei# 'lig'!l'nal band Pr'"ein ele!"r'9'rei# 'lig'!l'nal band Pr'"ein ele!"r'9'rei# 'lig'!l'nal band   Un"%! mende"e!i 'lig'!l'nal band mengg%na!an agar'e gel Un"%! mende"e!i 'lig'!l'nal band mengg%na!an agar'e gel ele!"r'9erei ele!"r'9erei   Ele!"r'9'rei da$a" dig%na!an %n"%! Ele!"r'9'rei da$a" dig%na!an %n"%! mende"e!i mende"e!i 3e,al%ai4 3e,al%ai4 1 1 in9e!i in9e!i ,ir% ,ir% & & ba!"eri ba!"eri 1 "%m'r SSP 1 "%m'r SSP 1 diagn'i MS 1 diagn'i MS   Olig'!l'nal band :Im%n'gl'b%lin abn'rm Olig'!l'nal band :Im%n'gl'b%lin abn'rmal # gel al # gel "a8am "a8am F ering di"em%!an $ada $aien dgn ggn i"em F ering di"em%!an $ada $aien dgn ggn i"em im%n "erma%! im%n "erma%! I I   Penin Pening!a"an gamma gl'b%lin & g!a"an gamma gl'b%lin & 'lig'!l'nal band 'lig'!l'nal band 1 1 M MS S 1 1 b b% %r r! !i i" " l li im m9 9' 'm ma a 1 n 1 ne e% %r r' ' i i= =l li i  1 1  % %b ba a! !% %"  " ! !l le er r' ' i in ng g $ $a an ne en n e e9 9a al li i" "i i  1 1 G GB BS S 1 1 m me en ni in ng gi i" "i i  b ba a! !" "e er ri i & & , ,i ir r% %  1 AIDS 1 AIDS Barne" R na"han# ++)# lini/al Lab'ra"'r; Barne" R na"han# ++)# lini/al Lab'ra"'r; Medi/ine Medi/ine
  • 59. 58 58 'nnie R mah'n# ++2# Diagn'"i/ 'nnie R mah'n# ++2# Diagn'"i/ Mi/r'bi'l'g; Mi/r'bi'l'g;
  • 60. 59 59 Pemeri!aan !l'rida Pemeri!aan !l'rida Pemeri!aan !l'rida Pemeri!aan !l'rida   Kadar $d LS di$engar%hi 'leh !adar dlm darah Kadar $d LS di$engar%hi 'leh !adar dlm darah   P Pemeri!aan ini anga" b emeri!aan ini anga" berman9aa" bg $en%n8ang erman9aa" bg $en%n8ang dH. Meningi"i dH. Meningi"i 1 M. A!%" F !adar l W 3@ 26+ mg 74 1 M. A!%" F !adar l W 3@ 26+ mg 74 1 M. TB F !adar l W 3@ 2++ mg 74 1 M. TB F !adar l W 3@ 2++ mg 74   Kadar l n'rmal di"em%!an $ada : Kadar l n'rmal di"em%!an $ada : 1$eradangan e"em$a" 1$eradangan e"em$a" 1n'n ba!"eri 1n'n ba!"eri 1$'li'mieli"i 1$'li'mieli"i 1ne%r'l%e 1ne%r'l%e 1"%m'r '"a! 1"%m'r '"a! Barne" Barne" R R Na"han# Na"han# ++)# ++)# lini/al lini/al Lab'ra"'r; Medi/ine Lab'ra"'r; Medi/ine
  • 61. 60 60 P Pemeri!aan emeri!aan Gl%"amin Gl%"amin P Pemeri!aan emeri!aan Gl%"amin Gl%"amin   Gl%"amin diin"ea dari am'nia & X !e"' gl%"ara" Gl%"amin diin"ea dari am'nia & X !e"' gl%"ara"   Gl%"amin 34  menanda!an adan;a %a"% Gl%"amin 34  menanda!an adan;a %a"% me!anime %n"%! men;ing!ir!an am'nia me!anime %n"%! men;ing!ir!an am'nia 3 $r'd%! ia me"ab'li! ;g "'!i!4 3 $r'd%! ia me"ab'li! ;g "'!i!4   Pening! Pening!a"an gl%"amin $ada a"an gl%"amin $ada : : ◦ ◦ e$a"i! ene9al'$a"i e$a"i! ene9al'$a"i ◦ ◦ Sindr'm Re;eY Sindr'm Re;eY   Kadar ? 50mg<dl da$a" menimb%l!an ggn Kadar ? 50mg<dl da$a" menimb%l!an ggn !eadaran !eadaran Barne" Barne" R R Na"han# Na"han# ++2# ++2# lini/al lini/al Lab'ra"'r; Lab'ra"'r; Medi/ine Medi/ine
  • 62. 61 61 P Pemeri!aan Aam emeri!aan Aam la!"a" la!"a" P Pemeri!aan Aam emeri!aan Aam la!"a" la!"a"   Aam la!"a" ber%mber dari me"ab'lime anaer'b SSP Aam la!"a" ber%mber dari me"ab'lime anaer'b SSP   Ker%a!an 8aringan $d SSPF ggn '!igenai F Ker%a!an 8aringan $d SSPF ggn '!igenai F $e  aam la!"a" $e  aam la!"a"   Pening!a"an aam la!"a" da$a" "er8adi $d Pening!a"an aam la!"a" da$a" "er8adi $d 1 M. ba!"eri 1 M. ba!"eri 1 T%m'r<abe 1 T%m'r<abe 1 in9ar!<i!emi! 1 in9ar!<i!emi! 1 "ra%ma erebri 1 "ra%ma erebri F $r'gn' F $r'gn'e 8ele! e 8ele! 1 !e8ang 1 !e8ang Bernard Bernard J J enr;# enr;# ++2# ++2# lini/al lini/al Diagn'i Diagn'i  and and Managemen" Managemen" b; b; Lab'ra"'r; Me"h'd Lab'ra"'r; Me"h'd
  • 63. 62 62 P Pemeri!aan emeri!aan LD LD P Pemeri!aan emeri!aan LD LD 3La!"a" dehidr'genae i'en;m4 3La!"a" dehidr'genae i'en;m4 3La!"a" dehidr'genae i'en;m4 3La!"a" dehidr'genae i'en;m4   LD beraal dari LD beraal dari 1 di9%i mll bl''d brain 1 di9%i mll bl''d brain barrier3BBB4 barrier3BBB4 1 a!"i="a el 3 1 a!"i="a el 3 le!' le!'i"# ba!"eri# "%m'r4 i"# ba!"eri# "%m'r4   Pe LD a!iba" dari !er%a!an BBB Pe LD a!iba" dari !er%a!an BBB di"em%!an $ada di"em%!an $ada 1 M.ba!"eri 1 M.ba!"eri 1 M. ,ir% F elal% dii!%"i 'l. Ene9ali"i F$r'gn'e 1 M. ,ir% F elal% dii!%"i 'l. Ene9ali"i F$r'gn'e 8ele! 8ele! 1 mai9 /erebr',a!%lar a//iden" 1 mai9 /erebr',a!%lar a//iden" 1 1 le%!em le%!emia<lim9'ma ia<lim9'ma 1 me"a"a"i! a 1 me"a"a"i! a 'nnie 'nnie R R Mah'n# Mah'n# ++2# ++2# Diagn'"i/ Diagn'"i/ Mi/r'bi'l'g; Mi/r'bi'l'g;
  • 64. 63 63 Pe"anda "%m'r $ada SS Pe"anda "%m'r $ada SS Pe"anda "%m'r $ada SS Pe"anda "%m'r $ada SS = =e e i is s ' '  B Bi ia a) ) ( (s si is s  i il la ai i  ( (r rm ma al l .D' .D' alfa fet(pr(tei: alfa fet(pr(tei: Bis)ermi(ma$ Bis)ermi(ma$ mei)eal Ca mei)eal Ca - 1$5 m)/mL - 1$5 m)/mL > >e et ta ) a )l, l, ,r ,r( ( i id das ase e ! !A Ae e i i) )ea eal l ade(karsi(ma ade(karsi(ma !mel(%lastik !mel(%lastik le,kemia ak,t le,kemia ak,t - 49 m/L - 49 m/L - 70 m/L - 70 m/L Cari(em%r(ik Cari(em%r(ik .) C?.: .) C?.: Aei)eal Aei)eal ari(mat(sis ari(mat(sis -0$6 m)/ml -0$6 m)/ml "C Aem%edaka "C Aem%edaka dis)ermi(ma/mars dis)ermi(ma/mars i(ma i(ma -0$21/L -0$21/L
  • 65. 64 64 Barne" R Na"han# ++)# lini/al Lab'ra"'r; Medi/ine Barne" R Na"han# ++)# lini/al Lab'ra"'r; Medi/ine P Pemeri!aan emeri!aan Ba!"eri'l'gi Ba!"eri'l'gi P Pemeri!aan emeri!aan Ba!"eri'l'gi Ba!"eri'l'gi   P Penge/a"an gram # TT# Z enge/a"an gram # TT# Zeihl NeelenF eihl NeelenF dilan8%"!an dilan8%"!an dgn K%l"%r LS dgn K%l"%r LS   P Pemeri!aan Ag $ei=! %n emeri!aan Ag $ei=! %n"%! ba!"eri "%! ba!"eri Ag e%ai "i$e Ag e%ai "i$e !%man !%man 1IE 3/'%n"erim%ne 1IE 3/'%n"erim%ne ele!"'9'rei ele!"'9'rei4 4 1 la"eH agl%"ina"i'n 3lebih eni"i9 dr IE4 1 la"eH agl%"ina"i'n 3lebih eni"i9 dr IE4   Lim%l% l;a"e : Lim%l% l;a"e : %n"%! mende"e!i end'"'!in ba!"eri dgn %n"%! mende"e!i end'"'!in ba!"eri dgn mengg%na!an lia" dr !e$i"ing Fend'"'!in 34 F mengg%na!an lia" dr !e$i"ing Fend'"'!in 34 F a!an memben"%! gel a!an memben"%! gel "er%"ama %n. Ba!"eri gram 314 "er%"ama %n. Ba!"eri gram 314 3)++ 7 eni"i94 3)++ 7 eni"i94 Barne" Barne" R R Na"han# Na"han# ++)# ++)# lini/al lini/al Lab'ra"'r; Medi/ine Lab'ra"'r; Medi/ine
  • 66. 65 65 PR 3$'limerae /hain rea/"i'n< DNA am$li=/a"i'n4 PR 3$'limerae /hain rea/"i'n< DNA am$li=/a"i'n4   Sanga" eni"i9 dan $ei=! %n"! mende"e!i DNA dari Sanga" eni"i9 dan $ei=! %n"! mende"e!i DNA dari ba!"eri #!%man TB dan ,ir% ba!"eri #!%man TB dan ,ir%   P Pemeri!an menda$a"!an hail dlm emeri!an menda$a"!an hail dlm a!"% ing!a" a!"% ing!a"   Mende"e!i an"ib'di # gen'm mi!r'ba dan "'!in $ei=! Mende"e!i an"ib'di # gen'm mi!r'ba dan "'!in $ei=!   Memerl%!an 8%mlah LS 8a%h Memerl%!an 8%mlah LS 8a%h lebih edi!i" dibanding!an lebih edi!i" dibanding!an !%l"%r !%l"%r Barne" R Na"han# ++)# lini/al Lab'ra"'r; Barne" R Na"han# ++)# lini/al Lab'ra"'r; Medi/ine Medi/ine
  • 67. 66 66 P Pemeri!aan emeri!aan Jam%r Jam%r P Pemeri!aan emeri!aan Jam%r Jam%r   India In! "ain India In! "ain 1 %n"%! membeda!an 8am%r /r;$"'/'//% den el 1 %n"%! membeda!an 8am%r /r;$"'/'//% den el m'n'n%!lear m'n'n%!lear 1 8am%r "am$a! berhal' 1 8am%r "am$a! berhal' 1 eni"i="a 0+1*+ 7 1 eni"i="a 0+1*+ 7   r;$"'/'//al An"igen aa; 3RAG4 r;$"'/'//al An"igen aa; 3RAG4 1 lebih eni"i9 dari 1 lebih eni"i9 dari India In! "ain # nam%n lebih lama India In! "ain # nam%n lebih lama 1 1 mende"e!i mende"e!i "i"er "i"er "hd "hd Ag Ag /r;$"'/'//% /r;$"'/'//% 1 "i"er ): 6 3 1 "i"er ): 6 3 %$e/"ed /ae4 %$e/"ed /ae4 1 AIDS 3"i"er ):)+- <d ):)+.+++4 1 AIDS 3"i"er ):)+- <d ):)+.+++4 Bernard Bernard J J enr;# enr;# ++2# ++2# lini/al lini/al Diagn'i Diagn'i and and Managemen" Managemen" b; b; Lab'ra"'r; Me"h'd Lab'ra"'r; Me"h'd
  • 68. 67 67 P Pemeri!aan emeri!aan er'l'gi i=li er'l'gi i=li Pemeri!aan er'l'gi i=li Pemeri!aan er'l'gi i=li  T Te er'l'gi e er'l'gi 1 n'n $ei=! 3DRL4 1 n'n $ei=! 3DRL4 1 $ei=! "re$'nema an"ib'di 3 TPA# T1ABS4 1 $ei=! "re$'nema an"ib'di 3 TPA# T1ABS4  T Te DRL $d LS di! e DRL $d LS di!er8a!an bila DRL er%m 34 er8a!an bila DRL er%m 34  DRL "ida! dig%na!an %n"%! 9'll' %$ "era$i DRL "ida! dig%na!an %n"%! 9'll' %$ "era$i  ale 34 a!%" : 1 in9e!i a!%" ba!"eri & ,ir% ale 34 a!%" : 1 in9e!i a!%" ba!"eri & ,ir%   ale 34 ale 34 !r'ni! : SLE# "ir'idi"i# hem'li"i! !r'ni! : SLE# "ir'idi"i# hem'li"i! anemia anemia 'nnie 'nnie R R Mah'n# Mah'n# ++2# ++2# Diagn'"i/ Diagn'"i/ Mi/r'bi'l'g; Mi/r'bi'l'g;
  • 69. 68 68
  • 70. 69 69
  • 71. .eni!armila.bl'g$'"./'m .eni!armila.bl'g$'"./'m .eni!armila.bl'g$'"./'m .eni!armila.bl'g$'"./'m 70 70 DAT DATAR AR PU PUST STAKA AKA DATAR PUSTAKA DATAR PUSTAKA   Bernar Bernard d J J enr;# enr;# ++2# ++2# lini/al lini/al Diagn'i Diagn'i and and Managemen" Managemen" b; b; Lab'ra"'r; Lab'ra"'r; Me"h'd Me"h'd 6 6"h "h edi"i'n # edi"i'n # ha$"er )> $age.-+51-)0. ha$"er )> $age.-+51-)0.   Barne" R Barne" R. Na"han# ++)# . Na"han# ++)# lini/al Lab'ra"'r; Medi/ine lini/al Lab'ra"'r; Medi/ine L. ha$"er 2# $age 0))10>. L. ha$"er 2# $age 0))10>.   'nnei R Mah'n# ++2# TeHb''! '9 Diagn'"i/ 'nnei R Mah'n# ++2# TeHb''! '9 Diagn'"i/ Mi/r'bi'l'g; Mi/r'bi'l'g;#"hird edi"i'n# / #"hird edi"i'n# /ha$"er 50#$age >6+1>>-. ha$"er 50#$age >6+1>>-.   Da,id L 9el"en# +)+# Ne""erY A"la '9 Ne%r'/ien/e Da,id L 9el"en# +)+# Ne""erY A"la '9 Ne%r'/ien/e nd Edi"i'n# anada nd Edi"i'n# anada   Eri/ R Kandel# ++2# Prin/i$le '9 Ne%ral S/ien/e# Eri/ R Kandel# ++2# Prin/i$le '9 Ne%ral S/ien/e# 9'%r"h Ed"i'n. M/ Gra ill# $age )661)5++. 9'%r"h Ed"i'n. M/ Gra ill# $age )661)5++.   Ra;m'nd Adam# )>>6# Prin/i$le '9 ne%r'l'g;# iH"h Ra;m'nd Adam# )>>6# Prin/i$le '9 ne%r'l'g;# iH"h Edi"i'n# /ha$"er # $age )1)*. Edi"i'n# /ha$"er # $age )1)*.
  • 73. 72 72 K K're! 're!i i B B   B 'b B added B 'b B added B added  B added   bld H RB /9  bld H RB /9 RB RB bld bld
  • 74. 73 73
  • 75. 74 74
  • 76. 75 75
  • 77. 76 76
  • 78. 77 77  Ser'l'gi & mi!r'bi'l'gi3n'rmal SS4 Ser'l'gi & mi!r'bi'l'gi3n'rmal SS4 DRL DRL : : nega"i9 nega"i9 B Ba a! !" "e er ri i : : " "i id da a! ! a ad da a  i ir r% %  : : " "i id da a! ! a ad da a I In nd de e! !  a an n" "i ib b' 'd di i : : ? ?) )# #0 0 3 3$ $r r' ' e e  inammai !r'ni!4 inammai !r'ni!4 @ @ +#- +#- 3m%ng!in 3m%ng!in b%!an b%!an $r'e inamai $r'e inamai a!%"4 a!%"4
  • 79. 78 78 ara Pemeri!aan Mi!r'!'$i! ara Pemeri!aan Mi!r'!'$i! ara Pemeri!aan Mi!r'!'$i! ara Pemeri!aan Mi!r'!'$i!   Pemeri!aan dila!%!an egera 3#5+ meni"4'! Pemeri!aan dila!%!an egera 3#5+ meni"4'! 1 1 D$" menimb%l!an i"'lii D$" menimb%l!an i"'lii 1 1 Sel mengenda$ hg %li" %n"%! menda$a" LS Sel mengenda$ hg %li" %n"%! menda$a" LS h'm'gen h'm'gen 1 1 Sel "er$erang!a$ dlm $eli!el Sel "er$erang!a$ dlm $eli!el 1 1 Sel mengalami $er%bahan ben"%! Sel mengalami $er%bahan ben"%!   Ala" & reagen Ala" & reagen ) $i$e" $engen/er "h'ma ) $i$e" $engen/er "h'ma   reagen reagen : : "%r! "%r! r'en"hal r'en"hal 5 !amar hi"%ng : %/h1 r'en"hal 5 !amar hi"%ng : %/h1 r'en"hal Im$r',eed Im$r',eed Ne%ba%er Ne%ba%er
  • 80. 79 79   Pr'ed%r !er8a Pr'ed%r !er8a LS di!'/'!F h'm'gen LS di!'/'!F h'm'gen ia$ reagen F !md hia$ LS F$engen/eran )+<> ia$ reagen F !md hia$ LS F$engen/eran )+<> !'/'! !'/'! lm lm 5mn" 5mn" F F "ega! l%r% "ega! l%r% %mb% %mb% $i$e" $i$e" "iga "e"e $er"ama dib%ang '! "di i!%" $engen/eran "iga "e"e $er"ama dib%ang '! "di i!%" $engen/eran "e"e!an dalam !amar hi"%ng Fbiar!an 0 mn" "e"e!an dalam !amar hi"%ng Fbiar!an 0 mn" hi"%ng el hi"%ng el r%m% : )<5 N el <mm5 3R4 r%m% : )<5 N el <mm5 3R4 0<- 0<- N N el<mm5 el<mm5 3IN4 3IN4
  • 81. 80 80 Collooidal Gold Reaction Collooidal Gold Reaction Collooidal Gold Reaction Collooidal Gold Reaction   Berdaar! Berdaar!an "e $rei$i"ai %$eni an "e $rei$i"ai %$eni dgn g'ld /'l'idal dgn g'ld /'l'idal $ada )+ erial $engen/eran 3del%"i'n4 $ada )+ erial $engen/eran 3del%"i'n4 ):+ am$ai ):0.)+ ):+ am$ai ):0.)+   In"er$re"ai : In"er$re"ai : ◦ ◦ + : "d! ada $er%b.arna + : "d! ada $er%b.arna ◦ ◦ ) ) : $ : $er% er%b. b.d!" d!" 3me 3merah rah gel gela$4 a$4 ◦ ◦   : : L Li il la a/ / ◦ ◦ 5 5 : : B Bi ir r% % ◦ ◦ - - : Bi : Bir% r% $ $r re ei$ i$i"a i"ai i ◦ ◦ 0 0 : 8er : 8ernih  ! nih  !'m$ 'm$li" $r li" $rei ei$i"a $i"ai i
  • 82.   Pr Prei$i"ai "g" ei$i"ai "g" 8ml gl'b%lin dan alb%min 8ml gl'b%lin dan alb%min 81 81   In"er$re"ai : In"er$re"ai : N'rmal : "ida! ada $er%bahan arna N'rmal : "ida! ada $er%bahan arna !%r,a !%r,a : : da"ar da"ar 3++++++++++4 3++++++++++4 Abn'rmal !%r,a Abn'rmal !%r,a I : $rei$i"ai ma!imal "8d $ada "ab%ng $er"ama I : $rei$i"ai ma!imal "8d $ada "ab%ng $er"ama mi. 0000--5)+ mi. 0000--5)+ II : $rei$i"ai ma!imal $ada "ab%ng "engah II : $rei$i"ai ma!imal $ada "ab%ng "engah mi. +)5-0-5+ mi. +)5-0-5+ III : $rei$i"ai ma!imal $ada "ab%ng dgn III : $rei$i"ai ma!imal $ada "ab%ng dgn $engen/era $engen/eran n "era!hir "era!hir mi. ++++))5-0 mi. ++++))5-0
  • 83. 82 82   In"er$re"ai !%r,a /'l'idal g'ld In"er$re"ai !%r,a /'l'idal g'ld I I : : $ $e e     g ga am mm ma a g gl' l'b b%l %lin in $ $a ad da a N Ne e%r %r' 'i i= =li li# # MS MS# # S%ba/%"e $anene9ali"i S%ba/%"e $anene9ali"i II II : : $e $e   gamma gamma gl'b%lin gl'b%lin III III : : $e $e   $r'"ein $r'"ein 3alb%min? 3alb%min? gl'b%lin4 gl'b%lin4 3!%r,a meningi"i4 3!%r,a meningi"i4 da$a" da$a" "er8adi $ada: "er8adi $ada: m.$%r%len m.$%r%len a!%"# a!%"# bl'! bl'! $inal # $inal # $erdrhan %bara!n'id $erdrhan %bara!n'id
  • 84. 83 83 ara Pemeri!aan Pr'"ein ara Pemeri!aan Pr'"ein ara Pemeri!aan Pr'"ein ara Pemeri!aan Pr'"ein 3"'"al $r'"ein<!%an"i"a"i94 3"'"al $r'"ein<!%an"i"a"i94 3"'"al $r'"ein<!%an"i"a"i94 3"'"al $r'"ein<!%an"i"a"i94   Pr'ed%r ! Pr'ed%r !er8a er8a : : ma%!!an )1 // LS +#6 di"iled a"er // ma%!!an )1 // LS +#6 di"iled a"er // SSA 0 7 SSA 0 7 biar!an "ega! elama 0 mn" biar!an "ega! elama 0 mn" ba/a dgn !al'rime"er "hd "andar %$. Pr'"ein ba/a dgn !al'rime"er "hd "andar %$. Pr'"ein ;g "elah di!e"ah%i ;g "elah di!e"ah%i Bila !adar $r'" "inggi dila!%!an $engen/eran Bila !adar $r'" "inggi dila!%!an $engen/eran Perhi"%ngan: Perhi"%ngan: mm "andar<mm 3%n!n'n4H 0+  [. Mg mm "andar<mm 3%n!n'n4H 0+  [. Mg $r'"<)++// L/ $r'"<)++// L/
  • 85. 84 84 ara Pemeri!aan Gl%!'a ara Pemeri!aan Gl%!'a ara Pemeri!aan Gl%!'a ara Pemeri!aan Gl%!'a   Pr'ed%r !er8a: Pr'ed%r !er8a: 1 // 1 // LS LS egar  egar  ) "" ) "" 9'rmaldeh;de 9'rmaldeh;de )+ 7 )+ 7 1 im$an dlm re9rigera"'r 1 im$an dlm re9rigera"'r 1 lima 1 lima "ab%ng !e/il#maing1ma "ab%ng !e/il#maing1maing dii ing dii lar lar. Benedi/" . Benedi/" )// )// 1 $ana!an 0 mn" F 1 $ana!an 0 mn" F liha" red%!i liha" red%!i 1 In"er$re"ai: 1 In"er$re"ai: !elima !elima "ab%ng 34 "ab%ng 34 : : 0+ 0+ mg7 mg7 "b. "b. 10 3 10 34 4 :-+10 :-+10+ mg 7 + mg 7 "a "ab 5 b 510 10 3 34 4 :5 :5+1 +1-+ -+ mg mg 7 7 "a "ab - b -10 10 3 34 4 :  : +1 +15+ 5+ mg mg 7 7 " "a ab b 0 0 3 3 4 4 : : ) )+ +1 1 + + m mg g 7 7 3 31 14 4 : : + +1 1) )+ + m mg g 7 7
  • 86. 85 85 Pne%m'ene9al'gra= & Pne%m'ene9al'gra= & Pne%m'ene9al'gra= & Pne%m'ene9al'gra= & en"ri!%l'gra= en"ri!%l'gra= en"ri!%l'gra= en"ri!%l'gra=   Udara dima%!!an !e dalam r.%bara!n'id dan !e dlm Udara dima%!!an !e dalam r.%bara!n'id dan !e dlm %%nan %%nan ,en"ri! ,en"ri!el el melal%i melal%i $%ngi $%ngi   Pne%m'ene9al'gra= : !'n"raindi! Pne%m'ene9al'gra= : !'n"raindi!ai $d ai $d TIK TIK     T Te!ni! Pne%m'ene9al'gra=: e!ni! Pne%m'ene9al'gra=: 1 LP 1 LP F !md F !md $H d%d%!# $H d%d%!# !e$ala !e$ala d!" e!i d!" e!i Fma%!!an Fma%!!an %dara %dara !e !e r r.%bar .%bara!n'id a!n'id 1 b%a" 1 b%a" 9'"' !e$ala3AP<La"4 9'"' !e$ala3AP<La"4 1 bila 1 bila "ern;a"a "ern;a"a ,en"ri!el ,en"ri!el "erii %dara "erii %dara F biar! F biar!an LS an LS mene"e !el%ar mene"e !el%ar 1 e"ia$ )+ // LS F ma%!!an )+ // %dara# e 1 e"ia$ )+ // LS F ma%!!an )+ // %dara# el%r%hn;a l%r%hn;a +15+ // +15+ //
  • 87. 1 bila "ern;a"a ,en" %dara 1 bila "ern;a"a ,en" %dara 314 F!e$ala di%bah 314 F!e$ala di%bah e!i<e!"eni e!i<e!"eni Fma%!!an Fma%!!an %dara %dara )+ )+ // // F F b%a" b%a" 9'"' 9'"' 86 86   en"ri!%l'gra= en"ri!%l'gra= di!er8 di!er8a!an a!an %n"%! %n"%! mende"e!i mende"e!i "%m'r i "%m'r in"ra!ranial n"ra!ranial   T Te!ni! : e!ni! : b%a" e$aang l%bang di daerah $arie"''!i$i"al b%a" e$aang l%bang di daerah $arie"''!i$i"al ma%!!an 8ar%m am$ai di ma%!!an 8ar%m am$ai di !'r !'rn% '!i$i"al ,en" n% '!i$i"al ,en" la" !i<!a la" !i<!a ma%!!an ma%!!an )+ // )+ // %dara mll %dara mll ,en" ! ,en" !anan F LS me anan F LS mene"e ne"e !md ma%!!an )+ // %dara $d ,en" !iri !md ma%!!an )+ // %dara $d ,en" !iri el%r%hn;a +15+ // %dara el%r%hn;a +15+ // %dara   Penilaian : Penilaian : elal% "am$a! ,en"ri!el "erii %dara & elal% "am$a! ,en"ri!el "erii %dara & li! li!%'r %'r %dara diebelah a"a#li!%'r bag. Baah %dara diebelah a"a#li!%'r bag. Baah $r';e!i $r';e!i APF APF !%$%1!%$% !%$%1!%$% $r';e!i PA F b%r%ng "erbang $r';e!i PA F b%r%ng "erbang $r';e!i h'ri'n"al F "am$a!gari h'ri'n"al $r';e!i h'ri'n"al F "am$a!gari h'ri'n"al
  • 88. $r';e!i $r';e!i la" la" DS<SD DS<SD F F "am$a! "am$a! ,en"ri!el ,en"ri!el 87 87
  • 89. 88 88
  • 90. 89 89
  • 91. 90 90
  • 92. 91 91 T Te Q%e/! e Q%e/!en"ed" en"ed" T Te Q%e/! e Q%e/!en"ed" en"ed"
  • 96. Da,id Da,id L L  al"en# al"en# +)+# +)+# Ne""erY Ne""erY A"la A"la '9 '9 Da,id L al"en# +)+# Ne""erY A"la '9 Da,id L al"en# +)+# Ne""erY A"la '9 Ne%r'/ien/e Ne%r'/ien/e Ne%r'/ien/e Ne%r'/ien/e 95 95
  • 97. 96 96 S%b'//i$i"al P%n!i S%b'//i$i"al P%n!i S%b'//i$i"al P%n!i S%b'//i$i"al P%n!i  Ma%!!an 8ar%m !edalam /i"erna Ma%!!an 8ar%m !edalam /i"erna magna dgn men%%!!an 8ar%m di magna dgn men%%!!an 8ar%m di an"ara  ) & ' '//i$i"al an"ara  ) & ' '//i$i"al  Ki"a la!%! Ki"a la!%!an $ada an $ada miel'gra$h; miel'gra$h; dgn mengg%na!an /airan !'n"ra dgn mengg%na!an /airan !'n"ra ;ang lebih bera". ;ang lebih bera".
  • 98. arne" R Na"han# lini/al arne" R Na"han# lini/al Lab'ra"'r;Medi/in Lab'ra"'r;Medi/in 97 97 en"ri/%lar P%n!i en"ri/%lar P%n!i en"ri/%lar P%n!i en"ri/%lar P%n!i  Sanga" 8arang# "a$i da$a" diindi!ai!an Sanga" 8arang# "a$i da$a" diindi!ai!an $ada $H dgn herniai '"a!. Dila!%!an di $ada $H dgn herniai '"a!. Dila!%!an di OK. L%bang diben"%! dgn OK. L%bang diben"%! dgn memb'r memb'r /al,aria & 8ar%m lang%ng dima%!!an /al,aria & 8ar%m lang%ng dima%!!an !e dalam ,en"ri/le. !e dalam ,en"ri/le.  Pr'ed%r $eng%m$%lan S e$er"i Pr'ed%r $eng%m$%lan S e$er"i $ada $r'ed%re $emaangan P 1 $ada $r'ed%re $emaangan P 1 Sh%n". Sh%n".
  • 99. Ra;m'nd Adam# )>>6# Prin/i$le '9 Ra;m'nd Adam# )>>6# Prin/i$le '9 Ne%r'l'g; Ne%r'l'g; 98 98 ndikasi Lu"$al Punksi( ndikasi Lu"$al Punksi( ndikasi Lu"$al Punksi( ndikasi Lu"$al Punksi( • • Un"%! menge"ah%i "e!anan dan Un"%! menge"ah%i "e!anan dan mengambil am$el %n"%! $emeri!an mengambil am$el %n"%! $emeri!an el# !imia dan ba!"eri'l'gi el# !imia dan ba!"eri'l'gi • • Un"%! memban"% $eng'ba"an melal%i Un"%! memban"% $eng'ba"an melal%i $inal# $emberian an"ibi'"i!a# an"i $inal# $emberian an"ibi'"i!a# an"i "%m'r dan $inal ana"ei "%m'r dan $inal ana"ei • • Un"%! memban"% diagn'a Un"%! memban"% diagn'a dengan dengan $en;%n"i!an %dara $ada $en;%n"i!an %dara $ada $ne%m'en/e$hal'gra=# dan a" $ne%m'en/e$hal'gra=# dan a" !'n"ra $ada m;el'gra= !'n"ra $ada m;el'gra=
  • 100. Eri/ Eri/ R R Kandel# Kandel# ++2# ++2# Prin/i$le Prin/i$le '9 '9 Ne%ral Ne%ral S/ien/e S/ien/e 99 99 Kontra ndikasi Lu"$al Kontra ndikasi Lu"$al Kontra ndikasi Lu"$al Kontra ndikasi Lu"$al Punski( Punski( Punski( Punski(  Adan;a $eninggian "e!anan in"ra Adan;a $eninggian "e!anan in"ra !ranial dengan "anda1"anda n;eri !ranial dengan "anda1"anda n;eri !e$ala# m%n"ah dan $a$il edema !e$ala# m%n"ah dan $a$il edema  Pen;a!i" ggn 9aal hem'"a"i! ;ang Pen;a!i" ggn 9aal hem'"a"i! ;ang bera" bera"  Ada in9e!i l'!al $ada "em$a" L%mbal Ada in9e!i l'!al $ada "em$a" L%mbal P%n!i P%n!i
  • 101. Eri/ R Kandel# ++2# Prin/i$le '9 Eri/ R Kandel# ++2# Prin/i$le '9 Ne%ral Ne%ral S/ien/e S/ien/e 100 100 eknik Lu"$al Punksi( eknik Lu"$al Punksi(  ekni eknik k Lu"$ Lu"$al al Punk Punksi( si( • • Paien $ada $inggir "em$a" "id%r# Paien $ada $inggir "em$a" "id%r# dalam $'ii la"eral de/%bi"% dalam $'ii la"eral de/%bi"%   leher# leher# $%ngg%ng# $ingg%l dan "%mi" lema. $%ngg%ng# $ingg%l dan "%mi" lema. • • P%ngi $ada /elah !'l%mna ,e"ebrali P%ngi $ada /elah !'l%mna ,e"ebrali e"inggi L 51- 3/ri"a ilia/a4. e"inggi L 51- 3/ri"a ilia/a4.   "ida! "ida! berhail di/'ba !e a"a a"a% !e baah. berhail di/'ba !e a"a a"a% !e baah. Pada ba;i dan ana! e"inggi Pada ba;i dan ana! e"inggi in"er,er"ebrale L-10 in"er,er"ebrale L-10 Eri/ Eri/ R R Kandel# Kandel# ++2# ++2# Prin/i$le Prin/i$le '9 '9 Ne%ral Ne%ral S/ien/e S/ien/e
  • 102. 101 101  Berih!an dengan ;'di%m dan Berih!an dengan ;'di%m dan al! al!'h'l daerah 'h'l daerah ;ang a!an di$%ngi# ;ang a!an di$%ngi# ana"hei l'!al lid'/ain L ana"hei l'!al lid'/ain L • • Sar%ng Sar%ng "angan# "angan# 8ar%m 8ar%m "eril "eril   la! la!%!an $%n!i# %!an $%n!i# ma%!!an 8ar%m ma%!!an 8ar%m "ega! l%r% arah %mbili!% "ega! l%r% arah %mbili!% • • Bila "elah menemb% 8aringan Bila "elah menemb% 8aringan meningen $en%%!an dihen"i!an. meningen $en%%!an dihen"i!an.
  • 103. Eri/ R Kandel# ++2# Prin/i$le '9 Eri/ R Kandel# ++2# Prin/i$le '9 Ne%ral S/ien/e Ne%ral S/ien/e 102 102 • • Bila di$erl%!an da$a" dila!%!an Bila di$erl%!an da$a" dila!%!an $emeri!aan "e!anan dengan $emeri!aan "e!anan dengan man'me"er 3"e" Q%e/!en"ed"4 man'me"er 3"e" Q%e/!en"ed"4 • • Kem%dian ambil am$el %n"%! Kem%dian ambil am$el %n"%! $emeri!aan 8%mlah dan 8eni el# $emeri!aan 8%mlah dan 8eni el# !adar g%la# $r'"ein# !%l"%r ba!"eri !adar g%la# $r'"ein# !%l"%r ba!"eri dan ebagain;a. dan ebagain;a.
  • 104. Eri/ Eri/ R R Kandel# Kandel# ++2# ++2# Prin/i$le Prin/i$le '9 '9 Ne%ral S/ien/e Ne%ral S/ien/e 103 103 B B# #A A. .+ +  B B+ +S S# #R RB B? ?R R  S S? ?D D L L C CS SD D S ST T B B+ +? ?S S ? ? ' '? ?C CT T? ?B B R R? ?S S L LT T C C# #A AA A? ? T T + + fe fe t ti i, ,s s A Ae e i i ) )i it ti is s p p, ,r r, ,l le e t t ' 'r r$ $) )l l$ $ e el ll l  t ts s$ $) )s s$ $  $ $( (p p Epr$F )l$ECSD 'As$)s ad $ Epr$F )l$ECSD 'As$)s ad $ %aterial a)Gs$ E (p$ E L. %aterial a)Gs$ E (p$ E L. rpt((al a) ad idia ik i rpt((al a) ad idia ik i rpt((al mei)itis rpt((al mei)itis Ae Aei i) )it itis is . .se sept pti i pr pr$) $)l$ l$el ell l ts ts Epr$l )l$ECSD H>C 10!1000 Epr$l )l$ECSD H>C 10!1000 m((, ell/mm3: m((, ell/mm3: 'As p(ssi%le i earl asepti 'As p(ssi%le i earl asepti mei)itis mei)itis ?ep&alitis ?ep&alitis pr$) pr$)l$ell l$ell ts$ ts$ )s$ )s$ midl Epr 50!100 m)/dL:$) midl Epr 50!100 m)/dL:$) )l$ECSD H>C 50!100/mm3 )l$ECSD H>C 50!100/mm3 m(((,t: m(((,t: "erpes simple "erpes simple eep&alitis$Ra%ies eep&alitis$Ra%ies " "+ +  ? ?  e ep p& &a al l( (p pa at t  p pr r$ $$ $) )l l$ $ e el ll l  t ts s$ $ m mi id dd dl l  E Ep pr r$ $  l l ) )l l$ $  l l ( (r r f fe e< < H H> >C C e,r(sp&ilis e,r(sp&ilis a,te: a,te: BRL$pr$ BRL$pr$)l$ )l$ Epr$ I45 m)/dL:$ EH>C 5!500 Epr$ I45 m)/dL:$ EH>C 5!500 m((,l/mm3:BRL m((,l/mm3:BRL CSD parameters m %e (rmal CSD parameters m %e (rmal T,%er,l(sa T,%er,l(sa mei)itis mei)itis pr$) pr$)l$ell ts$(p$aid fast l$ell ts$(p$aid fast stai$ stai$ Epr$10 Epr$100!200m)/dL:F)l 0!200m)/dL:F)l -45 -45 m)/dL:$ EH>C 25!100 m)/dL:$ EH>C 25!100 m((,/mm3:$E(p m((,/mm3:$E(p m %e spial %l(kJ stai ad m %e spial %l(kJ stai ad ,lt,re re,ire lar)e amt (f ,lt,re re,ire lar)e amt (f CSD CSD . .% %s s e es ss s  ( (t t r re e ( (m mm me e d de ed d C Cr re e, ,t ts sf fe el ld dt t! != =a a ( (% % p pr r$ $) )l l$ $ e el ll l  t ts s  ( (r rm ma al l C C s st ti i e er r ( (s si is s p pr r$ $) )l l$ $ e el ll l  t ts s$ $( (p p Epr$ F )l$E H>C Epr$ F )l$E H>C mi</e,si(p&ilia$F(p mi</e,si(p&ilia$F(p CSD e(si(p&ils (stit,te 20! CSD e(si(p&ils (stit,te 20! 70* 70*
  • 105. 104 104 Barne" R Na"han# ++)# lini/al Lab'ra"'r; Medi/ine Barne" R Na"han# ++)# lini/al Lab'ra"'r; Medi/ine B B# #A A. .+ +  B B+ +S S# #R RB B? ?R R  S S? ?D D L L C CS SD D S ST T B B+ +? ?S S ? ? ' '? ?C CT T? ?B B R R? ?S S L LT T C C# #A AA A? ? T T C Ce er re e% %r r( (  a as s , ,l la ar r S St tr r( (k ke e ' 'r r$ $ e el ll l  t ts s m mi id dd dl l  E Ep pr r$ $ H H> >C C  ( (t t r r( (, ,t ti i e e p pe er rf f( (r rm me ed dJ J E EL LB B" "$ $ . .S ST T a a d d C CK K! !> >> > i i   ( (r rt ti i a al l C C . . S S, ,% %a ar ra a & & ( (i id d & &e em m( (r ra a) )i i  p pr r$ $) )l l$ $ e el ll l  t ts s$ $ ( (l l( (r r E EE Ep pr r$ $F F ) )l l$ $E EE ER R> >C C$ $E E H H> >C C$ $ a a t t( ( p pr r  a a  % %e e  ( (r rm ma al l ( (r r s si i) ) i if fi i a a t t E E$ $) )l l  a a  % %e e  ( (r rm ma al l ( (r r s sl li i) )& &t tl l  F F  e e ( (, ,s s t tr r( (m m% %( (s si is s  e el ll l  t ts s$ $( (p p E ER R> >C C$ $ E E( (p p H H> >C C m ma a  % %e e E Ei if f 2 2 t t( ( s se ep pt ti i  t tr rm m% %( (s si is s . .l lM M& &e ei im me er rG Gs s d ds s p pr r$ $) )l l$ $ e el ll l  t ts s$ $  ( (r rm ma al l p pa ar ra am me et te er r a a% % ( (r rm ma al l C CS SD D & &e el lp ps s r r/ /( ( . .B B " ", , t ti i ) )t t( ( G Gs s d ds s p pr r$ $) )l l$ $ e el ll l  t ts s$ $  ( (r rm ma al l a a% % ( (r rm ma al l C CS SD D & &e el lp ps s r r/ /( ( " ", , t ti i ) )t t( ( G Gs s d ds s H Hi il ls s( ( G Gs s d ds s p pr r$ $) )l l$ $ e el ll l  t ts s$ $  ( (r rm ma al l a a% % ( (r rm ma al l C CS SD D & &e el lp ps s r r/ /( ( H Hi il ls s( ( G Gs s d ds s m me e i i ) )e ea al l  a ar rs si i ( (m ma a p pr r$ $) )l l$ $ e el ll l  t ts s$ $  t t$ $( (p p E Ep pr r  2 24 4! !1 12 20 00 0 m m) )/ /d dL L: :$ $F F ) )l l$ $E E H H> >C C  ' 'A A : :$ $  C C t t$ $ E E( (p p L La ar r) )e e  ( (l l, ,m me e ( (f f C CS SD D a a d d m m, ,l lt ti ip pl le e L L' 'G Gs s i i  r re ea as se e   t t  i ie el ld d C Cr ra a i i( (p p& &a ar r  ) )i i( (m ma a  e el ll l  t ts s E E H H> >C C  m m( ( ( ( , , : : . .  a a, ,s se e ( (f f  r r( ( i i   & &e em mi i a al l m me e i i ) )i it ti is s & &e ep pa at ti i  e e  e ep p& &a al l( (p pa at t  p pr r$ $ ( (l l( (r r E Ep pr r$ $ p p( (s si i% %l le e  a a t t( (: :  ( (t t r r( (, ,t ti i e e p pe er rf f( (r rm me ed d , ,r re em mi i  e e  e ep p& &a al l( (p pa at t  p pr r$ $ e el ll l  t ts s$ $, ,r re ea a m mi id dd dl l  E Ep pr r$ $ H H> >C C$ $ E E, ,r re ea a  ( (t t r r( (, ,t ti i e e p pe er rf f( (r rm me ed d B Be em m e el li i i it ti  i ) ) A A, ,l lt ti ip pl le e s s l le er r( s ( si is s p r p r$ $ ) l ) l$ $ e el l l l  t ts s$ $ # #C C> >$ $ A A> >' '$ $+ +) )  i i d de e  E Ep r p r$ $m mi id dl l  H > H >C C$ $ l l ) )l l # #C C> >$ $ A A> >' 'E E + +) )  i i d  de e  a a% % ( (r rm ma al l C CS SD D i i  9 90 0* * ( (f f  a as se es sJ J p r p r$ $ a a d d  e  el ll l  t ts s  l  l 2 2/ /3 3 #t&er dis(rder #t&er dis(rder (rmal 'ress,re (rmal 'ress,re &dr(ep&al,s &dr(ep&al,s Bi Bia) a)( (si sis s &i &i)& )& ( (l l L' L'$ $(p (p )a )ait it a ad d m me eta tal l st stat at,s im ,s impr pr( (em eme et t af afte ter r L' L'$ $ l l (p (p &i &i)& )& ( (l, l,m me e L' L'4 40! 0!50 50  (f (fCS CSD: D: 'se,d(t,m(r 'se,d(t,m(r ere%ri ere%ri p pr r$ $ e el ll l  t ts s$ $( (p p F Fp pr r$ $  l l  e el ll l  t ts s$ $ E E( (p p  2 25 50 0! !6 60 00 0 m mm m " "2 2# # C CS SD D r re em m( ( a al l m ma a  % %e e t t& &e er ra ap pe et ti i  i i  s s( (m me e  a as se es s eeraliMed eeraliMed seiM,re seiM,re p pr r$ $ e el ll l  t ts s$ $( (p p  l l E Ep pr r$ $ m mi il ld dE E H H> >C C p p( (s st t i i t ta al l (pti (pti e,ritis e,ritis pr$ )l$ell ts$ #C> pr$ )l$ell ts$ #C> mild Epr45 t( 60 m)/dL:$ 50* <it& mild E H>C m((,: mild Epr45 t( 60 m)/dL:$ 50* <it& mild E H>C m((,: #C> #C> #C> irease risk (f AS #C> irease risk (f AS '(li(melitis '(li(melitis pr pr$ $ )l )l$ $el ell  l ts ts m mil ild E d Epr pr5 50 t 0 t( 2 ( 200 00 m) m)/d /dL: L:$  $ l l )l )l$ $ mi mild ld E E CS CSD D H> H>C C m m( (( (, ,: : CS CSD H D H> >C F C F<i <it& t& ti tim me e
  • 106. Spial Spial (rd (rd t,m(r t,m(r p pr r$ $ ) )l l$ $ e el ll l  t ts s$ $   t t m ma a  % %e e E EE E p pr r$ $  l l ) )l l$ $ E E H H> >C C  m m( ( ( ( , , : :$ $     t t D Dr r( (i i G Gs s s s  d dr r( (m me e Teta,s Teta,s p pr r$ $ ) )l l$ $ e el ll l  t ts s E Ep pr r 9 90 0 t t( ( 1 15 50 0 m m) )/ /d dL L: :$ $  l l ) )l l$ $  l l  e el ll l  t ts s are m,st take (t t( id,e teta (rmal ell ts are m,st take (t t( id,e teta (rmal ell ts differetiate differetiate fr(mmei)itis fr(mmei)itis 105 105 Barne" R na"han# ++)# lini/al Lab'ra"'r; Medi/ine Barne" R na"han# ++)# lini/al Lab'ra"'r; Medi/ine B B# #A A. .+ +  B B+ +S S# #R RB B? ?R R  S S? ?D D L L C CS SD D S ST T B B+ +? ?S S ? ? ' '? ?C CT T? ?B B R R? ?S S L LT T C C# #A AA A? ? T T A( A(t( t(r r e e,r ,r( (  . .LS LS p pr r$ $  e el ll l  t ts s m mi il ld dE E p pr r a a d d  e el ll l  t ts s  ( (  d di ia a) ) ( (s st ti i  >S >S p pr r$ $  e el ll l  t ts s E Ep pr r$ $  l l  e el ll l  t ts s pr peak %et<ee 1 ad3 <ks pr peak %et<ee 1 ad3 <ks Cell ts I 5ms&(,ld pr(mt Cell ts I 5ms&(,ld pr(mt sear& f(r a(t&er a,se sear& f(r a(t&er a,se %ra&ial %ra&ial ple(pat& ple(pat& pr$ ell ts pr$ ell ts mild Epr 50!60 m)/dL:$ l ell mild Epr 50!60 m)/dL:$ l ell ts ts m(pat& (r m(pat& (r m(sitis m(sitis (t (t r(,tie r(,tie perf(rmed perf(rmed ere%ellitis ere%ellitis pr$)l$ell ts pr$)l$ell ts mildl Epr$ l )l$ ell ts mildl Epr$ l )l$ ell ts ,ss,al ,ss,al -100 / mm -100 / mm ,ss,al se(dar t( ,ss,al se(dar t( ariella!M((ster ariella!M((ster parae(plasti parae(plasti ere%elar ds ere%elar ds pr$ell ts$ a%s pr$ell ts$ a%s mildl mildl Epr$ Epr$ midl midl EH>C 8!20 EH>C 8!20 ell/mm3: ati !N# (r ati ", ell/mm3: ati !N# (r ati ", a% a% .ti!N( .ti!N( i (aria$ ,terie$ (r i (aria$ ,terie$ (r %reast C.$ ati!", see i %reast C.$ ati!", see i l,) C. l,) C.  e e, ,r r( (p pa at t& &  B Bi ia a% %e et ti i  pr$ )l$ell ts pr$ )l$ell ts E pr 50 t( 400 m) E pr 50 t( 400 m) /dL:$ l ell /dL:$ l ell ts$ E)l ts$ E)l
  • 107. 106 106 Barne" Barne" R R Na"han# Na"han# ++)# ++)# lini/al lini/al Lab'ra"'r; Lab'ra"'r; Medi/ine Medi/ine