medicinal chemistry drug discovery graham patrick book enzyme structure and function 150 year scientific quest history of quinine synthesis quinine quinoline chemistry of n-heterocycle organic synthesis origin of dye industry natural product total synthesis malaria drug cellulose glucose cell surface carbohydrates renewable chemicals renewable energy polysaccharides monosaccharides carbohydrate chemistry introduction carbohydrate basic carbohydrate function carbohydrate structure drug protein interaction basic medicinal chemistry protein structure sar receptor structure and function receptor and signal transduction g patrick book
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