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BEST PRACTICES / E B P
DR RAJESH G KONNUR
PROFESSOR
1
CONCEPT OF EBP:
• Evidence based practice is an approach that enables
clinicians to provide the highest quality of care in
meeting the multiphase needs to their parents and
family.
2
INTRODUCTION:
Evidence-based practice (EBP) is a problem-solving approach to the delivery of health care
that integrates the best evidence from studies and patient care data with clinician expertise
and patient preferences and values. (Fineout-Overholt E, 2010).
EBP is the integration of clinical expertise, patient values, and the best research evidence
into the decision making process for patient care.
Clinical expertise refers tothe clinician’s cumulated experience, education & clinical skills.
The patient brings to the encounter his or her own personal preferences and unique
concerns, expectations, and values.
3
DEFINITION
 Evidence based practice (EBP) is the process of making clinical decisions based
upon evidence,combined with clinical experienceand patientsexpectations.
 Evidence based practice is the conscientious explicit and judicious use of current. Best
evidence in making decision about the care of individual patients.The practiceof
evidence based medicine means integrating individual clinical expertisewith the best
availableexternalclinicalevidence fro systematic research.
(Sackett. et al1996)
4
CONT…
• Health care that is evidence-based and conducted in a
caring context leads to better clinical decisions and
patient outcomes. Gaining knowledge and skills in the
EBP process provides dentists and other clinicians the
tools needed to take ownership of their practices and
transform health care.
5
CONT…
6
WAYS OF ACQUIRING KNOWLEDGE IN DENTISTRY /
MEDICAL SCIENCE
Traditions
Borrowing
Trial & Error
Personal Experience
Role Modeling
Intuition
Reasoning
Research
7
KEY COMPONENTS OF EBP
A.Research evidence.
B.Clinical expertise, judicious
use.
C.Patient values and
circumstances.
8
KEY COMPONENTS OF EBP
Resear
ch
Eviden
ce
Patient Values,
Circumstances
Randomized
controlled trials
Laboratory
experiments Clinical
trials Epidemiological
research Outcomes
research Qualitative
research
Expert practice
knowledge,
inductive
reasoning
Clinical
Expertise
Knowledge gained
from practice over time
Inductive reasoning
Unique preferences
Concerns
Expectations
Financial resources
Social support
9
AIMS OF EVIDENCE BASED PRACTICE
 To provide the high quality and most cost-efficient care possible.
 To advance quality of care provided by dental practioners.
 To increase satisfaction among patients.
 To focus on medical practice away from habits and tradition to evidence and
research.
 It results in better patient outcomes.
 It contributes to the science of medical / dental science.
 It keeps practices current and relevant.
 It increases confidence in decision-making.
10
FEATURES OF EBP
Problem based and within the scope of the practitioners experience.
It brings together the best available evidence and current practice by combining
research with knowledge and theory. So it narrows the research practice gap. It
facilitates application of research into practice by including both primary and secondary
research findings.
It concerned with quality of service and is therefore a Quality assurance
activity.
EBP projects are team projects and therefore require team support and collaborative
action.
It support research projects and outcomes that are cost effective EBP de- emphasizes
ritual, isolated and unsystematic clinical experiences ungrounded opinions and tradition
as a basis of practice. It stresses the use of research findings.
11
WHY IS EBP RELEVANT TO THE MEDICAL PRACTICE?
There is a gap between what we know and what we do. Medical
practice can and must be changed from tradition-based to
science-based:
Research-practice gap: Much of what is known from research
has not been applied in practice. This is known as Research-
Practice Gap.
12
STEPS OF EBP
13
THREE COMPONENTS OF EBD
• Is an approach to oral health care.
• Is a method to acquire, understand
and apply the most current science.
Evidence
Patients’
needs &
preferences
Clinical
Expertise
14
STEPS OF EVIDENCE BASED
PRACTICE
Step 1: formulating a well built question.
Step 2: collecting the most relevant and best
evidence to answer the clinical question including
searching for systematic reviews / identifying articles.
Step 3: Critically appraising the evidence that has been
collected for its validity, relevance and applicability.
15
Step 4: integrating the evidence with ones clinical expertise,
assessment of patient’s condition and available health care
resources along with the patients preferences and values to
implement the evidence.
Step 5: Evaluating the change resulting from application of evidence
in practice.
- Determine the areas for improvement.
16
STEP1: FORMULATING THE
QUESTION
With clinical areas ,there is often a barrage of details to
digest. a well built question includes the following
components
the patients disorder or disease
the intervention or finding under review
a comparison intervention
the question should be in PICOT or PICO format
17
PICOT FORMAT
Patient, Population or Problem :
What are the characteristics of the patient or population?
What is the condition or disease you are interested in?
( i.e. age, gender, ethnicity, with a certain disorder)
Intervention or exposure :
What do you want to do with this patient (e.g. treat, diagnose, observe)?
(exposure to a disease, risk behavior, prognostic factor)
18
CONT…
• Comparison:
• What is the alternative to the intervention (e.g. placebo, different drug,
• surgery)?
•(could be a placebo or "business as usual" as in no disease, absence of risk
factor, Prognostic factor B )
19
Outcome
What are the relevant outcomes (e.g. morbidity, death,
complications, risk of disease, accuracy of a diagnosis, rate of
occurrence of adverse outcome)
Time
What time it takes to demonstrate an outcome (e.g. the time it
takes for the intervention to achieve an outcome or how long
participants are observed).
20
ARE INSULIN PUMPS MORE EFFECTIVE THAN
CONVENTIONAL THERAPIES IN MANAGING TYPE 2
DIABETES IN PREGNANT WOMEN?
Patient/Population - Pregnant women with type 2
diabetes.
Intervention - Insulin pump therapy.
Comparison - Conventional insulin therapy.
Outcome - Improved management of glucose levels.
21
SEARCH STRATEGIES BACKGROUND
INFORMATION
Background information may be found in sources
such as:
reference book entries
textbooks, chapters, appendices
drug monographs, guides to diagnostic tests
the library’s Bobcat catalog
selected electronic Reference Tools for Background
information in the health science.
22
STEP 2. DATABASE /RESOURCE
SEARCHI
NG
Once a clinical practice question has been selected, the
next step is to search and assemble research evidence
on the topic. In doing a literature review as a background
for a new study, the central goal is to discover where the
gap are and how best to advance knowledge. The
resourses falls into 3 categories:
23
General information/background resourses-
to collect the past information of a particular disease. e.g measles has been nearly
eradicated, but there has been a fairly recent outbreak. If you need to refresh your
knowledge of the clinical presentation, diagnosis etc of measles, a background
resource would be the best place to start.
Filtered resourses-
If you are trying to decide on a course of action for a patient (diagnosis, treatment
etc)and want to base your decision on the best available evidence, consult a filtered
resource. clinical experts and subject specialists pose a question and then synthesize
evidence to state conclusions based on the available research. because of this pre
evaluation, the clinician does not have to do the literature searching and evaluate each
study that comes up, saving time and ensuring a level of completeness.
24
· Unfiltered resources-
If you don’t find an appropriate answer in the filtered resourses
,you will need to search unfiltered resourses (the primary literature) to
locate studies that answer your question. unfiltered resourses provide
the most recent information ,but its upto to the clinician to evaluate
each study found to determine its validity and applicability to the
patient.
Effectvely searching and evaluating the studies found in unfiltered
resources takes more time and skill, which is why filtered resources
are the first choice of answering clinical questions.
25
EBP RESOURCES
A. PRE-APPRAISED RESOURCES: Filtered resource have
been reviewed for quality and relevance to clinical care.
ACP Journal Club. This Web site comprises a 10- year
archive of the cumulative electronic contents of "ACP Journal
Club", with recurrent weeding of out-of- date articles. The
content is carefully selected from over 100 clinical journals
through reliable application of explicit criteria for scientific merit,
followed by assessment of relevance to medical practice by
clinical specialists.
26
Clinical Evidence.
Clinical Evidence describes the best available evidence from systematic reviews,
RCTs, and observational studies when appropriate for assessing the benefits and
harms of treatments.
Dynamed.
Dynamed is a point-of-care reference resource designed to provide clinicians with
current, evidence-based information to support clinical decision-making.
Essential Evidence.
Essential Evidence is a one-stop reference that includes evidence-based answers
to clinical questions concerning symptoms, diseases, and treatment.
27
FPIN Clinical Inquiries.
Clinical Inquiries provides answers to clinical questions by
using a structured search, critical appraisal, clinical
perspective, and rigorous peer review. FPIN Clinical
Inquiries deliver evidence for point of care use.
UpToDate.
UpToDate is an evidence-based, peer reviewed information
resource available via the Web, desktop/laptop computer,
and PDA/mobile device.
28
DATABASES:
PubMed. PubMed comprises more than 22 million citations for biomedical
articles from MEDLINE and life science journals. Citations may include links to
full-text articles from PubMed Central or publisher web sites.
Cochrane Library. The Cochrane Library contains high- quality, independent
evidence to inform healthcare decision-making. It includes reliable evidence
from Cochrane systematic reviews and a registry of published clinical trials. The
methodology used to create the Cochrane reviews is recognized as the gold
standard for developing systematic reviews.
Center for Reviews and Dissemination (DARE). The databases DARE,
NHS, EED and HTA assist decision- makers by identifying and describing
systematic reviews and economic evaluations, appraising their quality, and
highlighting their relative strengths and weaknesses.
29
ELECTRONIC TEXTBOOKS AND LIBRARIES:
AccessMedicine: Access Medicine is an online resource that provides students,
residents, clinicians, researchers, and other health professionals with access to
"Harrisons Online".
Scientific American Medicine. Formerly known as ACP Medicine, Scientific
American Medicine includes science, medicine, health and technology
information. It is also available from Stat!Ref.
ACP Smart Medicine. Formerly known as ACP PIER, ACP Smart Medicine is an
online clinical tool that provides evidence-based clinical guidance to improve clinical
care. It is free to ACP members or can be purchased as asubscription.
Stat!Ref. STAT!Ref is a collection of online electronic textbooks for healthcare
professionals.
30
META-SEARCH ENGINES:
Trip. The TRIP Database searches across multiple
internet sites for evidence-based content. It covers
key medical journals, Cochrane Systematic
reviews, clinical quidelines, and other highly
relevant websites to help health professionals find
high quality clinical evidence for clinical practice.
31
STEP3. CRITICALLY APPRAISING THE
ARTIC
LE
The assessment of evidence by systematically reviewing its relevance,
validity and results of specific situations.
In determining the implementation potential of an innovation in a particular
setting, several issues should be considered, particularly the transferability of the
innovation, the feasibility of implementing it and its cost benefit ratio. For
example, the traditional method for verifying the placement of a nasogastric tube
was air insufflation.
However, according to current research, the accurate method for verifying
placement is radiologic examination (Metheny & Titler, 2001).
32
If the implementation assessment suggests that
there might be problems in testing the innovation
in that particular practice setting, then the team
can either identify a new problem and begin the
process anew or consider adopting the plan to
improve the implementation potential (e.g.
seeking external resources if cost were the
inhibiting factors).
33
STEP 4. APPLYING THE
EVIDENCE/INTEGRATING
EVIDENCE
WITH ONES
CLINICAL
EXPERTISE
If the implementation criteria are met the team can design and plot the
innovation. To reach your conclusion you may consult questions related
to diagnosis ,therapy, harm and prognosis keep in mind that you must
interpret the information based on a number of criteria and depending
on your skill and experience ,you may need to confer with a peer.
example- Sample evidence practice e.g. consider a nine year old
girl present in the ER with abdominal pain and you suspect
appendicitis. which imaging modality is best for making the
diagnosis CT or ultrasound.
34
STEP 5. EVALUATING THE CHANGE
The fifth step of the process, outcome evaluation, attempts to interpret
the results and evaluate the outcomes of the applied evidence
(intervention). Outcome measures may be psychosocial (quality of life,
improved patient perception of care, reduction in depressive and
anxiety symptoms), physiologic
(improved health, reduced complications), or functional improvement.
Evaluation of the process and the results may occur through peer
assessment, audit, or even self reflection. Depending on the type of
outcomes achieved, it may be possible to compare the outcomes of a
study with similar outcomes on a local, regional, national, or
international level.
35
MODELS FOR EVIDENCE BASED MEDICAL CARE
T
H
EM
O
D
E
L
SOFFER GUIDELINES FOR DESIGNING AND IMPLEMENTING A
UTILIZATION PROJECT IN A PRACTICE SETTING. THE TWO MODELS
STELTER MODEL AND IOWA MODEL INCORPORATE EVIDENCE
PRACTICE PROCESSES RATHER THAN RESEARCH UTILIZATION ALONE.
John Hopkins Model
Stelter Model
CURN
Iowa Model of Evidence Based Practice
36
A. THE STELTER MODEL
The stelter model was designed with the assumption
that Research Utilization could be undertaken.
not only by organizations but by individual clinicians and
managers. It was a model designed to promote and
facilititate critical thinking about the application of research
findings in practice.
The current model presented graphically involves five
sequential phases:
37
38
Preparation
In this phase, the medics define the underlying purpose and outcomes of the project, search,
sort and select sources of research evidence.
She considers external factors that can influence potential application and internal factors that
can diminish objectivity and affirm the priority of perceived problem.
Validation
This phase involves a utilization of focused critique of each source of evidence, focusing in
particular on whether it is sufficiently sound for potential application in practice.
Comparative evaluation and decision- making :
This phase involves a synthesis of findings and application of criteria that taken together are
used to determine the desirability and feasibility of applying findings from validated source to
medical practice. The end result of the comparative evaluation is to make a decision about
using the study findings.
39
Translation/application:
This phase involves activities to conform how the findings will
be used (e.g. formally or informally) and spell out the
operational details of the application and implement them.
Evaluation:
In the final phase, the application is evaluated.
Informal use of the innovation versus formal use would
lead to different evaluative strategies.
40
IOWA MODEL
Efforts to use research evidence to improve medical / nursing practice
are often addressed by group of doctors /nurses interested in the same
practice issues.
This model, like the stelter model, was revised recently an renamed the
Iowa Model of evidence Based Practice to promote quality of care.
The current version of Iowa Model acknowledges that formal RU/EB
Project begins with a trigger an impetus to explore possible changes to
practice. The start point can be either knowledge focused trigger that
emerges from awareness of innovative research findings.
41
42
The model outlines a series of activities with three
clinical decision points.
I. Deciding whether the problem is a sufficient priority for the
organization exploring possible changes; if yes, a team is formed to
proceed with the project: if No, a new trigger would be sought.
II. Deciding whether there is sufficient Research base; if Yes, the
innovation is piloted in the practice setting. If No, the team would
either search for other sources of evidence or conduct its own
research.
III. Deciding whether the change is appropriate for adoption in
practice; if yes, a change would be instituted and monitored. If No;
the team would continue to evaluate quality of care and search for
new knowledge.
43
The points of entry to this model were problem and knowledge
focused triggers.
Problem focused triggers encompassed frequently encountered clinical problems, risk
management and quality improvement data and total quality management programs/ in
contrast,
Knowledge focused triggers include new information that resulted from such sources as the
Agency for Health care policy and Research, specialty organizations and research
publications.
When a trigger was identified the next step included assembling, critiquing, and evaluating the
applicability of relevant research literature.
After the research base was evaluated and critiqued, a decision was made regarding whether
or not a change in practice was warranted. If, however, a sufficient and appropriate research
base was found that supported modification of current practice, changes were initiated that
were congruent with those suggested by the research results. If research base had
insufficiencies, further research was conducted, experts were consulted and applications of
scientific principles were considered.
44
To translate research findings into practice several steps
were necessary:
1) Expected outcomes of the change and baseline or current status were
documented.
2) Dental/ Nursing/ multidisciplinary interventions were designed
3) Practice changes were implemented on a pilot unit.
4) Process and outcomes were evaluated; and
5) The interventions were modified as necessary
The next critical decision point involved determination of whether practice
changes should be made for all patient populations affected by the research
based interventions. Considerations included cost of implementations, overall
impact on quality of care, staff competency and support of administration.
45
This model used a process of planned change . staff need to
be empowered with ownership of the change, as well as,
with the knowledge and resources necessary to make this
change.
This model supported the monitoring of patient outcomes by unit
staff members for atleast two consecutive quarters after
implementation. These activities assisted in maintaining the
practice change and facilitating feedback to the staff. Outcome
measurements are also focused on the effects of change on the
staff and fiscal parameters. Without thorough monitoring of all
these areas an accurate reflection of the cost/benefit
relationship could not be realized.
46
47
48
THE EVIDENCE HIERARCHY:
The best evidence for interventions comes from systematic reviews and
RCTs as we move down this hierarchy in evidence, we usually have less
good information available.
Systematic review
Randomized controlled trial
Cohort study
Case control study
Cross-section analytical study
Descriptive/narrative study
49
THE EVIDENCE HIERARCHY
50
LIMITATIONS
Resistant to changes in clinical practice.
Ability to critically appraise research findings.
Time, workload pressures, and competing priorities.
Lack of continuing education programs.
Fearof "stepping on one'stoes“
Poor administrative support.
51
THE CLINICIAN’S ROLE :
 Information
 Data
 Statistics
 Knowledge
 Judgment
 Values
 Decisions
52
ACKNOWLEDGING THE DIFFERENCE BETWEEN EBP AND
TRADITIONAL PRACTICE:
Evidence-Based Practice
• Uses best evidence
• Systematic appraisal of quality of
evidence
• Objective, transparent, less biased
• Acceptance of levels of uncertainty
Traditional Practice
• Unknown basis of evidence
• Limited/incomplete appraisal of
quality of evidence
• Subjective, opaque, potentially
biased
• Black and white conclusions
53
THE VALUE OF EVIDENCE-BASED PRACTICE
54
BARRIERS TO CHANGE :
• Time
• Access
• Complexity of
information
55
WHAT IS EVIDENCE?
56
What is pre-appraised evidence?
Clinical practice
guidelines
Critical summaries of
systematic reviews
Systematic reviews
57
Systematic reviews Implementation into
clinical practice
1. Clinical Practice
Guidelines
2. Critical summaries
of systematic reviews
3. Independent
appraisal of systematic
reviews (and/or other
trials)
TIERED APPROACH TO FINDING EVIDENCE-BASED
INFORMATION
58
HOW DO I FIND THE BEST EVIDENCE-BASED
INFORMATION TO GUIDE MY PRACTICE?
59
60
ADA CLINICAL PRACTICE GUIDELINES:
61
What are the levels of primary evidence?
Randomized
Controlled Trial
Controlled study
without
randomization
Non-experimental studies
(i.e. cohort and case-control)
Expert committee reports or opinions or
clinical experience of respected authorities
62
HOW DOES EBD WORK?
63
The EBD Process
Ask
Access
Appraise
Apply
Assess
64
Population or Problem
STEP 1: FRAMING THE ANSWERABLE QUESTION
Intervention
Comparison (Optional)
Outcome
65
• Framing the question
• Increase chances of finding the answer
• Know when you’ve found the answer
• Help to find it quickly
• Identify search terms
66
IN PATIENTS WITH PERIODONTAL
DISEASE, WILL SHORT-TERM SYSTEMIC
ANTIBIOTICS, WHEN COMPARED TO
SURGERY, REDUCE POCKET DEPTH?
Population
67
IN PATIENTS WITH PERIODONTAL
DISEASE, WILL SHORT-TERM SYSTEMIC
ANTIBIOTICS, WHEN COMPARED TO
SURGERY, REDUCE POCKET DEPTH?
Population
68
IN PATIENTS WITH PERIODONTAL
DISEASE, WILL SHORT-TERM
SYSTEMIC ANTIBIOTICS, WHEN
COMPARED TO SURGERY, REDUCE
POCKET DEPTH?
Intervention
69
IN PATIENTS WITH PERIODONTAL DISEASE,
WILL SHORT-TERM SYSTEMIC ANTIBIOTICS,
WHEN COMPARED TO SURGERY, REDUCE
POCKET DEPTH?
Intervention
70
IN PATIENTS WITH PERIODONTAL DISEASE,
WILL SHORT-TERM SYSTEMIC ANTIBIOTICS,
WHEN COMPARED TO SURGERY, REDUCE
POCKET DEPTH?
Comparison
71
IN PATIENTS WITH PERIODONTAL DISEASE,
WILL SHORT-TERM SYSTEMIC ANTIBIOTICS,
WHEN COMPARED TO SURGERY, REDUCE
POCKET DEPTH?
Comparison
72
IN PATIENTS WITH PERIODONTAL
DISEASE, WILL SHORT-TERM SYSTEMIC
ANTIBIOTICS, WHEN COMPARED TO
SURGERY, REDUCE POCKET DEPTH?
Outcome
73
IN PATIENTS WITH PERIODONTAL DISEASE,
WILL SHORT-TERM SYSTEMIC ANTIBIOTICS,
WHEN COMPARED TO SURGERY, REDUCE
POCKET DEPTH?
Outcome
74
Ask
Access
Appraise
Apply
Assess
75
Formulate question (PICO)
Develop list of search terms
Guidelines and Summaries
NO
Systematic Reviews
NO
Primary Studies
EBD website ebd.ada.org YES STOP
EBD website and PubMed YES STOP
PubMed
(Clinical Studies)
YES STOP
SEARCH STRATEGY
76
Ask
Access
Appraise
Apply
Assess
77
OTHER LEVELS OF EVIDENCE :
Population
Intervention
Outcome
Control
Outcome
78
Ask
Access
Appraise
Apply
Assess
79
1.Are the results valid?
Quality
• Are the studies well designed and
executed?
• What types of studies are there?
Quantity
• How many studies are there?
• What are the population sizes?
Consistency
• How consistent are their results?
80
1.Are the results valid?
2.What are the results?
• Certainty of the
effect
• Magnitude of
the effect
81
1.Are the results valid?
2.What are the results?
3.Can the results be
applied to my patient?
• Is the
population
similar?
• Is the provider
similar?
• Is the setting
similar?
82
Ask
Access
Appraise
Apply
Assess
83
The better the research, the more confident the
decision. Victor Montori, Mayo Clinic
Evidence alone is never sufficient to make a
clinical decision. Victor Montori, Mayo Clinic
External clinical evidence can inform, but can
never replace, individual clinical expertise. David
Sackett
84
Summary /
Conclusion:
Health Research is systematic inquiry to develop knowledge about issues
of importance to practitioners. Health practioners like nurses, doctors ,
allied health practioners are developing an evidence – based practice
(EBP) that incorporates research findings into their clinical decisions. Best
practice includes choosing the appropriate research finding related to
care aspect.
85
Thanks
86

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Best practice dental class

  • 1. BEST PRACTICES / E B P DR RAJESH G KONNUR PROFESSOR 1
  • 2. CONCEPT OF EBP: • Evidence based practice is an approach that enables clinicians to provide the highest quality of care in meeting the multiphase needs to their parents and family. 2
  • 3. INTRODUCTION: Evidence-based practice (EBP) is a problem-solving approach to the delivery of health care that integrates the best evidence from studies and patient care data with clinician expertise and patient preferences and values. (Fineout-Overholt E, 2010). EBP is the integration of clinical expertise, patient values, and the best research evidence into the decision making process for patient care. Clinical expertise refers tothe clinician’s cumulated experience, education & clinical skills. The patient brings to the encounter his or her own personal preferences and unique concerns, expectations, and values. 3
  • 4. DEFINITION  Evidence based practice (EBP) is the process of making clinical decisions based upon evidence,combined with clinical experienceand patientsexpectations.  Evidence based practice is the conscientious explicit and judicious use of current. Best evidence in making decision about the care of individual patients.The practiceof evidence based medicine means integrating individual clinical expertisewith the best availableexternalclinicalevidence fro systematic research. (Sackett. et al1996) 4
  • 5. CONT… • Health care that is evidence-based and conducted in a caring context leads to better clinical decisions and patient outcomes. Gaining knowledge and skills in the EBP process provides dentists and other clinicians the tools needed to take ownership of their practices and transform health care. 5
  • 7. WAYS OF ACQUIRING KNOWLEDGE IN DENTISTRY / MEDICAL SCIENCE Traditions Borrowing Trial & Error Personal Experience Role Modeling Intuition Reasoning Research 7
  • 8. KEY COMPONENTS OF EBP A.Research evidence. B.Clinical expertise, judicious use. C.Patient values and circumstances. 8
  • 9. KEY COMPONENTS OF EBP Resear ch Eviden ce Patient Values, Circumstances Randomized controlled trials Laboratory experiments Clinical trials Epidemiological research Outcomes research Qualitative research Expert practice knowledge, inductive reasoning Clinical Expertise Knowledge gained from practice over time Inductive reasoning Unique preferences Concerns Expectations Financial resources Social support 9
  • 10. AIMS OF EVIDENCE BASED PRACTICE  To provide the high quality and most cost-efficient care possible.  To advance quality of care provided by dental practioners.  To increase satisfaction among patients.  To focus on medical practice away from habits and tradition to evidence and research.  It results in better patient outcomes.  It contributes to the science of medical / dental science.  It keeps practices current and relevant.  It increases confidence in decision-making. 10
  • 11. FEATURES OF EBP Problem based and within the scope of the practitioners experience. It brings together the best available evidence and current practice by combining research with knowledge and theory. So it narrows the research practice gap. It facilitates application of research into practice by including both primary and secondary research findings. It concerned with quality of service and is therefore a Quality assurance activity. EBP projects are team projects and therefore require team support and collaborative action. It support research projects and outcomes that are cost effective EBP de- emphasizes ritual, isolated and unsystematic clinical experiences ungrounded opinions and tradition as a basis of practice. It stresses the use of research findings. 11
  • 12. WHY IS EBP RELEVANT TO THE MEDICAL PRACTICE? There is a gap between what we know and what we do. Medical practice can and must be changed from tradition-based to science-based: Research-practice gap: Much of what is known from research has not been applied in practice. This is known as Research- Practice Gap. 12
  • 14. THREE COMPONENTS OF EBD • Is an approach to oral health care. • Is a method to acquire, understand and apply the most current science. Evidence Patients’ needs & preferences Clinical Expertise 14
  • 15. STEPS OF EVIDENCE BASED PRACTICE Step 1: formulating a well built question. Step 2: collecting the most relevant and best evidence to answer the clinical question including searching for systematic reviews / identifying articles. Step 3: Critically appraising the evidence that has been collected for its validity, relevance and applicability. 15
  • 16. Step 4: integrating the evidence with ones clinical expertise, assessment of patient’s condition and available health care resources along with the patients preferences and values to implement the evidence. Step 5: Evaluating the change resulting from application of evidence in practice. - Determine the areas for improvement. 16
  • 17. STEP1: FORMULATING THE QUESTION With clinical areas ,there is often a barrage of details to digest. a well built question includes the following components the patients disorder or disease the intervention or finding under review a comparison intervention the question should be in PICOT or PICO format 17
  • 18. PICOT FORMAT Patient, Population or Problem : What are the characteristics of the patient or population? What is the condition or disease you are interested in? ( i.e. age, gender, ethnicity, with a certain disorder) Intervention or exposure : What do you want to do with this patient (e.g. treat, diagnose, observe)? (exposure to a disease, risk behavior, prognostic factor) 18
  • 19. CONT… • Comparison: • What is the alternative to the intervention (e.g. placebo, different drug, • surgery)? •(could be a placebo or "business as usual" as in no disease, absence of risk factor, Prognostic factor B ) 19
  • 20. Outcome What are the relevant outcomes (e.g. morbidity, death, complications, risk of disease, accuracy of a diagnosis, rate of occurrence of adverse outcome) Time What time it takes to demonstrate an outcome (e.g. the time it takes for the intervention to achieve an outcome or how long participants are observed). 20
  • 21. ARE INSULIN PUMPS MORE EFFECTIVE THAN CONVENTIONAL THERAPIES IN MANAGING TYPE 2 DIABETES IN PREGNANT WOMEN? Patient/Population - Pregnant women with type 2 diabetes. Intervention - Insulin pump therapy. Comparison - Conventional insulin therapy. Outcome - Improved management of glucose levels. 21
  • 22. SEARCH STRATEGIES BACKGROUND INFORMATION Background information may be found in sources such as: reference book entries textbooks, chapters, appendices drug monographs, guides to diagnostic tests the library’s Bobcat catalog selected electronic Reference Tools for Background information in the health science. 22
  • 23. STEP 2. DATABASE /RESOURCE SEARCHI NG Once a clinical practice question has been selected, the next step is to search and assemble research evidence on the topic. In doing a literature review as a background for a new study, the central goal is to discover where the gap are and how best to advance knowledge. The resourses falls into 3 categories: 23
  • 24. General information/background resourses- to collect the past information of a particular disease. e.g measles has been nearly eradicated, but there has been a fairly recent outbreak. If you need to refresh your knowledge of the clinical presentation, diagnosis etc of measles, a background resource would be the best place to start. Filtered resourses- If you are trying to decide on a course of action for a patient (diagnosis, treatment etc)and want to base your decision on the best available evidence, consult a filtered resource. clinical experts and subject specialists pose a question and then synthesize evidence to state conclusions based on the available research. because of this pre evaluation, the clinician does not have to do the literature searching and evaluate each study that comes up, saving time and ensuring a level of completeness. 24
  • 25. · Unfiltered resources- If you don’t find an appropriate answer in the filtered resourses ,you will need to search unfiltered resourses (the primary literature) to locate studies that answer your question. unfiltered resourses provide the most recent information ,but its upto to the clinician to evaluate each study found to determine its validity and applicability to the patient. Effectvely searching and evaluating the studies found in unfiltered resources takes more time and skill, which is why filtered resources are the first choice of answering clinical questions. 25
  • 26. EBP RESOURCES A. PRE-APPRAISED RESOURCES: Filtered resource have been reviewed for quality and relevance to clinical care. ACP Journal Club. This Web site comprises a 10- year archive of the cumulative electronic contents of "ACP Journal Club", with recurrent weeding of out-of- date articles. The content is carefully selected from over 100 clinical journals through reliable application of explicit criteria for scientific merit, followed by assessment of relevance to medical practice by clinical specialists. 26
  • 27. Clinical Evidence. Clinical Evidence describes the best available evidence from systematic reviews, RCTs, and observational studies when appropriate for assessing the benefits and harms of treatments. Dynamed. Dynamed is a point-of-care reference resource designed to provide clinicians with current, evidence-based information to support clinical decision-making. Essential Evidence. Essential Evidence is a one-stop reference that includes evidence-based answers to clinical questions concerning symptoms, diseases, and treatment. 27
  • 28. FPIN Clinical Inquiries. Clinical Inquiries provides answers to clinical questions by using a structured search, critical appraisal, clinical perspective, and rigorous peer review. FPIN Clinical Inquiries deliver evidence for point of care use. UpToDate. UpToDate is an evidence-based, peer reviewed information resource available via the Web, desktop/laptop computer, and PDA/mobile device. 28
  • 29. DATABASES: PubMed. PubMed comprises more than 22 million citations for biomedical articles from MEDLINE and life science journals. Citations may include links to full-text articles from PubMed Central or publisher web sites. Cochrane Library. The Cochrane Library contains high- quality, independent evidence to inform healthcare decision-making. It includes reliable evidence from Cochrane systematic reviews and a registry of published clinical trials. The methodology used to create the Cochrane reviews is recognized as the gold standard for developing systematic reviews. Center for Reviews and Dissemination (DARE). The databases DARE, NHS, EED and HTA assist decision- makers by identifying and describing systematic reviews and economic evaluations, appraising their quality, and highlighting their relative strengths and weaknesses. 29
  • 30. ELECTRONIC TEXTBOOKS AND LIBRARIES: AccessMedicine: Access Medicine is an online resource that provides students, residents, clinicians, researchers, and other health professionals with access to "Harrisons Online". Scientific American Medicine. Formerly known as ACP Medicine, Scientific American Medicine includes science, medicine, health and technology information. It is also available from Stat!Ref. ACP Smart Medicine. Formerly known as ACP PIER, ACP Smart Medicine is an online clinical tool that provides evidence-based clinical guidance to improve clinical care. It is free to ACP members or can be purchased as asubscription. Stat!Ref. STAT!Ref is a collection of online electronic textbooks for healthcare professionals. 30
  • 31. META-SEARCH ENGINES: Trip. The TRIP Database searches across multiple internet sites for evidence-based content. It covers key medical journals, Cochrane Systematic reviews, clinical quidelines, and other highly relevant websites to help health professionals find high quality clinical evidence for clinical practice. 31
  • 32. STEP3. CRITICALLY APPRAISING THE ARTIC LE The assessment of evidence by systematically reviewing its relevance, validity and results of specific situations. In determining the implementation potential of an innovation in a particular setting, several issues should be considered, particularly the transferability of the innovation, the feasibility of implementing it and its cost benefit ratio. For example, the traditional method for verifying the placement of a nasogastric tube was air insufflation. However, according to current research, the accurate method for verifying placement is radiologic examination (Metheny & Titler, 2001). 32
  • 33. If the implementation assessment suggests that there might be problems in testing the innovation in that particular practice setting, then the team can either identify a new problem and begin the process anew or consider adopting the plan to improve the implementation potential (e.g. seeking external resources if cost were the inhibiting factors). 33
  • 34. STEP 4. APPLYING THE EVIDENCE/INTEGRATING EVIDENCE WITH ONES CLINICAL EXPERTISE If the implementation criteria are met the team can design and plot the innovation. To reach your conclusion you may consult questions related to diagnosis ,therapy, harm and prognosis keep in mind that you must interpret the information based on a number of criteria and depending on your skill and experience ,you may need to confer with a peer. example- Sample evidence practice e.g. consider a nine year old girl present in the ER with abdominal pain and you suspect appendicitis. which imaging modality is best for making the diagnosis CT or ultrasound. 34
  • 35. STEP 5. EVALUATING THE CHANGE The fifth step of the process, outcome evaluation, attempts to interpret the results and evaluate the outcomes of the applied evidence (intervention). Outcome measures may be psychosocial (quality of life, improved patient perception of care, reduction in depressive and anxiety symptoms), physiologic (improved health, reduced complications), or functional improvement. Evaluation of the process and the results may occur through peer assessment, audit, or even self reflection. Depending on the type of outcomes achieved, it may be possible to compare the outcomes of a study with similar outcomes on a local, regional, national, or international level. 35
  • 36. MODELS FOR EVIDENCE BASED MEDICAL CARE T H EM O D E L SOFFER GUIDELINES FOR DESIGNING AND IMPLEMENTING A UTILIZATION PROJECT IN A PRACTICE SETTING. THE TWO MODELS STELTER MODEL AND IOWA MODEL INCORPORATE EVIDENCE PRACTICE PROCESSES RATHER THAN RESEARCH UTILIZATION ALONE. John Hopkins Model Stelter Model CURN Iowa Model of Evidence Based Practice 36
  • 37. A. THE STELTER MODEL The stelter model was designed with the assumption that Research Utilization could be undertaken. not only by organizations but by individual clinicians and managers. It was a model designed to promote and facilititate critical thinking about the application of research findings in practice. The current model presented graphically involves five sequential phases: 37
  • 38. 38
  • 39. Preparation In this phase, the medics define the underlying purpose and outcomes of the project, search, sort and select sources of research evidence. She considers external factors that can influence potential application and internal factors that can diminish objectivity and affirm the priority of perceived problem. Validation This phase involves a utilization of focused critique of each source of evidence, focusing in particular on whether it is sufficiently sound for potential application in practice. Comparative evaluation and decision- making : This phase involves a synthesis of findings and application of criteria that taken together are used to determine the desirability and feasibility of applying findings from validated source to medical practice. The end result of the comparative evaluation is to make a decision about using the study findings. 39
  • 40. Translation/application: This phase involves activities to conform how the findings will be used (e.g. formally or informally) and spell out the operational details of the application and implement them. Evaluation: In the final phase, the application is evaluated. Informal use of the innovation versus formal use would lead to different evaluative strategies. 40
  • 41. IOWA MODEL Efforts to use research evidence to improve medical / nursing practice are often addressed by group of doctors /nurses interested in the same practice issues. This model, like the stelter model, was revised recently an renamed the Iowa Model of evidence Based Practice to promote quality of care. The current version of Iowa Model acknowledges that formal RU/EB Project begins with a trigger an impetus to explore possible changes to practice. The start point can be either knowledge focused trigger that emerges from awareness of innovative research findings. 41
  • 42. 42
  • 43. The model outlines a series of activities with three clinical decision points. I. Deciding whether the problem is a sufficient priority for the organization exploring possible changes; if yes, a team is formed to proceed with the project: if No, a new trigger would be sought. II. Deciding whether there is sufficient Research base; if Yes, the innovation is piloted in the practice setting. If No, the team would either search for other sources of evidence or conduct its own research. III. Deciding whether the change is appropriate for adoption in practice; if yes, a change would be instituted and monitored. If No; the team would continue to evaluate quality of care and search for new knowledge. 43
  • 44. The points of entry to this model were problem and knowledge focused triggers. Problem focused triggers encompassed frequently encountered clinical problems, risk management and quality improvement data and total quality management programs/ in contrast, Knowledge focused triggers include new information that resulted from such sources as the Agency for Health care policy and Research, specialty organizations and research publications. When a trigger was identified the next step included assembling, critiquing, and evaluating the applicability of relevant research literature. After the research base was evaluated and critiqued, a decision was made regarding whether or not a change in practice was warranted. If, however, a sufficient and appropriate research base was found that supported modification of current practice, changes were initiated that were congruent with those suggested by the research results. If research base had insufficiencies, further research was conducted, experts were consulted and applications of scientific principles were considered. 44
  • 45. To translate research findings into practice several steps were necessary: 1) Expected outcomes of the change and baseline or current status were documented. 2) Dental/ Nursing/ multidisciplinary interventions were designed 3) Practice changes were implemented on a pilot unit. 4) Process and outcomes were evaluated; and 5) The interventions were modified as necessary The next critical decision point involved determination of whether practice changes should be made for all patient populations affected by the research based interventions. Considerations included cost of implementations, overall impact on quality of care, staff competency and support of administration. 45
  • 46. This model used a process of planned change . staff need to be empowered with ownership of the change, as well as, with the knowledge and resources necessary to make this change. This model supported the monitoring of patient outcomes by unit staff members for atleast two consecutive quarters after implementation. These activities assisted in maintaining the practice change and facilitating feedback to the staff. Outcome measurements are also focused on the effects of change on the staff and fiscal parameters. Without thorough monitoring of all these areas an accurate reflection of the cost/benefit relationship could not be realized. 46
  • 47. 47
  • 48. 48
  • 49. THE EVIDENCE HIERARCHY: The best evidence for interventions comes from systematic reviews and RCTs as we move down this hierarchy in evidence, we usually have less good information available. Systematic review Randomized controlled trial Cohort study Case control study Cross-section analytical study Descriptive/narrative study 49
  • 51. LIMITATIONS Resistant to changes in clinical practice. Ability to critically appraise research findings. Time, workload pressures, and competing priorities. Lack of continuing education programs. Fearof "stepping on one'stoes“ Poor administrative support. 51
  • 52. THE CLINICIAN’S ROLE :  Information  Data  Statistics  Knowledge  Judgment  Values  Decisions 52
  • 53. ACKNOWLEDGING THE DIFFERENCE BETWEEN EBP AND TRADITIONAL PRACTICE: Evidence-Based Practice • Uses best evidence • Systematic appraisal of quality of evidence • Objective, transparent, less biased • Acceptance of levels of uncertainty Traditional Practice • Unknown basis of evidence • Limited/incomplete appraisal of quality of evidence • Subjective, opaque, potentially biased • Black and white conclusions 53
  • 54. THE VALUE OF EVIDENCE-BASED PRACTICE 54
  • 55. BARRIERS TO CHANGE : • Time • Access • Complexity of information 55
  • 57. What is pre-appraised evidence? Clinical practice guidelines Critical summaries of systematic reviews Systematic reviews 57
  • 58. Systematic reviews Implementation into clinical practice 1. Clinical Practice Guidelines 2. Critical summaries of systematic reviews 3. Independent appraisal of systematic reviews (and/or other trials) TIERED APPROACH TO FINDING EVIDENCE-BASED INFORMATION 58
  • 59. HOW DO I FIND THE BEST EVIDENCE-BASED INFORMATION TO GUIDE MY PRACTICE? 59
  • 60. 60
  • 61. ADA CLINICAL PRACTICE GUIDELINES: 61
  • 62. What are the levels of primary evidence? Randomized Controlled Trial Controlled study without randomization Non-experimental studies (i.e. cohort and case-control) Expert committee reports or opinions or clinical experience of respected authorities 62
  • 63. HOW DOES EBD WORK? 63
  • 65. Population or Problem STEP 1: FRAMING THE ANSWERABLE QUESTION Intervention Comparison (Optional) Outcome 65
  • 66. • Framing the question • Increase chances of finding the answer • Know when you’ve found the answer • Help to find it quickly • Identify search terms 66
  • 67. IN PATIENTS WITH PERIODONTAL DISEASE, WILL SHORT-TERM SYSTEMIC ANTIBIOTICS, WHEN COMPARED TO SURGERY, REDUCE POCKET DEPTH? Population 67
  • 68. IN PATIENTS WITH PERIODONTAL DISEASE, WILL SHORT-TERM SYSTEMIC ANTIBIOTICS, WHEN COMPARED TO SURGERY, REDUCE POCKET DEPTH? Population 68
  • 69. IN PATIENTS WITH PERIODONTAL DISEASE, WILL SHORT-TERM SYSTEMIC ANTIBIOTICS, WHEN COMPARED TO SURGERY, REDUCE POCKET DEPTH? Intervention 69
  • 70. IN PATIENTS WITH PERIODONTAL DISEASE, WILL SHORT-TERM SYSTEMIC ANTIBIOTICS, WHEN COMPARED TO SURGERY, REDUCE POCKET DEPTH? Intervention 70
  • 71. IN PATIENTS WITH PERIODONTAL DISEASE, WILL SHORT-TERM SYSTEMIC ANTIBIOTICS, WHEN COMPARED TO SURGERY, REDUCE POCKET DEPTH? Comparison 71
  • 72. IN PATIENTS WITH PERIODONTAL DISEASE, WILL SHORT-TERM SYSTEMIC ANTIBIOTICS, WHEN COMPARED TO SURGERY, REDUCE POCKET DEPTH? Comparison 72
  • 73. IN PATIENTS WITH PERIODONTAL DISEASE, WILL SHORT-TERM SYSTEMIC ANTIBIOTICS, WHEN COMPARED TO SURGERY, REDUCE POCKET DEPTH? Outcome 73
  • 74. IN PATIENTS WITH PERIODONTAL DISEASE, WILL SHORT-TERM SYSTEMIC ANTIBIOTICS, WHEN COMPARED TO SURGERY, REDUCE POCKET DEPTH? Outcome 74
  • 76. Formulate question (PICO) Develop list of search terms Guidelines and Summaries NO Systematic Reviews NO Primary Studies EBD website ebd.ada.org YES STOP EBD website and PubMed YES STOP PubMed (Clinical Studies) YES STOP SEARCH STRATEGY 76
  • 78. OTHER LEVELS OF EVIDENCE : Population Intervention Outcome Control Outcome 78
  • 80. 1.Are the results valid? Quality • Are the studies well designed and executed? • What types of studies are there? Quantity • How many studies are there? • What are the population sizes? Consistency • How consistent are their results? 80
  • 81. 1.Are the results valid? 2.What are the results? • Certainty of the effect • Magnitude of the effect 81
  • 82. 1.Are the results valid? 2.What are the results? 3.Can the results be applied to my patient? • Is the population similar? • Is the provider similar? • Is the setting similar? 82
  • 84. The better the research, the more confident the decision. Victor Montori, Mayo Clinic Evidence alone is never sufficient to make a clinical decision. Victor Montori, Mayo Clinic External clinical evidence can inform, but can never replace, individual clinical expertise. David Sackett 84
  • 85. Summary / Conclusion: Health Research is systematic inquiry to develop knowledge about issues of importance to practitioners. Health practioners like nurses, doctors , allied health practioners are developing an evidence – based practice (EBP) that incorporates research findings into their clinical decisions. Best practice includes choosing the appropriate research finding related to care aspect. 85

Notes de l'éditeur

  1. Script: If we think about Evidence, Clinical Expertise and Patients’ Needs and Preferences as three circles then EBD is right in the center where all three circles overlap  It is important for us to understand that EBD is an approach to practice, an approach to making clinical decisions and is just one component used to arrive at best treatment decisions. EBD is a method to stay up to date on the current science.
  2. Script: Sometimes it is not clear how the clinician’s expertise is incorporated into EBD. Science is data, information, statistics and knowledge. It does not have judgments or values, and it cannot tell us what to do. That is the role of the dentists. He/she must understand the data, and the information revealed with the data. This is incorporated with judgments and values to develop recommendations and help a patient make a decision about his/her individualized treatment. The danger is in ignoring the science. Science should be embraced and utilized to form the basis for clinical decisions. It informs, but does not dictate, decisions. The clinician forms the judgment on how the science can be applied, and the patient’s needs and preferences form the value-basis for the individualized decision.
  3. Script: In traditional practice, we don’t actively look for emerging evidence, we depend on what we learned in school or what we hear speakers say. We never ask if the speaker is talking from his experiences and his study findings or if his presentation is based on a systematic assessment of all the evidence. We look for “Yes/No” answers. In contrast, EBD is about using the best available evidence after a systematic assessment of the literature and accepting that sometimes we don’t have the answers and we should be ready to change when these answers are found. Such a process is a change in perspective i.e. we need to begin to look at things in a different way. Note to presenter: Please try to use an example from your experience highlighting these differences.
  4. Note to presenter: A short story on why you became interested in EBD would help the audience associate with this presentation. You may also use an example of a clinical situation when you used evidence to manage a patient. Some talking points include: As a practitioner you gain… Improved clinical decision-making capability Greater self-confidence in treatment planning Satisfaction derived from creating customized treatment plans Greater respect from improved communication with patients Your Patients gain… More trust and confidence in you and your practice Greater incentive to invest in quality oral health care Increased pride from being a patient of a community thought leader and a distinctive practice Your Dental Team and Practice gain… Increased staff confidence, pride, trust and personal satisfaction Enhanced recognition in the community and with peers Greater opportunity to conserve practice financial resources by enabling wiser decisions in product, equipment and therapeutic selections
  5. Script: Understanding the changes and a willingness to move forward puts us face to face with the challenges that confront us. But this needs time. I know I don’t have time. In the course of running a busy practice, it is difficult to find the time to conduct a literature search, read all identified articles, critically assess the articles, and come to some conclusion Even if I have time, the typical private practice or small practice nature of most dental offices does not provide access to a wide variety of journals. Finally, many articles published in scientific formats are not user-friendly for chairside application But these are just some walls we need to learn to climb. The ADA and many other agencies offer several resources to help apply evidence in practice. So our goal should be to find such sources and use this information. If you have limited time, consider starting with clinical practice guidelines and the secondary sources of evidence such as summaries and systematic reviews. (Note that a list appears on Slides 32, 33 and 34)
  6. Script “Pre-appraised” evidence means that the evidence has been evaluated according to standard methods by a group of experts with experience and skills in the area of evidence-based dentistry. The ADA offers two types of pre-appraised evidence: clinical practice guidelines and critical summaries of systematic reviews; and also a database for easy access to systematic reviews. Note that the ADA also generates its own systematic reviews as the foundation for the clinical practice guidelines. Clinical practice guidelines are statements that include recommendations intended to optimize patient care that are informed by a systematic review of evidence and an assessment of the benefits and harms of alternative care options. At the ADA, the Council on Scientific Affairs appoints an expert panel including stakeholders to develop the guidelines according to a comprehensive and transparent process. Critical summaries of systematic reviews are developed by trained ADA Evidence Reviewers mentored by evidence-based dentistry experts called the Critical Review Panel. These summaries are one-page snapshots that provide an overview of the systematic review, an assessment of both the level of evidence on the topic as well as the quality of the systematic review, and the clinical implications of the information. In a systematic review, the authors try to identify all evidence on a particular topic and analyze the data cumulatively. The advantages of this type of document are that it is based on multiple studies not just one, it follows a systematic process, and it provides a big picture of what ALL the evidence on a topic points to.
  7. The Center for EBD promotes a 3-step process to find evidence. You should first look for Clinical Practice Guidelines on the question of interest. If none exist, then you should look for Critical Summaries of systematic reviews on the topic. Finally, if those are unavailable you then need to perform your own literature search to find relevant systematic reviews which you would need to critically appraise and interpret independently.
  8. Script: So, you are probably asking, how do I find the best evidence-based information to guide my practice given all the barriers that I face?
  9. The ADA has six clinical practice guidelines published. Five are caries-prevention focused, including: Topical fluoride – update (2013) Non-fluoride caries preventive agents (2011) Infant formula (2011) Fluoride supplements (2010) Sealants (2008) The sixth is on screening for oral cancer (2010) A new guideline on nonsurgical treatments for chronic periodontal disease as well as an update on the sealants guideline are currently being developed.
  10. Script If there are no clinical practice guidelines, critical summaries, or systematic reviews on your topic of interest, then you need to look to primary evidence to answer your clinical question. The level of evidence does depend on the question that you are asking; however, traditionally evidence is depicted according to a pyramid, where higher levels on the pyramid represent higher levels of evidence, which in turn indicates a lower risk for bias. The highest level of primary evidence is a randomized controlled trial or an RCT. This is the highest level of a clinical study. If a trial is not randomized, but it has a control, then it falls one level below the RCT. There are other types of clinical studies like the cohort studies, case control, case series and case reports, which are called “observational studies”. Right under the clinical studies are the expert opinions especially those developed through consensus panels followed by animal research and bench-top research. In an IDEAL world we prefer RCTs to answer all our questions, especially with respect to “what interventions perform the best?”.
  11. Note to presenter: This slide includes an animation which will work with each click of your mouse. Please try out. Script: The first step is to define a clinically relevant, focused question. In defining a question we must pay attention to four elements – what is the population (children/adults or smokers/non-smokers etc.), what is the intervention, what are we comparing it to and what is the outcome that we need? The second step focuses on systematically searching for evidence published or unpublished, that may help to answer this question. The third step of the EBD process is focused on appraising the validity and reliability of the evidence. Important questions to ask at this point – What is the level of evidence used to come to the conclusion? Does this apply to my patient? The fourth step of the EBD process involves using the evidence in treatment planning. Based on my clinical expertise, and the patient’s needs and preferences, how strongly should I recommend this to my patient? The final step involves assessing treatment outcomes for the patient.
  12. SCRIPT: The clinical question is usually asked in a PICO format. P is the population of interest. I is the intervention. This can be thought of as the new treatment that is being studied. C is the comparison treatment. And O is the outcome. You can think of this as what exactly is being measured.
  13. Script: Why is a PICO question important? A PICO question helps to focus and frame your question. It increases your chance of finding the answer, and finding it quickly. By having a searchable question, you can identify key words to use for searching. And lastly, it will help you know when you’ve found the answer to your question. When used effectively, PICO questions can make searching for answers easier and faster. Now, let’s practice…..
  14. Script: Now, let’s run through an example. In this question, can you identify the POPULATION?
  15. Script: What is the INTERVENTION
  16. Script: What is the COMPARISON?
  17. SCRIPT: What is the Outcome?
  18. SCRIPT: The next step in the EBD process is accessing the evidence. There are many ways to do this, and searching is a skill that needs to be developed and refined over time.
  19. Script: When searching for evidence, one strategy is to look for summaries and guidelines first. If you can get an answer to your question, then you are done! The primary website that can be used to search for guidelines and summaries is the ADA’s EBD website. If you do not have an answer to your question, the next step is to search for systematic reviews. The EBD Website is the first place to look for systematic reviews since its database only includes dental systematic reviews. But if you don’t find your answer there, then the next place to look is PubMed. If you do not find any systematic reviews answering your question, then the next step is to look for primary studies on PubMed. This strategy allows you to look for the simplest source of evidence first, documents (guidelines and summaries), where someone else has critically assessed a wide amount of evidence. Only if you don’t find an answer do you need to start looking for and searching more complex websites.
  20. SCRIPT: The next step in the EBD process is to critically appraise the evidence. Not all studies are created equal, and we need to understand the strengths and weaknesses of each study. This is a learned skill, and one of the other advantages of using guidelines or summaries is that someone else has critically appraised the research for you. But if you do not find a guideline or summary, you will need to take the time to read an article, especially the methods section, to determine the quality of the research.
  21. Script: Well then, why can’t we only use RCTs for evidence? The simple answer of course is because our world is not ideal! But specifically because: One, RCTs may not be available. RCTs have not been conducted to address all clinical questions. Two, they may not be applicable. There are circumstances where an RCT is either unnecessary or unethical to answer a clinical question. A typical example is that there is no need to do an RCT to determine if using a parachute will save lives when jumping from an airplane. We know the answer to this without doing an RCT. Sometimes after a systematic assessment of the literature if we find that expert opinion is THE ONLY evidence available it is graded as a weak level of evidence. In such a situation we accept the levels of uncertainty and use our judgment to determine how strongly we might recommend this approach to our patients. We understand that further research is needed in this case and that results may very likely change the way we might approach a similar situation in the future.
  22. SCRIPT: The next step is to decide whether or not to apply the evidence in practice. To do this you need to consider three questions…..
  23. Script: The first question is: Is it VALID? For this you want to look at the quality of the study (this is the critical appraisal), the quantity (the number of studies and the number of subjects), and the consistency (do all the studies have similar results?).
  24. Script: The second question is: What are the RESULTS? For this you want to determine how certain the researchers (and you) are about the results, and also how large the results are.
  25. Script: The third question is: Can the results be APPLIED to my patient? For this you want to understand if the population, provider and setting are similar. If so, then you can expect to have similar results with your patients.
  26. SCRIPT: The final step in the EBD process is Assessing the results. This is understanding what impact the treatment has had on your patients. Did it work? If not, why?
  27. SCRIPT: In closing, here are some quotes that will help us reflect on the importance of EBD, and how we can use it when treating our patients.