1. Nefropatía Diabetica Jorge Arturo Bustos Martinez Residente de primer año medicina interna UN

2. Contenido Epidemiologia Definición Fisiopatologia Historia Natural Clasificación Screening y tratamiento

3. Epidemiologia Robert G. Nelson, MD, Katherine R. Tuttle. Clinical Practice Guidelines and Clinical Practice Recommendations for DIABETES AND CHRONIC KIDNEY DISEASE. American Journal of Kidney Diseases, Vol 49, No 2, Suppl 2 (February), 2007: pp S10-S11

4. Definición Lesiones microangiopaticas renales Complicación vascular crónica especifica de la diabetes Alteraciones funcionales y estructurales. Proliferación de la matriz y celularidadmesangial-> aumento del grosor de la MB glomerular -> esclerosis glomerular. Robert G. Nelson, MD, Katherine R. Tuttle. Clinical Practice Guidelines and Clinical Practice Recommendations for DIABETES AND CHRONIC KIDNEY DISEASE. American Journal of Kidney Diseases, Vol 49, No 2, Suppl 2 (February), 2007: pp S10-S11

5. Definicion Robert G. Nelson, MD, Katherine R. Tuttle. Clinical Practice Guidelines and Clinical Practice Recommendations for DIABETES AND CHRONIC KIDNEY DISEASE. American Journal of Kidney Diseases, Vol 49, No 2, Suppl 2 (February), 2007: pp S10-S11

6. Histopatología Hipertrofia glomerular: Celularidadmesangial: Kimmelstiel-Wilson: Engrosamiento mesangial: Suma Dronavalli, Irena Duka and George L Bakris. The pathogenesis of diabetic nephropathy. nature clinical practice ENDOCRINOLOGY & METABOLISM. AUGUST 2008 vol 4 no 8

7. Fisiopatologia Suma Dronavalli, Irena Duka and George L Bakris. The pathogenesis of diabetic nephropathy. nature clinical practice ENDOCRINOLOGY & METABOLISM. AUGUST 2008 vol 4 no 8

8. Fisiopatologia Suma Dronavalli, Irena Duka and George L Bakris. The pathogenesis of diabetic nephropathy. nature clinical practice ENDOCRINOLOGY & METABOLISM. AUGUST 2008 vol 4 no 8

9. Fisiopatologia Prorrenina-> Proteincinasas activadas por mitogenos (MAPK) Citoquinas. Estrés oxidativo Susceptibilidad genetica. Suma Dronavalli, Irena Duka and George L Bakris. The pathogenesis of diabetic nephropathy. nature clinical practice ENDOCRINOLOGY & METABOLISM. AUGUST 2008 vol 4 no 8

10. Historia Natural. Richard J. MacIsaac and George Jerums. Diabetic kidney disease with and without albuminuria. CurrentOpinion in Nephrologyand Hypertension2011, 20:000–000

11. Historia Natural Richard J. MacIsaac and George Jerums. Diabetic kidney disease with and without albuminuria. CurrentOpinion in Nephrologyand Hypertension2011, 20:000–000

12. Riesgo de Muerte Robert G. Nelson, MD, Katherine R. Tuttle. Clinical Practice Guidelines and Clinical Practice Recommendations for DIABETES AND CHRONIC KIDNEY DISEASE. American Journal of Kidney Diseases, Vol 49, No 2, Suppl 2 (February), 2007: pp S10-S11

13. Clasificación Robert G. Nelson, MD, Katherine R. Tuttle. Clinical Practice Guidelines and Clinical Practice Recommendations for DIABETES AND CHRONIC KIDNEY DISEASE. American Journal of Kidney Diseases, Vol 49, No 2, Suppl 2 (February), 2007: pp S10-S11

14. Clasificación Mogenssen: Catalá M, Rosalén R. Nefropatía diabética. Medicine 1993;6(34):1442-61

15. Screening y Tratamiento Robert G. Nelson, MD, Katherine R. Tuttle. Clinical Practice Guidelines and Clinical Practice Recommendations for DIABETES AND CHRONIC KIDNEY DISEASE. American Journal of Kidney Diseases, Vol 49, No 2, Suppl 2 (February), 2007: pp S10-S11

16. Screening y Tratamiento Robert G. Nelson, MD, Katherine R. Tuttle. Clinical Practice Guidelines and Clinical Practice Recommendations for DIABETES AND CHRONIC KIDNEY DISEASE. American Journal of Kidney Diseases, Vol 49, No 2, Suppl 2 (February), 2007: pp S10-S11

17. Screening y Tratamiento Albuminuria: - DM tipo 1: después de 5 años del diagnostico. - DM tipo 2: en todos a partir del diagnostico. Creatinina: - En todos los diabeticos Anualmente Robert G. Nelson, MD, Katherine R. Tuttle. Clinical Practice Guidelines and Clinical Practice Recommendations for DIABETES AND CHRONIC KIDNEY DISEASE. American Journal of Kidney Diseases, Vol 49, No 2, Suppl 2 (February), 2007: pp S10-S11

18. Tratamiento (A) Robert G. Nelson, MD, Katherine R. Tuttle. Clinical Practice Guidelines and Clinical Practice Recommendations for DIABETES AND CHRONIC KIDNEY DISEASE. American Journal of Kidney Diseases, Vol 49, No 2, Suppl 2 (February), 2007: pp S10-S11

19. Conclusiones Prevención primaria Detección temprana Tratamiento optimo

20. Tequila http://micro.magnet.fsu.edu/cocktails/pages/tequila.html