translational pharmacology

1. S U B M I T T E D TO - P R E S E N T E D B Y-
M R S . J Y O T H I Y. B H AV YA R E WA R I
A S S T. P R O F F. , M . P H A R M , I S T Y E A R
D E PA RT M E N T O F P H A R M A C O L O G Y
K R U PA N I D H I C O L L E G E O F P H A R M A C Y, B A N G A L O R E
Translational
Pharmacology
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2. Contents
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 Introduction
 Need of Translational Pharmacology
 Objectives
 Importance of Translational Pharmacology
 Hurdles in Translational Pharmacology
 Reference

3. Introduction
 Translational pharmacology is the application of
biomedical research, conducted to support drug
development, which aids in patient selection, dosing
regimen and segmentation of diseases
 It is the concept of translating the laboratory
findings into the clinic i.e. patient care, for achieving
better patient treatment
 This concept is called as ‘ Bench to Bedside’
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 It may involve the process of molecular research of
drug in laboratory to clinical care
 This is often termed as ‘molecular medicine’ or
‘personalized medicine’

5. It encompasses the following-
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 The definition of guidelines of drug development or
for the identification and validation of clinically
relevant biomarkers
 Experimental, non-human or non-clinical conducted
to develop principles for the discovery of new
therapeutic strategies
 Clinical investigations that provide a biological
foundation for the development of improved
therapies
 Basic science studies that define the biological effect
of therapeutics in humans

6. Need of Translational Pharmacology
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 Pharmacology as a discipline, spans from molecular
studies to investigations in animal models and
human clinical trials
 With increase in specialization in all branches of
biological and clinical sciences, there is an increased
need to bridge the sciences through translational
pharmacology
 Advanced technologies such as genomics,
proteonomics, bioinformatics etc are powerful tools
for translational research

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 Preclinical work may be significantly dissimilar to
that in human models and results may not be
extrapolated
 Therefore, Translational Pharmacology is the term
which appropriately describes the successful
integration of scientific discoveries with their
applications in treatment of human beings

8. Objectives
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 To discover the origin, pathway and mechanism of
diseases including the responsible biomarkers
 To systematically discover and develop new
diagnostics and therapeutic methods
 To discover drugs in short duration of time

9. Importance of Translational
Pharmacology
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 Translational Pharmacology can answer to some
simple questions, once a drug has emerged from a
screening cascade
 By testing an agent in a number of models of
human diseases, one can achieve better pre-clinical
results
 Dosing schedules can be tested in the clinic for
maximum therapeutic benefits with minimum
toxicity, based on the profile of the molecule and
data from the clinical models

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 Proof of mechanism
 Proof of concept
 Proof of principle/ biology
 Actual benefits of the concerned molecule

11. Bench side studies
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 These include-
i. In silico
ii. In vitro
iii. In vivo

12. In silico
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 These methods include developing and validating
complex mathematical models capable of
representing human disease and response to the
therapeutic interventions
 Not this alone, it also includes the computational
forms screening i.e. virtual screening
 Results obtained in the clinical settings can then be
refactored into integrated mathematical models to
enhance their translational potential

13. Hurdles in Translational
Pharmacology
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 Scientific hurdles
 Ethical hurdles
 Regulatory hurdles
 Inadequate financial support
 Shortage of investigators

14. Reference
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 Maiti Rituparna,” Postgraduate Topics in
Pharmacology”, page number-249-256, 1st edition,
Paras Medical Books.