The document summarizes the Transderm Ionto system, an FDA-cleared device that uses dermoelectroporation to deliver drugs transdermally as an alternative to injections. It is manufactured by Mattioli Engineering and distributed in the US by Saratoga Aesthetics. The system combines microdermabrasion with low-current pulses to enhance delivery of both small and large drug molecules without needles or associated pain, bruising, or swelling of injections.

1. Transderm ® Ionto The Only FDA Approved Alternative to Injections

6. The Transderm ® Uses Dermoelectroporation ® Dermoelectroporation ® uses continuous reversed polarity current pulses to deliver low-weight and heavy-weight molecules without compromising the integrity of the solution.

7. Just Two Easy Steps Step One: Microdermabrasion to Ensure Penetration and Reproducibility Step Two: Dermoelectroporation ® for Transdermal Drug Delivery

10. Advantages of Dermoelectroporation ®

13. Other Configurations Face and Body Applications Microdermabrasion System Not Included Face Application Only Microdermabrasion System Not Included

14. Precision Liquid Dispenser and Disposable Caps Probe for Face Probe for Body Disposable Accessories

15. A Sterile System All of the accessories for the Transderm ® come pre-sterilized and individually wrapped

17. Transderm ® Results Pilot clinical study to evaluate the efficacy of the Transdermal Ionto device to minimize pain and discomfort associated with dermatological cosmetic procedures Mark Nestor, MD, PhD and Alex Cazzaniga Center for Cosmetic Enhancement, Aventura, Florida

18. Transderm ® Results Before After © Saratoga Aesthetics • 2006 • All rights reserved

19. Transderm ® Results Before After © Saratoga Aesthetics • 2006 • All rights reserved

20. Transderm ® Results Before After © Saratoga Aesthetics • 2006 • All rights reserved

21. Transderm ® Results Before After © Saratoga Aesthetics • 2006 • All rights reserved

22. Transderm ® Results Before After © Saratoga Aesthetics • 2006 • All rights reserved

23. Transderm ® Results Before After © Saratoga Aesthetics • 2006 • All rights reserved

24. Transderm ® Results Before After © Saratoga Aesthetics • 2006 • All rights reserved