2. Learning Objectives
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Definition of Jaundice
Mechanism of Bilirubin metabolism
Types of jaundice and its clinical characteristics
Obstructive jaundice
Approach to jaundice.
3. What Is Jaundice??
Condition which is characterized by yellowish
discoloration of the skin, sclera and mucous
membrane due to increase concentration of
bilirubin above normal level.
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4. • Normal Value:- 0.2 to 0.8 mg/dl
• Latent Jaundice :1 mg to 1.9 mg/dl
• Clinical Jaundice : more than 2 mg / dl
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9. Physiological Jaundice
In neonates, jaundice tends to develop because of
• More RBC mass
• Life span of RBC is less (90 days)
• Breakdown of fetal hemoglobin as it is replaced
with adult hemoglobin
• Increased intrahepatic circulation
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10. • Relatively immature hepatic metabolic pathways of
liver, which are unable to conjugate and excrete
bilirubin as quickly as an adult
• Resulting in accumulation of bilirubin in the blood
(hyperbilirubinemia), leading to the symptoms of
jaundice
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11. Pathological Jaundice
Jaundice that is visible during the first 24 hours and
after 2 weeks of life is likely to be non physiological
Neonates who present with jaundice after 3-4 days
of life may also require closer monitoring
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12. Breast Milk Jaundice
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Indirect hyperbilirubinemia in a breast feed new
born that develop after 4-7 days of life.
Progesterone Present in breast milk inhibit UDP-
glucuronyl transferase
Decrease UDP-glucuronyl activity in new born
Increase concentration of nonesterified free fatty
acids that inhibit hepatic glucuronyl transferase.
13. Where To Look For…....
Sclera
Ventral surface of Tongue
Palmar Crease
Sole of foot
Whole body
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15. Causes Of Jaundice
In neonatal period
Surgical cause
Biliary atresia
Choledochal cyst
Medical Cause
Breast feeding jaundice
Hemolytic disease
Hypothyroidism
16. In infantile period
Surgical causes
• Biliary atresia
• Choledocal cyst
• Choledocholithiasis
• Sclerosing cholangitis
• Pyogenic cholangitis
• Traumatic stricture
• Benign or malignant tumor of CBD
• Extramural compression.
• Worm In CBD
18. When To Concern…...
Jaundice is progressive
Medical management fail
It lasts for more than two weeks
It is associated with Hepatosplenomegaly
History suggestive of obstructive cause – Dark urine,
pale stool
19. Clinical Features
Yellowish discoloration of skin, sclera & mucous membrane
Pale or clay colored stools
Dark colored urine
May have high grade fever with or without chills and rigor
Itching all over body
Loss of appetite
Nausea and vomiting
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20. How To Proceed ?
History taking
Age
Jaundice
Onset
Fluctuation
Progression
Association with other symptoms like pain , fever &
itching
21. Cont.
Colour of Urine
Colour of Stool
Weight loss
Drug History
Ante-natal History ( TORCH of Mother )
Family history of jaundice
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23. ON SYSTEMIC EXAMINATION
Gastrointestinal System:
Inspection:
Yellowish coloration of skin, Abdomen Distended,
Engorged vein , Position of Umbilicus ,Scar marks
Palpation:
Hepatosplenomegaly
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25. Investigation
Blood : CBC,ESR, Hb % ,Peripheral Blood Film
: LFT ( Serum Bilirubin, ALT, AST, Alk Phos,PT, )
: Viral Marker
Imaging: Usg of hepatobiliary system
: CT of hepatobiliary system
: MRCP
: HIDA
Urine : Urine RE, Urobilinogen
26. Table Of Diagnostic Tests
Function test Pre-hepatic jaundice Hepatic jaundice Post-hepatic jaundice
Total bilirubin Normal / increased Increased
Conjugated bilirubin Normal Increased Increased
Unconjugated bilirubin Normal / increased Increased Normal
Urobilinogen Normal / increased Decreased Decreased / negative
Urine color Normal
Dark (urobilinogen +
conjugated bilirubin)
Dark (conjugated
bilirubin)
Stool color Normal Normal/pale Pale
Alkaline phosphatase
levels
Normal
Increased
Alanine transferase and
aspartate transferase
levels
Increased
Conjugated bilirubin in
urine
Not present Present
Splenomegaly Present Present Absent
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28. GENERAL MANAGEMENT
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PRINCIPLES OF GENERAL MANAGEMENT
• Correction of dehydration and electrolyte
• Correction of coagulation profile
• To prevent hepatic failure
• Control/prevention of infection
• To prevent translocation of gut organism
29. Correction Of Dehydration &
Electrolyte
Adequate hydration by intravenous fluid infusion
Correction of electrolyte imbalance
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30. Correction of coagulation
profile
Inj. Vitamin-K IM/IV once daily for 3 days.
Then check the prothrombin time; if not corrected then
repeat this treatment and again check for prothrombin
time.
If not corrected then arrange Fresh Frozen Plasma
(FFP) before operation and perform operation.
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