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DIGESTION
Digestion is the process by
which
 insoluble food, consisting of large molecules is
broken down into soluble compounds
What are starch, proteins & fats
broken down into?
enzyme
STARCH

Glucose
enzyme

PROTEIN

Amino acids
enzyme

FAT

Fatty acids &
glycerol
Why must food be digested?
1

Food in
intestine

2
Blood

Food in
intestine
enzyme

Blood

Wall of
intestine

3 Food in

intestine

Blood

To be small enough
to be absorbed
through the wall of
intestine.
Digestion
starts at the
mouth and
ends at the
anus
……………….
Food is broken down by two actions:

1. PHYSICAL
/MECHANICAL

2. CHEMICAL
1. PHYSICAL DIGESTION by:
 teeth
 peristalsis of the alimentary
canal

Chewing (mastication)
Why is it important to break down
food physically?
To increase the surface area for enzyme action.
Question: SEP, 2009
Give TWO reasons why food must be masticated
before swallowed. (4)
1. Increased surface area for enzymes to act
quickly.
2. Easier to manipulate by tongue to form a
bolus.
2. CHEMICAL DIGESTION by:
 enzymes

Digestive enzymes are the chemicals that break
large insoluble food molecules into smaller soluble
molecules.
Four stages in feeding & digestion:
2. Digestion

3. Absorption into
the bloodstream

4. Egestion

1. Ingestion
Digested food is absorbed & then
assimilated by the cells
Absorption

Assimilation

Digestive
system

Body
cell
Circulatory
system
Digestive tract is also
called:
 Alimentary canal / tract
 Gut
Mucus is produced
throughout the gut:
 For lubrication
 To protect gut wall
from digestive enzymes
Fig. 1
The human
digestive
system.
The 1st stage of nutrition:

1. Ingestion

2. Digestion
3. Absorption

4. Egestion
DIGESTION
IN THE
MOUTH
 salivary glands produce SALIVA
(pH = 7-8)
Salivation is a reflex action which
is triggered by:
 Sight

 Smell

 Thinking
of food
Saliva contains:
 mucus
 water
 sodium hydrogen
carbonate
 salivary amylase
(ptyalin [old term])
Functions of mucus in saliva:
1. lubricates the food
2. sticks the food particles together

bolus
Salivary
amylase
In swallowing, food is directed into
the gullet / oesophagus
A person cannot breathe while
swallowing. Why?
1. The soft palate closes
the nasal cavity .
2. The epiglottis closes the
trachea.
Swallowing
Peristalsis:
 wave-like motions of the alimentary
canal which move the food forwards
Digestive tract

Bolus

1

Wave of
relaxation

Bolus
moves

2

2

Wave of
contraction
Peristalsis:
Peristalsis is possible as gut wall is
muscular
 contraction of circular & longitudinal
muscles alternate to push food
Food is pushed when:
Circular muscle
above bolus
CONTRACTS
What does the
longitudinal muscle
do at the same time?

Relaxes
Food reaches the
stomach
The stomach stores
food for some time &
releases it slowly
 Food stays for 2-6 hours in the
stomach

Chyme:
creamy liquid leaving
the stomach
Food remains inside stomach due to
contraction of two sphincters
Oesophagus
Cardiac sphincter

Pyloric sphincter

Lining of
mucus

Duodenum

Churning due to:
Layers of muscle
Which sphincter is contracted?
Cardiac sphincter:
Pyloric sphincter:
relaxes to let chyme
into the duodenum

contracted
Gastric glands
secrete
gastric juice
What happens to food inside the
stomach?
Gastric juice contains:
1. HYDROCHLORIC ACID
2. PEPSIN
3. RENNIN

What is the pH in
the stomach?

1-2
Functions of hydrochloric acid:
1. creates the optimum pH for pepsin
HCl
Pepsinogen
2.
(inactive form)

Pepsin
(active enzyme)

3. kills bacteria taken in
with the food
Excessive production of gastric
juice: burning sensation
Gastric juice enters oesophagus:
not enough mucus to protect wall
Remedy for burning sensation in
throat and chest:
1. Drink milk
2. Take antacids
Doctors can see the
stomach lining by using
an:
oesophagus

endoscope
Stomach ulcers due to:
little mucus in stomach
Pepsin is a protease:
 breaks:
Proteins

Polypeptides
Which conditions are needed for a
piece of meat to be digested?

 Pepsin in acidic conditions
Question: MAY,2009
The following diagram represents the protein found
in egg white. Each circle represents an amino acid.
Complete the diagram below to show how pepsin
breaks down the protein found in egg white.

[Idea is that short chains representing polypeptides are
made.]
(Do NOT accept individual amino acids represented as single
circles or dipeptides represented as a pair of circles)
Question: MAY, 2012
List TWO reasons why amylase does not act on
starch in the stomach. (2)
i. pH in stomach is not optimum for amylase
ii. there is no enzyme in the stomach to break
starch
Some substances that are absorbed
by the stomach:






ethanol
vitamins
certain salts and drugs
some water
glucose

How did I
get drunk so
quickly?
Rennin
 is an enzyme found in the stomach of young
children
 Function:
Pepsin then acts
on the insoluble
protein
Soluble protein
in milk

Changes into
insoluble protein
In cheese-making, rennet [contains
rennin] is added to milk
THE INTESTINES:
Small intestine
7 m long
Large intestine

1.5 m long
The small
intestine is
composed of:

duodenum &
ileum
Two functions of the small
intestine:
1. digestion is completed
2. digested food is absorbed
Bloodstream
Products of
digestion
Duodenum
 U-shaped
 first part of small intestine (most digestion
occurs here)
 about 25 cm long
The duodenum receives secretions
from the:

Liver
[bile via the
bile duct]
Pancreas
[pancreatic juice via
the pancreatic duct]
DIGESTION IN THE
DUODENUM
Where is bile:
i) made? ii)stored?
Made in
liver

Stored
in gall
bladder
Bile:
 has no enzymes
 consists of:
 water
 sodium chloride
 bile salts
 bile pigments
 pH = 8
Functions of Bile:
 dilutes contents from stomach
 creates optimum pH for pancreatic enzymes
to work in duodenum
 contains bile salts which emulsify fats

Bile salts
Bile salts emulsify fats i.e.:
 break large fat globules into smaller globules
What is the benefit of emulsification?
The surface area where lipase can act is increased.

Emulsification
of fats
A person had his gall bladder removed.
Explain why the doctor told him to limit
fats in the diet.
Fats cannot be emulsified;
difficult to digest fats by lipase.
Three enzymes in
pancreatic juice:
Pancreas

Pancreatic amylase
Trypsin
Lipase

Action of
each
enzyme:
amylase
maltose

starch molecule
trypsin

proteins &
polypeptides

peptides

lipase

fat molecule

+
glycerol

fatty
acids
Question: MAY, 2012
Bile and pancreatic juice are involved in
digestion of fats.
a) Describe the role of both secretions in this
process. (4)
b) Explain why bile must be released before
pancreatic juice for the efficient digestion of
fats. (2)
DIGESTION
IN THE
ILEUM
The wall of the ileum has

intestinal glands
that produce
intestinal juice
Enzymes in intestinal juice
SUBSTRATE

ENZYME

END PRODUCT

Peptides
Lipids

Peptidase
Lipase

Maltose
Sucrose
Lactose

Maltase
Sucrase
Lactase

Amino acids
Fatty acids &
glycerol
Glucose + glucose
Glucose + fructose
Glucose + galactose
Remember:
Proteins
Pepsin

Polypeptides
Trypsin
Peptides
Peptidase
Amino acids
Remember: Digestion of starch
Starch
Salivary Amylase
(In Mouth)

Maltose
No digestion of starch in
stomach (amylase is
denatured)

Maltose
(in ileum)

Maltase

Glucose

Pancreatic
Amylase
Digestion is complete in the
ileum. What happens to the
digested food?
Model of the ileum showing numerous villi

Villus: a finger-like projection
Villi contain blood & lymph vessels
Structure of a villus
A villus is adapted for absorption
The ileum is adapted to absorb
digested food
 by providing a LARGE surface area:
 Folded walls
 Has villi
 Has microvilli
Ileum is adapted for absorption:
1. Ileum is long:
 more time for digestion
 a greater surface area for absorption
2. Villi:
 increase surface area for absorption
3. Microvilli in epithelium:
 increase surface area for absorption
4. Epithelium is very thin:
 soluble products of digestion pass through quickly
5. Dense capillary network:
 removes the digested food
THE
LARGE INTESTINE
The large intestine is composed of:

4. Colon

1.Caecum
2. Appendix

3. Rectum

Anus
Material in the large intestine
consists of:





water
mucus
dead cells
undigested matter

Most of the undigested matter is
cellulose. Why is this so?
Function of the:

Colon:
absorbs water

Rectum:
stores FAECES before being
expelled through the ANUS
The 4th stage of feeding &
digestion:

4. Egesting
I really have
to go to the
bathroom!

Egestion / Defaecation
 the process of removing
faeces
Caecum & Appendix are
 Vestigial in humans:
[small & no function]

Caecum
Appendix

 Large in herbivores
Question: SEP, 2011
Explain why the caecum /
appendix in humans is small
and non-functional. (4)

Human

Rabbit

Humans are omnivores.
Do not depend only upon vegetation for
nutrients.
A large caecum is found in herbivores and is full
of bacteria that produce cellulase to digest
cellulose.
Ingestion
(2 L)

Salivary gland secretions
(1 L)
Gastric secretions
(2 L)

Bile
(0.7 L)
Small intestine
secretions
(2 L)

1% in
faeces

Pancreatic secretions
(1.2 L)

Although 8.9 L of
water are ingested
or secreted daily,
the faeces are dry.
Explain.
Ingestion
(2 L)

Salivary gland secretions
(1 L)
Gastric secretions
(2 L)

Bile
(0.7 L)
Small intestine
secretions
(2 L)

1% in
faeces

Pancreatic secretions
(1.2 L)

Absorbed in the
small intestine &
colon.
ASSIMILATION OF DIGESTED
FOOD
FOOD

USE

STORE

Glucose

Respiration

Glycogen or Fat

Fats

Respiration,
Fat
to build cell structure,
as a store of energy
Build proteins for cell CANNOT BE STORED
– ARE DEAMINATED
structures, enzymes
& USED IN
RESPIRATION

Amino
acids
Deamination occurs in the liver
AMINO ACID
is broken into two:
Part with
nitrogen forms:
AMMONIA
UREA

The rest is
used for
energy
Question: MAY, 2007
Write the correct term for each of the following
processes:
i) the breakdown of excess amino acids
Deamination
ii) rhythmical muscular contractions that push
food along the digestive system
Peristalsis
iii) the elimination of indigestible food from
the body
Egestion / Defaecation
iv) the passage of digested food through the
gut wall in the blood stream.
Absorption
BLOOD SUPPLY OF THE LIVER
Blood supply to and away from the liver

HEART
HEPATIC VEIN
to heart
HEPATIC
PORTAL VEIN

Blood from
digestive system

LIVER
HEPATIC ARTERY

GUT

Oxygenated blood
from heart
Write an account of a controlled experiment
you would perform to show the action of the
enzyme amylase on starch. (6) [MAY, 1997]
1

Two spotting tiles are
prepared with a drop of
iodine solution in each
hole.

2

An equal volume of starch
is placed into two separate
test tubes, labelled A and B.
3

An equal volume of amylase is placed
into two separate test tubes, labelled C
and D.
Test tube C is boiled for 5 minutes to
denature the enzyme and so act as a
control.
4

All four test tubes are
placed in a water bath at
37C for 5 minutes to
acclimatise.
Starch in test tube A is
poured into amylase in test
tube D, mixed and the stop
watch is started.

5

6

After 30 seconds, a drop of the
mixture is taken and added to one
of the drops of iodine solution on
the spotting tile. This is repeated
until a yellow colour appears.
7

8

Starch in test tube B is poured
into amylase in test tube C,
mixed and the same method is
repeated.
Contents in test tube:
i) D give a yellow colour with
iodine solution after a few
minutes
ii) C continues to give a blueblack colour after 30 minutes.
9

10

The results show that amylase breaks down
starch.

If Benedict’s solution is added to
the contents of test tubes C and D
and heated for a few minutes, a
brick red colour is obtained only
in test tube D [unboiled amylase].
This shows that when starch
breaks down, reducing sugars are
formed.

C

D
THE END

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Digestion

  • 2. Digestion is the process by which  insoluble food, consisting of large molecules is broken down into soluble compounds
  • 3. What are starch, proteins & fats broken down into? enzyme STARCH Glucose enzyme PROTEIN Amino acids enzyme FAT Fatty acids & glycerol
  • 4. Why must food be digested? 1 Food in intestine 2 Blood Food in intestine enzyme Blood Wall of intestine 3 Food in intestine Blood To be small enough to be absorbed through the wall of intestine.
  • 5. Digestion starts at the mouth and ends at the anus ……………….
  • 6. Food is broken down by two actions: 1. PHYSICAL /MECHANICAL 2. CHEMICAL
  • 7. 1. PHYSICAL DIGESTION by:  teeth  peristalsis of the alimentary canal Chewing (mastication)
  • 8. Why is it important to break down food physically? To increase the surface area for enzyme action.
  • 9. Question: SEP, 2009 Give TWO reasons why food must be masticated before swallowed. (4) 1. Increased surface area for enzymes to act quickly. 2. Easier to manipulate by tongue to form a bolus.
  • 10. 2. CHEMICAL DIGESTION by:  enzymes Digestive enzymes are the chemicals that break large insoluble food molecules into smaller soluble molecules.
  • 11. Four stages in feeding & digestion: 2. Digestion 3. Absorption into the bloodstream 4. Egestion 1. Ingestion
  • 12. Digested food is absorbed & then assimilated by the cells Absorption Assimilation Digestive system Body cell Circulatory system
  • 13. Digestive tract is also called:  Alimentary canal / tract  Gut
  • 14. Mucus is produced throughout the gut:  For lubrication  To protect gut wall from digestive enzymes
  • 16. The 1st stage of nutrition: 1. Ingestion 2. Digestion 3. Absorption 4. Egestion
  • 18.  salivary glands produce SALIVA (pH = 7-8)
  • 19. Salivation is a reflex action which is triggered by:  Sight  Smell  Thinking of food
  • 20. Saliva contains:  mucus  water  sodium hydrogen carbonate  salivary amylase (ptyalin [old term])
  • 21. Functions of mucus in saliva: 1. lubricates the food 2. sticks the food particles together bolus
  • 23. In swallowing, food is directed into the gullet / oesophagus
  • 24. A person cannot breathe while swallowing. Why? 1. The soft palate closes the nasal cavity . 2. The epiglottis closes the trachea.
  • 26. Peristalsis:  wave-like motions of the alimentary canal which move the food forwards Digestive tract Bolus 1 Wave of relaxation Bolus moves 2 2 Wave of contraction
  • 28. Peristalsis is possible as gut wall is muscular  contraction of circular & longitudinal muscles alternate to push food
  • 29. Food is pushed when: Circular muscle above bolus CONTRACTS What does the longitudinal muscle do at the same time? Relaxes
  • 31. The stomach stores food for some time & releases it slowly  Food stays for 2-6 hours in the stomach Chyme: creamy liquid leaving the stomach
  • 32. Food remains inside stomach due to contraction of two sphincters Oesophagus Cardiac sphincter Pyloric sphincter Lining of mucus Duodenum Churning due to: Layers of muscle
  • 33. Which sphincter is contracted? Cardiac sphincter: Pyloric sphincter: relaxes to let chyme into the duodenum contracted
  • 35. What happens to food inside the stomach?
  • 36. Gastric juice contains: 1. HYDROCHLORIC ACID 2. PEPSIN 3. RENNIN What is the pH in the stomach? 1-2
  • 37. Functions of hydrochloric acid: 1. creates the optimum pH for pepsin HCl Pepsinogen 2. (inactive form) Pepsin (active enzyme) 3. kills bacteria taken in with the food
  • 38. Excessive production of gastric juice: burning sensation
  • 39. Gastric juice enters oesophagus: not enough mucus to protect wall
  • 40. Remedy for burning sensation in throat and chest: 1. Drink milk 2. Take antacids
  • 41. Doctors can see the stomach lining by using an: oesophagus endoscope
  • 42. Stomach ulcers due to: little mucus in stomach
  • 43. Pepsin is a protease:  breaks: Proteins Polypeptides
  • 44. Which conditions are needed for a piece of meat to be digested?  Pepsin in acidic conditions
  • 45. Question: MAY,2009 The following diagram represents the protein found in egg white. Each circle represents an amino acid. Complete the diagram below to show how pepsin breaks down the protein found in egg white. [Idea is that short chains representing polypeptides are made.] (Do NOT accept individual amino acids represented as single circles or dipeptides represented as a pair of circles)
  • 46. Question: MAY, 2012 List TWO reasons why amylase does not act on starch in the stomach. (2) i. pH in stomach is not optimum for amylase ii. there is no enzyme in the stomach to break starch
  • 47. Some substances that are absorbed by the stomach:      ethanol vitamins certain salts and drugs some water glucose How did I get drunk so quickly?
  • 48. Rennin  is an enzyme found in the stomach of young children  Function: Pepsin then acts on the insoluble protein Soluble protein in milk Changes into insoluble protein
  • 49. In cheese-making, rennet [contains rennin] is added to milk
  • 50. THE INTESTINES: Small intestine 7 m long Large intestine 1.5 m long
  • 51. The small intestine is composed of: duodenum & ileum
  • 52. Two functions of the small intestine: 1. digestion is completed 2. digested food is absorbed Bloodstream Products of digestion
  • 53. Duodenum  U-shaped  first part of small intestine (most digestion occurs here)  about 25 cm long
  • 54. The duodenum receives secretions from the: Liver [bile via the bile duct] Pancreas [pancreatic juice via the pancreatic duct]
  • 56. Where is bile: i) made? ii)stored?
  • 58. Bile:  has no enzymes  consists of:  water  sodium chloride  bile salts  bile pigments  pH = 8
  • 59. Functions of Bile:  dilutes contents from stomach  creates optimum pH for pancreatic enzymes to work in duodenum  contains bile salts which emulsify fats Bile salts
  • 60. Bile salts emulsify fats i.e.:  break large fat globules into smaller globules What is the benefit of emulsification? The surface area where lipase can act is increased. Emulsification of fats
  • 61. A person had his gall bladder removed. Explain why the doctor told him to limit fats in the diet. Fats cannot be emulsified; difficult to digest fats by lipase.
  • 62. Three enzymes in pancreatic juice: Pancreas Pancreatic amylase Trypsin Lipase Action of each enzyme:
  • 64. Question: MAY, 2012 Bile and pancreatic juice are involved in digestion of fats. a) Describe the role of both secretions in this process. (4) b) Explain why bile must be released before pancreatic juice for the efficient digestion of fats. (2)
  • 66. The wall of the ileum has intestinal glands that produce intestinal juice
  • 67. Enzymes in intestinal juice SUBSTRATE ENZYME END PRODUCT Peptides Lipids Peptidase Lipase Maltose Sucrose Lactose Maltase Sucrase Lactase Amino acids Fatty acids & glycerol Glucose + glucose Glucose + fructose Glucose + galactose
  • 69. Remember: Digestion of starch Starch Salivary Amylase (In Mouth) Maltose No digestion of starch in stomach (amylase is denatured) Maltose (in ileum) Maltase Glucose Pancreatic Amylase
  • 70. Digestion is complete in the ileum. What happens to the digested food?
  • 71. Model of the ileum showing numerous villi Villus: a finger-like projection
  • 72. Villi contain blood & lymph vessels
  • 73. Structure of a villus
  • 74. A villus is adapted for absorption
  • 75. The ileum is adapted to absorb digested food  by providing a LARGE surface area:  Folded walls  Has villi  Has microvilli
  • 76. Ileum is adapted for absorption: 1. Ileum is long:  more time for digestion  a greater surface area for absorption 2. Villi:  increase surface area for absorption 3. Microvilli in epithelium:  increase surface area for absorption 4. Epithelium is very thin:  soluble products of digestion pass through quickly 5. Dense capillary network:  removes the digested food
  • 78. The large intestine is composed of: 4. Colon 1.Caecum 2. Appendix 3. Rectum Anus
  • 79. Material in the large intestine consists of:     water mucus dead cells undigested matter Most of the undigested matter is cellulose. Why is this so?
  • 80.
  • 81. Function of the: Colon: absorbs water Rectum: stores FAECES before being expelled through the ANUS
  • 82. The 4th stage of feeding & digestion: 4. Egesting
  • 83. I really have to go to the bathroom! Egestion / Defaecation  the process of removing faeces
  • 84. Caecum & Appendix are  Vestigial in humans: [small & no function] Caecum Appendix  Large in herbivores
  • 85. Question: SEP, 2011 Explain why the caecum / appendix in humans is small and non-functional. (4) Human Rabbit Humans are omnivores. Do not depend only upon vegetation for nutrients. A large caecum is found in herbivores and is full of bacteria that produce cellulase to digest cellulose.
  • 86. Ingestion (2 L) Salivary gland secretions (1 L) Gastric secretions (2 L) Bile (0.7 L) Small intestine secretions (2 L) 1% in faeces Pancreatic secretions (1.2 L) Although 8.9 L of water are ingested or secreted daily, the faeces are dry. Explain.
  • 87. Ingestion (2 L) Salivary gland secretions (1 L) Gastric secretions (2 L) Bile (0.7 L) Small intestine secretions (2 L) 1% in faeces Pancreatic secretions (1.2 L) Absorbed in the small intestine & colon.
  • 88. ASSIMILATION OF DIGESTED FOOD FOOD USE STORE Glucose Respiration Glycogen or Fat Fats Respiration, Fat to build cell structure, as a store of energy Build proteins for cell CANNOT BE STORED – ARE DEAMINATED structures, enzymes & USED IN RESPIRATION Amino acids
  • 89. Deamination occurs in the liver AMINO ACID is broken into two: Part with nitrogen forms: AMMONIA UREA The rest is used for energy
  • 90. Question: MAY, 2007 Write the correct term for each of the following processes: i) the breakdown of excess amino acids Deamination ii) rhythmical muscular contractions that push food along the digestive system Peristalsis
  • 91. iii) the elimination of indigestible food from the body Egestion / Defaecation iv) the passage of digested food through the gut wall in the blood stream. Absorption
  • 92. BLOOD SUPPLY OF THE LIVER
  • 93. Blood supply to and away from the liver HEART HEPATIC VEIN to heart HEPATIC PORTAL VEIN Blood from digestive system LIVER HEPATIC ARTERY GUT Oxygenated blood from heart
  • 94. Write an account of a controlled experiment you would perform to show the action of the enzyme amylase on starch. (6) [MAY, 1997] 1 Two spotting tiles are prepared with a drop of iodine solution in each hole. 2 An equal volume of starch is placed into two separate test tubes, labelled A and B.
  • 95. 3 An equal volume of amylase is placed into two separate test tubes, labelled C and D. Test tube C is boiled for 5 minutes to denature the enzyme and so act as a control. 4 All four test tubes are placed in a water bath at 37C for 5 minutes to acclimatise.
  • 96. Starch in test tube A is poured into amylase in test tube D, mixed and the stop watch is started. 5 6 After 30 seconds, a drop of the mixture is taken and added to one of the drops of iodine solution on the spotting tile. This is repeated until a yellow colour appears.
  • 97. 7 8 Starch in test tube B is poured into amylase in test tube C, mixed and the same method is repeated. Contents in test tube: i) D give a yellow colour with iodine solution after a few minutes ii) C continues to give a blueblack colour after 30 minutes.
  • 98. 9 10 The results show that amylase breaks down starch. If Benedict’s solution is added to the contents of test tubes C and D and heated for a few minutes, a brick red colour is obtained only in test tube D [unboiled amylase]. This shows that when starch breaks down, reducing sugars are formed. C D