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Plaque characterization with oct
Plaque characterization with oct
Society for Heart Attack Prevention and Eradication
Rumberg 4
Rumberg 4
Society for Heart Attack Prevention and Eradication
509 chromosome 6p linked to high hdl
509 chromosome 6p linked to high hdl
Society for Heart Attack Prevention and Eradication
Polymophism in the promoter
Polymophism in the promoter
Society for Heart Attack Prevention and Eradication
Recent results and findings.
Recent results and findings.
Society for Heart Attack Prevention and Eradication
Esv2n35
Esv2n35
Society for Heart Attack Prevention and Eradication
091 vascular dysfunction in hypercholesterolemic rabbits
091 vascular dysfunction in hypercholesterolemic rabbits
Society for Heart Attack Prevention and Eradication
Accv porg
Accv porg
Society for Heart Attack Prevention and Eradication
Recommandé
Plaque characterization with oct
Plaque characterization with oct
Society for Heart Attack Prevention and Eradication
Rumberg 4
Rumberg 4
Society for Heart Attack Prevention and Eradication
509 chromosome 6p linked to high hdl
509 chromosome 6p linked to high hdl
Society for Heart Attack Prevention and Eradication
Polymophism in the promoter
Polymophism in the promoter
Society for Heart Attack Prevention and Eradication
Recent results and findings.
Recent results and findings.
Society for Heart Attack Prevention and Eradication
Esv2n35
Esv2n35
Society for Heart Attack Prevention and Eradication
091 vascular dysfunction in hypercholesterolemic rabbits
091 vascular dysfunction in hypercholesterolemic rabbits
Society for Heart Attack Prevention and Eradication
Accv porg
Accv porg
Society for Heart Attack Prevention and Eradication
Statins are associated
Statins are associated
Society for Heart Attack Prevention and Eradication
Preset3
Preset3
Society for Heart Attack Prevention and Eradication
Stroes
Stroes
Society for Heart Attack Prevention and Eradication
Esv2n41
Esv2n41
Society for Heart Attack Prevention and Eradication
Acc 2005-1, v pl-vp
Acc 2005-1, v pl-vp
Society for Heart Attack Prevention and Eradication
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Society for Heart Attack Prevention and Eradication
Taylor.aeha cac imt progression talk.1
Taylor.aeha cac imt progression talk.1
Society for Heart Attack Prevention and Eradication
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Vascular interventions atalar- johns hopkins
Society for Heart Attack Prevention and Eradication
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Society for Heart Attack Prevention and Eradication
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Society for Heart Attack Prevention and Eradication
AHA SHAPE Symposium 2017 Dr. Naghavi Presentation
AHA SHAPE Symposium 2017 Dr. Naghavi Presentation
Society for Heart Attack Prevention and Eradication
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AHA SHAPE Symposium 2017 Dr. Kloner Presentation
Society for Heart Attack Prevention and Eradication
AHA SHAPE Symposium 2017 Dr. Greenland Presentation
AHA SHAPE Symposium 2017 Dr. Greenland Presentation
Society for Heart Attack Prevention and Eradication
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AHA SHAPE Symposium 2017 Dr. Yen Presentation
Society for Heart Attack Prevention and Eradication
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AHA SHAPE Symposium 2017 Dr. Slomka Presentation
Society for Heart Attack Prevention and Eradication
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Vu lplaque1 pasterkamp
Society for Heart Attack Prevention and Eradication
Vulnerable plaque vulnerable patient
Vulnerable plaque vulnerable patient
Society for Heart Attack Prevention and Eradication
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Vulnerable plaque overview
Society for Heart Attack Prevention and Eradication
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Vulnerable patient talk in poland
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Vulnerable patient slides without movies
Society for Heart Attack Prevention and Eradication
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Vulnerable patient mar 04
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En vedette
Statins are associated
Statins are associated
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Preset3
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Stroes
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Society for Heart Attack Prevention and Eradication
Esv2n41
Esv2n41
Society for Heart Attack Prevention and Eradication
Acc 2005-1, v pl-vp
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Society for Heart Attack Prevention and Eradication
Taylor.aeha cac imt progression talk.1
Taylor.aeha cac imt progression talk.1
Society for Heart Attack Prevention and Eradication
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Society for Heart Attack Prevention and Eradication
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En vedette
(11)
Statins are associated
Statins are associated
Preset3
Preset3
Stroes
Stroes
Esv2n41
Esv2n41
Acc 2005-1, v pl-vp
Acc 2005-1, v pl-vp
Esv3n4
Esv3n4
Scd
Scd
Taylor.aeha cac imt progression talk.1
Taylor.aeha cac imt progression talk.1
Vascular interventions atalar- johns hopkins
Vascular interventions atalar- johns hopkins
Esv2n47
Esv2n47
Ricenano
Ricenano
Plus de Society for Heart Attack Prevention and Eradication
AHA SHAPE Symposium 2017 Dr. Naghavi Presentation
AHA SHAPE Symposium 2017 Dr. Naghavi Presentation
Society for Heart Attack Prevention and Eradication
AHA SHAPE Symposium 2017 Dr. Kloner Presentation
AHA SHAPE Symposium 2017 Dr. Kloner Presentation
Society for Heart Attack Prevention and Eradication
AHA SHAPE Symposium 2017 Dr. Greenland Presentation
AHA SHAPE Symposium 2017 Dr. Greenland Presentation
Society for Heart Attack Prevention and Eradication
AHA SHAPE Symposium 2017 Dr. Yen Presentation
AHA SHAPE Symposium 2017 Dr. Yen Presentation
Society for Heart Attack Prevention and Eradication
AHA SHAPE Symposium 2017 Dr. Slomka Presentation
AHA SHAPE Symposium 2017 Dr. Slomka Presentation
Society for Heart Attack Prevention and Eradication
Vu lplaque1 pasterkamp
Vu lplaque1 pasterkamp
Society for Heart Attack Prevention and Eradication
Vulnerable plaque vulnerable patient
Vulnerable plaque vulnerable patient
Society for Heart Attack Prevention and Eradication
Vulnerable plaque overview
Vulnerable plaque overview
Society for Heart Attack Prevention and Eradication
Vulnerable patient talk in poland
Vulnerable patient talk in poland
Society for Heart Attack Prevention and Eradication
Vulnerable patient slides without movies
Vulnerable patient slides without movies
Society for Heart Attack Prevention and Eradication
Vulnerable patient mar 04
Vulnerable patient mar 04
Society for Heart Attack Prevention and Eradication
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Vulnerable (thrombogenic blood
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Vuln shape aha 2005
Society for Heart Attack Prevention and Eradication
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Vuln plaque poster burke
Society for Heart Attack Prevention and Eradication
Vp watch editorial_slide 25short-
Vp watch editorial_slide 25short-
Society for Heart Attack Prevention and Eradication
Vp watch editorial_slide25
Vp watch editorial_slide25
Society for Heart Attack Prevention and Eradication
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Vp watch editorial_slide25short-
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Society for Heart Attack Prevention and Eradication
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Society for Heart Attack Prevention and Eradication
Plus de Society for Heart Attack Prevention and Eradication
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AHA SHAPE Symposium 2017 Dr. Naghavi Presentation
AHA SHAPE Symposium 2017 Dr. Naghavi Presentation
AHA SHAPE Symposium 2017 Dr. Kloner Presentation
AHA SHAPE Symposium 2017 Dr. Kloner Presentation
AHA SHAPE Symposium 2017 Dr. Greenland Presentation
AHA SHAPE Symposium 2017 Dr. Greenland Presentation
AHA SHAPE Symposium 2017 Dr. Yen Presentation
AHA SHAPE Symposium 2017 Dr. Yen Presentation
AHA SHAPE Symposium 2017 Dr. Slomka Presentation
AHA SHAPE Symposium 2017 Dr. Slomka Presentation
Vu lplaque1 pasterkamp
Vu lplaque1 pasterkamp
Vulnerable plaque vulnerable patient
Vulnerable plaque vulnerable patient
Vulnerable plaque overview
Vulnerable plaque overview
Vulnerable patient talk in poland
Vulnerable patient talk in poland
Vulnerable patient slides without movies
Vulnerable patient slides without movies
Vulnerable patient mar 04
Vulnerable patient mar 04
Vulnerable (thrombogenic blood
Vulnerable (thrombogenic blood
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Vuln shape aha 2005
Vuln plaque poster burke
Vuln plaque poster burke
Vp watch editorial_slide 25short-
Vp watch editorial_slide 25short-
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Vp watch editorial_slide25
Vp watch editorial_slide25short-
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Stenosis severity and risk benefit
1.
Stenosis Severity &
Risk of Coronary Occlusion 0 10 20 30 40 50 60 70 80 90 100 1st Qtr 2nd Qtr 3rd Qtr 4th Qtr East West North 0 50 100 150 200 250 300 350 400 2161 None 5-49% 50-80% 81-95% 52 21 1% 2% 10% 24% Stenosis Severity at Baseline CoronarySegments(n) Occlusions at 5-Year Follow-Up Alderman et al, JACC 1993;22:1141-1154
2.
Stenosis Severity and
Associated Risk of MI 0 10 20 30 40 50 60 70 80 90 100 1st Qtr 2nd Qtr 3rd Qtr 4th Qtr East West North 0 100 200 300 2674 0% 2% 50% 75% 90-99% 29 10 0.3% 3.5% 4.1% 7.9% Stenosis Severity Prior to MI CoronarySegments(n) MI Culprit Lesions at Follow-Up Nobuyoshi et al, JACC 1991;18:904-910 8.7%
3.
Majority of Infarcts
Evolve from Angiographically Mild to Moderate Stenoses Falk et al, Circulation 1995;92:657-671 0 10 20 30 40 50 60 70 80 90 100 1st Qtr 2nd Qtr 3rd Qtr 4th Qtr East West North 0 10 20 30 40 50 60 70 80 90 100 MIPatients(n) Ambrose 1988 Little 1988 Nobuyoshi 1991 Giroud 1992 All Stenosis Prior to MI >70% 50-70% <50% 0 20 40 60 80 100 120 140 160 180 200 68% 18% 14%
4.
235 103 18 237 108 18 313 101 16 0 50 100 150 200 250 300 350 Niacin + resin,
n=27 Lovastatin + resin, n=32 Diet + resin, n=53 Mild stenosis <40% Moderate stenosis 40-70% Severe stenosis >70% Coronarysegments(n) 4 41 2 1 1 4/785 5/312 4/52 Stenosis Severity and Associated Risk of ACS Insights from FATS
5.
•Severely stenotic plaques
progress to total occlusion and myocardial infarction more frequently than mildly stenotic plaques Key Points
6.
•Two-thirds of acute
CAD syndromes evolve from mildly obstructive plaques because they by far outnumber the severely obstructive lesions Key Points
7.
• Ruptured plaques
have: Large lipid cores Thin fibrous cap Increased inflammation and MMPs Increased neovascularity Reduced collagen and SMCs Key Points
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