2. The physiology of edema. By Dr Irum Junaid

4. Body Fluid Compartments Copyright 2009, John Wiley & Sons, Inc.

10. Determinants of Capillary Filtration Capillary Pressure (P c ) Plasma Colloid Osmotic Pressure ( π c ) Interstitial Fluid Pressure ( P if ) Interstitial Colloid Osmotic Pressure ( π if ) K f FILT = K f (P c - P if - π c + π if )

16. Normal Filtration FILT = K f x Net Filt Pressure = 6.6 x ( 17.3 - (-3) - 28 +8) = 6.6 x ( + 0.3) = 1.89 ml/min FILT = 2722 ml/day Where does all of this fluid (and protein in it) go? FILT = K f (P c - P if - π c + π if )

28. I. Low Tissue Compliance and Negative Interstitial Fluid Hydrostatic Pressure Interstitial Volume Interstitial Fluid Hydrostatic Pressure Capillary Filtration

29. Interstitial Fluid Volume (liters) Interstitial Fluid Pressure (mmHg) Free Fluid Gel Fluid Low compliance High Compliance Copyright © 2006 by Elsevier, Inc. - 8 - 4 0 + 4 12 24 36 48 60 0

31. Interstitial Fluid Volume (liters) Interstitial Fluid Pressure (mmHg) Free Fluid Gel Fluid Low compliance High Compliance Copyright © 2006 by Elsevier, Inc. - 8 - 4 0 + 4 12 24 36 48 60 0

34. II. Increased Lymph Flow Interstitial Volume Interstitial Fluid Hydrostatic Pressure Lymph Flow

35. Lymph Flow ( x normal) 20 10 1 - 6 - 4 - 2 0 2 4 Interstitial Fluid Pressure ( mmHg) Effect of Interstitial Fluid Pressure on Lymph Flow

36. III. “Wash-down” of Interstitial Fluid Proteins Interstitial Volume Interstitial Fluid Oncotic Pressure Capillary Filtration Interstitial Fluid Hydrostatic Pressure Lymph Flow Protein Removal From Tissues

37. 2 4 6 8 0 Plasma Protein Concentration Rate of Non-Visceral Lymph Flow (ml/hr) Interstitial Fluid Protein concentration (gm/100 ml) Wash-down of Interstitial Proteins 0 20 40 60 80 100 120 140 160 180