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Imperial Innovations Group plc 4 th  and 5 th  July 2010 Technology Transfer Officer Training Identifying Commercially Viable IP in a Research Institute Creating, building and investing in ground-breaking technology opportunities addressing large international markets Imperial Innovations Group plc
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],1.1 Introduction to Programme Wednesday 14 July 2010
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],1.1 Introduction to Programme Wednesday 14 July 2010
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],1.1 Introduction to Programme Wednesday 14 July 2010
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],1.2 Introduction to Imperial Innovations Wednesday 14 July 2010
1.2 Introduction to Imperial Innovations Innovations Group plc Wednesday, July 14, 2010 2008 Innovations realises £4.0 million from partial Ceres Power sale Created FSA regulated subsidiary , Imperial Innovations Investment Management Ltd Circassia raises Series B £11.0 million Thiakis sold to Wyeth for £100.0 million RespiVert raises Series A £13.0 million The business The portfolio 2010 Veryan Medical raises £3.6m Polytherics raises £3m MET sold to Evonik AG for €4.5m RespiVert sold to Centocor (J&J) for $100m 2004 Ceres Power floats on Alternative Investment Market 2006 £26m Imperial Innovations Group plc floats on AIM raising £26 million Inforsense raises Series A £5.3 million 2005 Private Placement of shares in Imperial Innovations raises £10 million for the Company £10m Thiakis raises Series A £10.0 million 2007 £30m Raised £30 million through private placement of shares Circassia raises Series A £6.25 million Nexeon raises  Series A £4.25 million Veryan raises Series A £5.3 million 2009 Nexeon raises Series B £10.0m Inforsense sold to IBDS Circassia raises Series C £15.25 million
1.2 Introduction to Imperial Innovations Investment strategy – segmented portfolio ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Wednesday, July 14, 2010 Healthcare Engineering & Energy
[object Object],[object Object],[object Object],1.2 Introduction to Imperial Innovations The Business – consistently creating strong companies 2006   2007  2008  2009  2010 Healthcare Engineering Wednesday, July 14, 2010
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Investment and support Assessing market opportunity Wednesday, July 14, 2010
Investment and support Matching management with scientific talent ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Wednesday, July 14, 2010
Investment and support Staged funding – major rounds completed Wednesday, July 14, 2010 2006 2007 2005 2008 2009 Total £0.5m IVO £0.25m  Total £10m IVO £1.5m  Total £11m IVO £1.75m  Total £13m IVO £2m  Total £3.1m IVO £2.2m  Total £10m IVO £4m  Sold  £100m IVO £16.1m Total £3m IVO £1m  Total £2.6m IVO £2.5m  Total £15.3m IVO £3.75m  2010 Total £3.6m IVO £1.2m  Sold IVO £9.5m Total £4.3m IVO £1.95m  Total £6.3m IVO £2.0m  Total £0.9m IVO £0.3m  Total £2.6m IVO £0.5m
1.2 Introduction to Imperial Innovations Successful Realisations ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Wednesday, July 14, 2010
[object Object],[object Object],1.2 Introduction to Imperial Innovations Licensing update Wednesday, July 14, 2010 Licensing highlights – deals concluded Novartis Vaccines and Diagnostics Novel Meningitis B Vaccine candidate Future Fuels Licence for 'Green coal' technology using recycled waste Cell Medica Exclusive licence for T-cell platform technology to generate specific t-lymphocytes for treatment of infection and cancer Medtronic Option agreement for treatment of sleep apnoea through pacemaker timing Medimmune Supply agreement for reagents for COPD and asthma markets
1.2 Introduction to Imperial Innovations Progress in Prospective Next Ten Wednesday, July 14, 2010 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
1.2 Introduction to Imperial Innovations Maturing Portfolio: Nexeon ,[object Object],[object Object],[object Object],Wednesday, July 14, 2010 The Company The Progress £6.2m £11.3m 35.0% November 2009 – Evonik Degussa Deputy Chairman and CTO Joins Nexeon Board December 2009 – revealed plans to commercialise lithium-ion technology. January 2010 – UK consortium including Nexeon was awarded £1m by Technology Strategy Board to develop new high energy density battery chemistry for plug-in electric vehicles March 2010 – achieved important milestone as cells successfully completed 500 full charge / discharge cycles at capacity of 1200mAh/g (4x the capacity of conventional carbon-based anode technology) without significant fade being observed.  Cost Value Equity share
1.2 Introduction to Imperial Innovations Maturing Portfolio: Circassia ,[object Object],[object Object],[object Object],Wednesday, July 14, 2010 The Company The Progress Cost £7.5m Value £13.4m Equity share 14.2% November 2009 – announced successful results from its Phase II clinical study in which its ToleroMune® T-cell vaccine for cat allergy dramatically reduced allergy symptom levels.  December 2009 – raised £15.25m in oversubscribed round Dec 09 led by Innovations.  January 2010 – initiated phase II clinical trials targeting house dust mite and cat allergies.   February 2010 – announced positive Phase II clinical results with its vaccine for Ragweed allergy.
1.2 Introduction to Imperial Innovations Exit: RespiVert ,[object Object],[object Object],[object Object],Wednesday, July 14, 2010 The Company The Progress IVO Investment £2.0m Return to IVO £9.5m December 2009 – filed number of patents in 2009 which include chemical composition of matter and biological mode of action.  January 2010 – confirmed that product profile is expected to be once daily inhaled administration used stand alone or in combination, targeting a first-line anti-inflammatory therapy for all patients with COPD.  January 2010 – announced plans to commence Phase I single ascending and repeat dose studies using both inhaled and intranasal delivery.  June 2010 – sold to Centocor Ortho Biotech, a Johnson and Johnson company
1.2 Introduction to Imperial Innovations Polytherics – replenishing “the 6” ,[object Object],[object Object],[object Object],Wednesday, July 14, 2010 The Company The Progress Cost £2.75m Value £3.0m Equity share 35.0% July 2009 - patent allowed covering the targeted PEGylation of proteins by the US and Europe.  October 2009 - Sally Waterman appointed Chief Operating Officer and Jeff Edwards also joined as Director of Development February 2010 – raised £3.0m in a round led by Innovations March 2010 – collaborative research deals announced with Minapharm, Celtic Pharma and Zealand Pharma April 2010 – awarded TSB grant to develop a low cost way of producing fusion proteins using its linker technology
1.3 Introduction to Commercialisation Wednesday 14 July 2010 Project Pipeline Project Development Investment Build Relationships Invention Disclosure  & Commercial assessment Validation of Market Need Spin-out Pre-Seed Seed and Incubation Post Seed and Exit ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Licence Marketing Negotiation Licence Management ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],2.1 Key Business and Commercialisation Concepts Wednesday 14 July 2010
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],2.1 Key Business and Commercialisation Concepts Wednesday 14 July 2010
[object Object],[object Object],[object Object],[object Object],[object Object],2.1 Key Business and Commercialisation Concepts Wednesday 14 July 2010
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],2.1 Key Business and Commercialisation Concepts Wednesday 14 July 2010
[object Object],[object Object],[object Object],[object Object],[object Object],2.1 Key Business and Commercialisation Concepts Wednesday 14 July 2010
[object Object],[object Object],[object Object],[object Object],[object Object],2.1 Key Business and Commercialisation Concepts Wednesday 14 July 2010
[object Object],3.1 Core Competencies for a TTO Serving Academic Needs Wednesday 14 July 2010
[object Object],[object Object],[object Object],[object Object],[object Object],3.1 Core Competencies for a TTO Serving Academic Needs Wednesday 14 July 2010
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],3.1 Core Competencies for a TTO Serving Academic Needs Wednesday 14 July 2010
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],3.1 Core Competencies for a TTO Serving Academic Needs Wednesday 14 July 2010
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],3.1 Core Competencies for a TTO Serving Academic Needs Wednesday 14 July 2010
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],3.1 Core Competencies for a TTO Serving Academic Needs Wednesday 14 July 2010
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],4.1 Core Skills for a TTO Working with Academics Wednesday 14 July 2010
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],4.1 Core Skills for a TTO Working with Academics Wednesday 14 July 2010
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],4.1 Core Skills for a TTO Working with Academics Wednesday 14 July 2010
[object Object],[object Object],[object Object],[object Object],[object Object],4.1 Core Skills for a TTO Working with Academics Wednesday 14 July 2010
4.1 Core Skills for a TTO Working with Academics Wednesday 14 July 2010 4 Product Scale 5 Project Attractiveness Component/Sub Assembly Single application product Platform or multiple application product Target Markets 1 2 3 Target Markets 1 2 3 Target Markets 1 2 3 <£1m £1-5m £5-10m £10-50m £50-100m £100-500m >£500m
4.1 Core Skills for a TTO Working with Academics Wednesday 14 July 2010 6 What is the Technology Readiness Level (TRL)? Stage Duration Cost Potential Source of Funding Identified? PoC Demonstrator to sell the technology to a commercial partner <1yr <£25k 1-3yrs £50-100k >3yrs >£100k To produce field trial demonstrators and conduct field trials <1yr <£100k 1-3yrs £100-250k >3yrs >£250 To produce launch a product (i.e. first sales) <1yr <£250k 1-3yrs £250-£500k >3yrs >£500k 1 2 3 4 5 6 7 8 9
4.1 Core Skills for a TTO Working with Academics Wednesday 14 July 2010 Technology Readiness Level 1. Basic principles observed and reported 2. Technology concept and/or application formulated 3. Analytical and experimental critical function and/or characteristic proof of concept 4. Component and/or breadboard validation in laboratory environment 5. Component and/or breadboard validation in relevant environment 6. System/subsystem model or prototype demonstration in a relevant environment 7. System prototype demonstration in an operational environment 8. Actual system completed and 'flight qualified' through test and demonstration 9. Actual system 'flight proven' through successful mission operations
4.1 Core Skills for a TTO Working with Academics Wednesday 14 July 2010 7 Competitive Intensity 8 IP Strength Low High Weak Strong Unmet technical need no other supplier has anything comparable A new emerging technology area with few established suppliers An established but dynamic market with several high market share suppliers Mature market where the new technology is an alternative readily available to existing products/technologies Many similar suppliers/products with similar features/benefits and strong incumbent  positions in mature markets IP is largely published but some know how/copy right IP remains Nothing patentable, but high level of unpublished know how/copyright Patentable but with narrow claims, not much know can be developed  Patentable, with fairly wide claims, know how needs to be developed and there is a high level of related prior art Broad patent with high degree of freedom to operate and know-how required
4.1 Core Skills for a TTO Working with Academics Wednesday 14 July 2010
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],4.1 Core Skills for a TTO Working with Academics Wednesday 14 July 2010
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],4.1 Core Skills for a TTO Working with Academics Wednesday 14 July 2010
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],4.1 Core Skills for a TTO Working with Academics Wednesday 14 July 2010
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],4.1 Core Skills for a TTO Working with Academics Wednesday 14 July 2010
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],4.1 Core Skills for a TTO Working with Academics Wednesday 14 July 2010
[object Object],[object Object],[object Object],[object Object],[object Object],4.1 Core Skills for a TTO Working with Academics Wednesday 14 July 2010
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],5.1 Organising the TTO Wednesday 14 July 2010
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],5.1 Organising the TTO Wednesday 14 July 2010
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],5.1 Organising the TTO Wednesday 14 July 2010
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],5.1 Organising the TTO Wednesday 14 July 2010
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],5.1 Organising the TTO Wednesday 14 July 2010
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],5.1 Organising the TTO Wednesday 14 July 2010
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],5.1 Organising the TTO Wednesday 14 July 2010
6.1 Case Study from Imperial Innovations  Veryan Medical ,[object Object],[object Object],Wednesday, July 14, 2010 The Company The Progress Cost £5.2m Value £6.2m Equity share 55.7% February 2010 - start of First-in-Man study for BioMimic 3D stent at Herz Zentrum, Bad Krozingen, Germany.  March 2010 – raised £3.6m in round co-led by Innovations and new investor, Seroba Kernel Life Sciences.  March 2010 – initial results of first in human man study were excellent and appear to confirm the attributes that Veryan had seen in pre-clinical studies.

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Imperial Innovations Group Technology Transfer Officer Training

  • 1. Imperial Innovations Group plc 4 th and 5 th July 2010 Technology Transfer Officer Training Identifying Commercially Viable IP in a Research Institute Creating, building and investing in ground-breaking technology opportunities addressing large international markets Imperial Innovations Group plc
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  • 6. 1.2 Introduction to Imperial Innovations Innovations Group plc Wednesday, July 14, 2010 2008 Innovations realises £4.0 million from partial Ceres Power sale Created FSA regulated subsidiary , Imperial Innovations Investment Management Ltd Circassia raises Series B £11.0 million Thiakis sold to Wyeth for £100.0 million RespiVert raises Series A £13.0 million The business The portfolio 2010 Veryan Medical raises £3.6m Polytherics raises £3m MET sold to Evonik AG for €4.5m RespiVert sold to Centocor (J&J) for $100m 2004 Ceres Power floats on Alternative Investment Market 2006 £26m Imperial Innovations Group plc floats on AIM raising £26 million Inforsense raises Series A £5.3 million 2005 Private Placement of shares in Imperial Innovations raises £10 million for the Company £10m Thiakis raises Series A £10.0 million 2007 £30m Raised £30 million through private placement of shares Circassia raises Series A £6.25 million Nexeon raises Series A £4.25 million Veryan raises Series A £5.3 million 2009 Nexeon raises Series B £10.0m Inforsense sold to IBDS Circassia raises Series C £15.25 million
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  • 11. Investment and support Staged funding – major rounds completed Wednesday, July 14, 2010 2006 2007 2005 2008 2009 Total £0.5m IVO £0.25m Total £10m IVO £1.5m Total £11m IVO £1.75m Total £13m IVO £2m Total £3.1m IVO £2.2m Total £10m IVO £4m Sold £100m IVO £16.1m Total £3m IVO £1m Total £2.6m IVO £2.5m Total £15.3m IVO £3.75m 2010 Total £3.6m IVO £1.2m Sold IVO £9.5m Total £4.3m IVO £1.95m Total £6.3m IVO £2.0m Total £0.9m IVO £0.3m Total £2.6m IVO £0.5m
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  • 36. 4.1 Core Skills for a TTO Working with Academics Wednesday 14 July 2010 4 Product Scale 5 Project Attractiveness Component/Sub Assembly Single application product Platform or multiple application product Target Markets 1 2 3 Target Markets 1 2 3 Target Markets 1 2 3 <£1m £1-5m £5-10m £10-50m £50-100m £100-500m >£500m
  • 37. 4.1 Core Skills for a TTO Working with Academics Wednesday 14 July 2010 6 What is the Technology Readiness Level (TRL)? Stage Duration Cost Potential Source of Funding Identified? PoC Demonstrator to sell the technology to a commercial partner <1yr <£25k 1-3yrs £50-100k >3yrs >£100k To produce field trial demonstrators and conduct field trials <1yr <£100k 1-3yrs £100-250k >3yrs >£250 To produce launch a product (i.e. first sales) <1yr <£250k 1-3yrs £250-£500k >3yrs >£500k 1 2 3 4 5 6 7 8 9
  • 38. 4.1 Core Skills for a TTO Working with Academics Wednesday 14 July 2010 Technology Readiness Level 1. Basic principles observed and reported 2. Technology concept and/or application formulated 3. Analytical and experimental critical function and/or characteristic proof of concept 4. Component and/or breadboard validation in laboratory environment 5. Component and/or breadboard validation in relevant environment 6. System/subsystem model or prototype demonstration in a relevant environment 7. System prototype demonstration in an operational environment 8. Actual system completed and 'flight qualified' through test and demonstration 9. Actual system 'flight proven' through successful mission operations
  • 39. 4.1 Core Skills for a TTO Working with Academics Wednesday 14 July 2010 7 Competitive Intensity 8 IP Strength Low High Weak Strong Unmet technical need no other supplier has anything comparable A new emerging technology area with few established suppliers An established but dynamic market with several high market share suppliers Mature market where the new technology is an alternative readily available to existing products/technologies Many similar suppliers/products with similar features/benefits and strong incumbent positions in mature markets IP is largely published but some know how/copy right IP remains Nothing patentable, but high level of unpublished know how/copyright Patentable but with narrow claims, not much know can be developed Patentable, with fairly wide claims, know how needs to be developed and there is a high level of related prior art Broad patent with high degree of freedom to operate and know-how required
  • 40. 4.1 Core Skills for a TTO Working with Academics Wednesday 14 July 2010
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