Ce diaporama a bien été signalé.
Nous utilisons votre profil LinkedIn et vos données d’activité pour vous proposer des publicités personnalisées et pertinentes. Vous pouvez changer vos préférences de publicités à tout moment.
Hypo & Hyperthyroidism Dr. Salman Pharmacology LMDC
Hypothyroidism <ul><li>It is treated with the hormone itself! </li></ul><ul><ul><li>Thyroxine , or 3,5,3',5'-tetraiodothyr...
Antihyperthyroid Drugs
The synthesis of thyroid hormone and action and effects of antithyroid agents
Inhibited by propranolol, and propylthioiracil  Conversion of T 4  to T 3  via 5’ deiodinase in peripheral tissues 6 Inhib...
 
Thioamides: Propylthiouracil and Methimazole <ul><li>Use in uncomplicated hyperthyroid conditions;  </li></ul><ul><li>High...
Iodide <ul><li>KI +  iodine (Lugol's solution) possible use in thyrotoxicosis: used preoperatively,  ->↓  gland size, frag...
Prochain SlideShare
Chargement dans…5
×

Hypo & hyperthyroidism pharmacotherapy

1 592 vues

Publié le

To my students

Publié dans : Santé & Médecine
  • Identifiez-vous pour voir les commentaires

Hypo & hyperthyroidism pharmacotherapy

  1. 1. Hypo & Hyperthyroidism Dr. Salman Pharmacology LMDC
  2. 2. Hypothyroidism <ul><li>It is treated with the hormone itself! </li></ul><ul><ul><li>Thyroxine , or 3,5,3',5'-tetraiodothyronine (often abbreviated as T4) </li></ul></ul><ul><ul><li>Injected T 4 </li></ul></ul>
  3. 3. Antihyperthyroid Drugs
  4. 4. The synthesis of thyroid hormone and action and effects of antithyroid agents
  5. 5. Inhibited by propranolol, and propylthioiracil Conversion of T 4 to T 3 via 5’ deiodinase in peripheral tissues 6 Inhibited by high doses of iodide Proteolytic release of T 3 and T 4 from thyroglobulin 5 4 3 2 1 Inhibited by thioamides Coupling of MIT and MIT to form T 3 and T 4 Inhibited by thioamides Iodination of tyrosyl residues on thyroglobulin from MIT and DIT Inhibited by thioamides Oxidation of iodide by peroxidases Basis for selective cell destruction of 131I Active accumulation of iodide into the gland Effects of antithyroid agents Thyroid hormone synthesis and action
  6. 7. Thioamides: Propylthiouracil and Methimazole <ul><li>Use in uncomplicated hyperthyroid conditions; </li></ul><ul><li>High-dose propylthiouracil inhibits 5' deiodinase </li></ul><ul><li>Common maculopapular rash </li></ul><ul><li>Less common  prothrombin, hypersensitivity, and immune-based arthralgia, </li></ul><ul><li>jaundice, lupus, and vasculitis </li></ul><ul><li>Both drugs cross the placental barrier, but PTU is safer in pregnancy because it is </li></ul><ul><li>extensively protein bound </li></ul>
  7. 8. Iodide <ul><li>KI + iodine (Lugol's solution) possible use in thyrotoxicosis: used preoperatively, ->↓ gland size, fragility, and vascularity </li></ul><ul><li>No long-term use because thyroid gland &quot;escapes&quot; from effects after 10-14 days </li></ul>

×