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Infertility

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Pharmacology

Publié dans : Santé & Médecine
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Infertility

  1. 1. Infertility Drug treatment
  2. 2. TREATMENT OPTIONS • Treatment options for infertility include: – clomiphene citrate – aromatase inhibitors – Gonadotropins • chorionic gonadotropins, gonadotropin- releasing hormone, gonadotropin-releasing hormone agonists, gonadotropin-releasing hormone antagonists – follitropins, and other miscellaneous agents
  3. 3. CLOMIPHENE CITRATE • a first-line agent for women with ovulatory dysfunction • Mechanism: – nonsteroidal estrogen receptor modulator that inhibits the negative feedback response on the hypothalamus by competing with estrogen for estrogen receptor-binding sites. This action leads to an increase in FSH and LH levels, promoting follicular growth and maturation, allowing ovulation to occur by increasing the number of eggs • Use: fertility drug • Adverse effect:  multiple births
  4. 4. AROMATASE INHIBITORS Anastrozole, Letrozole • Aromatase inhibitor  estrogen synthesis • Use: Estrogent – dependant postmenopausal breast cancer
  5. 5. GONADOTROPINS • Human menopausal gonadotropin (hMG) – menotropins (parentral) – used to produce ovulation
  6. 6. CHORIONIC GONADOTROPINS • Human chorionic gonadotropin – Choriogonadotropin alfa for injection
  7. 7. GONADOTROPIN-RELEASING HORMONE • Gonadorelin acetate – The pulsatile administration of mimics the endogenous release of GnRH from the hypothalamus. It is indicated for the induction of ovulation in women with primary hypothalamic amenorrhea. – Gonadorelin is contraindicated in women with pituitary prolactinoma and in those with ovarian cysts
  8. 8. GONADOTROPIN-RELEASING HORMONE AGONISTS • Leuprolide acetate. • Nafarelin acetate • Triptorelin pamoate • Goserelin acetate.
  9. 9. GONADOTROPIN-RELEASING HORMONE ANTAGONISTS • Ganirelix acetate – It is indicated for the inhibition of premature surges of LH in women undergoing COH (controlled ovarian hyperstimulation )
  10. 10. PROGESTERONE • Progesterone prepares the endometrial lining for implantation • Once the embryo has been implanted, progesterone helps maintain the pregnancy
  11. 11. FOLLITROPINS • human follicle-stimulating hormones (hFSH) or urofollitropins and recombinant human follicle-stimulating hormones (r-hFSH) • treatment of infertility when clomiphene therapy is inadequate
  12. 12. MISCELLANEOUS AGENTS • Metformin • Dopamine agonists – Cabergoline – Bromocriptine
  13. 13. Testosterone • T Injection • Supplements – Tribulus terrestris – Date palm pollen extracts

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