2. ABSTRACT
In the present survey paper, we have collected the developmental
history of utilization of transition metal complexes as drugs to treat
several human diseases like diabetes, and neurological disorders. With
the help of relevant literature medicinal use of transition metal
complexes is discussed. The paper integrates all such discoveries
relevant to the Metal-based co- ordination compounds that have been
used throughout the history of human medicine to treat various chronic
diseases. The structural characteristics of NSAID complexes with
copper(II) or zinc(II) previously reported are presented in this paper.
We also outlined chalcone based metal coordination complexes as
suitable bioactive agents.
3. Chalconemetalcomplexesasanticanceragents
• Chalcone based metal complexes are used as effective
antiproliferative drugs.
• These are used as effective alternative therapy as bacterias have
developed resistance against drugs therefore,drugs based on metal
coordination complexes have been widely used and worked upon.
• For instance it has been found that, Pd(II)-tetracycline combination
has sixteen times the potency of tetracycline against resistant E.coli
bacteria.
• The emergence of chloroquine resistance necessitates the new
effective antiparasitic agents. For this, the gold and ruthenium
complexes of chloroquine and clotrimazole have been prepared and
evaluated against Plasmodium.
4. Nonplatinum based complexes forcancer
treatment
The idea of substituting alternative metal ions for platinum has been
investigated in attempt to develop novel complexes with minimal
systemic toxicity and activity against malignancies resistant to cisplatin.
•Ruthenium complexes
Ruthenium(II) forms either penta- or hexa-coordinated complexes, while
ruthenium(III) only hexa-coordinated ones. Both of them show antitumor
activity, but Ru(III) is probably in vivo first reduced to Ru(II) acting
rather as a prodrug. A prodrug is an inactive form of a drug which have
little or no pharmacological activity which gets activated by enzymatic or
chemical reactions.
• For instance, Ru(ii) complex [Ru(biphenyl)(en)Cl]PF6 binds DNA either
by intercalation through the aromatic ligand or by covalent binding with
the metal ion. Ru(III) complexes is the [Ru(HIn)2Cl4](H2In) which reacts
with DNA and induces apoptosis.
5. Gold and
Titanium coordi-
nation
complexes as
anticancer
agent
Auranofin is a gold coordination complex which is
used to treat rheumatoid arthritis. Auranofin is a
thioredoxin reductase (TR) inhibitor made up of Au(I)
and a phosphine ligand. The inhibition of TR induces
mitochondria-dependent apoptosis. Au(III) complexes
have also been widely explored as its chemistry is
comparable to that of Pt(ii) .Au(III) is isoelectronic
with Pt(II) and forms square planar complexes.
Titanocene dichloride, a titanium coordination
complex showing anti-tumor activity. The titanocene
dichloride, binds DNA via the phosphate backbone,
inducing apoptosis
