Carbamazepine is an anticonvulsant. It works by decreasing nerve impulses that cause seizures and nerve pain, such as trigeminal neuralgia and diabetic neuropathy. Carbamazepine is also used to treat bipolar disorder.

1. CARBAMAZEPINE
Class – B. Pharm. 3rd year ( 5th semester)
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Subject – Medicinal Chemistry – 1
Session – 2020-2024

2. Content
 Introduction.
 Structure of Carbamazepine.
 Properties of Carbamazepine.
 Mechanism of action.
 Synthesis of Carbamazepine.
 Therapeutic Uses of Carbamazepine.
 Side effects of Carbamazepine.
 Storage and Dosage forms.
 Refference

3. INTRODUCTION
 8122330

4. Structure of Carbamazepine
THE STRUCTURE CARBAMAZEPINE MOLECULE IS ILLUSTRATED
BELOW

5. Properties of Carbamazepine
 Molecular formula – C15H12N2O
 Molecular weight – 236.27 g/mol
 Water solubility – 17.7 mg/L ( 20°C )
 Pka – 13.9
 Toxicity – Mild ingestion cause vomiting,
drowsiness,ataxia, slurred speech.
 Affected Organisms – Human and aquatic organisms

6. Mechanism of action
 Carbamazepine binds and blocks neuronal
sodium channels / voltage sensitive calcium
channels.
 This results in blockage or suppression of
neuronal depolarization and
hypersynchronization.

7. Synthesis of Carbamazepine

8. Therapeutic Uses of Carbamazepine
Prevention and control of seizures.
Providing relieve from certain nerve pains.

9. Side effects of Carbamazepine
 Drowsiness.
 Nausea.
 Vomiting.
 Dry mouth.
 Headaches.
 Liver problems.
 Dark urine.
 Mouth sores.

10. Storage – it should be stored in well closed
airtight container.
Dosage forms – Carbamazepine tablets
B.P.

11. Refference
 Textbook of Medicinal Chemistry vol – 1,
V. Alagarsamy, 3rd Edition, CBS Publisher
and Distributors, Anticonvulsants, page
321-325.