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breast cancer pharmacotherapy
1. DEPARTMENT : PHARMACOTHERPEUTICS
D.SUGUNA KUMARI
15T71T0001
III/VI PHARMD
NOVA COLLEGE OF PHARAMCY
WEST GODAVARI ,AP
MAIL :SUGUNAPHARMD@GMAIL.COM
CHEMOTHERAPY OF BREAST
CANCER
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CHEMOTHERAPY OF BREAST CANCER
2. INTRODUCTION :
Breast cancer is the cancer that
develops from the breast tissue .
It is the 2nd causing of cancer deaths
in women fear most.
80% of breast cancers in women older
than age 50.
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CHEMOTHERAPY OF BREAST
3. AETIOLOGY :
The 2 variables most strongly associated
with strongly with the occurrence of breast
cancer are GENDER and AGE .
It is also caused by a genetic abnormality
Only 50% of cancers are due to
abnormality inherited from your father /
mother.
About 90% of breast cancers due to genetic
abnormality . 3
CHEMOTHERAPY OF BREAST
5. EPIDEMOLOGY :
Most common cancer in women
worldwide leading causes of death .
According to IARC report on cancer 2012
:
*1.7 million new cases (25% cancer in
female.
*522.000 DEATHS (15% Cancer )
The life time risk of dying of breast cancer is
approximately 3.4%.
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CHEMOTHERAPY OF BREAST
7. RISK FACTORS :
Gender : female ( 1% male )
Race : more common in white people .
Age : increases as women get older
Family history
Menstrual history
Child birth
Obesity
Diet
70% have no risk factors .
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CHEMOTHERAPY OF BREAST
CANCER
9. CLINICAL MANIFESTATION :
GENERAL: The patient “may not have any
symptoms”, as breast cancer may be detected
in asymptomatic patients through routine
screening mammography.
LOCAL SIGN AND SYMPTOMS: A Painless,
palatable lump is most common.
Less common : Pain ,nipple discharge
,retraction or dimpling ,skin edema ,redness
/warmth
Palpable local: regional lymph nodes may also
be present
9CHEMOTHERAPY OF BREAST
CANCER
10. DIAGNOSIS :
LAB TESTS: tumor markers such as cancer antigen (CA 27.29)
or carcinoembryogenic antigen (CEA) may be elevated
Alkaline phosphates or liver function tests may be elevated in
metastatic disease .
OTHER TESTS: Mammogram (with /without ultra sound,
breast MRI /BOTH.
Biopsy for pathology review or determination of tumor estrogen
/progesterone receptor (ER/PR ) STATUS &ER2 Status .
Systemic staging test may include chest x-ray , chest CT Scan
,Bone scan, abdominal CT /ULTRA SOUND SOUND /MRI.
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CHEMOTHERAPY OF BREAST
CANCER
11. GOALS OF THERAPY :
Cure, improve overall survival ,improve time
to progression /time to treatment failure
,minimize symptoms related to the disease
,prevent c/o related to the disease ,improve
overall quality of life .
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CHEMOTHERAPY OF BREAST
CANCER
12. NON – PHARMACOLOGICAL THERAPY :
•Taking aspirin ,avoid exposure to pesticides .
•No /limit alcohol.
•Maintain healthy weight.
•Avoid LT –HORMONE therapy.
•Stay physically active .
•Eat high fiber food ,emphasize olive oil .
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CHEMOTHERAPY OF BREAST CANCER
13. PHARMACOLOGICAL THERAPY :
The type & Stage of cancer , sensitivity of cancer to certain
hormones ,the medical H/O of Treatment plans for breast cancer
are developed based on a several factors :
The main types of treatment are :
Surgery
Radiation therapy /radiotherapy
Chemotherapy
Hormone therapy
Targeted therapy
Bone –directed therapy
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CANCER
