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Treatment of breast cancer by Dr.Syed Alam Zeb

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Syed Alam Zeb
Syed Alam Zeb
Santé & Médecine
1  sur  51
Treatment of breast cancer Dr.Syed Alam Zeb
Classification ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Staging ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Staging (cont) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Staging (cont) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Staging (cont) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Breast cancer is commonly treated by various combinations of: ,[object Object],[object Object],[object Object],[object Object]
Prognosis and selection of therapy may be influenced by: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Since criteria for menopausal status vary widely, some studies have substituted age older than 50 years as a surrogate for the postmenopausal state.
Patient management following initial suspicion of breast cancer generally includes: ,[object Object],[object Object],[object Object],[object Object]
Ductal Carcinoma In Situ ,[object Object],[object Object],[object Object],[object Object]
Treatment options for DCIS ,[object Object],[object Object],[object Object]
Lobular Carcinoma In Situ ,[object Object],[object Object]
Treatment of Lobular Carcinoma In Situ ,[object Object],[object Object],[object Object],[object Object],[object Object]
Treatment options for patients with LCIS ,[object Object],[object Object],[object Object],[object Object]
Management of Stage I, II, IIIA, and Operable IIIC Breast Cancer ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Locoregional therapy ,[object Object],[object Object],[object Object]
Options for surgical management of the primary tumor include: ,[object Object],[object Object],[object Object]
Selection of a local therapeutic approach depends on: ,[object Object],[object Object],[object Object],[object Object],[object Object]
relative contraindications to breast-conserving therapy ,[object Object],[object Object],[object Object],[object Object]
surgical techniques used include: ,[object Object],[object Object],[object Object]
Which option? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Dealing with axillary lymph nodes ,[object Object],[object Object],[object Object]
Sentinel lymph node biopsy ,[object Object],[object Object],[object Object],[object Object],[object Object]
Radiation therapy ,[object Object],[object Object]
Radiation therapy following Breast conservation ,[object Object],[object Object],[object Object],[object Object]
Radiation therapy following mastectomy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Adjuvant systemic therapy ,[object Object],[object Object],[object Object]
Hormone therapy ,[object Object],[object Object],[object Object]
Tamoxifen ,[object Object],[object Object],[object Object],[object Object]
Tamoxifen toxic effects ,[object Object],[object Object],[object Object],[object Object]
Aromatase inhibitors: anastrozole ,[object Object]
Aromatase inhibitors: exemestane ,[object Object],[object Object],[object Object]
Aromatase inhibitors: letrozole ,[object Object],[object Object],[object Object]
Ovarian Ablation ,[object Object],[object Object]
Chemotherapy ,[object Object],[object Object]
Duration of CMF-based chemotherapy ,[object Object]
Anthracycline based chemotharapy ,[object Object],[object Object]
Role of Preoperative adjuvant chemotherapy ,[object Object]
Monoclonal antibodies ,[object Object],[object Object]
Risk Categories for Women With Node-Negative Breast Cancer Low risk (has all listed factors)   Intermediate risk High risk (has at least 1 listed factor)   Tumor size ≤ 1cm 1-2 cm >2 cm ER or PR Status positive positive negative Tumor grade Grade 1 grade 1-2 grade 2-3
Adjuvant systemic treatment for node negative premenopausal women Patient group   Low risk   Intermediate risk   High risk   ER-positive or PR-positive None or tamoxifen 1.T ± C 2.Ov Ab 3.GnRH analog ,[object Object],[object Object],[object Object],[object Object],[object Object],ER-negative or PR-negative — — Chemotherapy
Adjuvant systemic treatment for node negative postmenopausal women Patient group   Low risk   Intermediate risk   High risk   ER-positive or PR-positive None or tamoxifen T ± C T ± C ER-negative or PR-negative — — Chemotherapy Older than 70 years None or tamoxifen T ± C T. Consider chemotherapy if ER-negative or PR-negative
Adjuvant systemic treatment for node positive premenopausal women Patient group   Treatments   ER or PR-positive ,[object Object],[object Object],[object Object],[object Object],[object Object],ER-negative or PR-negative Chemotherapy
Adjuvant systemic treatment for node positive postmenopausal women Patient group   Treatments   ER or PR-positive T ± C ER-negative or PR-negative Chemotherapy Older than 70 years Tamoxifen alone; consider chemotherapy if receptor-negative
Candidates for whom adjuvant therapy may not be necessary ,[object Object],[object Object]
Inoperable stage IIIB or IIIC or inflammatory breast cancer ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Stage IV breast cancer ,[object Object],[object Object]
Stage IV breast cancer (cont) ,[object Object],[object Object]
Stage IV breast cancer (cont) ,[object Object],[object Object],[object Object]
Follow-up ,[object Object],[object Object]

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Treatment of breast cancer by Dr.Syed Alam Zeb

  • 1. Treatment of breast cancer Dr.Syed Alam Zeb
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  • 9. Since criteria for menopausal status vary widely, some studies have substituted age older than 50 years as a surrogate for the postmenopausal state.
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  • 41. Risk Categories for Women With Node-Negative Breast Cancer Low risk (has all listed factors)   Intermediate risk High risk (has at least 1 listed factor)   Tumor size ≤ 1cm 1-2 cm >2 cm ER or PR Status positive positive negative Tumor grade Grade 1 grade 1-2 grade 2-3
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  • 43. Adjuvant systemic treatment for node negative postmenopausal women Patient group   Low risk   Intermediate risk   High risk   ER-positive or PR-positive None or tamoxifen T ± C T ± C ER-negative or PR-negative — — Chemotherapy Older than 70 years None or tamoxifen T ± C T. Consider chemotherapy if ER-negative or PR-negative
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  • 45. Adjuvant systemic treatment for node positive postmenopausal women Patient group   Treatments   ER or PR-positive T ± C ER-negative or PR-negative Chemotherapy Older than 70 years Tamoxifen alone; consider chemotherapy if receptor-negative
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