1. Electronic Clinical Trial Recruitment System
Dave Richter
General Manager Clinical Innovation LabsGeneral Manager, Clinical Innovation Labs
November 10, 2010
The data in this presentation is representative of theThe data in this presentation is representative of the
information known at the time of printing
(11/11/2010) and should be confirmed by the UMN
Technology Marketing Manager.

2. Office for Technology Commercialization 2
The Problem
Slow translation of clinical research into practice
Research productivity in the U.S. is facing a crisis 1
Recruitment is labor intensive, time consuming costly
Delayed and/or inadequate trial enrollment costs
sponsors in excess of $1 billion annually 2
1. Innovation or Stagnation: Challenge and Opportunity on the
Critical Path to New Medical Products, U.S. Department of Health
and Human Services, FDA, March 2004.
2. Estimate derived from internal research and discussions with leading trial recruitment firm.

3. Office for Technology Commercialization 3
Background
Medical research spend estimated at $116 billion annually 1
Growth in clinical IT systems fueled by $19 billion stimulus (ARRA)
Proprietary clinical systems create inaccessible silos of
information
Mandate to exchange data complicated by confidentiality laws
and lack of interoperability standards
Practicing‐physicians lack time to engage in research
No commercial IT systems currently‐offered to address the
problem!
1. PricewaterhouseCoopers’ Health Research Institute, Research Rewired, 2008

4. Office for Technology Commercialization 4
Today’s Methods
Multi‐media marketing campaigns,
advertising, direct mail, elevator posters,
telemarketing, etc.
Purchased research advising where to dig
Manual labor‐intensive chart reviews
Consumer initiated internet search

5. Office for Technology Commercialization 5
At the core….
■ We liberate clinical data
■ We leverage clinical data
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6. Office for Technology Commercialization 6
The Solution
Electronic Clinical Trial Recruitment System
Research
Portal
EMR
Practice 3
Florida
EMR
Practice 2
Oregon
EMR
Practice 1
Minnesota
Research
Sponsor
$$
EMR
Practice 4
Arizona
114
87
63
121
N = 385
Investigator
Electronic Process
Flagged
Qualified
Enrolled
With enrollment completed
and confidentiality agreements
signed, data is shared
electronically with the
investigator and the study
begins.

7. Office for Technology Commercialization 7
Value Propositions
Electronic Clinical Trial Recruitment System
Research
Sponsor
- Speed to market
- Lower costs
Investigator
- Faster study design
- Faster execution
Medical Practice
- Improved clinical care
- Participation fees
- Performance tools
Patients
- Engagement in research
- Improved clinical care

8. Office for Technology Commercialization 8
Market Opportunity
1. CenterWatch 2009
Annual # studies 50,000
1
Patients per study 100
Total patient enrollment 5,000,000
Recruitment cost per enrollee $500
Total recruitment spend $2,500,000,000
Addressable market @ 10% $250,000,000

9. Office for Technology Commercialization 9
Potential Customer Segments
■ Patient recruitment firms
■ Healthcare delivery systems
■ Medical practices
■ Healthcare information exchanges
■ Research networks
■ Contract research organizations
■ Device and pharma research sponsors

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Differentiated Value Propositions
■ Federated network model
■ Optimized query capability of many millions of records
■ Deep expertise in object models, data mapping,
classification and vocabulary services

11. Office for Technology Commercialization 11
Kevin A. Peterson, MD, MPH
Principal Investigator
Background
• Associate Professor, University of Minnesota
• Director of Research, Family Medicine and
Community Health
• Practicing‐physician
Research Interests
• Diabetes
• IT based research networks
• Improving clinical performance

12. Office for Technology Commercialization 12
Status
■ Incubating within business unit at UMN
■ Moving from concept to demonstration pilot phase
■ Developing software with international partners
■ Discussing pilot projects with potential launch partners
■ Developing business model and go‐to‐market strategies

13. Office for Technology Commercialization 13
Electronic Clinical Trial Recruitment System
Q & A