Introduce how to development RNA delivery platform and methods

3. Domain architectures of selected capsid (CA)–containing mammalian Gag homologs
CA: capsid
NC: nucleocapsid
PR: protease
RT: reverse transcriptase
LTR: long terminal repeat
MA: matrix
IN: integrase

4. Capsid (CA):the protein shell of a virus

5. TEMs and Cyto TEM of the Mm orthologs of the CA domain–containing proteins

6. Quantification of extracellular CA domain–containing proteins

7. MmPEG10 protein and mRNA are secreted in vesicles by cells in vitro

8. Key domains for RNA-binding

9. 5-UTR and 3-UTR are the main binding site for MmPEG10

10. Flanking mRNA with MmPeg10 5 and 3 UTRs enables functional
intercellular transfer of mRNA into a target cell

11. SEND: selective endogenous encapsidation for cellular delivery

12. True SEND: selective endogenous encapsidation for cellular delivery

13. PEG10 is a modular platform for RNA delivery