Domain architectures of selected capsid (CA)–containing mammalian Gag homologs
CA: capsid
NC: nucleocapsid
PR: protease
RT: reverse transcriptase
LTR: long terminal repeat
MA: matrix
IN: integrase

Capsid (CA):the protein shell of a virus

TEMs and Cyto TEM of the Mm orthologs of the CA domain–containing proteins

Quantification of extracellular CA domain–containing proteins

MmPEG10 protein and mRNA are secreted in vesicles by cells in vitro

Key domains for RNA-binding

5-UTR and 3-UTR are the main binding site for MmPEG10

Flanking mRNA with MmPeg10 5 and 3 UTRs enables functional
intercellular transfer of mRNA into a target cell

SEND: selective endogenous encapsidation for cellular delivery

True SEND: selective endogenous encapsidation for cellular delivery

PEG10 is a modular platform for RNA delivery