short note

2.  Inflammation of blood vessel and its
complication.

3. Large vessel
Takayasu
Giant cell
arthritis
Medium
vessel
Polyarteritis
nodosa
kawasaki
Small vessel
Anca
associated
Immune
complex

4.  Pulseless disease, young female
arteritis, or Harbitiz-Raedu syndrome
 F>>M ;<40years
 Takayasu’s disease is a chronic vasculitis
mainly involving the aorta and its main
branches such as the brachiocephalic,
carotid, subclavian, vertebral and renal
arteries as well as the coronary and
pulmonary arteries.

5.  : The early symptoms are non-specific.
 These include fever, myalgia, arthralgia
,weightloss,anorexia.
 tenderness of carotid artery
 subclavian, vertebral and renal
 arteries as well as the coronary and
pulmonary arteries

6.  This form of systemic connective tissue
disease occurs in the elderly, in the sixth and
seventh decades.
 It is characterized by panarteritis with giant
cell infiltration, predominantly affecting the
cranial vessels.
 The etiology is not established.

7.  Both sexes are equally affected
 Onset is with severe,unilateral or bilateral
headache in the temporal or less commonly in
the occipital regions( visual loss), associated with
vomiting.
 Diagnostic feature is the palpably thickened,
tender and non pulsatile temporal arteries.
 Loss of vision due to occlusion of the ophthalmic
 artery is a dreaded complication.
 Rarely patients present as facial neuralgia with
jaw claudication on chewing, deafness, necrosis
of the tongue, or an associated widespread
necrotizing arteritis of small vessels which
presents as peripheral neuropathy.

8.  ESR often exceeds 100 mm
 Temporal artery biopsy
 Arterial doppler

10.  Characterised by severe pain and stiffness in
the neck, back, shoulder, upper arms and
thighs, particularly worse in the morning

11.  Polyarteritis nodosa (PAN) is characterized by
the formation of multiple nodules along
blood vessels, mainly affecting the smaller
arteries, arterioles, and adjacent veins.
Capillaries are spared.
 Pathologically the lesion consists of
polymorphonuclear infiltration, necrosis and
aneurysmal dilatation of the arterial wall

12.  Idiopathic
 Hepatitis B

13.  Though all ages may be affected, adults
suffer more frequently.
 Males predominate.
 The onset is variable.
 The onset is with general symptoms like
fever, muscle pains, arthralgia, rash and
anorexia.

14.  Skin manifestation
 Inflammatory nodules ranging in size from 5-
10 mm may be palpable over the superficial
arteries.
 These nodules are tender.
 Livido reticularis

16.  Rheumatoid Arthritis is a chronic
inflammatory autoimmune disease that
involves the joints and may cause systemic
manifestations.