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Current and Future Treatments for Azoospermia

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The Turek Clinics
The Turek Clinics

The 2nd Gulf Andrology Conference Riyadh Military Hospital, Ministry of Defense Riyadh, Saudi Arabia, March 3-4, 2012 Lectures: Current and Future Treatments for Azoospermia

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Sperm! Detection! Rate! FNA Sites/Testicle!
Finding Sperm in Nonobstructive Azoospermia Microdissection FNA Mapping
“Directed” TESE Sperm Present <2 sites >2 FNA All FNA sperm/map sites/map sites/map TESE TESA (n=29) (n=38)
What Exactly is Metabolomics? !!
In the testis, somatic cells are metabolically “quiet” compared to rapidly dividing germ cells! Analogy: A pile of bricks along a desert road- indicates something is being built.!
The Metabolomic Signature of a Testicle Phosphocholine (PC)! Glycerophosphocholine (GPC)! Total Choline! Choline! Normal/Fertile ! Aaronson et al. ! Creatine! Hum Reprod. 2010! Alanine! Lactate! Azoospermic Men with Sertoli Cell Only !
Aaronson et al. Hum Reprod. 2010
Leydig cells! Stromal cells! Sertoli cells! Fibronectin!
Current and Future Treatments for Azoospermia
Current and Future Treatments for Azoospermia
Current and Future Treatments for Azoospermia

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Current and Future Treatments for Azoospermia

  • 1.
  • 2.
  • 3.
  • 4.
  • 5.
  • 6.
  • 7.
  • 8. Sperm! Detection! Rate! FNA Sites/Testicle!
  • 9.
  • 10. Finding Sperm in Nonobstructive Azoospermia Microdissection FNA Mapping
  • 11.
  • 12.
  • 13.
  • 14. “Directed” TESE Sperm Present <2 sites >2 FNA All FNA sperm/map sites/map sites/map TESE TESA (n=29) (n=38)
  • 15.
  • 16.
  • 17.
  • 18. What Exactly is Metabolomics? !!
  • 19. In the testis, somatic cells are metabolically “quiet” compared to rapidly dividing germ cells! Analogy: A pile of bricks along a desert road- indicates something is being built.!
  • 20. The Metabolomic Signature of a Testicle Phosphocholine (PC)! Glycerophosphocholine (GPC)! Total Choline! Choline! Normal/Fertile ! Aaronson et al. ! Creatine! Hum Reprod. 2010! Alanine! Lactate! Azoospermic Men with Sertoli Cell Only !
  • 21. Aaronson et al. Hum Reprod. 2010
  • 22.
  • 23.
  • 24.
  • 25.
  • 26.
  • 27.