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Film Casting Line
Laboratory & Pilot
Scale Machine
Umang Pharmatech Pvt. Ltd.
Survey No. 146, H. No.1 (PT),Vasai Phata Highway Junction, Pelhar,Nh8, Vasai (E) - 401 208, Maharashtra (India).
Tel. : (+91-0250) 6681600-10, E-mail: marketing@umangpharmatech.com, Website: www.umangpharmatech.com | www.umangengineering.com
100% Customer delight at all touch points
w High Shear Granulator
w Extruder
w UICE-Lab
w Axial Extruder
w Cone Extruder
w Radial Extruder
w Die Roller Extruder
w Basket Extruder
w Hot Melt Extruder
w Spheronizer
w Mini Dryer
w Mini Lab
w UFBM-1
w UFBM-3/5
w UFBM-30
w Solid Drug Layering
w Tru Sifter
w Tru Sphere
w Spray Dryer
w Pan Coater
w Homogenizer
w MDF Lab
w Pell-Drop Mini
w Continuous Tray Dryer
w Vacuum Drying
w Roll Compactor
1
w Film Mixing Tank
w Film Casting M/C
w Film Slitting M/C
w Strip Packing Line
w Film Processing Line
w Transdermal Patche Line
w Transdermal Packing Line
5
Products
Film Casting
Line
Laboratory & Pilot
Scale Machine
2 / 40
1 Laboratory & Pilot
Scale Machine
UICE-LabHigh Shear Granulator Cone ExtruderAxial Extruder Radial Extruder
Basket ExtruderDie Roller
Extruder
SpheronizerHot Melt Extruder
Mini Dryer Mini Lab UFBM-1 UFBM-3/5
Tru Sphere
Spray Dryer Pan Coater Homogenizer MDF Lab
Pell Drop Mini Continuous Tray
Dryer
Vacuum Drying
Roll Compactor
Solid Drug Layering Tru SifterUFBM-30
3 / 40
High Shear Granulator
1 Laboratory & Pilot Scale Machine
Ÿ Stainless steel 316 construction / glass contact parts or glass rest Stainless steel 304 / polycarbonate.
Ÿ Process vessel in stainless steel extra with or without jacketing.
Ÿ Jacketed process vessel for granulation.
Ÿ PLC Automated touch screen controls. 21CFR controls possible on options.
Ÿ Siemens / Allen Bradley based automated controls.
Ÿ mixing / Pellet processing efciencies ensure highest level of product performance.
Ÿ Efcient product processing for nearly 100% product recovery.
This design of granulation is for high shear wet granulation, pelletization, etc. suitable for pre-formulation development,
formulation assurance, process consistency applications and academic laboratory use. The outstanding feature of the
high shear granulator range is the integrated. Connections, cabling and supplies are completely integrated, covered and
sealed so the outside of the machine is smooth and very easy to clean. The innovative discharge valve design and
optimized seals inside the bowl allow for CIP. As a result of this the our High shear granulator is highly exible, quick
product changeover increases productivity and cost effectiveness.
The High Shear Granulator ranges from 1 - 5 liters featuring through the wall design and movable head, allowing
operation with platform and dust - free discharging via a linked mill directly into an IBC. The HIGH SHEAR GRANULATOR
can be stand - alone or linked to a uid bed to form an integrated system.
Features
Benets
Ÿ Variable speed mixer and chopper.
Ÿ Mixer torque (%). Glass process vessel for 300 - 700 gms./batch
and /or vessel set for 100 - 200 gms/batch
Ÿ Touch screen controls with traceability.
Ÿ Easy Cleaning & Maintenance Switch from one product to
another with minimal downtime, reducing the costs of labor and
tooling replacements.
Ÿ Liquid dosing system. Product temperature measurement.
Ÿ Critical process data : mixer torque (%), product temperature and
chopper speed, liquid dosing, speed / volume.
Throughput/Output:
Model
Capacity
USMG - 1/2
250 - 1000 gms/batch
4 / 40
1 Laboratory & Pilot Scale Machine
Extruder - UICE Lab
Continuous Technology
UICE is an integrated machine for the uninterrupted process for making granules, the innovative technology is the
outcome of 35 years of know how experience in pelletization machinery, and being one of the largest supplier of Extruders
& Spherodizer we provide best technology solutions to our customers. The integrated Extruder - Spherodizer is designed
to suit the pharmaceutical application of producing spherical pellets. The machine fully complies with cGMP norms and
easy to use. It is suitable for large scale production of spheres from the wet mass. It is also suitable for scale-up studies. The
machine is delivered with an Cone Extruder (UTCE - 110) & Single Spherodizer (USPH - 900). The porosity of the mesh is as
per customer requirement and it a format part. The size of the spheres is mainly depended on the diameter of extrudes and
the cross hatched disc grove on the chequered plate of the Spherodizer. In this machine, Extruder output to be collected in
bucket & load into Spherodizer.
Features
Ÿ Compact design and GMP Suites for continuous pellet production.
Ÿ System components easily accessible for cleaning and
maintenance.
Ÿ Fully integrated with Allen Bradley PLC controls 21 CFR certied.
Ÿ Spheronizer equipped with wash in place nozzle.
Ÿ Integrated Plate lifting device for twin Spheronizer plate.
Ÿ Stainless steel 316 GMP design with high polish nish.
Ÿ Standard cone extruder with feed hopper (optional extruders cab
be tted) .
Ÿ Variable speed for extruder (20-100 rpm), twin Spheronizer (50-
1500 rpm).
Ÿ Standard set up 1mm, optional size of cone meshes (0.3, 0.4, 0.5,
0.6, 0.8, 1.0, 1.2, 1.5, 2mm).
Ÿ Twin bucket assembly with Load cell measurement for exact
Spheronization volume per batch.
Ÿ Standard chequed plate 3.2mm. Optional size is 1mm, 2mm,
6.5mm.
Ÿ Recording of critical process data in software.
Ÿ Controls by 12.1 IPC by a touch panel control with trends. (21 CFR
part 11 Certied).
Ÿ Report can be transferred to USB to view on computer.
Benets
Ÿ Transfer bucket on load cell and it's PLC controlled auto
discharge ensures uniform weight for every transfer and there
by quality pellets.
Ÿ Fully automatic there by standardized consistent pellets.
Ÿ Fully Qualied & Documented.
Ÿ All the m/c components are precisely machined by CNC,
hence interchangeability is assured.
Throughput/Output:
Model
Capacity 50-1000 gms/hr
UICE - 41 (UTCE-70+Twin SPH-500)
5-50 kgs/hr
UICE - 21(USSE-60+SPH-380)
0.5-10 kgs/hr
UICE - LAB
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1 Laboratory & Pilot Scale Machine
Extruder - Axial Extruder
Ÿ Axial extruder is widely used for making pellets of different sizes starting from minimum 200 microns to maximum 2000
microns. Axial Extruder gives mild compaction and is ideal for most of the Pharmaceutical formulation related to
pelletization.
Ÿ Axial extruder consist of Hopper for loading of wet mass, Hopper as internal blades connected to gear to rotate and
push material in a systematic manner in to the feed hopper of Extruder Chamber, Extrusion chamber is Jacketed from
outside for circulation of cold water to maintain temperature of the product in case the product is sensitive in nature.
Ÿ Extrusion chamber consist of twin screws which transfer the material towards the pressing cam and out from the
perforation of the screen of desired dia.
Ÿ Axial extruder is available from R&D to Production batches with minimum output of 250 gms and maximum 500 kgs/hr
Axial Extruder are cGMP complied equipments with self standing model for Production scale & table top model for R&D
scale
Ÿ HMI control operation with built in electrical panel for ease in maintenance.
Ÿ Higher version of Axial Extruder comes along with Scada & 21 CFR Part 11 module with report options and online
printing of day to day activity carried on the equipment.
Features
Ÿ Stainless steel 316 construction contact parts rest Stainless steel 304.
Ÿ PLC Automated touch screen controls. 21CFR controls possible on options.
Ÿ Siemens / Allen Bradley based automated controls.
Ÿ Pellet processing efciencies ensure highest level of product performance.
Ÿ Efcient product processing for nearly 100% product recovery.
Ÿ Different axial meshes (0.3, 0.4,0.5 , 0.6, 0.8, 1.0, 1.2, 2, 3, and 5mm).
Ÿ Low ne generation. Different sizes on Axial mesh (0.2 mm - 2mm).
Ÿ Various mesh thickness possible.
Benets
Ÿ Axial mesh with feed hopper and pressing cams and screws.
Ÿ Variable speed of extruder (20-100 rpm).
Ÿ Touch screen controls with traceability.
Ÿ Easy Cleaning & Maintenance Switch from one product to
another with minimal downtime, reducing the costs of labor
and tooling replacements.
Ÿ Minimal Capital Investment Single platform with
interchangeable extrusion design heads permits selection of
the optimal pellet processing technology with a minimal capital
investment.
Throughput/Output:
Model
Capacity
USSE - 60
250gms - 6kgs / hr
UICE - LAB
50gms - 1kgs / hr
6 / 40
1 Laboratory & Pilot Scale Machine
Extruder - Cone Extruder
Features
Benets
Throughput/Output:
Ÿ Cone extruder is widely used for making pellets of different sizes starting from minimum 500 microns to maximum 2000
microns.
Ÿ Cone Extruder gives mild compaction and is ideal for most of the Pharmaceutical formulation related to pelletization.
Ÿ Cone extruder consist of Hopper for loading of wet mass, Hopper as internal blades connected to gear to rotate and
push material in a systematic manner in to the feed hopper of Extruder Chamber, Extrusion chamber is Jacketed from
outside for circulation of cold water to maintain temperature of the product in case the product is sensitive in nature.
Ÿ Extrusion chamber consist of twin screws which transfer the material towards the pressing cam and out from the
perforation of the screen of desired dia.
Ÿ Cone extruder is available from R&D to Production batches with minimum output of 250 gms and maximum 500 kgs/hr.
Ÿ Cone Extruder are cGMP complied equipments with self standing model for Production scale & table top model for R&D
scale HMI control operation with built in electrical panel for ease in maintenance.
Ÿ Higher version of Cone Extruder comes along with Scada & 21 CFR Part 11 module with report options and online
printing of day to day activity carried on the equipment.
Ÿ Stainless steel 316 construction contact parts rest Stainless steel 304.
Ÿ PLC Automated touch screen controls. 21CFR controls possible on options.
Ÿ Siemens / Allen Bradley based automated controls.
Ÿ Pellet processing efciencies ensure highest level of product performance.
Ÿ Efcient product processing for nearly 100% product recovery.
Ÿ Different cone meshes (0.4, 0.5, 0.6, 0.8, 1.0 and 1.2mm).
Ÿ Low ne generation.
Ÿ Cone mesh with pressing cams and screws with feed hopper.
Ÿ Variable speed of extruder (40-100 rpm). Touch screen controls
with traceability.
Ÿ Easy Cleaning & Maintenance Switch from one product to
another with minimal downtime, reducing the costs of labor and
tooling replacements.
Ÿ Minimal Capital Investment Single platform with
interchangeable extrusion design heads permits selection of the
optimal pellet processing technology with a minimal capital
investment.
Model
Capacity
USSE - 60
250gms - 6kgs / hr
UICE - LAB
50gms - 1kgs / hr
7 / 40
1 Laboratory & Pilot Scale Machine
Features
Benets
Throughput/Output:
Extruder - Radial Extruder
Ÿ Radial Extruder is the new extrusion range that build on the proven Umang technology and it benets. Similar design
of process screws, cams and meshes ensure right size of extrusion from 400 - 1500 microns.
Ÿ The design ensures low pressure extrusion for your products.
Ÿ Radial Extruder consist of Hopper for loading of wet mass, Hopper as internal blades connected to gear to rotate and
push material in a systematic manner in to the feed hopper of Extruder Chamber, Extrusion chamber is Jacketed from
outside for circulation of cold water to maintain temperature of the product in case the product is sensitive in nature.
Ÿ Extrusion chamber consist of twin screws which transfer the material towards the pressing cam and out from the
perforation of the screen of desired dia.
Ÿ Radial Extruder is available from R & D to Production batches with minimum output of 250 gms and maximum 150
kgs/hr Radial Extruder are cGMP complied equipments with self standing model for Production scale & table top
model for R&D scale.
Ÿ Stainless steel 316 construction contact parts rest Stainless steel 304.
Ÿ PLC Automated touch screen controls.
Ÿ 21CFR controls possible on options.
Ÿ Siemens / Allen Bradley based automated controls.
Ÿ Pellet processing efciencies ensure highest level of product performance.
Ÿ Efcient product processing for nearly 100% product recovery.
Ÿ Different radial meshes (0.3, 0.4, 0.5, 0.6, 0.8, 1.0 and 1.2mm).
Ÿ Low ne generation.
Ÿ Radial mesh with pressing cams, screws and feed hopper.
Ÿ Variable speed of extruder (20 - 100 rpm).
Ÿ Touch screen controls with traceability.
Ÿ Easy Cleaning & Maintenance Switch from one product to
another with minimal downtime, reducing the costs of labor
and tooling replacements.
Ÿ Minimal Capital Investment Single platform with
interchangeable extrusion design heads permits selection
of the optimal pellet processing technology with a minimal
capital investment.
Model
Capacity
USSE - 60
250gms - 6kgs / hr
UICE - LAB
50gms -1kgs / hr
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1 Laboratory & Pilot Scale Machine
Throughput/Output:
Benets
Extruder - Die Roller Extruder
Ÿ Die Roller Extruder as two rollers one is perforated and the second is knurling roller both are horizontally placed with
minimum gap of 0.3mm. Material is charged in the hopper manually, hopper consist of drum and blade provision
attached to the motor it rotates and drives the material into the feeding hopper in between the rollers and due to the
pressing nature material comes out from the perforation and we get extrudes.
Ÿ Material is charged in the hopper manually, hopper consist of drum and blade provision attached to the motor it rotates
and drives the material into the feeding hopper in between the rollers and due to the pressing nature material comes
out from the perforation and we get extrudes Die Roller Extruder as minimum 1000 microns (1.00 mm) Perforated roller
& maximum is 3000 microns (3.00 mm) Perforation.
Ÿ Die Roller Extruder is designed to provide better compaction and output. Die Roller Extruder is designed as per cGMP
requirements with assembling and disassembling on nuts and bolts for quick cleaning and installation. Die Roller
Extruder is an ideal equipment for R & D to Production scale batches for efcient and smooth performance. Die Roller
Extruder output in Production scale can be as high as 600 kgs/hr
Ÿ Cone extruder is available from R & D to Production batches with minimum output of 250 gms and maximum 150 kgs/hr.
Ÿ Die Roller Extruder can be with Scada & 21 CFR Part 11 concept for monitoring of the parameters set for the products
online & numerous reports can be generated related to the equipment performance and record purpose
Features
Ÿ Stainless steel 316 construction contact parts rest Stainless steel 304.
Ÿ PLC Automated touch screen controls. 21CFR controls possible on options.
Ÿ Siemens / Allen Bradley based automated controls.
Ÿ Pellet processing efciencies ensure highest level of product performance.
Ÿ Efcient product processing for nearly 100% product recovery.
Ÿ Different Die Rollers (0.8, 1.0, 1.2, 1.5, 2, 3mm).
Ÿ Low generation.
Model
Capacity
UDRE - 65
100gms - 15kgs / hr
Ÿ Die roller 1mm and knurling roller with feed hopper.
Ÿ Variable speed of extruder (20-100 rpm). Touch screen
controls with traceability.
Ÿ Easy Cleaning & Maintenance Switch from one product to
another with minimal downtime, reducing the costs of labor
and tooling replacements.
Ÿ Minimal Capital Investment Single platform with
interchangeable extrusion design heads permits selection of
the optimal pellet processing technology with a minimal
capital investment.
9 / 40
1 Laboratory & Pilot Scale Machine
Features
Throughput/Output:
Extruder - Basket Extruder
For less compaction and large output basket extruder is the best option. Mostly used in agro chemical industries. For
large scale production in pharmaceutical industries this equipment can be adapted since umang make is of gmp design
and can be validated. Extrusion take place centrifugally, and the mesh is of basket type in vertical position, hence called
basket extruder. This extruder range is of proven umang technology. In basket extruder, wet mass to charge manually in
to the top cone hopper.
Ÿ Modular, Compact, Cost efcient & GMP design.
Ÿ Continuous operation.
Ÿ All the m/c components are precisely processed in CNC, hence interchangeability is assured.
Ÿ Shaft assemblies are being provided with thrust and radial bearings.
Ÿ VFD Driven motor for innite variable speed of extruder (20-100 rpm) .
Ÿ Various mesh conguration with different perforation / area / thickness for product suitability.
Ÿ Fully integrated with Standard HMI / VFD controls , there by consistent Extrudes.
Ÿ Fully integrated with Standard ( AB / SIEMENS ) PLC / IPC controls for 21 CFR Part 11 compliance (optional).
Ÿ Different sizes of (1mm , 1.2mm, 1.5mm).
Ÿ Fully qualied and documented.
Advantages
Ÿ Batch Process.
Ÿ Zero black particle generation.
Ÿ HMI Touch screen operation.
Ÿ Built in Electrical controls.
Benets
Ÿ Proven design for effective operation.
Ÿ Pressing Roll with simple Radial construction.
Ÿ Low pressure extrusion for heat sensitive products.
Ÿ Ease of cleaning, and access to process components.
Ÿ Mass production.
Model
Capacity
UBRE - 150
1 - 10 kgs / hr
Pilot
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1 Laboratory & Pilot Scale Machine
Extruder - Hot Melt Extruder
Ÿ Hot Melt Extrusion is the upgraded version of Twin screw Extruder with heating as an element, the whole process
involves hopper for feeding the raw material along with waxes which is pre mixed in solid form.
Ÿ Hot Melt Extrusion is the new mixer extrusion range that builds on the proven Umang technology and its benets.
Similar design of the twin screws, extrusion die and cutting mechanism in the process and validation, so that there is no
difference to the extrusion process.
Ÿ This unique design of segmented twin screws, mixing attachments and cutting makes the not only a perfect hot melt
extrusion granulator but also an ideal machine for performing one stop operations.
Ÿ The outstanding feature of the Hot Melt Extrusion range is the the twin screw segmented barrel and twin screw feeders
attached to it for uniform and continuous product feeding. Connections, cabling and supplies are completely
integrated, covered and sealed so the outside of the machine is smooth and very easy to clean.
Ÿ Our system Melt extruder is a result of high level of engineering expertise and product technology knowledge, quick
product changeover increases productivity and cost effectiveness.
Ÿ The Hot Melt Extrusion capacity ranges from few 100 gms. to 150 kgs / hr featuring through the wall design and
movable head, allowing operation with platform and dust - free discharging via a linked mill directly into an IBC.
Ÿ The Hot Melt Extrusion can be stand-alone or linked to a Cone Mill or Multi Mill to form an integrated system. With its
special versions of the twin-screw extruder suitable for the production of pharmaceutical compounds, Umang is one of
the pioneers in the development of Pharmaceutical Hot Melt Extrusion. In this continuous production process, polymers
are mixed with binding materials, carrier materials and active pharmaceutical ingredients. This innovative, exibly
applicable process has recently become increasingly important.
Features
Ÿ Contact part hardened steel SS440, SS316, non contact part SS304.
Ÿ PLC Automated touch screen controls. 21CFR controls possible on
options.
Ÿ Siemens / Allen Bradley based automated controls.
Ÿ Pellet processing efciencies ensure highest level of product
performance.
Ÿ Efcient product processing for nearly 100% product recovery.
Ÿ Different Diameter of extrusion heads (1, 2, 3 and 5mm).
Ÿ Low ne generation.
Throughput/Output:
Model
Capacity
UMSE - 16
50gms - 1kgs/ hr
UMSE - 25
200gms - 2kgs/ hr
11 / 40
1 Laboratory & Pilot Scale Machine
Spheronizer
Introduction to Spher'onizer
The function of a spher'onizer is to convert extrudes in to spheroids. Spher'onization is the necessary second
step of granulation by extrusion - spher'onization process. spher'onization or marumarization is a rapid and
exible process where pharmaceutical products are made into small spheres or spheroids.
With vast experience of our team, we provide exceptional machineries which have proven technology and
efciency of forming extrudes in to spheroids. Different sizes of spher'onizer R&D model such as USPH 75, 150,
250, 380 the pilot scale Model USPH-500. Production scale model USPH-700, 900, 1100. The production scale,
USPH 1100 the enhanced production machine, are our standard design. Selection of spher'onizer depends
mainly on desired production characteristics. We provide customized solutions to match the requirement. Each
machine is designed keeping in mind the needs as one size does not t all. We believe in keeping ourselves
upgraded with the latest technology so that we provide our customer with the proven, safe & effective
technology.
Umang & Spher'onizer
Spher’odizer consists of a plate, which is having a special cross hatched groves, known as chequered plate.
This plate rotates inside a cylindrical bowl. The radial clearance between the plate and the bowl is kept
minimal (<0.3 mm) to reduce the powder leakage. Purging air is supplied in this gap to prevent the falling of
powder beneath the chequered plate. This air also helps for the evaporation of excess moisture from extrude
and prevent particle agglomeration.
Let’s understand the process
The manually loaded preformed extrudes on the chequered plate rotates along with the plate and centrifugal &
tangential movement of the product to get a torus motion. While rotating in the grooved plate with pre-desired
groove size, the vermicelli will fragmented into pieces with length equal to the diameter of extrudes. Broken
extrudes, because of the tangential force and centrifugal force, collide with the cylindrical wall of the
spher’odizer. The rotating rope type movement of extrudes at the outer border of the bowl give a rolling action
on the fragmented extrudes and it will be converted to spheres.
When the particles attain required spherical shape they are centrifugally discharged through the discharge
door which pneumatically opens into the discharge hopper at the predetermined time.
Extrudes -
Spher'onizationBreaking up Granules
Let’s Understand the process:-
Spherical pellets with
dense structure
Narrow grain size
distribution
Smooth Surface with
less abrasion
Better Solubility with
decreased hygroscopic
12 / 40
1 Laboratory & Pilot Scale Machine
Spheronizer
Ÿ Modular, Compact, Cost efcient & GMP design.
Ÿ Continuous operation.
Ÿ All the m/c components are precisely processed in CNC, hence interchangeability is assured.
Ÿ Cooling / Heating jacket for heat sensitive product.
Ÿ Shaft assembly is being provided with thrust and radial bearings.
Ÿ VFD Driven motor for innite variable speed for Checkered Plate.
Ÿ Various pitched ( 1 mm, 2 mm, 3.2 mm, 5 mm, 6.5 mm ) Checkered Plate for product suitability.
Ÿ Fully integrated with Standard HMI / VFD controls, there by consistent spheroids.
Ÿ Fully integrated with Standard ( AB / SIEMENS ) PLC / IPC controls for 21 CFR Part 11 compliance (optional).
Ÿ Fully qualied and documented.
Features
Ÿ Batch Process.
Ÿ Clearance can be adjusted between Pressing cam & Mesh to optimize the output.
Ÿ Zero black particle generation.
Ÿ Air purging from below to avoid material falling down.
Ÿ Built in Electrical controls.
Advantages
Ÿ Drum built in a single piece to avoid contamination.
Ÿ Since Shaft assembly is being provided with thrust
and radial bearings, the concentricity of checkered
plate with drum is maintained.
Ÿ Auto discharge and discharge hopper is special
design so that pellet cannot be damaged during
discharge.
Ÿ PLC program provides 5 different speed at set times
for Spher'onization.
Benets
Throughput/Output:
Model
Batch Cap./Kgs. 25gms/batch
USPH - 380USPH - 250USPH - 150USPH - 75
50gms/batch 250-500gms/batch 500gms-2kgs/batch
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1 Laboratory & Pilot Scale Machine
Throughput/Output:
Mini Dryer
Mini Dryer
The Mini dryer consists of an Inlet chamber, Product chamber & lter bag. The material is charged into the product
chamber. As per the material to be charged different meshes options are available. Air current is induced inside the
chamber by means of a blower. This air is heated by catridge heater.
The hot air stream passes through the bed of the material and gets uidized the product particles by creating the
turbulence in the product chamber. This turbulence inside the bed assists in the transportation of the material over the
length of the dryer. Due to uidization, the particles get surrounded by hot air, which leads quick & uniform heating and
drying.
Features
Ÿ Modular, Compact, Cost efcient & GMP design.
Ÿ Batch operation.
Ÿ VFD Driven motor for innite variable speed.
Ÿ Fully Qualied and documented.
Ÿ 3 bowl attachment for 100gms drying of product.
Advantages
Ÿ Batch Process.
Ÿ Uniform distribution of air through mesh.
Ÿ HMI & PLC operation.
Benets
Proven design for effective operation.
Model
Capacity
Mini Dryer - 1
0.3 - 1 kg/batch
Mini Dryer - 3/5
3 - 5 kg/batch
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1 Laboratory & Pilot Scale Machine
Throughput/Output:
Mini Lab
Small Compact Fluid Bed Multi Processor for bottom spray coating, top spray granulation & drying, Mini Lab It is ideal for
handling ne powders, pellets, granules, crystals and also tablets. A suitable binding agent is sprayed from the top into
the uidized product causing controlled agglomeration. The agglomerates formed are subsequently dried The Umang
Mini Lab Bottom top spray has been developed to meet the pharmaceutical industry’s requirements for exibility in unit
operations and is based on the principle that one basic unit can be used for numerous processes simply by interchanging
a module.
Process :
Ÿ Drying.
Ÿ Top spray granulation.
Ÿ Bottom spray wurster coating.
Mini Lab Bottom spray is the new FAST COATING WURSTER range that builds on the proven Umang technology and
its benets. Reversed air purging lters ensures inline cleaning at regular interval on automatic basis thereby ensuring
non choking of lters This unique design of the distribution plate and nozzles make it ideal machine for the fast and
uniform coating application on Pellets, Micro pellets & Granules.
tablets.
Ÿ Stainless steel 316 construction contact parts rest Stainless steel 304.
Ÿ PLC Automated touch screen controls. 21CFR controls possible on options.
Ÿ Siemens / Allen Bradley based automated controls.
Ÿ Pellet processing efciencies ensure highest level of product performance.
Ÿ Efcient product processing for nearly 100% product recovery.
Ÿ Low noise level. Liquid dosing speed / volume.
Features
Ÿ Process air lter for inlet air. Variable speed for exhaust blower
( 0-3000 rpm.).
Ÿ Touch screen controls with traceability. Easy Cleaning &
Maintenance Switch from one product to another with minimal
downtime, reducing the costs of labor and tooling replacements.
Ÿ 300 - 500 gms. batch capacity for wurster coating.
Ÿ 250 - 600 gms. batch capacity for top spray granulation. Anti-
static lter bag assembly.
Benets
Model
Capacity
MINI LAB
200 - 500gms/batch
UFBM - 1
300 -1000gms/batch
UFBM - 3
1 - 3 kgs/batch
15 / 40
1 Laboratory & Pilot Scale Machine
UFBM-1
1 Litre Fluid Bed Bottom & Top Spray (Mini Lab)
Mini - Lab is a table-top uid bed for laboratory use, sized for product volumes from 200 ml to 500ml. It is ideal for handling
ne powders, pellets, granules, crystals and also tablets.
A suitable binding agent is
sprayed from the top into the
fluidized product causing
controlled agglomeration.
The agglomerates formed are
subsequently dried.
A suitable liquid is sprayed from
the bottom (Pellets) ensuring
uniform coating. Multiple air
distributors, wurster & different
spray nozzles are available as
key features enabling various
product applications.
2 Litre Fluid Bed Bottom, Top Spray & Rotor
UFBM-1
DRYER WURSTER TOP SPRAY GRANULATOR ROTOR
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1 Laboratory & Pilot Scale Machine
UFBM-3/5
UFBM-3 is a self standing uid bed multiprocessor consisting top spray for granulation bottom spray coating and drying
and Rotor.
A suitable binding agent is
sprayed from the top into the
fluidized product causing
controlled agglomeration.
The agglomerates formed are
subsequently dried.
A suitable liquid is sprayed from
the bottom (Pellets) ensuring
uniform coating. Multiple air
distributors, wurster & different
spray nozzles are available as
key features enabling various
product applications.
6 Litre Fluid Bed Bottom, Top Spray & Rotor
The Umang Fluid Bed Multiple (UFBM) has been developed to meet the
pharmaceutical industry’s requirements for flexibility in unit operations and is
based on the principle that one basic unit can be used for numerous processes
simply by interchanging a module.
Ÿ Drying: Top Spray.
Ÿ Particle Coating: Bottom Spray (>50 microns).
Ÿ Granulating: Top Spray, Rotor Granulating.
Ÿ Pelletizing: Top Spray, Bottom Spray, Rotor Processing.
Ÿ Coating: Top Spray, Bottom Spray, Rotor Coating.
DRYER
WURSTER
TOP SPRAY
GRANULATOR
ROTOR
6 Litre Fluid Bed Bottom, Top Spray & Rotor
17 / 40
1 Laboratory & Pilot Scale Machine
UFBM-3/5
One of the most signicant advantages of the ROTOR is that pellets can be formed, this also applies to pellets containing
highly active substances. Layering, granulating and coating Processes can be carried out, depending upon the
composition and desired characteristic of the pellets. performulated active drug material are taken in the rotor with
chequered plate. The binder solution is sprayed till predetermined value and the disc is rotated at high speed giving the
direct pellets of drug. Different parameters decides the size of pellets. They can be dried and coated in same equipments.
Lyering, granulating and coating processses can be carried out, depending upon the composition and desired
characteristic of the pellets.
Process Rotor
Starting product (inert cores, crystals, etc) is lled into the plane plate
and set in motion. In the layering from liquids process, Pellets are
formed by spraying the active substance onto the cores as solution or
suspension, and simulataneously drying the pellets.
In the layering form powders and is bound to the spraying on a liquid
binder. The pellets are then dried.
Layering
Pellets are coated by spraying a liquid onto core material. Perforated
plate is to be used for this operation. Several layers of coating can be
applied using either the same or different coating liquids.
Coating
The ROTOR can be utilized as a medium - shear granulator. The
process is equivalent to the rst phase of wet granulation
pelletizing 75-250 microns pellets can be produced by this method.
Pelletization
Spheronization of Extrudates
Moist extrudates are fed into the ROTOR where they are rounded and
compacted by the chequered plate afterwards
the pellets are dried coated as appropriate.
18 / 40
1 Laboratory & Pilot Scale Machine
UFBM-30
SAMPLINGPORT
BOWLLOCKING
LIGHT
DISTRIBUTIONPLATE
WURSTERNOZZLES
AHU
PRODUCTBOWL
CIPNOZZLE
PUMP
Process Air
Exhaust Blower
Solution Tank
Pump
Explosion
Outlet
Fluid Bed Bottom Spray Coater - UFBM - 30
Umang Pharmatech, as a developer of innovative uid bed
processing and control technology, is able to provide all the
professional disciplines necessary to design, test, manufacture
and install the Fluid Bed system you require. Umang process
engineers, system-analysis and processing program
specialists, work with your development team to optimize all
aspects of the system with process trial at
our Indian site.
Fully integrated processing systems with matching accessories,
designed and manufactured by
Umang Pharmatech
REVERSEAIRPURGING
MESHFILTER
19 / 40
1 Laboratory & Pilot Scale Machine
Solid Drug Layering
Ÿ It is a centrifugal processing of single unit operation.
Ÿ The process involves the deposition of successive layers of an active compound onto nonpareil seeds resulting in the
formation of uniform size pellets.
Ÿ The operation is carried out using a Drug layering rotating plate, Dry powder dusted on nonpareils adheres seeds,
increasing their size and forming larger pellets. As per requirements.
Ÿ Growth occurs by a process of process of blending of powder / liquid binding and consolidation. After liquid addition
and layering of active creates the correct diameter pellets & with formation of rope movement uniform pellet size
happens.
Ÿ The requirements of process validation or Good Manufacturing practices (GMP) are simplied as the complete
spheroid production process is restricted to a single processor, min. size possible 500 microns.
Ÿ The requirements of process validation or good manufacturing practices (GMP) are simplied as the complete
spheroid production process is restricted to a single processor.
Ÿ Stainless steel 316 construction contact parts rest Stainless steel
304.
Ÿ PLC Automated touch screen controls. 21CFR controls possible on
options.
Ÿ Siemens / Allen Bradley based automated controls.
Ÿ Pellet processing efciencies ensure highest level of product
performance.
Ÿ Efcient product processing for nearly 98% product recovery.
Ÿ Different plate options available for optimum efciency. Low ne
generation.
Options
Ÿ Various nozzle sizes are available .
Ÿ Powder Feeder on load cell ensures uniform powder layering with
loss on weight concept.
Ÿ Water jacket on drum assembly.
Features
Benets
Ÿ Unique plate with zero crushing arrangement for starter cores
and hot air ow arrangement in the equipment.
Ÿ Spray gun with peristaltic pump and ml/min. ow rate
controls. Loss in weight powder feeder controls.
Ÿ Variable speed of rotating plate (50-300 rpm). Touch screen
controls with traceability.
Ÿ Easy Cleaning & Maintenance Switch from one product to
another with minimal downtime, reducing the costs of labor
and tooling replacements.
Ÿ Minimal Capital Investment Single platform permits optimal
pellet processing technology.
Throughput/Output:
Model
Capacity
USDL 220
200 - 600 gms/batch
USDL 400
1000 - 3000 gms/batch
20 / 40
1 Laboratory & Pilot Scale Machine
Tru Sifter
Tru Sifter 100
Operation of Machine:
A good concept in sifting which is not vibrating but rotating on its own axis with 03 different zones with their particular
meshes for getting undersize, desired size & over size of granules for further packing & re processing. Continuous sifter is
a round perforated drum with different sizes of perforation as per requirement. The entire perforated drum is xed to an
axis attached to gear & motor for control or RPM, below perforation there are separations that release the material for
packing and reprocessing.
The equipment is designed for continuous operations Specication of the Machine
Specication of Machine:
Description Specication
Production Capacity
Product
10-20 kg/ hr
Pellets
Standard Scope of Supply:
Description Specication
Meshes
Electrical accessories
MOC Contact parts
MOC. Non Contact parts
Finish
Motor
Control Panel
HMI
Switch Gear
Drive motor
VFD
Pneumatics
03 different meshes for undersize, oversize & correct size
415 V, 3 Phase, 50 Hz, 50 Amps
SS 316
SS 30
Non - FLP , 415 V, 3 Phase, 50 Hz, B5.
Built in Electrical and HMI Panel.
Make Delta 6”
Make Siemens / Salzer
Make Siemens / Bharat Bijlee, 22 Kw x 8 pole B5
Make ABB / Delta
Make Festo
Outside surface - Mat nish. 0.5 µ m Machine parts ‐
Machine nish 0.19 0.5 0.5 µ m (Insidedrum, Chequered plate etc).
Throughput/Output:
Model
Capacity
UTS - 100
1 - 10kgs / hr
21 / 40
1 Laboratory & Pilot Scale Machine
Throughput/Output:
Tru Sphere
Project & Principle of Operation
TS Technology is a new innovation of UPPL it is the solution for the critical problems faced by companies because of the
difference of variation in spheres / pellets size for optimization and standardization of spheronisation time. The
technology can be transferred to higher capacity for standardize the actual production module. On other side the
equipment is device for addition of value to the quality delivery of micro spheres to industry which is transferred at
moderate vibration to a heavy sorting methodology of segregation of non-spherical spheres from oblong size of pellets.
The benet to the user is the ability to get absolute size of pellets / spheres for further processing and its application.
Umang’s TS consists of a device with very minimum batch to a substantial high volume of process requirement. The
vibrating assembly of sorting tray and feeder extends from vertically to one corner of the tray. The complete assembly is
mounted on a platform with different sphere colleting chamber of its own nature with complete assembly on front side. The
equipment is equipped with a sorting tray and pellet feeder as a standard with the machine and additional would be
optional supply.
The system is suitable for pelletization process primarily focused in optimum and uniform pellet size which leads to
subsequent coating thereby causing accurate dissolution and disintegration in a respective media.The device is
advantageous for pelletization, formulation development, formulation assurance, process consistency,
application and academic purpose as well.
Equipment Features
Compact design & easy to scale up. Sorting Tray and feeder as a
standard supply. Easy to dismantle and clean. Vibration can be
regulated through for different degree of agitation during sorting
process. Collecting chamber for spherical spheres as well as oblong
series of spheres are separate Negligible product hold-up. Touch
screen control Industrial PC 12.1” with “PROCESS +” Software (21 CFR
compliant) with batch records on pen drive, machine has LAN network
capability and large printer connectivity serial port. 40 column thermal
printer as a standard.
Project Possibilities
R&D Application to sortout absolute spheres and ablong series
Pelletization sample
Plant Integration
A complete plant with Mixing, drying, sieving, blending even
coating as well which
Model
Capacity
UTS - 1
1 - 3 kg/hr
UTS - 5
5 - 10 kg/hr
22 / 40
1 Laboratory & Pilot Scale Machine
Spray Dryer
Aqueous Evaporation rate: 1 Ltrs / hr.
Design: Conrms to cGMP standards.
Contact parts: Glass / Teon / Stainless Steel 316.
Non-Contact parts: Stainless Steel 304.
Surface Finish: All fabricated part will be mirror polished inside & machine parts will be polished as required.
All corners rounded off to smooth nish.
Ÿ This proposal provides you with the exibility to use a Umang spray drying system tailored to your specic
process requirements. The proposal presents a Spray dryer along with options that maybe selected to
congure the system to meet your particular process and installation requirements.
Ÿ Please consult UMANG for requirements not listed in this proposal. The Spray dryer is designed and
constructed to facilitate efcient and effective cleaning to assist the customer in his conformance with
Current Good Manufacturing Practices.
Ÿ Main body of machine is constructed is Stainless Steel 304, the main purpose is to hold the complete
assembly i.e. Spray assembly, panel, controls & cyclone assembly; it needs a trolley for movement.
The main body is constructed in AISI Stainless steel 304, its main
purpose is to hold the machine rest AISI Stainless steel 316 / Teon /
Glass.
Ÿ Mini Spray Dryer consisting of the following:
Ÿ Glassware for drying chamber xed with collection bottle.
Ÿ Peristaltic pump with silicon tubing
Ÿ Cyclone (2)
Ÿ Product receiver (1)
Ÿ Scrubber (1)
Ÿ Spray nozzle made in Stainless steel 316 with automatic de-
blocking attachment. (One number)
Ÿ Spray gun would be Teon coated.
Technical Description
Throughput/Output:
Model
Capacity
UMSD - 1
100 - 1000ml / hr
UMSD - 3
2 - 3 Ltrs / hr
23 / 40
1 Laboratory & Pilot Scale Machine
Pan Coater
Throughput/Output:
Model
Capacity
UHPC - 6 / 8
150 - 500 gms/batch
UHPC - 12 / 15
1 - 3 kgs/batch
The Tablet coater consists of a 6” & 8” pan coater, the 6” pan works with 50–150 gms. (120–350 ml) Of tablets and 8” pan
works with 150–500 gms. (350–1000 ml) of tablets. The spray nozzle extends from the center of the pan. The complete
assembly is mounted inside a acrylic box. The equipment is equipped with 2 pans one 8” as a standard with the machine
and 6” as a optional supply. 3mm perforation on a pan is standard with high perforation area, smaller perforations can be
given for pellet coating.
Project & Principle of Opearation
Ÿ Compact design & easy to scale up. 8” pan as a standard supply.
Ÿ Minimum size of tablets it can process is 4mm. Easy to dismantle and clean.
Ÿ Hinged door. Negligible product hold-up.
Ÿ Touch screen control Industrial PC 12.1” with “PROCESS +” Software (21 CFR compliant) with batch records on pen
drive, machine has LAN network capability and large printer connectivity serial port. 40 column thermal printer as a
standard.
Ÿ Two interchangable pans.
Equipment Features
The machine takes tablets and does various types of coating like enteric, seal coating.
Project Possibilities
A complete plant with Mixing, High shear mixing, uid bed drying / granulator,
sieving , then tablet coating & Blending is possible as a integration.
Plant Integration
Product contact parts in AISI 316 stainless steel and non –
contact parts in AISI 304 stainless steel unless otherwise status.
The system operates in “under pressure”: the air goes through
the electrical heater, through the perforated drum and then
through the fan. Working in under-pressure gives us the
advantage that we use the same concept as is used in
production: particles can not leak into the environment, and the
motor or fan can not contaminate the process
Scope Of Supply
Umang Concept Tablet Coater
24 / 40
1 Laboratory & Pilot Scale Machine
Homogenizer
Including
1 x 2 Litre jacketed interchangeable Glass & Steel process vessels Infra Red temperature probe. Touch panel with control
of high-speed homogeniser (type Low Shear High Flow with rotor-stator) and contra-rotating mixing arm speeds Real-time
trends on screen of all measurement;
Excel batch report, saved on solid-state memory, High speed homogeniser speed.
Ÿ Contra-rotating mixing arm speed and torque.
Ÿ Product temperature.
Ÿ Process pressure (if optional vacuum pump ordered).
Ÿ Documentation set and CE label.
Ÿ Vacuum Pump with Pressure Control.
Ÿ Solid Dosing System.
Ÿ Calibration Documentation.
Ÿ Extra wear parts e.g. seals, o-rings Included.
Options
General
Ÿ The system is designed for lab scale semi-solid processing.
Ÿ As the jacketed process vessel is in glass, this system gives
maximum visual contact with your process.
Ÿ This system is equipped with torque read-out allowing accurate
process endpoint detection studies.
Ÿ The high-speed homogeniser and contra-rotating mixing arms
are driven through the vessel cover.
Ÿ The contra-rotating mixing arms have wall scrapers to create an
ideal mixing and energy transfer through the glass jacket.
Ÿ The design of the vessel results in a quick turnover time:
emptying, cleaning and loading in 5 minutes.
Detailed Specications
Jacketed Glass Processing Vessel :-
Ÿ The standard Homogeniser vessel is cylindrical shaped in
boro-silicate with at bottom and curved angels and has a
glass jacket with connections for in and outlet of
heating/cooling media.
Ÿ Remark: heating and cooling units are not included in the
scope of supply but could be quoted on request.
Product Volume : 2 litre Typical Capacity : 500-1000 ml
The high-speed homogeniser and the contra-rotating mixing arms
are “top-driven” through the lid of the process vessel. This set-up
offers easy changeover for cleaning and product change. Two other
openings are provided for product dosing and temperature
measurement.
The lid will be made out of stainless steel 316L :-
25 / 40
1 Laboratory & Pilot Scale Machine
Homogenizer
Quick connection system :-
The jacketed glass vessel is clamped to the lid by a threadless Quick Connection System.The vessel together with the
product can be taken away from the drive system by one simple turn.
Lid support box :-
A small lid support box, partly out of transparent material, supports the top plate. This cabinet allows visual contact with
process and provides an interlocked front door as a safety guard.
Drives & Agitators :-
The drive system is built on the cover with 2 drive motors, one for the central high speed homogeniser and the other one for
the contra-rotating mixing arm with wall scrapers. A gearbox is responsible for the contra-rotating mixing arm effect. The
high speed homogeniser is from the type “Low Shear High Flow with rotor/stator”.
Infrared measuring probe :-
For product temperature measurement in process including :
The probe itself, including necessary ttings logging to the real-time trend and into Excel.
Controls :-
Touch panel to directly measure and control all critical
parameters:
Ÿ Homogeniser speed contra-rotating mixing arm speed.
Ÿ Contra-rotating mixing arm torque.
Ÿ product temperature. Vacuum in process vessel.
Ÿ Endpoints: the stops automatically if the time or
temperature value exceeds the endpoint.
Ÿ Real-time trends on screen of all measurement.
Excel batch report, saved on solid-state memory, which
can be exported through a USB ash memory stick to any
PC.
Every batch can be recorded in an automatically
generated batch report in an Excel le with 3 different
sheets:
Identication sheet: Batch number
Data sheet: on this sheet, the raw data of all parameters
are registered every second and shown in column
Graph sheet: on this sheet, all parameters are visualised
in a graph.
Throughput/Output:
Model
Capacity
UHOM - 1/3 Ltr
1 Ltr / 3 Ltrs / batch
UHOM - 5/10 Ltr
5 Ltrs / 10 Ltrs / batch
26 / 40
1 Laboratory & Pilot Scale Machine
Standard Features
Ÿ equipment consist solution tank, lm casting and drying unit and manual strip packing.
Ÿ High Coating accuracy from design.
Ÿ Recording of all process related parameters.
Ÿ Variable speed of base lm.
Ÿ High quality stainless steel 316 construction with high quality nish.
Ÿ Liquid dosing system.
Ÿ Product temperatures & lm temperature measurement.
Ÿ Controls by Allen Bradley and 12.1” IPC by a touch panel control with trends.
Ÿ Web length 490mm. Coating thickness from 40 - 800 microns wet.
Ÿ Individual temperature adjustment zones.
Ÿ Left machinery compartment containing coating system.
Ÿ Uniform air ow throughout the machine.
Ÿ Stainless steel 304 rest contact parts.
Ÿ Thickness checking or wet & dry lm.
Ÿ Recording of critical process data in 21 CFR part 11 certied software.
Ÿ Report on Excel le can be exported to USB to view on computer.
Ÿ Equipment can be modied to make patch lm of desired size and desired web length.
Ÿ Cutting and Slitting line are a part of the complete processing line for oral strips.
Optional Features
Ÿ Cutting line for cutting into small uniform strips & individual strip packing line.
Ÿ Drying tunnel length can be varied.
Ÿ Homogenizers and mixing tanks for integrations for a complete MDF suite.
Ÿ Humidity control for the drying chamber.
Throughput/Output:
MDF Lab
Model
Capacity
UMDF - LAB
2500 strips/day
UMDF - 25
25,000 strips/day
UMDF - 50
50,000 strips/day
UMDF - 100
100,000 strips/day
UMDF - 200
200,000 strips/day
27 / 40
1 Laboratory & Pilot Scale Machine
Pell - Drop Mini
Pell-Drop processor for forming of the droplets, including :
Ÿ Die head for one die nozzle.
Ÿ Storage vessel (approx.3 litres ).
Ÿ IR heating elements.
Ÿ Oscillator controlled by amplier and frequency generator.
Ÿ (Vibrating of the melt in the die head)
Ÿ Stroboscope (monitoring the droplets after escaping from the die head ).
Ÿ Set of nozzles (hole diameter 0,15…1,6mm,in total 2 x 7 pieces ).
Ÿ Pressure regulator with gauge.
Ÿ Water cooling unit with vessel, pump and trough.
The Pell-Drop Mini can be used for in-house optimization of process parameters before going into large-scale
production. It also allows the production of sample quantities. The system is equipped with an exchangeable
single-hole die so that meaningful test runs may be made with just three liters of material. Pell-Drop Mini is
functionally equivalent to a full-scale Pell-Drop production line.
Pell-Drop Mini
The Equipment Consisting of the Following :
ITEM-1 :-
ITEM-2 :-
Electric control box, including :
Ÿ Frequency generator and amplier, Stroboscope controller,
Oscilloscope, Temperature controller, Power supply.
Electrical Requirements
Electric control box, including :
Ÿ Supply voltage : 230V AC single phase, 50 Hz +/- 3%
Ÿ Supply ampere :16 A
Ÿ Electrical standard : DIN-VDE
Ÿ Area classication : Not required
Ÿ Degree of protection : IP 30
Notes
Design of melt temperature : max.200°C
Size of the machine : 500mm*500mm*600mm
Weight : 50Kg
Throughput/Output:
Model
Capacity
UPD - 1
1kgs / hr output (wet)
28 / 40
1 Laboratory & Pilot Scale Machine
Continuous Tray Dryer
A revolutionary concept in drying of powder, granules, pellets & tablets in a continuous, cost effective, efcient manner
with minimum human interference.
Concept
Technical Details
Ÿ Equipment is designed keeping in mind GMP requirements, contact parts SS 316 & non contact parts SS 304.
Ÿ Capacity of the Equipment in continuous drying is 110-120 kgs/hr depending upon moisture content.
Ÿ Each and every part of the Equipment in contact with the product is cleanable.
Ÿ A 30ltrs Feed Hopper is at the top to charge the product which is transferred to rotating plates in a controlled manner,
each plate as a spreader to spread the material on the plate and after 01 complete rotation a wiper wipes the material
to plate below.
Ÿ In this way product is tumbled from 01 plate to another plate thereby enabling uniform and fast drying.
Ÿ The dried product from the last plate is discharged from the discharge funnel. Entire operation is controlled by PLC.
Equipment Consists of
Ÿ Circular Feeder driven by geared motor. Geared motor drive for the rotation of
rotary plates.
Ÿ Motor driven Timer belt drive for Lamina Flow Air Distribution System.
Ÿ Self standing body with jacketed interiors for insulation.
Ÿ 18 tray arrangement one above the another on a trolley which can be rolled to
washing area.
Ÿ Air Exhaust port provided. Air Handling Unit for Inlet Air with steam heating
provision.
Ÿ Built in electrical panel. PLC control system.
Benets Compared To Tray Dryer
Ÿ Tray dryer is the most economical way of drying with Equipment cost
& electricity consumption is the lowest, the only deciency the system
as is the upper part of the product gets dried fast and below part
needs to be tumbled for drying, it involves use of man power for
tumbling and there is no certainty that the drying will be uniform and
result may vary in LOD report.
Ÿ In a Continuous Tray Dryer material charging is from top and from 01
plate to another plate it keeps on tumbling thereby all the portions of
the material is subjected to hot air and dried product is disposed
from bottom with no human interference thereby avoiding problem
of contamination.
Ÿ Continuous output can be achieved from Rotary Tray Dryer
enhancing overall production.
Benets Compared To Fluid Bed Dryer
Ÿ Currently this is the best technology available in the market for drying which ensures uniform drying but operating heavy
motors to run the equipment is very costly affair thereby adding to the nal product cost.
Ÿ Due to the tumbling principle of Continuous Tray Dryer product drying become much more efcient and with less motor
power the cost saved to run this Equipment is more economical compared to Fluid Bed dryer.
Ÿ Limitation in operation compared to continuous process of Rotary Tray Dryer.
29 / 40
1 Laboratory & Pilot Scale Machine
Vacuum Drying
Vacuum drying can be applied in a range of processes in several industries, including
chemical, pharmaceutical, food, plastics, and metal powders.
Trays
Ÿ Tray size is 16 x 32 x 1.25 (h) inches
Ÿ Tray volume is 10 litres
Ÿ Tray height can be increased to a maximum of 2 inches
Ÿ Center to center distance between any two shelves is 4 inches
Special Features of Vacuum Drying
Ÿ All stainless steel 304 / 316 / 316L CGMP externals with stainless
steel internals (vapor and product contact parts)
Ÿ Hollow pad type heating shelves which are easily removable for
maintenance
Ÿ Condensor and condensate receiver tted on the dryer body or
stand alone for remote installation
Ÿ Fully welded skirt on vacuum dryer body for ush mounting
through the wall
Ÿ External insulation of dryer with protective panels in stainless
steel or mild steel powder coated
Ÿ Dedicated uid heating and circulating systems. These can be
steam or electrically heated. Fluid heating systems are
available for water as well as thermic uid ( for temperature
requirements above 95 degree centigrade)
Ÿ Validation ports and nitrogen purge nozzles
Ÿ Can be designed to customers specic requirements
Ÿ Steam sterilisatile models available
Ÿ Double door loading available for larger models
Ÿ Through wall design available
Model
Capacity in Trays
UVTD - 6
6
UVTD - 12 UVTD - 24 UVTD - 48 UVTD - 96
12 24 48 96
6 6 8 16 16
1 1 1 1 1
1 2 3 3 6
No of Shelves
Dummy Shelf
Trays Per Shelf
Technical Specication
30 / 40
Umang Roll Compactor
100 mm
Variable. 20-150 rpm
Three Phase, 415V+10%, 50/60Hz, 4Wire+PE.
300 Liters/ Hour @ 1 bar
integrated, Non-Flameproof Panel
15 Liters
Hydraulic cylinders (2 Nos) with a pressure of 130Kg/cm2
Gravity feeding to feed funnel and then pressed in to compacting roller by pressing screw.
Integrated, Non-Flameproof Panel
1 Hp
Operator Interface Terminal with 7", color, Touch screen
USB, RS485 Modbus, RS232, Printer
ABB / Delta
Visual and Audio
login control with username and password
Up to 100
Serial Printer Connectivity
DQ, IQ/OQ Operation Manual Component Test certificates
SS 316
SS 304
SS 304
Matt finished (220 grit)
Mirror finished(320 grit)
Compacting of Pharmaceutical grade powder
Natural flow with gravitational force
10-25 Kg/Hr (±10%)
600X500X600
5 H.P
3 KW (Approx)
500 Kg
TECHNICAL SPECIFICATIONS
Fully automatic. Manual mode and Recipe mode operations with "Umang Process -Lite" control a
interface software
Machine
Roller Diameter
Roller Speed
Machine control
Electrical Specification
Chilled water
Electrical Cabinet
Hopper capacity
Compacting Method
Feeding Method
Electrical Cabinet
Power pack motor capacity
User interface and Visualization
Communication ports
VFD for Motor control
Alarm
User control
Recipes
Other features
Standard Documents
MOC of Contact parts
MOC of Non- Contact parts
MOC of Frame
Surface Finish- outside surface of contacts parts
Surface Finish- inside surface of contacts parts
Standard Application
Discharge
Throughput*
Machine Dimensions (W X D X H in mm)
Connected Load (KW/hp)
Average Power Consumption
Machine Weight
1 Laboratory & Pilot Scale Machine
Roll Compactor
31 / 40
Film Casting Line5
Film Mixing Tank Film Casting Machine
Film Slitting
Machine
Strip
Packing Line
Transdermal Patche
Line
Film Processing
Line
Transdermal Packing
Line
32 / 40
5 Film Casting Line
Film Mixing Tank
This Machine is being used for making a homogenous Solution by mixing, stirring and heating.
Ÿ Main Stationary fabricated body with electrical panel and ON /OFF , PID Controls Switches.
Ÿ Jacketed & insulated solution tank on castor wheel.
Ÿ Stirrer Blade , for mixing the solution
Ÿ Top lid with reduction drive and ports.
Ÿ Lid lifting arrangements with balanced weights.
Ÿ Cartridge Heaters
Main parts of The Machine:
Ÿ Modular, Compact & GMP design.
Ÿ The tank is equipped with Thermic Fluid Heating jacket, Insulation, discharge valve & moving on castor wheel.
Ÿ Standard agitator assembled on lid which can be lifted manually with balanced counter weight.
Ÿ MOC. Of Product Contact parts are of Ss316.
Ÿ MOC. Of Non Contact Parts are of SS 304.
Ÿ All other hardware of standard make.
Ÿ Empty tanks needed for continuous plant operations.
The Design considerations for Solution Preparation Tank
Input material to be loaded. Connect the drum with lid. Activate the
machine. A.C driven agitator blade will shear & mix the ingredients at
required temperature which can be set-ted by PID Control on cartridge
heater witch heats the Thermic uid inside the jacket. Charging Port
provided on the lid can be used for addition of any small ingredient. Ball
valve provided at bottom can be opened for discharge after pre
determined time required.
Operation of machine
Specication of Machine:
Capacity
Temperature
Heating
Machine overall Dimension
Electrical Specication
100 Liters
o
50 to 100 C
Cartridge Heating
Length: 500mm Width: 980mm Height: 2000mm
415V, 3 Phase, 50 Hz, 8Amps
33 / 40
5 Film Casting Line
Film Casting Machine
General Introduction
Continuous Film Casting machine is designed to produce Pharmaceutical grade 'Mouth Dissolving lm' in Lab Scale ,
Pilot Scale and Production scale with variable thickness from 40 to 80 microns.
It consist of -
A set of roller arrangement for holding and smooth movement of substrate and caste lms. Set of heaters inside drying
chamber to heat air ow system which dries the lm. Coating assembly to coat continuously on a substrate lm with
solutions or dispersions in variable thickness with accuracy 500-900 microns Thickness adjusting mechanism by viewing a
built in thickness indicating micrometer dial.
Let’s understand the process -
The substrate lm will be released from the unwinding roll towards winding roll, the solution is coated on a substrate lm
at coating station in predetermined manner. The laminated wet solution lm moves through drying zones. The
temperature at drying zone is being sensed and set as required. A dried layer of product over the substrate lm will be
coming from the drying zone continuously and wound on a winding roll . The machine is equipped with web aligner , force
sensor and full automation Except for lab type.
Features
Product Properties Product Properties -
Ÿ Film is thin and elegant. Non obstructive. Adheres to the oral cavity easily.
Ÿ Processes fast disintegration without water.
Ÿ Rapid release.
Ÿ Proven design for effective operation
Ÿ Low shear for non - destruction of product properties
Ÿ Cantilever type design for winding and unwinding ,
hence substrate and product rolls can be simply
inserted from front
Ÿ Drying chambers jacketed for insulation there by
energy saving
Benets
Ÿ Continues Process
Ÿ Built in Electrical controls
Ÿ High Coating accuracy
Ÿ Uniform air ow throughout the machine
Ÿ Liquid dosing system there by minimal human
interference
Ÿ Recording of critical process data in 21 CFR part 11
certied software
Ÿ Report on Excel le can be exported to USB to view on
computer.
Ÿ Equipment can be modied to make patch lm of
desired size and desired web length
Advantages
Ÿ Modular, Compact, Cost efcient & GMP design.
£ Contact parts Stainless steel 316 construction non
contact parts Ss304
£ Precise closed coating system
Ÿ High efcient drying zones with double skin
Ÿ M/C components are precisely processed in CNC ,
hence interchangeability is assured
Ÿ Shaft assemblies are being provided with deep groove
ball bearings
Ÿ Cantilever type design for winding and unwinding rolls
Ÿ RTD sensors and temperature controls for individual
zones
Ÿ VFD Driven motor for innite variable speed
Ÿ Linear speed sensors
Ÿ Automatic web aligner
Ÿ Automatic Web tension through Force sensor
Ÿ Fully integrated Controls with Standard PLC , OIT ,
VFD , SCADA
Ÿ Fully qualied and documented
Throughput/Output:
Model
Capacity
UMDF - LAB
2500 strips/day
UMDF - 25
25,000 strips/day
UMDF - 50
50,000 strips/day
UMDF - 100
100,000 strips/day
UMDF - 200
200,000 strips/day
34 / 40
5 Film Casting Line
Film Slitting Machine
General Introduction
It is un economical to make small width lm. Hence commercial size to be made and it is to be cut to required width. It is un
practical to simply cut the foil and hence this machine. Slitting machine converts the mother product reel to several small
width child reels as required for further process.
It consist of -
Ÿ Unwinding Station for mother reel , Winding station of slit child reel
Ÿ Slitting Station, Drive Arrangement.
305 / 610 mm width Mother reel will be loaded on the Unwinding shaft, 3/6 Slitting blade will size the width to 105 mm X 2 / 4
Nos. with trim at each ends and mid and then rolled on the child reel. Then 105 mm width Child reel can be directly loaded
on to the strip packing machine, there it get further slit to 20 mm, striped to 30 mm + / - and packed.
Let’s understand the process -
Ÿ Perfect width
Product Properties Product Properties -
Ÿ Modular, Compact, Cost efcient & GMP design.
Ÿ Continuous operation.
Ÿ All the m/c components are precisely processed in CNC
,hence interchangeability is assured
Ÿ Shaft assemblies are being provided with deep groove
ball bearings
Ÿ Cantilever type design for winding and unwinding rolls
Ÿ Fully integrated Controls with Standard HMI / VFD
Ÿ Fully qualied and documented
Features
Ÿ Continues Process
Ÿ Built in Electrical controls
Advantages
Ÿ Proven design for effective operation
Ÿ Cantilever type design for winding and unwinding , hence
substrate and product rolls can be simply inserted from
front.
Benets
Throughput/Output:
Model
Capacity
USLT - LAB
2500 strips/day
USLT - 25
25,000 strips/day
USLT - 50
50,000 strips/day
USLT - 100
100,000 strips/day
USLT - 200
200,000 strips/day
35 / 40
5 Film Casting Line
Film Packing Line
Umang Pharmatech Pvt. Ltd.’ s USTP-50 K is a Four Track Automatic Strip Packing machine. The entire Assembly is visible
from outside. It ensures that, there is no place for hidden debris and product contamination. Tool‐less change over and
lm loading is possible in this machine. Laminated lm unwinding roll & Packing foil unwinding rolls can be loaded/
unloaded from the front side by simply sliding on to respective roll shafts. The speed of all the rollers are controlled by PLC
and Dancing roll Sensors. The Human Interface is a touch screen. The machine is controlled locally, without interlocking
with down-line machines.
General Introduction
Ÿ Set of roller arrangements for holding and smooth movement of Product lm & packing foils.
Ÿ Slitting Mechanism with high shear blades.
Ÿ Stripping station with high shear blade to strip the lm into required length.
Ÿ Pick and place system to picks the strips of lm and places on the bottom packing foil.
Ÿ Sealing station to seal the strip. Sealing is designed with unsealed holding area at sides,
Ÿ Servo motor driven Linear-indexing station to enable digital advance setting through HMI & Servo Drive .
Ÿ Blanking station to blank the strips to designed shape. Strip can be designed with Tear-Notch,
Ÿ Printing station to print batch no , code no , MRP, dates etc .
Ÿ Trim winding shafted roll with geared AC motor drive for scrap trims of packing foil.
Ÿ Conveyer with geared AC motor drive for conveying packed strip to it's container.
Ÿ Electrical / Pneumatic control panel. OIT panel.
105 mm width reel will be loaded on the Unwinding shaft. 6 Slitting
blade will size the width to 20 mm 4 Nos. with 12.5 mm trim at each
side and then pass through stripping station by pulling action of it'
s rolls. Stripping action takes place when the pickup cup hold the
slit product lms.
There it get striped to 30 mm + / - length. Picked strips is getting placed
on the bottom packing foil where the DOT sensor planned. and get
sandwiched between bottom and top packing foils. At sealing station
it get sealed, pulled by indexing and blanked at blanking station .
Let’s understand the process -
Product Properties Product Properties -
Ÿ Perfect width
Throughput/Output:
Model
Capacity
USTP - LAB
2500 strips/day
USTP - 25
25,000 strips/day
UMDF - 50
50,000 strips/day
USTP - 100
100,000 strips/day
USTP - 200
200,000 strips/day
36 / 40
5 Film Casting Line
Film Processing Line
Over the recent few decades, many groups of formulation scientists are concentrating on rapid release dosage forms in
oral cavity. Among all fast release dosage forms, oral dispersible lms are successful to attract pharmaceutical industry
due to ease of formulation and extension patent life. Films are popular in patients too because of quick onset and user
friendliness of dosage form
Complete integration from one source. Mixing, Film making , Film Slitting and Packing line
General Introduction
Umang' s MDF Line
A Fully integrated mouth dissolving lm line for making edible / oral strips. Suitable for pre-formulation development,
formulation assurance, process consistency applications and academic laboratory use
The production of MDF involves following 4 essential steps.
Umang’s Solution Preparation Tank
It consist of -
Let’s understand the process -
Ÿ A jacketed and insulated vessel for holding the solution
Ÿ Set of heaters inside the jacketing to heat transfer media
Ÿ Drive arrangement on lid with stirrer
Ÿ Pneumatic lifting Arrangement for lid with stirrer and motor
It is the process of uniform mixing of the ingredients with liquid by stirring & heating in a solution preparation tank which
is jacketed for heating and insulated for energy saving.
SOLUTION PREPARATION FILM CASTING FILM SLITTING STRIP PACKING.
37 / 40
5 Film Casting Line
Transdermal Patches Line
General Introduction
Continuous patches Casting machine is designed to produce Pharmaceutical grade patches in Lab Scale , Pilot Scale
and Production scale.
It consist of -
A set of roller arrangement for holding and smooth movement of substrate and caste lms. Set of heaters inside drying
chamber to heat air ow system which dries the patches. Coating assembly to coat continuously on a substrate lm with
solutions or dispersions in variable thickness with accuracy 500-900 microns Thickness adjusting mechanism by viewing a
built in thickness indicating micrometer dial.
Let’s understand the process -
The substrate patches will be released from the unwinding roll towards winding roll, the solution is coated on a substrate
patches at coating station in predetermined manner. The laminated wet solution patches moves through drying zones.
The temperature at drying zone is being sensed and set as required. A dried layer of product over the substrate patches
will be coming from the drying zone continuously and wound on a winding roll . The machine is equipped with web aligner
, force sensor and full automation Except for lab type.
Features
Product Properties Product Properties -
Ÿ Patches is thin and elegant. Non obstructive. Adheres to the oral cavity easily.
Ÿ Processes fast disintegration without water.
Ÿ Rapid release.
Ÿ Proven design for effective operation
Ÿ Low shear for non - destruction of product properties
Ÿ Cantilever type design for winding and unwinding ,
hence substrate and product rolls can be simply
inserted from front
Ÿ Drying chambers jacketed for insulation there by
energy saving
Benets
Ÿ Continues Process
Ÿ Built in Electrical controls
Ÿ High Coating accuracy
Ÿ Uniform air ow throughout the machine
Ÿ Liquid dosing system there by minimal human
interference
Ÿ Recording of critical process data in 21 CFR part 11
certied software
Ÿ Report on Excel le can be exported to USB to view on
computer.
Ÿ Equipment can be modied to make patch lm of
desired size and desired web length
Advantages
Ÿ Modular, Compact, Cost efcient & GMP design.
£ Contact parts Stainless steel 316 construction non
contact parts Ss304
£ Precise closed coating system
Ÿ High efcient drying zones with double skin
Ÿ M/C components are precisely processed in CNC ,
hence interchangeability is assured
Ÿ Shaft assemblies are being provided with deep groove
ball bearings
Ÿ Cantilever type design for winding and unwinding rolls
Ÿ RTD sensors and temperature controls for individual
zones
Ÿ VFD Driven motor for innite variable speed
Ÿ Linear speed sensors
Ÿ Automatic web aligner
Ÿ Automatic Web tension through Force sensor
Ÿ Fully integrated Controls with Standard PLC , OIT ,
VFD , SCADA
Ÿ Fully qualied and documented
Throughput/Output:
Model
Capacity
UMDF - LAB
2500 strips/day
UMDF - 25
25,000 strips/day
UMDF - 50
50,000 strips/day
UMDF - 100
100,000 strips/day
UMDF - 200
200,000 strips/day
38 / 40
5 Film Casting Line
Transdermal Packing Line
Umang Pharmatech Pvt. Ltd.’ s USTP-50 K is a Four Track Automatic Strip Packing machine. The entire Assembly is visible
from outside. It ensures that, there is no place for hidden debris and product contamination. Tool‐less change over and
lm loading is possible in this machine. Laminated lm unwinding roll & Packing foil unwinding rolls can be loaded/
unloaded from the front side by simply sliding on to respective roll shafts. The speed of all the rollers are controlled by PLC
and Dancing roll Sensors. The Human Interface is a touch screen. The machine is controlled locally, without interlocking
with down-line machines.
General Introduction
Ÿ Set of roller arrangements for holding and smooth movement of Product lm & packing foils.
Ÿ Slitting Mechanism with high shear blades.
Ÿ Stripping station with high shear blade to strip the lm into required length.
Ÿ Pick and place system to picks the strips of lm and places on the bottom packing foil.
Ÿ Sealing station to seal the strip. Sealing is designed with unsealed holding area at sides,
Ÿ Servo motor driven Linear-indexing station to enable digital advance setting through HMI & Servo Drive .
Ÿ Blanking station to blank the strips to designed shape. Strip can be designed with Tear-Notch,
Ÿ Printing station to print batch no , code no , MRP, dates etc .
Ÿ Trim winding shafted roll with geared AC motor drive for scrap trims of packing foil.
Ÿ Conveyer with geared AC motor drive for conveying packed strip to it's container.
Ÿ Electrical / Pneumatic control panel. OIT panel.
105 mm width reel will be loaded on the Unwinding shaft. 6 Slitting blade
will size the width to 20 mm 4 Nos. with 12.5 mm trim at each side and
then pass through stripping station by pulling action of it' s rolls.
Stripping action takes place when the pickup cup hold the slit product
lms.
There it get striped to 30 mm + / - length. Picked strips is getting placed
on the bottom packing foil where the DOT sensor planned. and get
sandwiched between bottom and top packing foils. At sealing station it
get sealed, pulled by indexing and blanked at blanking station .
Let’s understand the process -
Product Properties Product Properties -
Ÿ Perfect width
39 / 40
Survey No. 146, H. No.1 (PT),
Vasai Phata Highway Junction, Pelhar,
NH8, Vasai (E) - 401 208, Maharashtra (India).
Tel. : (+91-0250) 6681600-10
E-mail : marketing@umangpharmatech.com
Website : www.umangpharmatech.com | www.umangengineering.com
Global Presence
Connect With Us
40 / 40

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Pharmaceutical machines

  • 1. Film Casting Line Laboratory & Pilot Scale Machine Umang Pharmatech Pvt. Ltd. Survey No. 146, H. No.1 (PT),Vasai Phata Highway Junction, Pelhar,Nh8, Vasai (E) - 401 208, Maharashtra (India). Tel. : (+91-0250) 6681600-10, E-mail: marketing@umangpharmatech.com, Website: www.umangpharmatech.com | www.umangengineering.com 100% Customer delight at all touch points
  • 2. w High Shear Granulator w Extruder w UICE-Lab w Axial Extruder w Cone Extruder w Radial Extruder w Die Roller Extruder w Basket Extruder w Hot Melt Extruder w Spheronizer w Mini Dryer w Mini Lab w UFBM-1 w UFBM-3/5 w UFBM-30 w Solid Drug Layering w Tru Sifter w Tru Sphere w Spray Dryer w Pan Coater w Homogenizer w MDF Lab w Pell-Drop Mini w Continuous Tray Dryer w Vacuum Drying w Roll Compactor 1 w Film Mixing Tank w Film Casting M/C w Film Slitting M/C w Strip Packing Line w Film Processing Line w Transdermal Patche Line w Transdermal Packing Line 5 Products Film Casting Line Laboratory & Pilot Scale Machine 2 / 40
  • 3. 1 Laboratory & Pilot Scale Machine UICE-LabHigh Shear Granulator Cone ExtruderAxial Extruder Radial Extruder Basket ExtruderDie Roller Extruder SpheronizerHot Melt Extruder Mini Dryer Mini Lab UFBM-1 UFBM-3/5 Tru Sphere Spray Dryer Pan Coater Homogenizer MDF Lab Pell Drop Mini Continuous Tray Dryer Vacuum Drying Roll Compactor Solid Drug Layering Tru SifterUFBM-30 3 / 40
  • 4. High Shear Granulator 1 Laboratory & Pilot Scale Machine Ÿ Stainless steel 316 construction / glass contact parts or glass rest Stainless steel 304 / polycarbonate. Ÿ Process vessel in stainless steel extra with or without jacketing. Ÿ Jacketed process vessel for granulation. Ÿ PLC Automated touch screen controls. 21CFR controls possible on options. Ÿ Siemens / Allen Bradley based automated controls. Ÿ mixing / Pellet processing efciencies ensure highest level of product performance. Ÿ Efcient product processing for nearly 100% product recovery. This design of granulation is for high shear wet granulation, pelletization, etc. suitable for pre-formulation development, formulation assurance, process consistency applications and academic laboratory use. The outstanding feature of the high shear granulator range is the integrated. Connections, cabling and supplies are completely integrated, covered and sealed so the outside of the machine is smooth and very easy to clean. The innovative discharge valve design and optimized seals inside the bowl allow for CIP. As a result of this the our High shear granulator is highly exible, quick product changeover increases productivity and cost effectiveness. The High Shear Granulator ranges from 1 - 5 liters featuring through the wall design and movable head, allowing operation with platform and dust - free discharging via a linked mill directly into an IBC. The HIGH SHEAR GRANULATOR can be stand - alone or linked to a uid bed to form an integrated system. Features Benets Ÿ Variable speed mixer and chopper. Ÿ Mixer torque (%). Glass process vessel for 300 - 700 gms./batch and /or vessel set for 100 - 200 gms/batch Ÿ Touch screen controls with traceability. Ÿ Easy Cleaning & Maintenance Switch from one product to another with minimal downtime, reducing the costs of labor and tooling replacements. Ÿ Liquid dosing system. Product temperature measurement. Ÿ Critical process data : mixer torque (%), product temperature and chopper speed, liquid dosing, speed / volume. Throughput/Output: Model Capacity USMG - 1/2 250 - 1000 gms/batch 4 / 40
  • 5. 1 Laboratory & Pilot Scale Machine Extruder - UICE Lab Continuous Technology UICE is an integrated machine for the uninterrupted process for making granules, the innovative technology is the outcome of 35 years of know how experience in pelletization machinery, and being one of the largest supplier of Extruders & Spherodizer we provide best technology solutions to our customers. The integrated Extruder - Spherodizer is designed to suit the pharmaceutical application of producing spherical pellets. The machine fully complies with cGMP norms and easy to use. It is suitable for large scale production of spheres from the wet mass. It is also suitable for scale-up studies. The machine is delivered with an Cone Extruder (UTCE - 110) & Single Spherodizer (USPH - 900). The porosity of the mesh is as per customer requirement and it a format part. The size of the spheres is mainly depended on the diameter of extrudes and the cross hatched disc grove on the chequered plate of the Spherodizer. In this machine, Extruder output to be collected in bucket & load into Spherodizer. Features Ÿ Compact design and GMP Suites for continuous pellet production. Ÿ System components easily accessible for cleaning and maintenance. Ÿ Fully integrated with Allen Bradley PLC controls 21 CFR certied. Ÿ Spheronizer equipped with wash in place nozzle. Ÿ Integrated Plate lifting device for twin Spheronizer plate. Ÿ Stainless steel 316 GMP design with high polish nish. Ÿ Standard cone extruder with feed hopper (optional extruders cab be tted) . Ÿ Variable speed for extruder (20-100 rpm), twin Spheronizer (50- 1500 rpm). Ÿ Standard set up 1mm, optional size of cone meshes (0.3, 0.4, 0.5, 0.6, 0.8, 1.0, 1.2, 1.5, 2mm). Ÿ Twin bucket assembly with Load cell measurement for exact Spheronization volume per batch. Ÿ Standard chequed plate 3.2mm. Optional size is 1mm, 2mm, 6.5mm. Ÿ Recording of critical process data in software. Ÿ Controls by 12.1 IPC by a touch panel control with trends. (21 CFR part 11 Certied). Ÿ Report can be transferred to USB to view on computer. Benets Ÿ Transfer bucket on load cell and it's PLC controlled auto discharge ensures uniform weight for every transfer and there by quality pellets. Ÿ Fully automatic there by standardized consistent pellets. Ÿ Fully Qualied & Documented. Ÿ All the m/c components are precisely machined by CNC, hence interchangeability is assured. Throughput/Output: Model Capacity 50-1000 gms/hr UICE - 41 (UTCE-70+Twin SPH-500) 5-50 kgs/hr UICE - 21(USSE-60+SPH-380) 0.5-10 kgs/hr UICE - LAB 5 / 40
  • 6. 1 Laboratory & Pilot Scale Machine Extruder - Axial Extruder Ÿ Axial extruder is widely used for making pellets of different sizes starting from minimum 200 microns to maximum 2000 microns. Axial Extruder gives mild compaction and is ideal for most of the Pharmaceutical formulation related to pelletization. Ÿ Axial extruder consist of Hopper for loading of wet mass, Hopper as internal blades connected to gear to rotate and push material in a systematic manner in to the feed hopper of Extruder Chamber, Extrusion chamber is Jacketed from outside for circulation of cold water to maintain temperature of the product in case the product is sensitive in nature. Ÿ Extrusion chamber consist of twin screws which transfer the material towards the pressing cam and out from the perforation of the screen of desired dia. Ÿ Axial extruder is available from R&D to Production batches with minimum output of 250 gms and maximum 500 kgs/hr Axial Extruder are cGMP complied equipments with self standing model for Production scale & table top model for R&D scale Ÿ HMI control operation with built in electrical panel for ease in maintenance. Ÿ Higher version of Axial Extruder comes along with Scada & 21 CFR Part 11 module with report options and online printing of day to day activity carried on the equipment. Features Ÿ Stainless steel 316 construction contact parts rest Stainless steel 304. Ÿ PLC Automated touch screen controls. 21CFR controls possible on options. Ÿ Siemens / Allen Bradley based automated controls. Ÿ Pellet processing efciencies ensure highest level of product performance. Ÿ Efcient product processing for nearly 100% product recovery. Ÿ Different axial meshes (0.3, 0.4,0.5 , 0.6, 0.8, 1.0, 1.2, 2, 3, and 5mm). Ÿ Low ne generation. Different sizes on Axial mesh (0.2 mm - 2mm). Ÿ Various mesh thickness possible. Benets Ÿ Axial mesh with feed hopper and pressing cams and screws. Ÿ Variable speed of extruder (20-100 rpm). Ÿ Touch screen controls with traceability. Ÿ Easy Cleaning & Maintenance Switch from one product to another with minimal downtime, reducing the costs of labor and tooling replacements. Ÿ Minimal Capital Investment Single platform with interchangeable extrusion design heads permits selection of the optimal pellet processing technology with a minimal capital investment. Throughput/Output: Model Capacity USSE - 60 250gms - 6kgs / hr UICE - LAB 50gms - 1kgs / hr 6 / 40
  • 7. 1 Laboratory & Pilot Scale Machine Extruder - Cone Extruder Features Benets Throughput/Output: Ÿ Cone extruder is widely used for making pellets of different sizes starting from minimum 500 microns to maximum 2000 microns. Ÿ Cone Extruder gives mild compaction and is ideal for most of the Pharmaceutical formulation related to pelletization. Ÿ Cone extruder consist of Hopper for loading of wet mass, Hopper as internal blades connected to gear to rotate and push material in a systematic manner in to the feed hopper of Extruder Chamber, Extrusion chamber is Jacketed from outside for circulation of cold water to maintain temperature of the product in case the product is sensitive in nature. Ÿ Extrusion chamber consist of twin screws which transfer the material towards the pressing cam and out from the perforation of the screen of desired dia. Ÿ Cone extruder is available from R&D to Production batches with minimum output of 250 gms and maximum 500 kgs/hr. Ÿ Cone Extruder are cGMP complied equipments with self standing model for Production scale & table top model for R&D scale HMI control operation with built in electrical panel for ease in maintenance. Ÿ Higher version of Cone Extruder comes along with Scada & 21 CFR Part 11 module with report options and online printing of day to day activity carried on the equipment. Ÿ Stainless steel 316 construction contact parts rest Stainless steel 304. Ÿ PLC Automated touch screen controls. 21CFR controls possible on options. Ÿ Siemens / Allen Bradley based automated controls. Ÿ Pellet processing efciencies ensure highest level of product performance. Ÿ Efcient product processing for nearly 100% product recovery. Ÿ Different cone meshes (0.4, 0.5, 0.6, 0.8, 1.0 and 1.2mm). Ÿ Low ne generation. Ÿ Cone mesh with pressing cams and screws with feed hopper. Ÿ Variable speed of extruder (40-100 rpm). Touch screen controls with traceability. Ÿ Easy Cleaning & Maintenance Switch from one product to another with minimal downtime, reducing the costs of labor and tooling replacements. Ÿ Minimal Capital Investment Single platform with interchangeable extrusion design heads permits selection of the optimal pellet processing technology with a minimal capital investment. Model Capacity USSE - 60 250gms - 6kgs / hr UICE - LAB 50gms - 1kgs / hr 7 / 40
  • 8. 1 Laboratory & Pilot Scale Machine Features Benets Throughput/Output: Extruder - Radial Extruder Ÿ Radial Extruder is the new extrusion range that build on the proven Umang technology and it benets. Similar design of process screws, cams and meshes ensure right size of extrusion from 400 - 1500 microns. Ÿ The design ensures low pressure extrusion for your products. Ÿ Radial Extruder consist of Hopper for loading of wet mass, Hopper as internal blades connected to gear to rotate and push material in a systematic manner in to the feed hopper of Extruder Chamber, Extrusion chamber is Jacketed from outside for circulation of cold water to maintain temperature of the product in case the product is sensitive in nature. Ÿ Extrusion chamber consist of twin screws which transfer the material towards the pressing cam and out from the perforation of the screen of desired dia. Ÿ Radial Extruder is available from R & D to Production batches with minimum output of 250 gms and maximum 150 kgs/hr Radial Extruder are cGMP complied equipments with self standing model for Production scale & table top model for R&D scale. Ÿ Stainless steel 316 construction contact parts rest Stainless steel 304. Ÿ PLC Automated touch screen controls. Ÿ 21CFR controls possible on options. Ÿ Siemens / Allen Bradley based automated controls. Ÿ Pellet processing efciencies ensure highest level of product performance. Ÿ Efcient product processing for nearly 100% product recovery. Ÿ Different radial meshes (0.3, 0.4, 0.5, 0.6, 0.8, 1.0 and 1.2mm). Ÿ Low ne generation. Ÿ Radial mesh with pressing cams, screws and feed hopper. Ÿ Variable speed of extruder (20 - 100 rpm). Ÿ Touch screen controls with traceability. Ÿ Easy Cleaning & Maintenance Switch from one product to another with minimal downtime, reducing the costs of labor and tooling replacements. Ÿ Minimal Capital Investment Single platform with interchangeable extrusion design heads permits selection of the optimal pellet processing technology with a minimal capital investment. Model Capacity USSE - 60 250gms - 6kgs / hr UICE - LAB 50gms -1kgs / hr 8 / 40
  • 9. 1 Laboratory & Pilot Scale Machine Throughput/Output: Benets Extruder - Die Roller Extruder Ÿ Die Roller Extruder as two rollers one is perforated and the second is knurling roller both are horizontally placed with minimum gap of 0.3mm. Material is charged in the hopper manually, hopper consist of drum and blade provision attached to the motor it rotates and drives the material into the feeding hopper in between the rollers and due to the pressing nature material comes out from the perforation and we get extrudes. Ÿ Material is charged in the hopper manually, hopper consist of drum and blade provision attached to the motor it rotates and drives the material into the feeding hopper in between the rollers and due to the pressing nature material comes out from the perforation and we get extrudes Die Roller Extruder as minimum 1000 microns (1.00 mm) Perforated roller & maximum is 3000 microns (3.00 mm) Perforation. Ÿ Die Roller Extruder is designed to provide better compaction and output. Die Roller Extruder is designed as per cGMP requirements with assembling and disassembling on nuts and bolts for quick cleaning and installation. Die Roller Extruder is an ideal equipment for R & D to Production scale batches for efcient and smooth performance. Die Roller Extruder output in Production scale can be as high as 600 kgs/hr Ÿ Cone extruder is available from R & D to Production batches with minimum output of 250 gms and maximum 150 kgs/hr. Ÿ Die Roller Extruder can be with Scada & 21 CFR Part 11 concept for monitoring of the parameters set for the products online & numerous reports can be generated related to the equipment performance and record purpose Features Ÿ Stainless steel 316 construction contact parts rest Stainless steel 304. Ÿ PLC Automated touch screen controls. 21CFR controls possible on options. Ÿ Siemens / Allen Bradley based automated controls. Ÿ Pellet processing efciencies ensure highest level of product performance. Ÿ Efcient product processing for nearly 100% product recovery. Ÿ Different Die Rollers (0.8, 1.0, 1.2, 1.5, 2, 3mm). Ÿ Low generation. Model Capacity UDRE - 65 100gms - 15kgs / hr Ÿ Die roller 1mm and knurling roller with feed hopper. Ÿ Variable speed of extruder (20-100 rpm). Touch screen controls with traceability. Ÿ Easy Cleaning & Maintenance Switch from one product to another with minimal downtime, reducing the costs of labor and tooling replacements. Ÿ Minimal Capital Investment Single platform with interchangeable extrusion design heads permits selection of the optimal pellet processing technology with a minimal capital investment. 9 / 40
  • 10. 1 Laboratory & Pilot Scale Machine Features Throughput/Output: Extruder - Basket Extruder For less compaction and large output basket extruder is the best option. Mostly used in agro chemical industries. For large scale production in pharmaceutical industries this equipment can be adapted since umang make is of gmp design and can be validated. Extrusion take place centrifugally, and the mesh is of basket type in vertical position, hence called basket extruder. This extruder range is of proven umang technology. In basket extruder, wet mass to charge manually in to the top cone hopper. Ÿ Modular, Compact, Cost efcient & GMP design. Ÿ Continuous operation. Ÿ All the m/c components are precisely processed in CNC, hence interchangeability is assured. Ÿ Shaft assemblies are being provided with thrust and radial bearings. Ÿ VFD Driven motor for innite variable speed of extruder (20-100 rpm) . Ÿ Various mesh conguration with different perforation / area / thickness for product suitability. Ÿ Fully integrated with Standard HMI / VFD controls , there by consistent Extrudes. Ÿ Fully integrated with Standard ( AB / SIEMENS ) PLC / IPC controls for 21 CFR Part 11 compliance (optional). Ÿ Different sizes of (1mm , 1.2mm, 1.5mm). Ÿ Fully qualied and documented. Advantages Ÿ Batch Process. Ÿ Zero black particle generation. Ÿ HMI Touch screen operation. Ÿ Built in Electrical controls. Benets Ÿ Proven design for effective operation. Ÿ Pressing Roll with simple Radial construction. Ÿ Low pressure extrusion for heat sensitive products. Ÿ Ease of cleaning, and access to process components. Ÿ Mass production. Model Capacity UBRE - 150 1 - 10 kgs / hr Pilot 10 / 40
  • 11. 1 Laboratory & Pilot Scale Machine Extruder - Hot Melt Extruder Ÿ Hot Melt Extrusion is the upgraded version of Twin screw Extruder with heating as an element, the whole process involves hopper for feeding the raw material along with waxes which is pre mixed in solid form. Ÿ Hot Melt Extrusion is the new mixer extrusion range that builds on the proven Umang technology and its benets. Similar design of the twin screws, extrusion die and cutting mechanism in the process and validation, so that there is no difference to the extrusion process. Ÿ This unique design of segmented twin screws, mixing attachments and cutting makes the not only a perfect hot melt extrusion granulator but also an ideal machine for performing one stop operations. Ÿ The outstanding feature of the Hot Melt Extrusion range is the the twin screw segmented barrel and twin screw feeders attached to it for uniform and continuous product feeding. Connections, cabling and supplies are completely integrated, covered and sealed so the outside of the machine is smooth and very easy to clean. Ÿ Our system Melt extruder is a result of high level of engineering expertise and product technology knowledge, quick product changeover increases productivity and cost effectiveness. Ÿ The Hot Melt Extrusion capacity ranges from few 100 gms. to 150 kgs / hr featuring through the wall design and movable head, allowing operation with platform and dust - free discharging via a linked mill directly into an IBC. Ÿ The Hot Melt Extrusion can be stand-alone or linked to a Cone Mill or Multi Mill to form an integrated system. With its special versions of the twin-screw extruder suitable for the production of pharmaceutical compounds, Umang is one of the pioneers in the development of Pharmaceutical Hot Melt Extrusion. In this continuous production process, polymers are mixed with binding materials, carrier materials and active pharmaceutical ingredients. This innovative, exibly applicable process has recently become increasingly important. Features Ÿ Contact part hardened steel SS440, SS316, non contact part SS304. Ÿ PLC Automated touch screen controls. 21CFR controls possible on options. Ÿ Siemens / Allen Bradley based automated controls. Ÿ Pellet processing efciencies ensure highest level of product performance. Ÿ Efcient product processing for nearly 100% product recovery. Ÿ Different Diameter of extrusion heads (1, 2, 3 and 5mm). Ÿ Low ne generation. Throughput/Output: Model Capacity UMSE - 16 50gms - 1kgs/ hr UMSE - 25 200gms - 2kgs/ hr 11 / 40
  • 12. 1 Laboratory & Pilot Scale Machine Spheronizer Introduction to Spher'onizer The function of a spher'onizer is to convert extrudes in to spheroids. Spher'onization is the necessary second step of granulation by extrusion - spher'onization process. spher'onization or marumarization is a rapid and exible process where pharmaceutical products are made into small spheres or spheroids. With vast experience of our team, we provide exceptional machineries which have proven technology and efciency of forming extrudes in to spheroids. Different sizes of spher'onizer R&D model such as USPH 75, 150, 250, 380 the pilot scale Model USPH-500. Production scale model USPH-700, 900, 1100. The production scale, USPH 1100 the enhanced production machine, are our standard design. Selection of spher'onizer depends mainly on desired production characteristics. We provide customized solutions to match the requirement. Each machine is designed keeping in mind the needs as one size does not t all. We believe in keeping ourselves upgraded with the latest technology so that we provide our customer with the proven, safe & effective technology. Umang & Spher'onizer Spher’odizer consists of a plate, which is having a special cross hatched groves, known as chequered plate. This plate rotates inside a cylindrical bowl. The radial clearance between the plate and the bowl is kept minimal (<0.3 mm) to reduce the powder leakage. Purging air is supplied in this gap to prevent the falling of powder beneath the chequered plate. This air also helps for the evaporation of excess moisture from extrude and prevent particle agglomeration. Let’s understand the process The manually loaded preformed extrudes on the chequered plate rotates along with the plate and centrifugal & tangential movement of the product to get a torus motion. While rotating in the grooved plate with pre-desired groove size, the vermicelli will fragmented into pieces with length equal to the diameter of extrudes. Broken extrudes, because of the tangential force and centrifugal force, collide with the cylindrical wall of the spher’odizer. The rotating rope type movement of extrudes at the outer border of the bowl give a rolling action on the fragmented extrudes and it will be converted to spheres. When the particles attain required spherical shape they are centrifugally discharged through the discharge door which pneumatically opens into the discharge hopper at the predetermined time. Extrudes - Spher'onizationBreaking up Granules Let’s Understand the process:- Spherical pellets with dense structure Narrow grain size distribution Smooth Surface with less abrasion Better Solubility with decreased hygroscopic 12 / 40
  • 13. 1 Laboratory & Pilot Scale Machine Spheronizer Ÿ Modular, Compact, Cost efcient & GMP design. Ÿ Continuous operation. Ÿ All the m/c components are precisely processed in CNC, hence interchangeability is assured. Ÿ Cooling / Heating jacket for heat sensitive product. Ÿ Shaft assembly is being provided with thrust and radial bearings. Ÿ VFD Driven motor for innite variable speed for Checkered Plate. Ÿ Various pitched ( 1 mm, 2 mm, 3.2 mm, 5 mm, 6.5 mm ) Checkered Plate for product suitability. Ÿ Fully integrated with Standard HMI / VFD controls, there by consistent spheroids. Ÿ Fully integrated with Standard ( AB / SIEMENS ) PLC / IPC controls for 21 CFR Part 11 compliance (optional). Ÿ Fully qualied and documented. Features Ÿ Batch Process. Ÿ Clearance can be adjusted between Pressing cam & Mesh to optimize the output. Ÿ Zero black particle generation. Ÿ Air purging from below to avoid material falling down. Ÿ Built in Electrical controls. Advantages Ÿ Drum built in a single piece to avoid contamination. Ÿ Since Shaft assembly is being provided with thrust and radial bearings, the concentricity of checkered plate with drum is maintained. Ÿ Auto discharge and discharge hopper is special design so that pellet cannot be damaged during discharge. Ÿ PLC program provides 5 different speed at set times for Spher'onization. Benets Throughput/Output: Model Batch Cap./Kgs. 25gms/batch USPH - 380USPH - 250USPH - 150USPH - 75 50gms/batch 250-500gms/batch 500gms-2kgs/batch 13 / 40
  • 14. 1 Laboratory & Pilot Scale Machine Throughput/Output: Mini Dryer Mini Dryer The Mini dryer consists of an Inlet chamber, Product chamber & lter bag. The material is charged into the product chamber. As per the material to be charged different meshes options are available. Air current is induced inside the chamber by means of a blower. This air is heated by catridge heater. The hot air stream passes through the bed of the material and gets uidized the product particles by creating the turbulence in the product chamber. This turbulence inside the bed assists in the transportation of the material over the length of the dryer. Due to uidization, the particles get surrounded by hot air, which leads quick & uniform heating and drying. Features Ÿ Modular, Compact, Cost efcient & GMP design. Ÿ Batch operation. Ÿ VFD Driven motor for innite variable speed. Ÿ Fully Qualied and documented. Ÿ 3 bowl attachment for 100gms drying of product. Advantages Ÿ Batch Process. Ÿ Uniform distribution of air through mesh. Ÿ HMI & PLC operation. Benets Proven design for effective operation. Model Capacity Mini Dryer - 1 0.3 - 1 kg/batch Mini Dryer - 3/5 3 - 5 kg/batch 14 / 40
  • 15. 1 Laboratory & Pilot Scale Machine Throughput/Output: Mini Lab Small Compact Fluid Bed Multi Processor for bottom spray coating, top spray granulation & drying, Mini Lab It is ideal for handling ne powders, pellets, granules, crystals and also tablets. A suitable binding agent is sprayed from the top into the uidized product causing controlled agglomeration. The agglomerates formed are subsequently dried The Umang Mini Lab Bottom top spray has been developed to meet the pharmaceutical industry’s requirements for exibility in unit operations and is based on the principle that one basic unit can be used for numerous processes simply by interchanging a module. Process : Ÿ Drying. Ÿ Top spray granulation. Ÿ Bottom spray wurster coating. Mini Lab Bottom spray is the new FAST COATING WURSTER range that builds on the proven Umang technology and its benets. Reversed air purging lters ensures inline cleaning at regular interval on automatic basis thereby ensuring non choking of lters This unique design of the distribution plate and nozzles make it ideal machine for the fast and uniform coating application on Pellets, Micro pellets & Granules. tablets. Ÿ Stainless steel 316 construction contact parts rest Stainless steel 304. Ÿ PLC Automated touch screen controls. 21CFR controls possible on options. Ÿ Siemens / Allen Bradley based automated controls. Ÿ Pellet processing efciencies ensure highest level of product performance. Ÿ Efcient product processing for nearly 100% product recovery. Ÿ Low noise level. Liquid dosing speed / volume. Features Ÿ Process air lter for inlet air. Variable speed for exhaust blower ( 0-3000 rpm.). Ÿ Touch screen controls with traceability. Easy Cleaning & Maintenance Switch from one product to another with minimal downtime, reducing the costs of labor and tooling replacements. Ÿ 300 - 500 gms. batch capacity for wurster coating. Ÿ 250 - 600 gms. batch capacity for top spray granulation. Anti- static lter bag assembly. Benets Model Capacity MINI LAB 200 - 500gms/batch UFBM - 1 300 -1000gms/batch UFBM - 3 1 - 3 kgs/batch 15 / 40
  • 16. 1 Laboratory & Pilot Scale Machine UFBM-1 1 Litre Fluid Bed Bottom & Top Spray (Mini Lab) Mini - Lab is a table-top uid bed for laboratory use, sized for product volumes from 200 ml to 500ml. It is ideal for handling ne powders, pellets, granules, crystals and also tablets. A suitable binding agent is sprayed from the top into the fluidized product causing controlled agglomeration. The agglomerates formed are subsequently dried. A suitable liquid is sprayed from the bottom (Pellets) ensuring uniform coating. Multiple air distributors, wurster & different spray nozzles are available as key features enabling various product applications. 2 Litre Fluid Bed Bottom, Top Spray & Rotor UFBM-1 DRYER WURSTER TOP SPRAY GRANULATOR ROTOR 16 / 40
  • 17. 1 Laboratory & Pilot Scale Machine UFBM-3/5 UFBM-3 is a self standing uid bed multiprocessor consisting top spray for granulation bottom spray coating and drying and Rotor. A suitable binding agent is sprayed from the top into the fluidized product causing controlled agglomeration. The agglomerates formed are subsequently dried. A suitable liquid is sprayed from the bottom (Pellets) ensuring uniform coating. Multiple air distributors, wurster & different spray nozzles are available as key features enabling various product applications. 6 Litre Fluid Bed Bottom, Top Spray & Rotor The Umang Fluid Bed Multiple (UFBM) has been developed to meet the pharmaceutical industry’s requirements for flexibility in unit operations and is based on the principle that one basic unit can be used for numerous processes simply by interchanging a module. Ÿ Drying: Top Spray. Ÿ Particle Coating: Bottom Spray (>50 microns). Ÿ Granulating: Top Spray, Rotor Granulating. Ÿ Pelletizing: Top Spray, Bottom Spray, Rotor Processing. Ÿ Coating: Top Spray, Bottom Spray, Rotor Coating. DRYER WURSTER TOP SPRAY GRANULATOR ROTOR 6 Litre Fluid Bed Bottom, Top Spray & Rotor 17 / 40
  • 18. 1 Laboratory & Pilot Scale Machine UFBM-3/5 One of the most signicant advantages of the ROTOR is that pellets can be formed, this also applies to pellets containing highly active substances. Layering, granulating and coating Processes can be carried out, depending upon the composition and desired characteristic of the pellets. performulated active drug material are taken in the rotor with chequered plate. The binder solution is sprayed till predetermined value and the disc is rotated at high speed giving the direct pellets of drug. Different parameters decides the size of pellets. They can be dried and coated in same equipments. Lyering, granulating and coating processses can be carried out, depending upon the composition and desired characteristic of the pellets. Process Rotor Starting product (inert cores, crystals, etc) is lled into the plane plate and set in motion. In the layering from liquids process, Pellets are formed by spraying the active substance onto the cores as solution or suspension, and simulataneously drying the pellets. In the layering form powders and is bound to the spraying on a liquid binder. The pellets are then dried. Layering Pellets are coated by spraying a liquid onto core material. Perforated plate is to be used for this operation. Several layers of coating can be applied using either the same or different coating liquids. Coating The ROTOR can be utilized as a medium - shear granulator. The process is equivalent to the rst phase of wet granulation pelletizing 75-250 microns pellets can be produced by this method. Pelletization Spheronization of Extrudates Moist extrudates are fed into the ROTOR where they are rounded and compacted by the chequered plate afterwards the pellets are dried coated as appropriate. 18 / 40
  • 19. 1 Laboratory & Pilot Scale Machine UFBM-30 SAMPLINGPORT BOWLLOCKING LIGHT DISTRIBUTIONPLATE WURSTERNOZZLES AHU PRODUCTBOWL CIPNOZZLE PUMP Process Air Exhaust Blower Solution Tank Pump Explosion Outlet Fluid Bed Bottom Spray Coater - UFBM - 30 Umang Pharmatech, as a developer of innovative uid bed processing and control technology, is able to provide all the professional disciplines necessary to design, test, manufacture and install the Fluid Bed system you require. Umang process engineers, system-analysis and processing program specialists, work with your development team to optimize all aspects of the system with process trial at our Indian site. Fully integrated processing systems with matching accessories, designed and manufactured by Umang Pharmatech REVERSEAIRPURGING MESHFILTER 19 / 40
  • 20. 1 Laboratory & Pilot Scale Machine Solid Drug Layering Ÿ It is a centrifugal processing of single unit operation. Ÿ The process involves the deposition of successive layers of an active compound onto nonpareil seeds resulting in the formation of uniform size pellets. Ÿ The operation is carried out using a Drug layering rotating plate, Dry powder dusted on nonpareils adheres seeds, increasing their size and forming larger pellets. As per requirements. Ÿ Growth occurs by a process of process of blending of powder / liquid binding and consolidation. After liquid addition and layering of active creates the correct diameter pellets & with formation of rope movement uniform pellet size happens. Ÿ The requirements of process validation or Good Manufacturing practices (GMP) are simplied as the complete spheroid production process is restricted to a single processor, min. size possible 500 microns. Ÿ The requirements of process validation or good manufacturing practices (GMP) are simplied as the complete spheroid production process is restricted to a single processor. Ÿ Stainless steel 316 construction contact parts rest Stainless steel 304. Ÿ PLC Automated touch screen controls. 21CFR controls possible on options. Ÿ Siemens / Allen Bradley based automated controls. Ÿ Pellet processing efciencies ensure highest level of product performance. Ÿ Efcient product processing for nearly 98% product recovery. Ÿ Different plate options available for optimum efciency. Low ne generation. Options Ÿ Various nozzle sizes are available . Ÿ Powder Feeder on load cell ensures uniform powder layering with loss on weight concept. Ÿ Water jacket on drum assembly. Features Benets Ÿ Unique plate with zero crushing arrangement for starter cores and hot air ow arrangement in the equipment. Ÿ Spray gun with peristaltic pump and ml/min. ow rate controls. Loss in weight powder feeder controls. Ÿ Variable speed of rotating plate (50-300 rpm). Touch screen controls with traceability. Ÿ Easy Cleaning & Maintenance Switch from one product to another with minimal downtime, reducing the costs of labor and tooling replacements. Ÿ Minimal Capital Investment Single platform permits optimal pellet processing technology. Throughput/Output: Model Capacity USDL 220 200 - 600 gms/batch USDL 400 1000 - 3000 gms/batch 20 / 40
  • 21. 1 Laboratory & Pilot Scale Machine Tru Sifter Tru Sifter 100 Operation of Machine: A good concept in sifting which is not vibrating but rotating on its own axis with 03 different zones with their particular meshes for getting undersize, desired size & over size of granules for further packing & re processing. Continuous sifter is a round perforated drum with different sizes of perforation as per requirement. The entire perforated drum is xed to an axis attached to gear & motor for control or RPM, below perforation there are separations that release the material for packing and reprocessing. The equipment is designed for continuous operations Specication of the Machine Specication of Machine: Description Specication Production Capacity Product 10-20 kg/ hr Pellets Standard Scope of Supply: Description Specication Meshes Electrical accessories MOC Contact parts MOC. Non Contact parts Finish Motor Control Panel HMI Switch Gear Drive motor VFD Pneumatics 03 different meshes for undersize, oversize & correct size 415 V, 3 Phase, 50 Hz, 50 Amps SS 316 SS 30 Non - FLP , 415 V, 3 Phase, 50 Hz, B5. Built in Electrical and HMI Panel. Make Delta 6” Make Siemens / Salzer Make Siemens / Bharat Bijlee, 22 Kw x 8 pole B5 Make ABB / Delta Make Festo Outside surface - Mat nish. 0.5 µ m Machine parts ‐ Machine nish 0.19 0.5 0.5 µ m (Insidedrum, Chequered plate etc). Throughput/Output: Model Capacity UTS - 100 1 - 10kgs / hr 21 / 40
  • 22. 1 Laboratory & Pilot Scale Machine Throughput/Output: Tru Sphere Project & Principle of Operation TS Technology is a new innovation of UPPL it is the solution for the critical problems faced by companies because of the difference of variation in spheres / pellets size for optimization and standardization of spheronisation time. The technology can be transferred to higher capacity for standardize the actual production module. On other side the equipment is device for addition of value to the quality delivery of micro spheres to industry which is transferred at moderate vibration to a heavy sorting methodology of segregation of non-spherical spheres from oblong size of pellets. The benet to the user is the ability to get absolute size of pellets / spheres for further processing and its application. Umang’s TS consists of a device with very minimum batch to a substantial high volume of process requirement. The vibrating assembly of sorting tray and feeder extends from vertically to one corner of the tray. The complete assembly is mounted on a platform with different sphere colleting chamber of its own nature with complete assembly on front side. The equipment is equipped with a sorting tray and pellet feeder as a standard with the machine and additional would be optional supply. The system is suitable for pelletization process primarily focused in optimum and uniform pellet size which leads to subsequent coating thereby causing accurate dissolution and disintegration in a respective media.The device is advantageous for pelletization, formulation development, formulation assurance, process consistency, application and academic purpose as well. Equipment Features Compact design & easy to scale up. Sorting Tray and feeder as a standard supply. Easy to dismantle and clean. Vibration can be regulated through for different degree of agitation during sorting process. Collecting chamber for spherical spheres as well as oblong series of spheres are separate Negligible product hold-up. Touch screen control Industrial PC 12.1” with “PROCESS +” Software (21 CFR compliant) with batch records on pen drive, machine has LAN network capability and large printer connectivity serial port. 40 column thermal printer as a standard. Project Possibilities R&D Application to sortout absolute spheres and ablong series Pelletization sample Plant Integration A complete plant with Mixing, drying, sieving, blending even coating as well which Model Capacity UTS - 1 1 - 3 kg/hr UTS - 5 5 - 10 kg/hr 22 / 40
  • 23. 1 Laboratory & Pilot Scale Machine Spray Dryer Aqueous Evaporation rate: 1 Ltrs / hr. Design: Conrms to cGMP standards. Contact parts: Glass / Teon / Stainless Steel 316. Non-Contact parts: Stainless Steel 304. Surface Finish: All fabricated part will be mirror polished inside & machine parts will be polished as required. All corners rounded off to smooth nish. Ÿ This proposal provides you with the exibility to use a Umang spray drying system tailored to your specic process requirements. The proposal presents a Spray dryer along with options that maybe selected to congure the system to meet your particular process and installation requirements. Ÿ Please consult UMANG for requirements not listed in this proposal. The Spray dryer is designed and constructed to facilitate efcient and effective cleaning to assist the customer in his conformance with Current Good Manufacturing Practices. Ÿ Main body of machine is constructed is Stainless Steel 304, the main purpose is to hold the complete assembly i.e. Spray assembly, panel, controls & cyclone assembly; it needs a trolley for movement. The main body is constructed in AISI Stainless steel 304, its main purpose is to hold the machine rest AISI Stainless steel 316 / Teon / Glass. Ÿ Mini Spray Dryer consisting of the following: Ÿ Glassware for drying chamber xed with collection bottle. Ÿ Peristaltic pump with silicon tubing Ÿ Cyclone (2) Ÿ Product receiver (1) Ÿ Scrubber (1) Ÿ Spray nozzle made in Stainless steel 316 with automatic de- blocking attachment. (One number) Ÿ Spray gun would be Teon coated. Technical Description Throughput/Output: Model Capacity UMSD - 1 100 - 1000ml / hr UMSD - 3 2 - 3 Ltrs / hr 23 / 40
  • 24. 1 Laboratory & Pilot Scale Machine Pan Coater Throughput/Output: Model Capacity UHPC - 6 / 8 150 - 500 gms/batch UHPC - 12 / 15 1 - 3 kgs/batch The Tablet coater consists of a 6” & 8” pan coater, the 6” pan works with 50–150 gms. (120–350 ml) Of tablets and 8” pan works with 150–500 gms. (350–1000 ml) of tablets. The spray nozzle extends from the center of the pan. The complete assembly is mounted inside a acrylic box. The equipment is equipped with 2 pans one 8” as a standard with the machine and 6” as a optional supply. 3mm perforation on a pan is standard with high perforation area, smaller perforations can be given for pellet coating. Project & Principle of Opearation Ÿ Compact design & easy to scale up. 8” pan as a standard supply. Ÿ Minimum size of tablets it can process is 4mm. Easy to dismantle and clean. Ÿ Hinged door. Negligible product hold-up. Ÿ Touch screen control Industrial PC 12.1” with “PROCESS +” Software (21 CFR compliant) with batch records on pen drive, machine has LAN network capability and large printer connectivity serial port. 40 column thermal printer as a standard. Ÿ Two interchangable pans. Equipment Features The machine takes tablets and does various types of coating like enteric, seal coating. Project Possibilities A complete plant with Mixing, High shear mixing, uid bed drying / granulator, sieving , then tablet coating & Blending is possible as a integration. Plant Integration Product contact parts in AISI 316 stainless steel and non – contact parts in AISI 304 stainless steel unless otherwise status. The system operates in “under pressure”: the air goes through the electrical heater, through the perforated drum and then through the fan. Working in under-pressure gives us the advantage that we use the same concept as is used in production: particles can not leak into the environment, and the motor or fan can not contaminate the process Scope Of Supply Umang Concept Tablet Coater 24 / 40
  • 25. 1 Laboratory & Pilot Scale Machine Homogenizer Including 1 x 2 Litre jacketed interchangeable Glass & Steel process vessels Infra Red temperature probe. Touch panel with control of high-speed homogeniser (type Low Shear High Flow with rotor-stator) and contra-rotating mixing arm speeds Real-time trends on screen of all measurement; Excel batch report, saved on solid-state memory, High speed homogeniser speed. Ÿ Contra-rotating mixing arm speed and torque. Ÿ Product temperature. Ÿ Process pressure (if optional vacuum pump ordered). Ÿ Documentation set and CE label. Ÿ Vacuum Pump with Pressure Control. Ÿ Solid Dosing System. Ÿ Calibration Documentation. Ÿ Extra wear parts e.g. seals, o-rings Included. Options General Ÿ The system is designed for lab scale semi-solid processing. Ÿ As the jacketed process vessel is in glass, this system gives maximum visual contact with your process. Ÿ This system is equipped with torque read-out allowing accurate process endpoint detection studies. Ÿ The high-speed homogeniser and contra-rotating mixing arms are driven through the vessel cover. Ÿ The contra-rotating mixing arms have wall scrapers to create an ideal mixing and energy transfer through the glass jacket. Ÿ The design of the vessel results in a quick turnover time: emptying, cleaning and loading in 5 minutes. Detailed Specications Jacketed Glass Processing Vessel :- Ÿ The standard Homogeniser vessel is cylindrical shaped in boro-silicate with at bottom and curved angels and has a glass jacket with connections for in and outlet of heating/cooling media. Ÿ Remark: heating and cooling units are not included in the scope of supply but could be quoted on request. Product Volume : 2 litre Typical Capacity : 500-1000 ml The high-speed homogeniser and the contra-rotating mixing arms are “top-driven” through the lid of the process vessel. This set-up offers easy changeover for cleaning and product change. Two other openings are provided for product dosing and temperature measurement. The lid will be made out of stainless steel 316L :- 25 / 40
  • 26. 1 Laboratory & Pilot Scale Machine Homogenizer Quick connection system :- The jacketed glass vessel is clamped to the lid by a threadless Quick Connection System.The vessel together with the product can be taken away from the drive system by one simple turn. Lid support box :- A small lid support box, partly out of transparent material, supports the top plate. This cabinet allows visual contact with process and provides an interlocked front door as a safety guard. Drives & Agitators :- The drive system is built on the cover with 2 drive motors, one for the central high speed homogeniser and the other one for the contra-rotating mixing arm with wall scrapers. A gearbox is responsible for the contra-rotating mixing arm effect. The high speed homogeniser is from the type “Low Shear High Flow with rotor/stator”. Infrared measuring probe :- For product temperature measurement in process including : The probe itself, including necessary ttings logging to the real-time trend and into Excel. Controls :- Touch panel to directly measure and control all critical parameters: Ÿ Homogeniser speed contra-rotating mixing arm speed. Ÿ Contra-rotating mixing arm torque. Ÿ product temperature. Vacuum in process vessel. Ÿ Endpoints: the stops automatically if the time or temperature value exceeds the endpoint. Ÿ Real-time trends on screen of all measurement. Excel batch report, saved on solid-state memory, which can be exported through a USB ash memory stick to any PC. Every batch can be recorded in an automatically generated batch report in an Excel le with 3 different sheets: Identication sheet: Batch number Data sheet: on this sheet, the raw data of all parameters are registered every second and shown in column Graph sheet: on this sheet, all parameters are visualised in a graph. Throughput/Output: Model Capacity UHOM - 1/3 Ltr 1 Ltr / 3 Ltrs / batch UHOM - 5/10 Ltr 5 Ltrs / 10 Ltrs / batch 26 / 40
  • 27. 1 Laboratory & Pilot Scale Machine Standard Features Ÿ equipment consist solution tank, lm casting and drying unit and manual strip packing. Ÿ High Coating accuracy from design. Ÿ Recording of all process related parameters. Ÿ Variable speed of base lm. Ÿ High quality stainless steel 316 construction with high quality nish. Ÿ Liquid dosing system. Ÿ Product temperatures & lm temperature measurement. Ÿ Controls by Allen Bradley and 12.1” IPC by a touch panel control with trends. Ÿ Web length 490mm. Coating thickness from 40 - 800 microns wet. Ÿ Individual temperature adjustment zones. Ÿ Left machinery compartment containing coating system. Ÿ Uniform air ow throughout the machine. Ÿ Stainless steel 304 rest contact parts. Ÿ Thickness checking or wet & dry lm. Ÿ Recording of critical process data in 21 CFR part 11 certied software. Ÿ Report on Excel le can be exported to USB to view on computer. Ÿ Equipment can be modied to make patch lm of desired size and desired web length. Ÿ Cutting and Slitting line are a part of the complete processing line for oral strips. Optional Features Ÿ Cutting line for cutting into small uniform strips & individual strip packing line. Ÿ Drying tunnel length can be varied. Ÿ Homogenizers and mixing tanks for integrations for a complete MDF suite. Ÿ Humidity control for the drying chamber. Throughput/Output: MDF Lab Model Capacity UMDF - LAB 2500 strips/day UMDF - 25 25,000 strips/day UMDF - 50 50,000 strips/day UMDF - 100 100,000 strips/day UMDF - 200 200,000 strips/day 27 / 40
  • 28. 1 Laboratory & Pilot Scale Machine Pell - Drop Mini Pell-Drop processor for forming of the droplets, including : Ÿ Die head for one die nozzle. Ÿ Storage vessel (approx.3 litres ). Ÿ IR heating elements. Ÿ Oscillator controlled by amplier and frequency generator. Ÿ (Vibrating of the melt in the die head) Ÿ Stroboscope (monitoring the droplets after escaping from the die head ). Ÿ Set of nozzles (hole diameter 0,15…1,6mm,in total 2 x 7 pieces ). Ÿ Pressure regulator with gauge. Ÿ Water cooling unit with vessel, pump and trough. The Pell-Drop Mini can be used for in-house optimization of process parameters before going into large-scale production. It also allows the production of sample quantities. The system is equipped with an exchangeable single-hole die so that meaningful test runs may be made with just three liters of material. Pell-Drop Mini is functionally equivalent to a full-scale Pell-Drop production line. Pell-Drop Mini The Equipment Consisting of the Following : ITEM-1 :- ITEM-2 :- Electric control box, including : Ÿ Frequency generator and amplier, Stroboscope controller, Oscilloscope, Temperature controller, Power supply. Electrical Requirements Electric control box, including : Ÿ Supply voltage : 230V AC single phase, 50 Hz +/- 3% Ÿ Supply ampere :16 A Ÿ Electrical standard : DIN-VDE Ÿ Area classication : Not required Ÿ Degree of protection : IP 30 Notes Design of melt temperature : max.200°C Size of the machine : 500mm*500mm*600mm Weight : 50Kg Throughput/Output: Model Capacity UPD - 1 1kgs / hr output (wet) 28 / 40
  • 29. 1 Laboratory & Pilot Scale Machine Continuous Tray Dryer A revolutionary concept in drying of powder, granules, pellets & tablets in a continuous, cost effective, efcient manner with minimum human interference. Concept Technical Details Ÿ Equipment is designed keeping in mind GMP requirements, contact parts SS 316 & non contact parts SS 304. Ÿ Capacity of the Equipment in continuous drying is 110-120 kgs/hr depending upon moisture content. Ÿ Each and every part of the Equipment in contact with the product is cleanable. Ÿ A 30ltrs Feed Hopper is at the top to charge the product which is transferred to rotating plates in a controlled manner, each plate as a spreader to spread the material on the plate and after 01 complete rotation a wiper wipes the material to plate below. Ÿ In this way product is tumbled from 01 plate to another plate thereby enabling uniform and fast drying. Ÿ The dried product from the last plate is discharged from the discharge funnel. Entire operation is controlled by PLC. Equipment Consists of Ÿ Circular Feeder driven by geared motor. Geared motor drive for the rotation of rotary plates. Ÿ Motor driven Timer belt drive for Lamina Flow Air Distribution System. Ÿ Self standing body with jacketed interiors for insulation. Ÿ 18 tray arrangement one above the another on a trolley which can be rolled to washing area. Ÿ Air Exhaust port provided. Air Handling Unit for Inlet Air with steam heating provision. Ÿ Built in electrical panel. PLC control system. Benets Compared To Tray Dryer Ÿ Tray dryer is the most economical way of drying with Equipment cost & electricity consumption is the lowest, the only deciency the system as is the upper part of the product gets dried fast and below part needs to be tumbled for drying, it involves use of man power for tumbling and there is no certainty that the drying will be uniform and result may vary in LOD report. Ÿ In a Continuous Tray Dryer material charging is from top and from 01 plate to another plate it keeps on tumbling thereby all the portions of the material is subjected to hot air and dried product is disposed from bottom with no human interference thereby avoiding problem of contamination. Ÿ Continuous output can be achieved from Rotary Tray Dryer enhancing overall production. Benets Compared To Fluid Bed Dryer Ÿ Currently this is the best technology available in the market for drying which ensures uniform drying but operating heavy motors to run the equipment is very costly affair thereby adding to the nal product cost. Ÿ Due to the tumbling principle of Continuous Tray Dryer product drying become much more efcient and with less motor power the cost saved to run this Equipment is more economical compared to Fluid Bed dryer. Ÿ Limitation in operation compared to continuous process of Rotary Tray Dryer. 29 / 40
  • 30. 1 Laboratory & Pilot Scale Machine Vacuum Drying Vacuum drying can be applied in a range of processes in several industries, including chemical, pharmaceutical, food, plastics, and metal powders. Trays Ÿ Tray size is 16 x 32 x 1.25 (h) inches Ÿ Tray volume is 10 litres Ÿ Tray height can be increased to a maximum of 2 inches Ÿ Center to center distance between any two shelves is 4 inches Special Features of Vacuum Drying Ÿ All stainless steel 304 / 316 / 316L CGMP externals with stainless steel internals (vapor and product contact parts) Ÿ Hollow pad type heating shelves which are easily removable for maintenance Ÿ Condensor and condensate receiver tted on the dryer body or stand alone for remote installation Ÿ Fully welded skirt on vacuum dryer body for ush mounting through the wall Ÿ External insulation of dryer with protective panels in stainless steel or mild steel powder coated Ÿ Dedicated uid heating and circulating systems. These can be steam or electrically heated. Fluid heating systems are available for water as well as thermic uid ( for temperature requirements above 95 degree centigrade) Ÿ Validation ports and nitrogen purge nozzles Ÿ Can be designed to customers specic requirements Ÿ Steam sterilisatile models available Ÿ Double door loading available for larger models Ÿ Through wall design available Model Capacity in Trays UVTD - 6 6 UVTD - 12 UVTD - 24 UVTD - 48 UVTD - 96 12 24 48 96 6 6 8 16 16 1 1 1 1 1 1 2 3 3 6 No of Shelves Dummy Shelf Trays Per Shelf Technical Specication 30 / 40
  • 31. Umang Roll Compactor 100 mm Variable. 20-150 rpm Three Phase, 415V+10%, 50/60Hz, 4Wire+PE. 300 Liters/ Hour @ 1 bar integrated, Non-Flameproof Panel 15 Liters Hydraulic cylinders (2 Nos) with a pressure of 130Kg/cm2 Gravity feeding to feed funnel and then pressed in to compacting roller by pressing screw. Integrated, Non-Flameproof Panel 1 Hp Operator Interface Terminal with 7", color, Touch screen USB, RS485 Modbus, RS232, Printer ABB / Delta Visual and Audio login control with username and password Up to 100 Serial Printer Connectivity DQ, IQ/OQ Operation Manual Component Test certificates SS 316 SS 304 SS 304 Matt finished (220 grit) Mirror finished(320 grit) Compacting of Pharmaceutical grade powder Natural flow with gravitational force 10-25 Kg/Hr (±10%) 600X500X600 5 H.P 3 KW (Approx) 500 Kg TECHNICAL SPECIFICATIONS Fully automatic. Manual mode and Recipe mode operations with "Umang Process -Lite" control a interface software Machine Roller Diameter Roller Speed Machine control Electrical Specification Chilled water Electrical Cabinet Hopper capacity Compacting Method Feeding Method Electrical Cabinet Power pack motor capacity User interface and Visualization Communication ports VFD for Motor control Alarm User control Recipes Other features Standard Documents MOC of Contact parts MOC of Non- Contact parts MOC of Frame Surface Finish- outside surface of contacts parts Surface Finish- inside surface of contacts parts Standard Application Discharge Throughput* Machine Dimensions (W X D X H in mm) Connected Load (KW/hp) Average Power Consumption Machine Weight 1 Laboratory & Pilot Scale Machine Roll Compactor 31 / 40
  • 32. Film Casting Line5 Film Mixing Tank Film Casting Machine Film Slitting Machine Strip Packing Line Transdermal Patche Line Film Processing Line Transdermal Packing Line 32 / 40
  • 33. 5 Film Casting Line Film Mixing Tank This Machine is being used for making a homogenous Solution by mixing, stirring and heating. Ÿ Main Stationary fabricated body with electrical panel and ON /OFF , PID Controls Switches. Ÿ Jacketed & insulated solution tank on castor wheel. Ÿ Stirrer Blade , for mixing the solution Ÿ Top lid with reduction drive and ports. Ÿ Lid lifting arrangements with balanced weights. Ÿ Cartridge Heaters Main parts of The Machine: Ÿ Modular, Compact & GMP design. Ÿ The tank is equipped with Thermic Fluid Heating jacket, Insulation, discharge valve & moving on castor wheel. Ÿ Standard agitator assembled on lid which can be lifted manually with balanced counter weight. Ÿ MOC. Of Product Contact parts are of Ss316. Ÿ MOC. Of Non Contact Parts are of SS 304. Ÿ All other hardware of standard make. Ÿ Empty tanks needed for continuous plant operations. The Design considerations for Solution Preparation Tank Input material to be loaded. Connect the drum with lid. Activate the machine. A.C driven agitator blade will shear & mix the ingredients at required temperature which can be set-ted by PID Control on cartridge heater witch heats the Thermic uid inside the jacket. Charging Port provided on the lid can be used for addition of any small ingredient. Ball valve provided at bottom can be opened for discharge after pre determined time required. Operation of machine Specication of Machine: Capacity Temperature Heating Machine overall Dimension Electrical Specication 100 Liters o 50 to 100 C Cartridge Heating Length: 500mm Width: 980mm Height: 2000mm 415V, 3 Phase, 50 Hz, 8Amps 33 / 40
  • 34. 5 Film Casting Line Film Casting Machine General Introduction Continuous Film Casting machine is designed to produce Pharmaceutical grade 'Mouth Dissolving lm' in Lab Scale , Pilot Scale and Production scale with variable thickness from 40 to 80 microns. It consist of - A set of roller arrangement for holding and smooth movement of substrate and caste lms. Set of heaters inside drying chamber to heat air ow system which dries the lm. Coating assembly to coat continuously on a substrate lm with solutions or dispersions in variable thickness with accuracy 500-900 microns Thickness adjusting mechanism by viewing a built in thickness indicating micrometer dial. Let’s understand the process - The substrate lm will be released from the unwinding roll towards winding roll, the solution is coated on a substrate lm at coating station in predetermined manner. The laminated wet solution lm moves through drying zones. The temperature at drying zone is being sensed and set as required. A dried layer of product over the substrate lm will be coming from the drying zone continuously and wound on a winding roll . The machine is equipped with web aligner , force sensor and full automation Except for lab type. Features Product Properties Product Properties - Ÿ Film is thin and elegant. Non obstructive. Adheres to the oral cavity easily. Ÿ Processes fast disintegration without water. Ÿ Rapid release. Ÿ Proven design for effective operation Ÿ Low shear for non - destruction of product properties Ÿ Cantilever type design for winding and unwinding , hence substrate and product rolls can be simply inserted from front Ÿ Drying chambers jacketed for insulation there by energy saving Benets Ÿ Continues Process Ÿ Built in Electrical controls Ÿ High Coating accuracy Ÿ Uniform air ow throughout the machine Ÿ Liquid dosing system there by minimal human interference Ÿ Recording of critical process data in 21 CFR part 11 certied software Ÿ Report on Excel le can be exported to USB to view on computer. Ÿ Equipment can be modied to make patch lm of desired size and desired web length Advantages Ÿ Modular, Compact, Cost efcient & GMP design. £ Contact parts Stainless steel 316 construction non contact parts Ss304 £ Precise closed coating system Ÿ High efcient drying zones with double skin Ÿ M/C components are precisely processed in CNC , hence interchangeability is assured Ÿ Shaft assemblies are being provided with deep groove ball bearings Ÿ Cantilever type design for winding and unwinding rolls Ÿ RTD sensors and temperature controls for individual zones Ÿ VFD Driven motor for innite variable speed Ÿ Linear speed sensors Ÿ Automatic web aligner Ÿ Automatic Web tension through Force sensor Ÿ Fully integrated Controls with Standard PLC , OIT , VFD , SCADA Ÿ Fully qualied and documented Throughput/Output: Model Capacity UMDF - LAB 2500 strips/day UMDF - 25 25,000 strips/day UMDF - 50 50,000 strips/day UMDF - 100 100,000 strips/day UMDF - 200 200,000 strips/day 34 / 40
  • 35. 5 Film Casting Line Film Slitting Machine General Introduction It is un economical to make small width lm. Hence commercial size to be made and it is to be cut to required width. It is un practical to simply cut the foil and hence this machine. Slitting machine converts the mother product reel to several small width child reels as required for further process. It consist of - Ÿ Unwinding Station for mother reel , Winding station of slit child reel Ÿ Slitting Station, Drive Arrangement. 305 / 610 mm width Mother reel will be loaded on the Unwinding shaft, 3/6 Slitting blade will size the width to 105 mm X 2 / 4 Nos. with trim at each ends and mid and then rolled on the child reel. Then 105 mm width Child reel can be directly loaded on to the strip packing machine, there it get further slit to 20 mm, striped to 30 mm + / - and packed. Let’s understand the process - Ÿ Perfect width Product Properties Product Properties - Ÿ Modular, Compact, Cost efcient & GMP design. Ÿ Continuous operation. Ÿ All the m/c components are precisely processed in CNC ,hence interchangeability is assured Ÿ Shaft assemblies are being provided with deep groove ball bearings Ÿ Cantilever type design for winding and unwinding rolls Ÿ Fully integrated Controls with Standard HMI / VFD Ÿ Fully qualied and documented Features Ÿ Continues Process Ÿ Built in Electrical controls Advantages Ÿ Proven design for effective operation Ÿ Cantilever type design for winding and unwinding , hence substrate and product rolls can be simply inserted from front. Benets Throughput/Output: Model Capacity USLT - LAB 2500 strips/day USLT - 25 25,000 strips/day USLT - 50 50,000 strips/day USLT - 100 100,000 strips/day USLT - 200 200,000 strips/day 35 / 40
  • 36. 5 Film Casting Line Film Packing Line Umang Pharmatech Pvt. Ltd.’ s USTP-50 K is a Four Track Automatic Strip Packing machine. The entire Assembly is visible from outside. It ensures that, there is no place for hidden debris and product contamination. Tool‐less change over and lm loading is possible in this machine. Laminated lm unwinding roll & Packing foil unwinding rolls can be loaded/ unloaded from the front side by simply sliding on to respective roll shafts. The speed of all the rollers are controlled by PLC and Dancing roll Sensors. The Human Interface is a touch screen. The machine is controlled locally, without interlocking with down-line machines. General Introduction Ÿ Set of roller arrangements for holding and smooth movement of Product lm & packing foils. Ÿ Slitting Mechanism with high shear blades. Ÿ Stripping station with high shear blade to strip the lm into required length. Ÿ Pick and place system to picks the strips of lm and places on the bottom packing foil. Ÿ Sealing station to seal the strip. Sealing is designed with unsealed holding area at sides, Ÿ Servo motor driven Linear-indexing station to enable digital advance setting through HMI & Servo Drive . Ÿ Blanking station to blank the strips to designed shape. Strip can be designed with Tear-Notch, Ÿ Printing station to print batch no , code no , MRP, dates etc . Ÿ Trim winding shafted roll with geared AC motor drive for scrap trims of packing foil. Ÿ Conveyer with geared AC motor drive for conveying packed strip to it's container. Ÿ Electrical / Pneumatic control panel. OIT panel. 105 mm width reel will be loaded on the Unwinding shaft. 6 Slitting blade will size the width to 20 mm 4 Nos. with 12.5 mm trim at each side and then pass through stripping station by pulling action of it' s rolls. Stripping action takes place when the pickup cup hold the slit product lms. There it get striped to 30 mm + / - length. Picked strips is getting placed on the bottom packing foil where the DOT sensor planned. and get sandwiched between bottom and top packing foils. At sealing station it get sealed, pulled by indexing and blanked at blanking station . Let’s understand the process - Product Properties Product Properties - Ÿ Perfect width Throughput/Output: Model Capacity USTP - LAB 2500 strips/day USTP - 25 25,000 strips/day UMDF - 50 50,000 strips/day USTP - 100 100,000 strips/day USTP - 200 200,000 strips/day 36 / 40
  • 37. 5 Film Casting Line Film Processing Line Over the recent few decades, many groups of formulation scientists are concentrating on rapid release dosage forms in oral cavity. Among all fast release dosage forms, oral dispersible lms are successful to attract pharmaceutical industry due to ease of formulation and extension patent life. Films are popular in patients too because of quick onset and user friendliness of dosage form Complete integration from one source. Mixing, Film making , Film Slitting and Packing line General Introduction Umang' s MDF Line A Fully integrated mouth dissolving lm line for making edible / oral strips. Suitable for pre-formulation development, formulation assurance, process consistency applications and academic laboratory use The production of MDF involves following 4 essential steps. Umang’s Solution Preparation Tank It consist of - Let’s understand the process - Ÿ A jacketed and insulated vessel for holding the solution Ÿ Set of heaters inside the jacketing to heat transfer media Ÿ Drive arrangement on lid with stirrer Ÿ Pneumatic lifting Arrangement for lid with stirrer and motor It is the process of uniform mixing of the ingredients with liquid by stirring & heating in a solution preparation tank which is jacketed for heating and insulated for energy saving. SOLUTION PREPARATION FILM CASTING FILM SLITTING STRIP PACKING. 37 / 40
  • 38. 5 Film Casting Line Transdermal Patches Line General Introduction Continuous patches Casting machine is designed to produce Pharmaceutical grade patches in Lab Scale , Pilot Scale and Production scale. It consist of - A set of roller arrangement for holding and smooth movement of substrate and caste lms. Set of heaters inside drying chamber to heat air ow system which dries the patches. Coating assembly to coat continuously on a substrate lm with solutions or dispersions in variable thickness with accuracy 500-900 microns Thickness adjusting mechanism by viewing a built in thickness indicating micrometer dial. Let’s understand the process - The substrate patches will be released from the unwinding roll towards winding roll, the solution is coated on a substrate patches at coating station in predetermined manner. The laminated wet solution patches moves through drying zones. The temperature at drying zone is being sensed and set as required. A dried layer of product over the substrate patches will be coming from the drying zone continuously and wound on a winding roll . The machine is equipped with web aligner , force sensor and full automation Except for lab type. Features Product Properties Product Properties - Ÿ Patches is thin and elegant. Non obstructive. Adheres to the oral cavity easily. Ÿ Processes fast disintegration without water. Ÿ Rapid release. Ÿ Proven design for effective operation Ÿ Low shear for non - destruction of product properties Ÿ Cantilever type design for winding and unwinding , hence substrate and product rolls can be simply inserted from front Ÿ Drying chambers jacketed for insulation there by energy saving Benets Ÿ Continues Process Ÿ Built in Electrical controls Ÿ High Coating accuracy Ÿ Uniform air ow throughout the machine Ÿ Liquid dosing system there by minimal human interference Ÿ Recording of critical process data in 21 CFR part 11 certied software Ÿ Report on Excel le can be exported to USB to view on computer. Ÿ Equipment can be modied to make patch lm of desired size and desired web length Advantages Ÿ Modular, Compact, Cost efcient & GMP design. £ Contact parts Stainless steel 316 construction non contact parts Ss304 £ Precise closed coating system Ÿ High efcient drying zones with double skin Ÿ M/C components are precisely processed in CNC , hence interchangeability is assured Ÿ Shaft assemblies are being provided with deep groove ball bearings Ÿ Cantilever type design for winding and unwinding rolls Ÿ RTD sensors and temperature controls for individual zones Ÿ VFD Driven motor for innite variable speed Ÿ Linear speed sensors Ÿ Automatic web aligner Ÿ Automatic Web tension through Force sensor Ÿ Fully integrated Controls with Standard PLC , OIT , VFD , SCADA Ÿ Fully qualied and documented Throughput/Output: Model Capacity UMDF - LAB 2500 strips/day UMDF - 25 25,000 strips/day UMDF - 50 50,000 strips/day UMDF - 100 100,000 strips/day UMDF - 200 200,000 strips/day 38 / 40
  • 39. 5 Film Casting Line Transdermal Packing Line Umang Pharmatech Pvt. Ltd.’ s USTP-50 K is a Four Track Automatic Strip Packing machine. The entire Assembly is visible from outside. It ensures that, there is no place for hidden debris and product contamination. Tool‐less change over and lm loading is possible in this machine. Laminated lm unwinding roll & Packing foil unwinding rolls can be loaded/ unloaded from the front side by simply sliding on to respective roll shafts. The speed of all the rollers are controlled by PLC and Dancing roll Sensors. The Human Interface is a touch screen. The machine is controlled locally, without interlocking with down-line machines. General Introduction Ÿ Set of roller arrangements for holding and smooth movement of Product lm & packing foils. Ÿ Slitting Mechanism with high shear blades. Ÿ Stripping station with high shear blade to strip the lm into required length. Ÿ Pick and place system to picks the strips of lm and places on the bottom packing foil. Ÿ Sealing station to seal the strip. Sealing is designed with unsealed holding area at sides, Ÿ Servo motor driven Linear-indexing station to enable digital advance setting through HMI & Servo Drive . Ÿ Blanking station to blank the strips to designed shape. Strip can be designed with Tear-Notch, Ÿ Printing station to print batch no , code no , MRP, dates etc . Ÿ Trim winding shafted roll with geared AC motor drive for scrap trims of packing foil. Ÿ Conveyer with geared AC motor drive for conveying packed strip to it's container. Ÿ Electrical / Pneumatic control panel. OIT panel. 105 mm width reel will be loaded on the Unwinding shaft. 6 Slitting blade will size the width to 20 mm 4 Nos. with 12.5 mm trim at each side and then pass through stripping station by pulling action of it' s rolls. Stripping action takes place when the pickup cup hold the slit product lms. There it get striped to 30 mm + / - length. Picked strips is getting placed on the bottom packing foil where the DOT sensor planned. and get sandwiched between bottom and top packing foils. At sealing station it get sealed, pulled by indexing and blanked at blanking station . Let’s understand the process - Product Properties Product Properties - Ÿ Perfect width 39 / 40
  • 40. Survey No. 146, H. No.1 (PT), Vasai Phata Highway Junction, Pelhar, NH8, Vasai (E) - 401 208, Maharashtra (India). Tel. : (+91-0250) 6681600-10 E-mail : marketing@umangpharmatech.com Website : www.umangpharmatech.com | www.umangengineering.com Global Presence Connect With Us 40 / 40