23. Reinforcing actions of nicotine similar cocaine and Amphetamine-But SUBTLE Nicotine shuts down receptor shortly after binding to it Neither it nor Ach can stimulate for a while [longer and much more intense euphoria with cocaine ] Pleasure of nicotine is a desirable but small boost in the sensation of pleasure ("minirush"), -> decline until the smoker takes the next puff or smokes the next cigarette. Somewhat self-regulating – Behavioral effects less severe thancocaine