Blood products topic is very important for Medical students as they have to know which blood product will be much beneficial to patients when they go into clinical practice. This PPT provides all of them.
3. Blood
• Blood is considered as River of
life, Fluid of life, growth & health
• Average human has 5 litres of
blood i.e, 8% of total body weight
• It is a transporting fluid
• It carries vital substances to all
parts of the body
4. Properties Of Blood
• Colour range
• - Oxygen-rich blood is scarlet red bright
crimson
• - Oxygen-poor blood is purple red.
• Red colour comes from the several million
red cells, present in it
• pH must remain between 7.35–7.45
• Temp 38˚ c or 100.4˚ F
5. Properties Of Blood
• Blood is 5 times more viscous than
water.
• Blood is a specialized type of
connective tissue in which living
blood cells, (formed elements), are
suspended in a non living fluid matrix
called plasma.
• Cellular Part (Formed Elements)
• Non cellular part (Plasma)
7. Functions Of Blood
Blood performs a number of functions
• Distribution
• Regulation
• Protection
8. Distribution Functions
Nutritive
Respiratory
Excretory
Transport
Regulation Functions
Maintanence
Buffering
Protection Functions
Preventing blood loss
Defensive function
8
12. Whole Blood
BLOOD COMPONENTS
Slow Centrifugation
Packed Red Blood Cells Platelet Rich Plasma
High Speed Centrifugation
1 Unit of Random Donor
Platelets
1 Unit of Fresh Frozen Plasma
Thawing precipitates the
plasma proteins
Cryoprecipitate
14. Whole Blood
Indications
• Acute blood loss with hypovolaemia
• Exchange transfusion
- severe anaemia at birth
- severe hyperbilirubinaemia
• Massive transfusion
• Cardiovascular bypass surgery
15. Fresh Whole Blood
Packed Red Cells
Light spin, 22oC(within 8 hrs)
Platelet Rich Plasma
Heavy spin,22oC
Platelet Concentrate Fresh Plasma
Store at 22oC Freeze(FFP)
16. Red Cell Concentrate
• Also called Packed Red Cells
• Platelets and plasma are removed
• I Unit - 330ml
• Hct – 65 - 75%
• Shelf life - 35 days
• Stored at 2 - 4 ˚c
20. Fresh Frozen Plasma
Thaw at 4oC & heavy spin
Cryoprecipitate
-Refrozen within 1 hr
-Store at < - 18oC
Cryoremoved Plasma
Freeze -80oC immediately
Stored at < -18oC
21. Cryoprecipitate
• Fresh frozen plasma thawed at 4°C
• Rich in – F – VIII & Fibrinogen
• I unit = 15 - 20ml
• Stored at -30°C
• Shelf life – 2 years
23. Platelets Concentrate
• Platelet rich plasma – Cent.
• Stored at – 20 to 24 ˚c
• Shelf life – 5 days
• I unit = 15 - 20ml
• Uses =
Thrombocytopenia
Drug induced Hge
24. Prothrombin Complex Concentrate (PCC)
• Derived from pooled plasma
• Contains – F – II / IX / & X
• Emergency reversal of warfarin therapy
25. Autologous Blood
• Collection / infusion of client’s own blood
• Can be collected weekly as long as client’s
H & H are within safe range
• Upto 3 weeks before surgery
• Hct - 45%
• Stored at 2 - 6 ˚c
• Shelf life - 35 days
26.
27.
28. 1. Shelf life of Packed Red cells - ?
• A 5 days
• B 5 weeks
• C 5 months
•
• D 5 years
29. 2. Which of the following can be used in Inherited
defeciency of Factor VIII / Factor XIII ?
• A Fresh frozen plasma
•
• B Platelet concentrate
• C Cryoprecipitate
• D Packed cells
30. 3. All of the following are plasma derivatives
except -
• A Albumin
• B Immunoglobin
• C Coagulation factors
• D Stored plasma
31. 4. In Autologous blood transfusion, the blood
can be withdrawn upto - weeks before
surgery ?
• A 2 weeks
•
• B 3 weeks
• C 4 weeks
• D 5 weeks
32. 5. Patients on Aspirin who are actively bleeding
& undergoing major surgery may require - ?
• A Prothrombin concentrate
• B Packed red cells
• C Plasma – Fresh
• D Platelet concentrate