Fluroquinolones 2

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VIJAI KUMAR

Santé & Médecine Technologie

DR.VIJAY NAGDEV H.O. MEDICAL UNIT-I CHANDKA MEDICAL COLLEGE LARKANA

Background ,[object Object],[object Object]

MECHANISM OF ACTION ,[object Object],[object Object],[object Object]

RESISTANCE ,[object Object],[object Object],[object Object],[object Object]

Generations Drugs Spectrum 1 st (Quinolone) Nalidixic acid Cinoxacin Gram-ve but not Pseudomonas species 2nd Norfloxacin Ciprofloxacin Enoxacin Ofloxacin Gram- ve(including Pseudomonas species), some Gram+ (S. aureus) and some atypicals 3rd Levofloxacin Sparfloxacin Moxifloxacin Gemifloxacin Same as 2 nd generation with extended Gram+ve and atypical coverage 4th *Trovafloxacin Same as 3 rd generation with broad anaerobic coverage

Pharmacokinectics ,[object Object],[object Object],[object Object],[object Object],[object Object]

Distribution ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Drug interactions Drugs increasing levels of FQL FQL increasing the levels of : Theophyline Antidepressants NSAIDS Imipramine corticosteroids Caffene Theophyline Warfarin (INR –monitored)

Adverse effects. ,[object Object],[object Object],[object Object],[object Object],[object Object]

Cont. ,[object Object],[object Object],[object Object],[object Object]

Contraindication ,[object Object],[object Object],[object Object],[object Object],[object Object]

Ciprofloxacin ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Clinical uses ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],Oral Parentral Opthalmic 100 mg 200 mg iv 3mg/ml solution 250 mg 400 mg iv 3.3mg/mg ointment 500 mg

Levofloxacin ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Cont. ,[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],Oral Parentral Opthalmic 100 mg 5 mg/ml iv 5mg/ml solution 250 mg 25 mg/ml iv 500mg

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Fluroquinolones 2

1. DR.VIJAY NAGDEV H.O. MEDICAL UNIT-I CHANDKA MEDICAL COLLEGE LARKANA

8. Generations Drugs Spectrum 1 st (Quinolone) Nalidixic acid Cinoxacin Gram-ve but not Pseudomonas species 2nd Norfloxacin Ciprofloxacin Enoxacin Ofloxacin Gram- ve(including Pseudomonas species), some Gram+ (S. aureus) and some atypicals 3rd Levofloxacin Sparfloxacin Moxifloxacin Gemifloxacin Same as 2 nd generation with extended Gram+ve and atypical coverage 4th *Trovafloxacin Same as 3 rd generation with broad anaerobic coverage

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11. Drug interactions Drugs increasing levels of FQL FQL increasing the levels of : Theophyline Antidepressants NSAIDS Imipramine corticosteroids Caffene Theophyline Warfarin (INR –monitored)

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Fluroquinolones 2

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