Aspirin is the acetyl ester of salicylic acid, a nonsteroidal analgesic. It is commonly used as an antipyretic, for rheumatoid fever, and as an antiplatelet drug at doses of 40-80 mg/day. It has a peak concentration after 1 hour, is highly protein bound, and has a therapeutic effect for 2-3 hours with toxic levels persisting for 15-30 hours. The main metabolites are salicyluric acid and conjugated forms of salicylic acid, which are mainly excreted by the kidneys. Aspirin permanently inhibits platelet COX-1 and can increase bleeding time.

1. ASPIRIN VINOEDH NAIDU RAJA GOPAL_B.PHARM(HONS.)

4. PHARMACOKINETICS PEAK C P I hour PROTEIN BINDING 80-90% METABOLITES Salicyluric acid THERAPEUTIC 2-3 hours High/ toxic 15-30 hours