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U.S.: 1940s STD Experiments "Clearly Unethical" - World Watch - CBS News             Page 1 of 5




                                       World Watch                  October 1, 2010 11:19 AM


U.S.: 1940s STD Experiments "Clearly
       94
Unethical"
Posted by David S Morgan




(Credit: CBS/AP)
The U.S. government has formally apologized for a secret study conducted in the 1940s in which
Guatemalan prisoners, service members and mental hospital patients were secretly infected with
gonorrhea and syphilis without their knowledge or consent, calling the program "clearly
unethical."

In a joint statement issued Friday by Secretary of State Hillary Rodham Clinton and Secretary of
Health and Human Services Kathleen Sebelius, released in English and Spanish, the government
apologized to Guatemala and to those involved in the study, conducted by the U.S. Public Health
Service (PHS) between 1946 and 1948.

The results of the Sexually Transmitted Disease Inoculation Study were uncovered by a
Wellesley College researcher, Susan Reverby.

The story is uncomfortably similar to the "Tuskegee" Syphilis Study in the 1960s, in which the
PHS monitored, but did not treat, hundreds of African American men suffering from syphilis.

                                                                                   EXHIBIT
                                                                                     152

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U.S.: 1940s STD Experiments "Clearly Unethical" - World Watch - CBS News                 Page 2 of 5



Unlike that case, however, subjects in the Guatemala study were intentionally infected with
sexually transmitted diseases, and then given penicillin, to help determine the efficacy of the
drug to cure or even vaccinate against STDs.

Reverby wrote that the Guatemala syphilis inoculation project was run by a PHS physician, Dr.
John C. Cutler (who would later oversee the Tuskegee, Ala., study two decades later).

The study's doctors chose as subjects men incarcerated at the Guatemala National Penitentiary,
as well as army service members, and men and women confined in the National Mental Health
Hospital. There was a total of 696 people in the study. Guatemalan authorities (and not the
individuals themselves) granted permission, in exchange for supplies.

According to Reverby, who studied Cutler's records in the University of Pittsburgh archives,
doctors used infected prostitutes to pass the disease on to prisoners (conjugal visits were allowed
in Guatemalan jails). Direct inoculations of syphilis bacteria were made to other subjects.
Treatment by penicillin was also administered, though not always successfully.

Cutler seemed to recognize the delicate ethical quandaries their experiments posed, particularly
in the wake of the Nuremberg "Doctors' Trials," and was concerned about secrecy. "As you can
imagine," Cutler reported to his PHS overseer, "we are holding our breaths, and we are
explaining to the patients and others concerned with but a few key exceptions, that the treatment
is a new one utilizing serum followed by penicillin. This double talk keeps me hopping at time.
                                                                                            time."

Cutler also wrote that he feared "a few words to the wrong person here, or even at home, might
wreck it or parts of it ... "

PHS physician R.C. Arnold, who supervised Cutler, was more troubled, confiding to Cutler, "I
am a bit, in fact more than a bit, leery of the experiment with the insane people. They can not
give consent, do not know what is going on, and if some goody organization got wind of the
work, they would raise a lot of smoke. I think the soldiers would be best or the prisoners for they
can give consent."

Apparently difficulties in transmission, as well as in replicating results, added to concerns over
the study, and it was dropped after two years.

Cutler went on to participate in another Syphilis Study at Sing Sing Prison in Ossining, N.Y.
(although in that case the subjects were informed about the nature of the inoculations
administered to them).




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U.S.: 1940s STD Experiments "Clearly Unethical" - World Watch - CBS News               Page 3 of 5



"Although these events occurred more than 64 years ago, we are outraged that such
reprehensible research could have occurred under the guise of public health," today's State
Dept./DHS statement said. "We deeply regret that it happened, and we apologize to all the
individuals who were affected by such abhorrent research practices.

"The conduct exhibited during the study does not represent the values of the United States, or
our commitment to human dignity and great respect for the people of Guatemala. The study is a
sad reminder that adequate human subject safeguards did not exist a half-century ago."

The officials also announced an investigation into the specifics of the case from 1946, and will
also convene a meeting of international experts to devise methods that effectively ensure all
human medical research meets rigorous ethical standards.




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Print                                                                                                Page 1 of 3




The AIDS Conspiracy Handbook
Jeremiah Wright's paranoia, in context.

                                                              disinformation agent.
 By Juliet Lapidos
                                                              Similarly, the aptly named Boyd E. Graves
                                                                       y       p y           y
 Posted Wednesday, March 19, 2008, at 5:
                                                              (
                                                              (who calls himself a doctor although he
                                                                                                  g
 51 PM ET
                                                              has only a law degree) has postulated
                                                                      y           g )     p
                                                              that scientists in the employ of the U.S.
                                                                                        p y
 Barack Obama rebuked his former pastor
        k          rebuked               p
                                                              Special Virus Program modified Visna to
                                                                p                 g
 the Rev. Jeremiah Wright on Tuesday for
                            g              y
                                                              create HIV during the 1970s. The
                                                                                 g
 giving sermons in which he blamed the
 g     g
                                                              g
                                                              government, with help from
                                                                                      p
 g
 government for creating a racist state
                            g
                                                              p
                                                              pharmaceutical company Merck, added
                                                                                     p y
 and "inventing the HIV virus as a means
                 g
                                                              the virus to an experimental hepatitis B
                                                                                  p           p
 of g
    genocide against p p of color." W
                 g       people
                                                              vaccine, which was given to gay men and
                                                                                     g      g y
 right isn't the first to say that AIDS
   g                        y
                                                              blacks in New York and San Francisco.
 originated in the White House. Others
     g
 have attributed the epidemic to a
                         p
                                                              And then there's Gary Glum, author of
                                                                                     y      ,
 laboratory accident, malnutrition, or even
           y
                                                              Full Disclosure, who fronts the theory y
 God's divine will. H  Here's a field guide to
                                                              that scientists at the Cold Spring Harbor
                                                                                           p g
 the most prevalent conspiracy theories:
                                                              lab in New York engineered HIV, and that
                                                                                    g
                                                              the World Health Organization spread
                                                                                     g          p
 Government Involvement
                                                              the virus under cover of the smallpox
                                                                                                 p
 The belief cited by Wright—that the
                    y     g
                                                              eradication program. Glum believes the
                                                                           p g
 g
 government invented HIV—seems to have
                                                              virus was created to wipe out, or at least
 originated during the early y
    g             g         y years of the
 epidemic. In 1986, crackpot East German b
  p                         p
                                                              Advertisement
 iologist Jakob Segal p
     g             g published "AIDS:
 USA Home-Made Evil." According to the
                                     g
 p p
 pamphlet, scientists at a Fort Detrick,
 Md., military lab manufactured the
              y
 disease by synthesizing HTLV-1 (
           y y          g           (a
 retrovirus that causes T-cell leukemia) )
 with Visna (a sheep virus). The scientists
             (       p       )
 administered their lethal concoction to
 p
 prison inmates, who then introduced the
 disease into the general population. In
                  g        p p
 case you're wondering, Segal has since
      y                g      g
 been accused of being a Soviet



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 The AIDS Conspiracy Handbook
                                                            It's Not a Virus
 control, the black population. (According
                    p p          (
                                                            Among the most popular, and pernicious,
 to a study released in 2005 by the Rand
          y                    y
                                                            conspiracy theories is that AIDS isn't c
 Corp., more than one-quarter of African-
      p                 q
                                                            aused by a virus at all. Peter Duesberg, a
 Americans believe the disease was
                                                            biology professor at University of
 engineered in a g
    g             government lab, and 16
                                                            California-Berkeley, has argued that
 percent think it was created to control
 p
                                                            drugs and promiscuity are the principal
 the black population.)
                                                            causes of the disease in the United
                                                            States. He attributes AIDS in Africa to
 Laboratory Accident
                                                            malnutrition.
 Edward Hooper, a British journalist,
 argued in his 1999 book, The River, that
                                                            South African President Thabo Mbeki has
 Dr. Hilary Koprowski of the Wistar
                                                            voiced support for the so-called
 Research Institute unintentionally caused
                                                            Duesberg hypothesis, and his health
 the AIDS epidemic by using chimp
                                                            minister, Mantombazana Tshabalala-
 kidneys to produce an oral polio vaccine.
                                                            Msimang, has recommended treating
 The chimps, says Hooper, were infected
                                                            AIDS with foodstuffs, like garlic, rather
 with SIV (the simian precursor to AIDS).
                                                            than pharmaceuticals.
 Then, via an experimental mass-
 vaccination program in the Belgian
                                                            God's Punishment
 Congo, SIV made the jump from monkey
                                                            The Rev. Jerry Falwell famously argued
 to man.
                                                            that AIDS is a plague sent by God to
                                                            punish homosexuals and American
 Hooper's contaminated polio vaccine
                                                            society for tolerating homosexuality.
 thesis sounds less wacky than most
                                                             Advertisement
 conspiracy theories and has attracted
 support from a few notable academics—
 including late Oxford professor W.D.
 Hamilton. But it's definitely wrong.
 Hooper says Koprowski got his kidney
 samples from chimps in the Congo. The
 problem is that the SIV strain endemic to
 chimps from that region is
 phylogenetically distinct from HIV. The
 offending chimps probably came from
 Cameroon.




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 The AIDS Conspiracy Handbook

 Jerry Thacker, the publisher of Today's
 Christian Teen and other Christian
 magazines, has also called AIDS a "gay
 plague" and referred to homosexuality as
 "the death style." In 2003, the Bush
 administration nominated Thacker to
 serve on the Presidential Advisory
 Council on HIV and AIDS. He withdrew
 his name under pressure from gay rights
 groups and Democrats.

 Got a question about today's news? Ask
 the Explainer.

 Explainer thanks Martin Delaney of Project
 Inform and Michael Worobey of the
 University of Arizona.

 Juliet Lapidos is a Slate associate editor.




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How the AIDS Conspiracy Theory Emerged and Spread

  • 1. U.S.: 1940s STD Experiments "Clearly Unethical" - World Watch - CBS News Page 1 of 5 World Watch October 1, 2010 11:19 AM U.S.: 1940s STD Experiments "Clearly 94 Unethical" Posted by David S Morgan (Credit: CBS/AP) The U.S. government has formally apologized for a secret study conducted in the 1940s in which Guatemalan prisoners, service members and mental hospital patients were secretly infected with gonorrhea and syphilis without their knowledge or consent, calling the program "clearly unethical." In a joint statement issued Friday by Secretary of State Hillary Rodham Clinton and Secretary of Health and Human Services Kathleen Sebelius, released in English and Spanish, the government apologized to Guatemala and to those involved in the study, conducted by the U.S. Public Health Service (PHS) between 1946 and 1948. The results of the Sexually Transmitted Disease Inoculation Study were uncovered by a Wellesley College researcher, Susan Reverby. The story is uncomfortably similar to the "Tuskegee" Syphilis Study in the 1960s, in which the PHS monitored, but did not treat, hundreds of African American men suffering from syphilis. EXHIBIT 152 http://www.cbsnews.com/8301-503543_162-20018272-503543.html?tag=cbsnewsLeadSto... 10/2/2010
  • 2. U.S.: 1940s STD Experiments "Clearly Unethical" - World Watch - CBS News Page 2 of 5 Unlike that case, however, subjects in the Guatemala study were intentionally infected with sexually transmitted diseases, and then given penicillin, to help determine the efficacy of the drug to cure or even vaccinate against STDs. Reverby wrote that the Guatemala syphilis inoculation project was run by a PHS physician, Dr. John C. Cutler (who would later oversee the Tuskegee, Ala., study two decades later). The study's doctors chose as subjects men incarcerated at the Guatemala National Penitentiary, as well as army service members, and men and women confined in the National Mental Health Hospital. There was a total of 696 people in the study. Guatemalan authorities (and not the individuals themselves) granted permission, in exchange for supplies. According to Reverby, who studied Cutler's records in the University of Pittsburgh archives, doctors used infected prostitutes to pass the disease on to prisoners (conjugal visits were allowed in Guatemalan jails). Direct inoculations of syphilis bacteria were made to other subjects. Treatment by penicillin was also administered, though not always successfully. Cutler seemed to recognize the delicate ethical quandaries their experiments posed, particularly in the wake of the Nuremberg "Doctors' Trials," and was concerned about secrecy. "As you can imagine," Cutler reported to his PHS overseer, "we are holding our breaths, and we are explaining to the patients and others concerned with but a few key exceptions, that the treatment is a new one utilizing serum followed by penicillin. This double talk keeps me hopping at time. time." Cutler also wrote that he feared "a few words to the wrong person here, or even at home, might wreck it or parts of it ... " PHS physician R.C. Arnold, who supervised Cutler, was more troubled, confiding to Cutler, "I am a bit, in fact more than a bit, leery of the experiment with the insane people. They can not give consent, do not know what is going on, and if some goody organization got wind of the work, they would raise a lot of smoke. I think the soldiers would be best or the prisoners for they can give consent." Apparently difficulties in transmission, as well as in replicating results, added to concerns over the study, and it was dropped after two years. Cutler went on to participate in another Syphilis Study at Sing Sing Prison in Ossining, N.Y. (although in that case the subjects were informed about the nature of the inoculations administered to them). http://www.cbsnews.com/8301-503543_162-20018272-503543.html?tag=cbsnewsLeadSto... 10/2/2010
  • 3. U.S.: 1940s STD Experiments "Clearly Unethical" - World Watch - CBS News Page 3 of 5 "Although these events occurred more than 64 years ago, we are outraged that such reprehensible research could have occurred under the guise of public health," today's State Dept./DHS statement said. "We deeply regret that it happened, and we apologize to all the individuals who were affected by such abhorrent research practices. "The conduct exhibited during the study does not represent the values of the United States, or our commitment to human dignity and great respect for the people of Guatemala. The study is a sad reminder that adequate human subject safeguards did not exist a half-century ago." The officials also announced an investigation into the specifics of the case from 1946, and will also convene a meeting of international experts to devise methods that effectively ensure all human medical research meets rigorous ethical standards. http://www.cbsnews.com/8301-503543_162-20018272-503543.html?tag=cbsnewsLeadSto... 10/2/2010
  • 4. Print Page 1 of 3 The AIDS Conspiracy Handbook Jeremiah Wright's paranoia, in context. disinformation agent. By Juliet Lapidos Similarly, the aptly named Boyd E. Graves y p y y Posted Wednesday, March 19, 2008, at 5: ( (who calls himself a doctor although he g 51 PM ET has only a law degree) has postulated y g ) p that scientists in the employ of the U.S. p y Barack Obama rebuked his former pastor k rebuked p Special Virus Program modified Visna to p g the Rev. Jeremiah Wright on Tuesday for g y create HIV during the 1970s. The g giving sermons in which he blamed the g g g government, with help from p g government for creating a racist state g p pharmaceutical company Merck, added p y and "inventing the HIV virus as a means g the virus to an experimental hepatitis B p p of g genocide against p p of color." W g people vaccine, which was given to gay men and g g y right isn't the first to say that AIDS g y blacks in New York and San Francisco. originated in the White House. Others g have attributed the epidemic to a p And then there's Gary Glum, author of y , laboratory accident, malnutrition, or even y Full Disclosure, who fronts the theory y God's divine will. H Here's a field guide to that scientists at the Cold Spring Harbor p g the most prevalent conspiracy theories: lab in New York engineered HIV, and that g the World Health Organization spread g p Government Involvement the virus under cover of the smallpox p The belief cited by Wright—that the y g eradication program. Glum believes the p g g government invented HIV—seems to have virus was created to wipe out, or at least originated during the early y g g y years of the epidemic. In 1986, crackpot East German b p p Advertisement iologist Jakob Segal p g g published "AIDS: USA Home-Made Evil." According to the g p p pamphlet, scientists at a Fort Detrick, Md., military lab manufactured the y disease by synthesizing HTLV-1 ( y y g (a retrovirus that causes T-cell leukemia) ) with Visna (a sheep virus). The scientists ( p ) administered their lethal concoction to p prison inmates, who then introduced the disease into the general population. In g p p case you're wondering, Segal has since y g g been accused of being a Soviet http://www.slate.com/toolbar.aspx?action=print&id=2186860 Print Powered By http://www.slate.com/toolbar.aspx?action=print&id=2186860 10/2/2010
  • 5. Print Page 2 of 3 The AIDS Conspiracy Handbook It's Not a Virus control, the black population. (According p p ( Among the most popular, and pernicious, to a study released in 2005 by the Rand y y conspiracy theories is that AIDS isn't c Corp., more than one-quarter of African- p q aused by a virus at all. Peter Duesberg, a Americans believe the disease was biology professor at University of engineered in a g g government lab, and 16 California-Berkeley, has argued that percent think it was created to control p drugs and promiscuity are the principal the black population.) causes of the disease in the United States. He attributes AIDS in Africa to Laboratory Accident malnutrition. Edward Hooper, a British journalist, argued in his 1999 book, The River, that South African President Thabo Mbeki has Dr. Hilary Koprowski of the Wistar voiced support for the so-called Research Institute unintentionally caused Duesberg hypothesis, and his health the AIDS epidemic by using chimp minister, Mantombazana Tshabalala- kidneys to produce an oral polio vaccine. Msimang, has recommended treating The chimps, says Hooper, were infected AIDS with foodstuffs, like garlic, rather with SIV (the simian precursor to AIDS). than pharmaceuticals. Then, via an experimental mass- vaccination program in the Belgian God's Punishment Congo, SIV made the jump from monkey The Rev. Jerry Falwell famously argued to man. that AIDS is a plague sent by God to punish homosexuals and American Hooper's contaminated polio vaccine society for tolerating homosexuality. thesis sounds less wacky than most Advertisement conspiracy theories and has attracted support from a few notable academics— including late Oxford professor W.D. Hamilton. But it's definitely wrong. Hooper says Koprowski got his kidney samples from chimps in the Congo. The problem is that the SIV strain endemic to chimps from that region is phylogenetically distinct from HIV. The offending chimps probably came from Cameroon. http://www.slate.com/toolbar.aspx?action=print&id=2186860 Print Powered By http://www.slate.com/toolbar.aspx?action=print&id=2186860 10/2/2010
  • 6. Print Page 3 of 3 The AIDS Conspiracy Handbook Jerry Thacker, the publisher of Today's Christian Teen and other Christian magazines, has also called AIDS a "gay plague" and referred to homosexuality as "the death style." In 2003, the Bush administration nominated Thacker to serve on the Presidential Advisory Council on HIV and AIDS. He withdrew his name under pressure from gay rights groups and Democrats. Got a question about today's news? Ask the Explainer. Explainer thanks Martin Delaney of Project Inform and Michael Worobey of the University of Arizona. Juliet Lapidos is a Slate associate editor. Advertisement http://www.slate.com/toolbar.aspx?action=print&id=2186860 Print Powered By http://www.slate.com/toolbar.aspx?action=print&id=2186860 10/2/2010