Sheepman 121
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ABSTRACT
Over the last decade, diabetes mellitus has emerged as an important clinical and public health
problem throughout the world. The aim of the study is perceive the Potentiality of a newer oral
Antihyperglycemic combination therapy over conventional therapy in type 2 diabetes. The
prospective study was conducted over a period of six months in the department of Medicine,
Guntur City Hospital. The prevalence of type2 diabetes was high in male 65.79 % than female
34.21%. Majority of the patients (23.68 %) belonged to age group of 51–55 years. Majority of
patients (55.26%) having a family history of Diabetes. Majority of patients receiving Combination
of Glibenclamide + Metformin (60.53%), evaluated for effect on FPG for both combinations. The
mean changes in FPG were noted. In the same way effect on HbA1c also noted. Mean changes in
for every month HbA1c will be noted. Our study reveals that Combination therapy with Metformin
plus Glimepiride is more effective than Glibenclamide plus Metformin; in improving glycemic
control in type 2 diabetes, while also allowing a reduction of the dosage of each drug. Potentiality of a newer oral Anti hyperglycemic combination therapy over conv...
Potentiality of a newer oral Anti hyperglycemic combination therapy over conv...Dr. Raghavendra Kumar Gunda
Background: The main aim of present research investigation is to formulate the Risperidone Fast Dissolving tablets. Risperidone, an atypical antipsychotic, belongs to BCS Class-II and used for treating schizophrenia, bipolar mania and autism by blocking D2 and 5-HT2A receptors. Methods: The Fast Dissolving tablets of Risperidone were prepared employing different concentrations of Crospovidone and Croscarmellose sodium in different combinations as a Superdisintegrants by Direct Compression technique using 32 factorial design. The concentration of Crospovidone and Croscarmellose sodium was selected as independent variables, X1 and X2 respectively whereas, wetting time, Disintegration time, t50% ,t90%were selected as dependent variables. Results and Discussion:
Totally nine formulations were designed, preapred and are evaluated for hardness, friability, thickness, Assay, Wetting time, Disintegration time, In-vitro drug release. From the Results concluded that all the formulation were found to be with in the Pharmacopoeial limits and the In-vitro dissolution profiles of all formulations were fitted in to different Kinetic models, the statistical parameters like intercept (a), slope (b) & regression coefficient (r) were calculated. Polynomial equations were developed for Wetting time, Disintegration time, t50%, t90%. Validity of developed polynomial equations were verified by designing 2 check point formulations (C1, C2). According to SUPAC guidelines the formulation (F5) containing combination of 10% Crospovidone and 10% Croscarmellose, is the most similar formulation (similarity factor f2= 93.556, dissimilarity factor f1= 0.976& No significant difference, t= 0.022) to marketed product (RISPERDAL-4). Conclusion: The selected formulation (F5) follows First order, Higuchi’s kinetics, mechanism of drug release was found to be Fickian Diffusion (n= 0.383).
Formulation Development and Evaluation of Risperidone Fast Dissolving Tablets
Formulation Development and Evaluation of Risperidone Fast Dissolving TabletsDr. Raghavendra Kumar Gunda
ABSTRACT
Purpose: The objective of this present study is designed to evaluate its anti-inflammatory activity of aqueous
extract of leaves of solena amplexicaulis by sub cutanias. Against fresh egg white induced inflammation on
Swiss albino rats.
Methods: solena amplexicaulis was investigated for activity in Swiss albino rats against Diclofenac sodium drug
(20mg/kg) as standard reference and normal saline as control by Randall and Baroth method. The time to
achieve reduction of inflammation in the rat paw was determined.
Results: The sub cutanias .administration of solena amplexicaulis exhibited significant anti-inflammatory
activity when compare with the Diclofenac sodium drug and normal saline.
CONCLUSION: The sub cutanias administration of aqueous extract of leaves of solena amplexicaulis has antiinflammatory
effect on Swiss albino rats.Anti Inflammatory Activity of Aqueous Extract of Leaves of Solena Amplexicaulis
Anti Inflammatory Activity of Aqueous Extract of Leaves of Solena AmplexicaulisDr. Raghavendra Kumar Gunda
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ABSTRACT
Over the last decade, diabetes mellitus has emerged as an important clinical and public health
problem throughout the world. The aim of the study is perceive the Potentiality of a newer oral
Antihyperglycemic combination therapy over conventional therapy in type 2 diabetes. The
prospective study was conducted over a period of six months in the department of Medicine,
Guntur City Hospital. The prevalence of type2 diabetes was high in male 65.79 % than female
34.21%. Majority of the patients (23.68 %) belonged to age group of 51–55 years. Majority of
patients (55.26%) having a family history of Diabetes. Majority of patients receiving Combination
of Glibenclamide + Metformin (60.53%), evaluated for effect on FPG for both combinations. The
mean changes in FPG were noted. In the same way effect on HbA1c also noted. Mean changes in
for every month HbA1c will be noted. Our study reveals that Combination therapy with Metformin
plus Glimepiride is more effective than Glibenclamide plus Metformin; in improving glycemic
control in type 2 diabetes, while also allowing a reduction of the dosage of each drug. Potentiality of a newer oral Anti hyperglycemic combination therapy over conv...
Potentiality of a newer oral Anti hyperglycemic combination therapy over conv...Dr. Raghavendra Kumar Gunda
Background: The main aim of present research investigation is to formulate the Risperidone Fast Dissolving tablets. Risperidone, an atypical antipsychotic, belongs to BCS Class-II and used for treating schizophrenia, bipolar mania and autism by blocking D2 and 5-HT2A receptors. Methods: The Fast Dissolving tablets of Risperidone were prepared employing different concentrations of Crospovidone and Croscarmellose sodium in different combinations as a Superdisintegrants by Direct Compression technique using 32 factorial design. The concentration of Crospovidone and Croscarmellose sodium was selected as independent variables, X1 and X2 respectively whereas, wetting time, Disintegration time, t50% ,t90%were selected as dependent variables. Results and Discussion:
Totally nine formulations were designed, preapred and are evaluated for hardness, friability, thickness, Assay, Wetting time, Disintegration time, In-vitro drug release. From the Results concluded that all the formulation were found to be with in the Pharmacopoeial limits and the In-vitro dissolution profiles of all formulations were fitted in to different Kinetic models, the statistical parameters like intercept (a), slope (b) & regression coefficient (r) were calculated. Polynomial equations were developed for Wetting time, Disintegration time, t50%, t90%. Validity of developed polynomial equations were verified by designing 2 check point formulations (C1, C2). According to SUPAC guidelines the formulation (F5) containing combination of 10% Crospovidone and 10% Croscarmellose, is the most similar formulation (similarity factor f2= 93.556, dissimilarity factor f1= 0.976& No significant difference, t= 0.022) to marketed product (RISPERDAL-4). Conclusion: The selected formulation (F5) follows First order, Higuchi’s kinetics, mechanism of drug release was found to be Fickian Diffusion (n= 0.383).
Formulation Development and Evaluation of Risperidone Fast Dissolving Tablets
Formulation Development and Evaluation of Risperidone Fast Dissolving TabletsDr. Raghavendra Kumar Gunda
ABSTRACT
Purpose: The objective of this present study is designed to evaluate its anti-inflammatory activity of aqueous
extract of leaves of solena amplexicaulis by sub cutanias. Against fresh egg white induced inflammation on
Swiss albino rats.
Methods: solena amplexicaulis was investigated for activity in Swiss albino rats against Diclofenac sodium drug
(20mg/kg) as standard reference and normal saline as control by Randall and Baroth method. The time to
achieve reduction of inflammation in the rat paw was determined.
Results: The sub cutanias .administration of solena amplexicaulis exhibited significant anti-inflammatory
activity when compare with the Diclofenac sodium drug and normal saline.
CONCLUSION: The sub cutanias administration of aqueous extract of leaves of solena amplexicaulis has antiinflammatory
effect on Swiss albino rats.Anti Inflammatory Activity of Aqueous Extract of Leaves of Solena Amplexicaulis
Anti Inflammatory Activity of Aqueous Extract of Leaves of Solena AmplexicaulisDr. Raghavendra Kumar Gunda
A B S T R A C T
The main objective of the present study is to formulate and evaluate a poly herbal ointment with antiseptic activity.
Ointments were formulated using methanolic extracts of Eclipta alba, Ocimum sanctum, Azadiracta indica and Achyranthes
aspera which were evaluated for its physicochemical property, antibacterial and antioxidant activity. Ointments were
prepared using different concentrations of the extracts such as 2%, 4%, 6% w/w by fusion method using emulsifying
ointment as base. Formulations were then tested for its physicochemical properties which gave satisfactory results. The
prepared formulations were also stable at 4ºC, 25ºC and 37ºC. Further, Polyherbal formulations were evaluated for its antibacterial
activity against Betadine (5%w/w) as the standard. All the formulations showed Predominant activity against
selected species. Formulations were also evaluated for anti-oxidant activity through reducing power assay, nitric oxide and
hydrogen peroxide scavenging method. The results showed that the scavenging activity of the formulations increased with
increase in concentration and this is due to the presence of flavanoids and tannins. The presence of both antibacterial and
antioxidant activity reveals that the prepared ointment can also be used for wound healing. Hence an attempt was made to
formulate a Polyherbal ointment, and to evaluate for its physical parameter, in-vitro anti-oxidant activity and to compare its
antibacterial activity with a marketed formulation (5% w/w Betadine).Overall result of this study reveals that this is an
effective Polyherbal antiseptic ointment.
Keywords: Eclipta alba, Ocimum sanctum, Azadiracta indica, Achyranthes aspera Formulations, Spread ability,
ExtrudabilityPreparation and Evaluation of Antimicrobial and Antioxidant Activity of Polyh...
Preparation and Evaluation of Antimicrobial and Antioxidant Activity of Polyh...Dr. Raghavendra Kumar Gunda
FORMULATION DEVELOPMENT AND EVALUATION OF LAMOTRIGINE SUSTAINED RELEASE TABLETS USING 32 FACTORIAL DESIGNFORMULATION DEVELOPMENT AND EVALUATION OF LAMOTRIGINE SUSTAINED RELEASE TABLE...
FORMULATION DEVELOPMENT AND EVALUATION OF LAMOTRIGINE SUSTAINED RELEASE TABLE...Dr. Raghavendra Kumar Gunda
ABSTRACT
Objective: The main objective of present investigation is to formulate the controlled release tablet of Lamivudine using 3² factorial design. Lamivudine, a basic molecule and antiretroviral drug belongs to BCS Class III, having low permeability and high solubility. Methods: The controlled release tablets of lamivudine were prepared employing different concentrations of Carboplol974P and Xanthan gum in different combinations as a rate retarding agent by Direct Compression technique using 32 factorial design. The quantity/ concentration of rate retarders, Carboplol974P and Xanthan gum required to achieve the desired drug release was selected as independent variables, X1 and X2 respectively whereas, time required for 10% of drug dissolution t10%, t50%, t75%,t90% were selected as dependent variables. Results: Totally nine formulations were designed and are evaluated for hardness, friability, thickness, % drug content, in-vitro drug release. From the results it was concluded that all the formulation were found to be with in the pharmacopoeial limits and the in-vitro dissolution profiles of all formulations were fitted in to different Kinetic models, the statistical parameters like intercept (a), slope (b) & regression coefficient (r) were calculated. Polynomial equations were developed for t10%, t50%, t75%,t90%. Conclusions: According to SUPAC guidelines the formulation (F5) containing combination of 10% Carboplol974P and 10% Xanthan gum, is the most similar formulation (similarity factor f2=85.04 & No significant difference, t= 0.20046) to Innovator product (Lamivir). The selected formulation (F5) follows Higuchi’s kinetics, and the mechanism of drug release was found to be Case-II transport or typical Zero order release (Non-Fickian, n= 0.915).Design, Formulation and Evaluation of Lamivudine Controlled Release Tablets
Design, Formulation and Evaluation of Lamivudine Controlled Release TabletsDr. Raghavendra Kumar Gunda
Abstract: The main objective of present investigation is to formulate the sustained release
tablet of Rosiglitazone Maleate using 32 factorial design. Rosiglitazone Maleate, an oral antidiabetic
agent. The SR tablets of Rosiglitazone Maleate were prepared employing different
concentrations of HPMCK15M and Carboplol934P in different combinations as a rate
retardants by Direct Compression technique using 32 factorial design. The quantity/
concentration of Polymers , HPMCK15M and Carboplol934P required to achieve the desired
drug release was selected as independent variables, X1 and X2 respectively whereas, time
required for 10% of drug dissolution (t10%), 50% (t50%), 75% (t75%) and 90% (t90%) were
selected as dependent variables. Totally nine formulations were designed and are evaluated
for hardness, friability, thickness, % drug content, In-vitro drug release. From the Results it
was concluded that all the formulation were found to be with in the Pharmacopoeial limits
and the In-vitro dissolution profiles of all formulations were fitted in to different Kinetic
models, the statistical parameters like intercept (a), slope (b) & regression coefficient (r)
were calculated. Polynomial equations were developed for t10%, t50%, t75%, t90%. Validity of
developed polynomial equations were verified by designing 2 check point formulations(C1,
C2). According to SUPAC guidelines the formulation (F5) containing combination of 25%
HPMCK15M and 20% Carboplol934P, is the most similar formulation (similarity factor
f2=93.1376, dissimilarity factor f1= 1.7642 & No significant difference, t= 0.06949) to
marketed product (AVANDIA). The selected formulation (F5) follows Higuchi’s kinetics,
and the mechanism of drug release was found to be Fickian Diffusion (n= 0.417).Formulation Development and Evaluation of Rosiglitazone Maleate Sustained Rel...
Formulation Development and Evaluation of Rosiglitazone Maleate Sustained Rel...Dr. Raghavendra Kumar Gunda
ABSTRACT
The main objective of present research work is to formulate the of Domperidone Maleate floating tablets.
Domperidone Maleate, an antiemetic and a prokinetic agent belongs to BCS Class-II and Indicated for treatment of
upper gastrointestinal motility disorders by blocking the action of Dopamine. The Floating tablets of Domperidone
Maleate were prepared employing different concentrations of HPMCK4M and Guar Gum in different combinations
as a release rate modifiers by Direct Compression technique using 32 factorial design. The concentration of
HPMCK4M and Guar Gum was selected as independent variables, X1 and X2 respectively whereas, time required
for drug dissolution t10%, t50%,t75%,t90%were selected as dependent variables. Totally nine formulations were designed
and are evaluated for hardness, friability, thickness, Assay, Floating Lag time, In-vitro drug release. From the
Results concluded that all the formulation were found to be with in the Pharmacopoeial limits and the In-vitro
dissolution profiles of all formulations were fitted in to different Kinetic models, the statistical parameters like
intercept (a), slope (b) & regression coefficient (r) were calculated. Polynomial equations were developed for t10%,
t50%, t75%, t90%. Validity of developed polynomial equations were verified by designing 2 check point formulations(C1,
C2). According to SUPAC guidelines the formulation (F5) containing combination of 18.75% HPMCK4M and
18.75% Guar Gum, is the most similar formulation (similarity factor f2=89.03, dissimilarity factor f1= 11.539& No
significant difference, t= 0.169) to marketed product (DOMSTAL OD). The selected formulation (F5) follows
Higuchi’s kinetics, and the mechanism of drug release was found to be Non-Fickian Diffusion (n= 0.925).
Keywords: Domperidone Maleate, 32Factorial Design, Gastro retentive Floating Tablet, HPMCK100M, Sodium
bicarbonate, Floating Lag Time, SUPAC, Non-Fickian Diffusion Mechanism.
Formulation design, optimization and evaluation of domperidone maleate gastro...
Formulation design, optimization and evaluation of domperidone maleate gastro...Dr. Raghavendra Kumar Gunda
Contenu connexe
En vedette
A B S T R A C T
The main objective of the present study is to formulate and evaluate a poly herbal ointment with antiseptic activity.
Ointments were formulated using methanolic extracts of Eclipta alba, Ocimum sanctum, Azadiracta indica and Achyranthes
aspera which were evaluated for its physicochemical property, antibacterial and antioxidant activity. Ointments were
prepared using different concentrations of the extracts such as 2%, 4%, 6% w/w by fusion method using emulsifying
ointment as base. Formulations were then tested for its physicochemical properties which gave satisfactory results. The
prepared formulations were also stable at 4ºC, 25ºC and 37ºC. Further, Polyherbal formulations were evaluated for its antibacterial
activity against Betadine (5%w/w) as the standard. All the formulations showed Predominant activity against
selected species. Formulations were also evaluated for anti-oxidant activity through reducing power assay, nitric oxide and
hydrogen peroxide scavenging method. The results showed that the scavenging activity of the formulations increased with
increase in concentration and this is due to the presence of flavanoids and tannins. The presence of both antibacterial and
antioxidant activity reveals that the prepared ointment can also be used for wound healing. Hence an attempt was made to
formulate a Polyherbal ointment, and to evaluate for its physical parameter, in-vitro anti-oxidant activity and to compare its
antibacterial activity with a marketed formulation (5% w/w Betadine).Overall result of this study reveals that this is an
effective Polyherbal antiseptic ointment.
Keywords: Eclipta alba, Ocimum sanctum, Azadiracta indica, Achyranthes aspera Formulations, Spread ability,
ExtrudabilityPreparation and Evaluation of Antimicrobial and Antioxidant Activity of Polyh...
Preparation and Evaluation of Antimicrobial and Antioxidant Activity of Polyh...Dr. Raghavendra Kumar Gunda
FORMULATION DEVELOPMENT AND EVALUATION OF LAMOTRIGINE SUSTAINED RELEASE TABLETS USING 32 FACTORIAL DESIGNFORMULATION DEVELOPMENT AND EVALUATION OF LAMOTRIGINE SUSTAINED RELEASE TABLE...
FORMULATION DEVELOPMENT AND EVALUATION OF LAMOTRIGINE SUSTAINED RELEASE TABLE...Dr. Raghavendra Kumar Gunda
ABSTRACT
Objective: The main objective of present investigation is to formulate the controlled release tablet of Lamivudine using 3² factorial design. Lamivudine, a basic molecule and antiretroviral drug belongs to BCS Class III, having low permeability and high solubility. Methods: The controlled release tablets of lamivudine were prepared employing different concentrations of Carboplol974P and Xanthan gum in different combinations as a rate retarding agent by Direct Compression technique using 32 factorial design. The quantity/ concentration of rate retarders, Carboplol974P and Xanthan gum required to achieve the desired drug release was selected as independent variables, X1 and X2 respectively whereas, time required for 10% of drug dissolution t10%, t50%, t75%,t90% were selected as dependent variables. Results: Totally nine formulations were designed and are evaluated for hardness, friability, thickness, % drug content, in-vitro drug release. From the results it was concluded that all the formulation were found to be with in the pharmacopoeial limits and the in-vitro dissolution profiles of all formulations were fitted in to different Kinetic models, the statistical parameters like intercept (a), slope (b) & regression coefficient (r) were calculated. Polynomial equations were developed for t10%, t50%, t75%,t90%. Conclusions: According to SUPAC guidelines the formulation (F5) containing combination of 10% Carboplol974P and 10% Xanthan gum, is the most similar formulation (similarity factor f2=85.04 & No significant difference, t= 0.20046) to Innovator product (Lamivir). The selected formulation (F5) follows Higuchi’s kinetics, and the mechanism of drug release was found to be Case-II transport or typical Zero order release (Non-Fickian, n= 0.915).Design, Formulation and Evaluation of Lamivudine Controlled Release Tablets
Design, Formulation and Evaluation of Lamivudine Controlled Release TabletsDr. Raghavendra Kumar Gunda
Abstract: The main objective of present investigation is to formulate the sustained release
tablet of Rosiglitazone Maleate using 32 factorial design. Rosiglitazone Maleate, an oral antidiabetic
agent. The SR tablets of Rosiglitazone Maleate were prepared employing different
concentrations of HPMCK15M and Carboplol934P in different combinations as a rate
retardants by Direct Compression technique using 32 factorial design. The quantity/
concentration of Polymers , HPMCK15M and Carboplol934P required to achieve the desired
drug release was selected as independent variables, X1 and X2 respectively whereas, time
required for 10% of drug dissolution (t10%), 50% (t50%), 75% (t75%) and 90% (t90%) were
selected as dependent variables. Totally nine formulations were designed and are evaluated
for hardness, friability, thickness, % drug content, In-vitro drug release. From the Results it
was concluded that all the formulation were found to be with in the Pharmacopoeial limits
and the In-vitro dissolution profiles of all formulations were fitted in to different Kinetic
models, the statistical parameters like intercept (a), slope (b) & regression coefficient (r)
were calculated. Polynomial equations were developed for t10%, t50%, t75%, t90%. Validity of
developed polynomial equations were verified by designing 2 check point formulations(C1,
C2). According to SUPAC guidelines the formulation (F5) containing combination of 25%
HPMCK15M and 20% Carboplol934P, is the most similar formulation (similarity factor
f2=93.1376, dissimilarity factor f1= 1.7642 & No significant difference, t= 0.06949) to
marketed product (AVANDIA). The selected formulation (F5) follows Higuchi’s kinetics,
and the mechanism of drug release was found to be Fickian Diffusion (n= 0.417).Formulation Development and Evaluation of Rosiglitazone Maleate Sustained Rel...
Formulation Development and Evaluation of Rosiglitazone Maleate Sustained Rel...Dr. Raghavendra Kumar Gunda
ABSTRACT
The main objective of present research work is to formulate the of Domperidone Maleate floating tablets.
Domperidone Maleate, an antiemetic and a prokinetic agent belongs to BCS Class-II and Indicated for treatment of
upper gastrointestinal motility disorders by blocking the action of Dopamine. The Floating tablets of Domperidone
Maleate were prepared employing different concentrations of HPMCK4M and Guar Gum in different combinations
as a release rate modifiers by Direct Compression technique using 32 factorial design. The concentration of
HPMCK4M and Guar Gum was selected as independent variables, X1 and X2 respectively whereas, time required
for drug dissolution t10%, t50%,t75%,t90%were selected as dependent variables. Totally nine formulations were designed
and are evaluated for hardness, friability, thickness, Assay, Floating Lag time, In-vitro drug release. From the
Results concluded that all the formulation were found to be with in the Pharmacopoeial limits and the In-vitro
dissolution profiles of all formulations were fitted in to different Kinetic models, the statistical parameters like
intercept (a), slope (b) & regression coefficient (r) were calculated. Polynomial equations were developed for t10%,
t50%, t75%, t90%. Validity of developed polynomial equations were verified by designing 2 check point formulations(C1,
C2). According to SUPAC guidelines the formulation (F5) containing combination of 18.75% HPMCK4M and
18.75% Guar Gum, is the most similar formulation (similarity factor f2=89.03, dissimilarity factor f1= 11.539& No
significant difference, t= 0.169) to marketed product (DOMSTAL OD). The selected formulation (F5) follows
Higuchi’s kinetics, and the mechanism of drug release was found to be Non-Fickian Diffusion (n= 0.925).
Keywords: Domperidone Maleate, 32Factorial Design, Gastro retentive Floating Tablet, HPMCK100M, Sodium
bicarbonate, Floating Lag Time, SUPAC, Non-Fickian Diffusion Mechanism.
Formulation design, optimization and evaluation of domperidone maleate gastro...
Formulation design, optimization and evaluation of domperidone maleate gastro...Dr. Raghavendra Kumar Gunda
En vedette (11)
Preparation and Evaluation of Antimicrobial and Antioxidant Activity of Polyh...
Preparation and Evaluation of Antimicrobial and Antioxidant Activity of Polyh...
FORMULATION DEVELOPMENT AND EVALUATION OF LAMOTRIGINE SUSTAINED RELEASE TABLE...
FORMULATION DEVELOPMENT AND EVALUATION OF LAMOTRIGINE SUSTAINED RELEASE TABLE...
Design, Formulation and Evaluation of Lamivudine Controlled Release Tablets
Design, Formulation and Evaluation of Lamivudine Controlled Release Tablets
Formulation Development and Evaluation of Rosiglitazone Maleate Sustained Rel...
Formulation Development and Evaluation of Rosiglitazone Maleate Sustained Rel...
Formulation design, optimization and evaluation of domperidone maleate gastro...
Formulation design, optimization and evaluation of domperidone maleate gastro...
Sheepman 121
- 1. Open inschrijving! Sheepman 121kijken naar wie je bent(van) binnen en (van) buiten Bewustzijnsprofiel Belevingsprogramma OrganicScoreCard Ervaren met schapen
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