Dr. Joan B Soriano

1. Joan B Soriano
Médico Epidemiólogo
Servicio de Neumología, Hospital Universitario de La Princesa, Madrid
Professor Associat de la UIB-Hospital Universitari Son Espases, Palma
Email: jbsoriano2@gmail.com
Hipótesis biológicas
sobre el papel de la
nicotina en la COVID-19
Jueves, 30 de abril 2020

2. I have the following disclosures that relate or not to this presentation:
-JBS received pharmaceutical company grants since 2016 to date from Linde and
GSK; and since 2020 from Novartis; all via Hospital Universitario de La Princesa
-JBS has participated in speaking activities, advisory committees and consultancies
during the period 2016-2020 sponsored by: AirLiquide, Almirall, AstraZeneca,
Boehringer-Ingelheim, CHEST, Chiesi, ERS, IHME, GEBRO, Grifols, GSK, Linde,
Lipopharma, Menarini, Mundipharma, Novartis, Pfizer, RiRL, Rovi, SEPAR and
Takeda
-JBS has not received directly or indirectly any funding from tobacco manufacturers
or its affiliates
Conflict of interest disclosures of Joan B Soriano
I declare I have no, real or perceived, conflicts of interest that relate to this presentation.

3. Allan M Brandt. The Cigarette Century: The Rise,
Fall, and Deadly Persistence of the Product That
Defined America. Basic Books. 2007.
“…Doubt was no longer a matter of culture or
training, but the carefully crafted center-piece
of an industry effort to sow confusion and
heighten debate through explicit attempts to
disrupt the process of normative science. The
TIRC marks one of the most intensive efforts by
an industry to derail independent science.”

4. La Vanguardia – 22 abril 2020.
El Economista – 2 abril 2020.
El Diario – 20 abril 2020.

5. “-… Then I see the disinfectant where it knocks it out in a minute, one
minute. Is there a way we can do something like that by injection inside?
Or almost a cleaning, ‘cause you see it gets in the lungs and it does a
tremendous number on the lungs. So it’d be interesting to check that. So
you’re going to have to use medical doctors but it sounds interesting to me,
so we’ll see but the whole concept of the light. The way it kills it in one
minute, that’s pretty powerful.
Epidemiologist-in-Chief Trump’s Ridiculous Behavior at
Pandemic Briefings Baffles a Watching World
Trump's disinfectant recommendation
leads to over 100 poisonings in the USA
New York Times, April 24, 2020.

6. 16 marzo 2020.
Meme Whatsup
16 marzo 2020.
Reason: Free minds and free markets
Ejercicio Online: ¿Cuál de estas noticias es “interesada”?

7. Búsqueda en PubMed (28-4-2020)
• COVID-19: 7,340 artículos (en 114 días = 2,6 artículos /hora)
• COVID-19 AND “smoking”: 23 artículos
• COVID-19 AND “tobacco”: 7 artículos

8. Cai G, et al. Am J Respir Crit Care Med. 2020 Apr 24.

9. Brake SJ, et al. J Clin Med 2020 Mar 20;9(3).

10. Olds JL, Kabbani N. FEBS J 2020 Mar 18.

11. Halpin D, et al. Lancet Respir Med 2020.
Ecological fallacy!!!!!

12. Vardavas CI, Nikitara K.
Tob Induc Dis. 2020 Mar 20;18:20.
Vázquez JC, Redolar-Ripoll D.
Tob Induc Dis. 2020 Apr 6;18:30.

13. Singh AG, Chaturvedi P. Head Neck 2020 Apr 27.

14. Conclusiones
• Parece ser que el receptor ECA es clave
en la respuesta inmune/cascada de
citocinas, y está relacionado con la
nicotina
• La mayoría de informaciones COVID-
19&smoking&tobacco son “interesadas”
• Often in science, our best is not good
enough (Olli S Miettinen)