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Quick Reminder of Amyloid formation and anti-amyloid drugs.
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Amyloid plaques
1.
Amyloid Plaques
2.
PHYSIOLOGICAL PATHWAY: Alpha
Secretase
3.
PATHOLOGICAL PATHWAY: Beta
Secretase
4.
Beta Secretase Inhibitors •
Merck: MK-8931 • Lilly: LY450139 Severe adverse Effects: cancer
5.
Gamma Secretase Inhibitors •
Merck: MK-8931 • Eisai: E 2609 • Lilly: LY2886721 In clinical trials
6.
Monoclonal Antibodies against
Abeta 42 *Solanezumab (Lilly) *Bepaneuzumaub (Pfizer) - failed
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