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Microwave Imaging of the Breast With Incorporated Structural Information   SPIE Medical Imaging 15 February, 2010 San Diego, CA Amir H. Golnabi Thayer School of Engineering at Dartmouth College, NH
1. Introduction ,[object Object],[object Object],[object Object],[object Object],[object Object],www.cancer.org
1. Introduction ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.amberusa.com/images/mammography Joy et al 2005, Smith-Bindman et al 2005
1. Introduction ,[object Object],[object Object],[object Object],http://www.nucleusinc.com  www.uwhealth.org/
2. Microwave Imaging Spectroscopy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
2. Microwave Imaging at Dartmouth ,[object Object],[object Object],[object Object]
2. Microwave Imaging at Dartmouth ,[object Object],[object Object],[object Object],[object Object],[object Object], 1 ,   1  2 ,   2
3. Microwave Image Reconstruction ,[object Object],[object Object]
4. Microwave Image Reconstruction  with Incorporated Anatomical Information
4. Inclusion of Spatial Information ,[object Object],[object Object],[object Object],[object Object]
5. Phantom Experiments
5. Phantom Experiments ,[object Object],[object Object]
5. Phantom Experiments ,[object Object],[object Object],[object Object],[object Object],[object Object]
5. Phantom Experiments: Results Square Inclusion L = 20 mm   Square Inclusion L = 10 mm
5. Phantom Experiments: Results Square Inclusion L = 20 mm, frequency range: 900-2100 MHz Relative Error = (exact – reconstructed)/exact
6. Initial Clinical Data
6. Initial Clinical Data Using high spatial resolution MR images as soft prior information in microwave image reconstruction:
6. Initial Clinical Data Reconstructed images at 1100 MHz with and without soft prior regularization:
7. Conclusion and Future Directions: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Acknowledgement ,[object Object],[object Object],[object Object],[object Object],Prof. Paul Meaney Prof. Keith Paulsen Shireen Geimer Margaret Fanning
References American Cancer Society , (2007, September 26). Breast Cancer Facts Figures 2007-2008. Website: http://www.cancer.org/downloads/STT/BCFF-Final.pdf Larsen, Lawrence, and John Jacobi. Medical Applications of Microwave Imaging. New York: IEEE Press, 1985. J. R. Reitz and F. J. Milford. Functions of electromagnetic theory. Addison Wesley Publishing Company, 1967 Von Hippel, A. R. Dielectric Materials and Applications. M.I.T. Press, 1954 Schwan, H. P. Electrical properties of tissue and cell suspensions. Adv, Biol. Med. Phys. Vol. 5 H.F. Cook, “The dielectric behavior of some types of human tissue at microwave frequencies,” Br. J. Appl. Phys., Vol 2, pp. 295-296, Oct. 1951. J. E. Roberts and H. F. Cook, “Microwave in medical and biological research,” Br. J. Appl. Phys., Vol. 3, pp. 33-40, Feb 1952. C. C. Johnson and A.W. Guy, “Nonionizing electromagnetic wave effects in biological materials and systems,” Proc. IEEE, Vol. 60, pp. 694-695, June 1972. Smith-Bindman R., Chu P., Miglioretti D. L., Quale C., Rosenberg R. D., Cutter G., Geller B., Bacchetti P., Sickles E. A., and Kerlikowske K., “Physician Predictors of Mammographic Accuracy,” Journal of the National Cancer Institute, Vol. 97(5), 358-367 (2005). Brooksby, B., Jiang, S., Dehghani, H., Pogue, B. W., Paulsen, K. D., Weaver, J., Kogel, C., and Poplack, S. P., “Combining near infrared tomography and magnetic resonance imaging to study in vivo breast tissue: implementation of a Laplacian-type regularization to incorporate magnetic resonance structure.” Journal of Biomedical Optics, Sep/Oct 2005. vol. 10(5). Meaney PM, Fang Q, Rubaek T, Demidenko E, Paulsen KD, “Log transformation benefits parameter estimation in microwave tomographic imaging,” Medical Physics, vol. 34, pp. 2014-2023, 2007. Q. Fang, “Computational methods for microwave medical imaging,” Ph.D. dissertation, Thayer School of Engineering, Dartmouth College, Hanover, NH, 2004. D. R. Lynch, Numerical partial differential equations for environmental scientists and engineers – A first practical course, Springer, Edition 1, 2005. P. K. Yalavarthy, H. Dehghani, B. W. Pogue, C. M. Carpenter, H. B. Jiang, and K. D. Paulsen, "Structural information within regularization matrices improves near infrared diffuse optical tomography," Optics Express, vol. 15, no. 13, pp. 8043 – 8058, 2007.
 

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Microwave Imaging Of The Breast With Incorporated Structural Information Final

  • 1. Microwave Imaging of the Breast With Incorporated Structural Information SPIE Medical Imaging 15 February, 2010 San Diego, CA Amir H. Golnabi Thayer School of Engineering at Dartmouth College, NH
  • 2.
  • 3.
  • 4.
  • 5.
  • 6.
  • 7.
  • 8.
  • 9. 4. Microwave Image Reconstruction with Incorporated Anatomical Information
  • 10.
  • 12.
  • 13.
  • 14. 5. Phantom Experiments: Results Square Inclusion L = 20 mm Square Inclusion L = 10 mm
  • 15. 5. Phantom Experiments: Results Square Inclusion L = 20 mm, frequency range: 900-2100 MHz Relative Error = (exact – reconstructed)/exact
  • 17. 6. Initial Clinical Data Using high spatial resolution MR images as soft prior information in microwave image reconstruction:
  • 18. 6. Initial Clinical Data Reconstructed images at 1100 MHz with and without soft prior regularization:
  • 19.
  • 20.
  • 21. References American Cancer Society , (2007, September 26). Breast Cancer Facts Figures 2007-2008. Website: http://www.cancer.org/downloads/STT/BCFF-Final.pdf Larsen, Lawrence, and John Jacobi. Medical Applications of Microwave Imaging. New York: IEEE Press, 1985. J. R. Reitz and F. J. Milford. Functions of electromagnetic theory. Addison Wesley Publishing Company, 1967 Von Hippel, A. R. Dielectric Materials and Applications. M.I.T. Press, 1954 Schwan, H. P. Electrical properties of tissue and cell suspensions. Adv, Biol. Med. Phys. Vol. 5 H.F. Cook, “The dielectric behavior of some types of human tissue at microwave frequencies,” Br. J. Appl. Phys., Vol 2, pp. 295-296, Oct. 1951. J. E. Roberts and H. F. Cook, “Microwave in medical and biological research,” Br. J. Appl. Phys., Vol. 3, pp. 33-40, Feb 1952. C. C. Johnson and A.W. Guy, “Nonionizing electromagnetic wave effects in biological materials and systems,” Proc. IEEE, Vol. 60, pp. 694-695, June 1972. Smith-Bindman R., Chu P., Miglioretti D. L., Quale C., Rosenberg R. D., Cutter G., Geller B., Bacchetti P., Sickles E. A., and Kerlikowske K., “Physician Predictors of Mammographic Accuracy,” Journal of the National Cancer Institute, Vol. 97(5), 358-367 (2005). Brooksby, B., Jiang, S., Dehghani, H., Pogue, B. W., Paulsen, K. D., Weaver, J., Kogel, C., and Poplack, S. P., “Combining near infrared tomography and magnetic resonance imaging to study in vivo breast tissue: implementation of a Laplacian-type regularization to incorporate magnetic resonance structure.” Journal of Biomedical Optics, Sep/Oct 2005. vol. 10(5). Meaney PM, Fang Q, Rubaek T, Demidenko E, Paulsen KD, “Log transformation benefits parameter estimation in microwave tomographic imaging,” Medical Physics, vol. 34, pp. 2014-2023, 2007. Q. Fang, “Computational methods for microwave medical imaging,” Ph.D. dissertation, Thayer School of Engineering, Dartmouth College, Hanover, NH, 2004. D. R. Lynch, Numerical partial differential equations for environmental scientists and engineers – A first practical course, Springer, Edition 1, 2005. P. K. Yalavarthy, H. Dehghani, B. W. Pogue, C. M. Carpenter, H. B. Jiang, and K. D. Paulsen, "Structural information within regularization matrices improves near infrared diffuse optical tomography," Optics Express, vol. 15, no. 13, pp. 8043 – 8058, 2007.
  • 22.