LIBYAN INTERNATIONAL MEDICAL UNIVERSITY students : Mohammed Elgheriyani , Mohammed Moaiter Mohamme Amsadef , Mohammed Alsanousi , Ali Hassen 1- Structure & forms Vitamin B1 2- Biochemical role & functions of Vitamin B1 3- Causes of Vitamin B1 deficiency 4- Clinical Manifestation of vitamin B1 deficiency

2. Vitamin B1
LIBYAN INTERNATIONAL
MEDICAL
UNIVERSITY
Presented by :
Group A Seminar, week 10
Mohammed Elgheriyani , Mohammed Moaiter
Mohamme Amsadef , Mohammed Alsanousi ,
Ali Hassen

3. 2
Objectives:
Structure & forms
Vitamin B1
Biochemical role & functions
of Vitamin B1
Clinical Manifestation of vitamin B1 deficiency
Sites & characteristic of the PNS
Causes of Vitamin B1 deficiency
1
2
3
4
5

4. Structure, forms & sources
VitaminB1
Presented By: Mohammed Elgheriyani
1

5. Thiamine is also called vitamin B1 (In old literature)
it is designated as Aneurine (it can relieve neuritis)
Or (antiberiberi factor)
VITAMIN B1
( thiamine )
Thiamine is one member of water-soluble
vitamin B-complex

6. Christiaan Eijkman
In 1900, Christian Eijkman produced beriberi
in chicken by feeding polished rice
1858-1930
Adolf windaus
elucidated the structure of the vitamin
(Nobel prize for chemistry 1928)
1876-1959
(Nobel Prize for physiology
1929)

7. Structure of Thiamine
Thiamine contains a substituted pyrimidine ring
connected to a substituted thiazole ring by
means of methylene bridge
+ +
Pyrimidine
ring
methylene Thiazole
ring
Thiamine

8. active co-enzyme form of thiamine ?
by addition
of two phosphate groups, with the help of ATP
It is catalyzed by thiamine pyrophospho-transferase.

9. active co-enzyme form of thiamine ?
so, the Active form of thiamine is
called
Thiamin-pyrophosphate

10. True or False:
The vitamin B1 is converted to active co-enzyme
form by addition of one phosphate group.
A . TRUE B.FALSE

11. Sources of
vitamin B1
nuts
Fish
Green
Peas
yeast
Aleurone of
cereals
Beans

12. Biochemical Role& Functions of
VitaminB1
2
Presented By : Mohammed Alsanousi

13. Biochemical role
Of Vitamin B1
The vitamin B1 has many role in our body :
oxidative decarboxylation of α-keto acids
oxidative decarboxylation of α-keto glutarate
transketolase in the reaction of HMP shunt

14. oxidative decarboxylation of α-keto acids

15. oxidative decarboxylation of α-keto glutarate

16. transketolase in the reaction of HMP shunt

17. True or False:
A . TRUE B.FALSE
Thiamine pyrophosphate (TTP) its is used in oxidative
decarboxylation of alpha keto acid

18. The main role of thiamine (TPP) is in carbohydrate
thiamine is increasedmetabolism. So, the requirement of
along with higher intake
of carbohydrates.

19. Causes of
VitaminB1
Presented By: Mohamme Amsadef
3
Deficiency

20. Increased
consumption
Increased
depletion
Decreased
Absorption
Causes of Vitamin B1
Deficiency
Lack of Thiamine
Intake

21. Increased
consumption
Diets high in carbohydrate or saturated fat intake
Pregnancy
Increased physical exercise
Fever – severe infection

22. Increased
depletion
Diarrhea
Diuretic therapies
hemodialysis

23. Decreased
absorption
Chronic intestinal disease
Alcoholism
Malnutrition
Malabsorption

24. True or False:
decreased physical exercise may causes
Vitamin B1 deficiency.
A . TRUE B.FALSE

25. Lack of Thiamine
Intake
Food containing a high level of thiaminase including
rice,raw freshwater fish
Food high in Anti-thiamine factor such as
Tea , coffee
Processed food with a high level of sulfite which
destroys thiamine

26. Presented By : Mohammed Moaiter
Clinical Manifestation of
vitaminB1 Deficiency
4

27. BERIBERI DISEASE
Singhalese word
anorexia
dyspepsia
weakness
Beriberi:

28. Beriberi may occur in four main:
Wet beriberi
Dry beriberi
Infantile beriberi
Wernicke-korsakoff { cerebral beriberi }

29. Wet beriberi
{ Affects the heart and circulatory system }
Normal heart Enlarged heartEdema

30. Dry beriberi
{ Affects the peripheral nervous system }
Paralysis !

31. infantile beriberi
common in infants whose
mothers are thiamine-deficient
Sleeplessness !

32. Wernicke-korsakoff (cerebral beriberi )
{ that occurs in conjunction with alcoholism }
ophthalmoplegia
cerebellar ataxia
psychosis

33. True or False:
A . TRUE B.FALSE
Dry beriberi Affects the heart and circulatory system.

34. It is common in
chronic alcoholics
Polyneuritis
May also be associated
with
Pregnancy & old age

35. 5
Presented By : Ali Hassen
sites & characteristics of
The peripheral nervous
System

36. Central Nervous
System
Peripheral Nervous
System
The nervous system

37. Brain Brain Stem
Spinal Cord
Central nervous system

38. Peripheral Nervous System
Sites :
Muscle
Neuromuscular junction
Peripheral nerves (spinal &
cranial)roots
Plexus

39. True or False:
Brain stem is one of sites of peripheral nervous
system.
A . TRUE B.FALSE

40. Peripheral Nervous System
Somatic
Autonomic
Sympathetic
Para
Sympathetic motor Sensory

41. Motor vs Sensory

42. Sympathetic VS ParaSympathetic

43. Summary
Thiamine is one member of water-soluble vitamin B-complex.
the Active form of thiamine is called Thiamin-
pyrophosphate.The vitamin B1 has many roles in our body, like oxidative
decarboxylation of α-keto acids.
Causes vary with inadequate intake, lack of absorption
alcoholism.
The nervous system is divided into the central and
peripheral nervous system.
Clinical manifestation range from beri-beri to Wernickes and
polyneuritis.

44. References
Vasudevan, D., Sreekumari, S., & Vaidyanathan, K. (2011). Textbook of
biochemistry for medical students. Kochi: Jaypee Brothers Medical
Pub.
Pamela C. Champe, Richard A. Harvey, Lippincott’s Illustrated Reviews of
Biochemistry, 5th ed, Philadelphia PA, Copyright © 2013 by Lippincott
Williams & Wilkins
https://www.slideshare.net/magdisasi/dr-magdi-sasi-cns-examination-1
Guyton, A., & Hall, J. (2006). Textbook of medical physiology (11th ed.).
Philadelphia: Saunders.

45. Thank you for your
attention