Joseph El Khoury Webinar July 2014

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Webinar presentation made by Dr. Joseph El Khoury on the 8th of July, 2014 at the live webinar: http://www.alzforum.org/webinars/mutations-impair-trem2-maturation-processing-and-microglial-phagocytosis

Santé & Médecine

(Hickman et al Nature Neuroscience 2013)

TREM2
Mutations
Decreased Aβ
Phagocytosis and
Clearance
Increased Inflammatory
Response
Neurotoxin
Production
(ROS, RNS)
Increased Aβ
Production
Increased Aβ
Accumulation
Microglia
(Hickman & El Khoury Biochemical Pharmacology 2014)

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Joseph El Khoury Webinar July 2014

1. (Hickman et al Nature Neuroscience 2013)

2. TREM2 Mutations Decreased Aβ Phagocytosis and Clearance Increased Inflammatory Response Neurotoxin Production (ROS, RNS) Increased Aβ Production Increased Aβ Accumulation Microglia (Hickman & El Khoury Biochemical Pharmacology 2014)