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Cells of multicellular organisms detect and respond to countless internal and extracellular signals that control their growth, division, and differentiation during development, as well as their behavior in adult tissues. At the heart of all these communication systems are regulatory proteins that produce chemical signals, which are sent from one place to another in the body or within a cell, usually being processed along the way and integrated with other signals to provide clear and effective communication. Study of cell signaling has traditionally focused on the mechanisms by which eukaryotic cells communicate with each other using extracellular signal molecules such as hormones and growth factors. Many bacteria, respond to chemical signals that are secreted by their neighbors and accumulate at higher population density. This process, called quorum sensing, allows bacteria to coordinate their behavior, including their motility, antibiotic production, spore formation, and sexual conjugation. Communication between cells in multicellular organisms is mediated mainly by extracellular signal molecules. Most cells in multicellular organisms both emit and receive signals. Reception of the signals depends on receptor proteins, usually (but not always) at the cell surface, which bind the signal molecule. The binding activates the receptor, which in turn activates one or more intracellular signaling pathways or systems. These systems depend on intracellular signaling proteins, which process the signal inside the receiving cell and distribute it to the appropriate intracellular targets. The targets that lie at the end of signaling pathways are generally called effector proteins, which are altered in some way by the incoming signal and implement the appropriate change in cell behavior. Depending on the signal and the type and state of the receiving cell, these effectors can be transcription regulators, ion channels, components of a metabolic pathway, or parts of the cytoskeleton.
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Cells of multicellular organisms detect and respond to countless internal and extracellular signals that control their growth, division, and differentiation during development, as well as their behavior in adult tissues. At the heart of all these communication systems are regulatory proteins that produce chemical signals, which are sent from one place to another in the body or within a cell, usually being processed along the way and integrated with other signals to provide clear and effective communication. Study of cell signaling has traditionally focused on the mechanisms by which eukaryotic cells communicate with each other using extracellular signal molecules such as hormones and growth factors. Many bacteria, respond to chemical signals that are secreted by their neighbors and accumulate at higher population density. This process, called quorum sensing, allows bacteria to coordinate their behavior, including their motility, antibiotic production, spore formation, and sexual conjugation. Communication between cells in multicellular organisms is mediated mainly by extracellular signal molecules. Most cells in multicellular organisms both emit and receive signals. Reception of the signals depends on receptor proteins, usually (but not always) at the cell surface, which bind the signal molecule. The binding activates the receptor, which in turn activates one or more intracellular signaling pathways or systems. These systems depend on intracellular signaling proteins, which process the signal inside the receiving cell and distribute it to the appropriate intracellular targets. The targets that lie at the end of signaling pathways are generally called effector proteins, which are altered in some way by the incoming signal and implement the appropriate change in cell behavior. Depending on the signal and the type and state of the receiving cell, these effectors can be transcription regulators, ion channels, components of a metabolic pathway, or parts of the cytoskeleton.
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the way of communication cell to cell or cell to their environment. they produce some stimuli to correspond to surroundings for survival. Cell signalling helps to defend, survive, production of chemicals and lots of other things. signalling can external and internal. in this presentation, paths are elaborated externally and internally. Hope it will help to understand cell signal in better way.
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Cell signalling
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Cell signaling is the fundamental process that lets a cell communicate, grow & respond to its surroundings. This presentation might hep you to understand the various mechanisms that a cell employs to perform the very vital activity for its survival.
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In today’s fast-paced digital world, harnessing the power of artificial intelligence (AI) can significantly enhance productivity and creativity across various domains. With the advent of advanced language models like ChatGPT, developers, marketers, data analysts, and professionals in numerous other fields can now leverage AI-generated prompts to spark innovative ideas and streamline their workflows.
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Lecture 7
1.
2.
3.
4.
Modulation of
Signal Pathways by Ligands
5.
6.
Signal Transduction Pathways
7.
Basic Mechanisms of
Chemical Signaling
8.
Pathways initiated by
intracellular receptor
9.
10.
11.
Receptor function as
ion channels Protein receptor constitute of ion channel Activation of the receptor by the first messenger The opening results increase diffusion of ions to the channel
12.
13.
14.
15.
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