1. Antacids
Classifications of Medications for the Gastrointestinal System Antacids Can decrease absorption of
sucralfate, anticholinergics, H2blockers, fluoroquinolones, iron,INH, phenothiazines, and tetracy-cline
Can cause loss of effect for enteric-coated tablets
Ex of drugs aluminum hydroxide (Amphojel)magnesium hydroxide (milk of Magnesia)aluminum
hydroxide and magnesium hydroxide combinations: Gelusil, Maalox, Mylanta
comments Neutralize gastric acid, inhibit gastricacid secretions, or provide mucosal protection Can
cause constipation or diarrhea depending on drug and/or dosage
Main indication Used for indigestion, reflux esophagitis, and peptic ulcers and other gastric irritants*
Remind the client to allow at least1 hour between eating or taking doses of antacid and taking
H2blockers.May cause dizziness and confusion.Use with caution in the elderly.cimetidine
(Tagamet)famotidine (Pepcid)ranitidine (Zantac)nizatidine (Axid) Cimetidine has many
interactionsleading to increased blood levelsand toxicity of many drugs, such astheophylline, diazepam,
and antico-agulants.Antacids and food delay absorptionof the H2blocker, although the ther-apeutic
effect will eventually be the same. Used for heartburn, prevention or treatment of active duodenal
ulcers, and gastric hypersecretionUsed as prophylaxis for stress ulcers
Histamines receptors antagonists H2 blockers
Remind the client to allow at least 1 hour between eating or taking doses of antacid and taking
H2blockers. May cause dizziness and confusion. Use with caution in the elderly.
cimetidine (Tagamet)famotidine (Pepcid)ranitidine (Zantac)nizatidine (Axid)
Cimetidine has many interactionsleading to increased blood levelsand toxicity of many drugs, such
astheophylline, diazepam, and antico-agulants.Antacids and food delay absorptionof the H2blocker,
although the ther-apeutic effect will eventually be the same.
Used for heartburn, prevention ortreatment of active duodenalulcers, and gastric hypersecretionUsed
as prophylaxis for stress ulcers.
Proton pump inhibitors
Used to treat esophagatis,Gerd, gastric and duodenal ulcers, Nsaid- related ulcers and H.pylori