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Ironing out the Facts
                                                                                         Why Plant Iron is Best

                               By Dr Justine Butler
                               VVF Senior Health Campaigner

                               One of the commonest food myths is that vegetarians and vegans have a higher risk of iron deficiency
                               anaemia because they don’t eat meat. This is simply not the case and many major health organisations
                               a g r e e – t h e B r i t i s h M e d i c a l A s s o c i a t i o n , t h e Wo r l d H e a l t h O r g a n i s a t i o n a n d t h e A m e r i c a n D i e t e t i c
                               A s s o c i a t i o n . H o w e v e r, so m e so - c al l ed ‘ h e al t h ’ o r g an i s a t i o n s, h e a l t h p r o f e ss io n a ls a n d f o o d w r it e r s p e r s is t
                               in promoting red meat as the best source of iron. They invariably fail to mention the health risks
                               associated with the type of iron found in meat as opposed to iron from plants. This fact sheet debunks the
                               We s t e r n m y t h o f p r o m o t i n g m e a t a s a g o o d s o u r c e o f i r o n a n d e x p l a i n s w h y p l a n t i r o n i s b e s t .

                               W h a t i s I r o n a n d W h y D o We N e e d I t ?                                          myoglobin (oxygen-carrying molecules in muscle) and makes up
                               Iron is an essential component of the pigment haemoglobin, found                              around half the iron found in red meat, poultry and fish.
                               in red blood cells. It helps carry oxygen to all parts of the body
                               and is essential for life. If iron intake is low, the amount of                               Non-Haem Iron makes up the other half of the iron in animal
                               haemoglobin in the red blood cells can fall leading to iron-                                  tissue and all of the iron found in plant foods, dairy foods (which
                               deficiency anaemia. Symptoms include tiredness, weakness, feeling                             contain a very small amount) and eggs. Around 90 per cent of
                               cold and an inability to concentrate.                                                         the iron in the average British diet is non-haem iron; the other
                                                                                                                             10 per cent comes mainly from the haemoglobin of meat (Bull
                               H o w M u c h I r o n D o We N e e d ?                                                        and Buss, 1980).
                               The UK recommended nutrient intake (RNI) for iron in adult
                               males is 8.7 mg per day and for women up to the age of 50 it is                               The UK’s Food Standards Agency (FSA) looked at sources of iron
                               14.8 mg per day (Department of Health, 1991). Women have                                      in their 2003 National Diet and Nutrition Survey and found that
                               higher requirements as they lose iron during menstruation. The                                17 per cent of total (haem and non-haem) iron came from meat,
                               RNIs for younger and older groups are given below.                                            three per cent from fish, three from eggs and one per cent from
                                                                                                                             dairy foods. The vast majority (over 75 per cent) of iron in the
                                Recommended daily intakes in the UK                                                          diet came from plant-based foods. Cereals (such as wholegrain
                                Age                                                 mg iron                                  pasta, brown rice and wholemeal bread) made the single biggest
                                0-3 months                                          1.7                                      contribution at 44 per cent (FSA, 2003a). This demonstrates the
                                4-6 months                                          4.3                                      important contribution plant foods make to iron intake in meat-
                                7-12 months                                         7.8                                      eaters and veggies alike.
                                1-3 years                                           6.9
                                4-6 years                                           6.1                                      T h e I r o n C o n t e n t o f P l a n t Fo o d s
                                7-10 years                                          8.7                                      The table below shows that there is no shortage of iron in plant
                                Men aged 11-18                                      11.3                                     foods. Pulses (peas, beans and lentils) and soya bean products
                                Men aged 19 and over                                8.7                                      (such as soya milk and tofu) provide an excellent source. As do
                                Women aged 11-50                                    14.8                                     dark green leafy vegetables (such as broccoli, pak choy and
                                Pregnant women                                      27.0                                     watercress), fortified breakfast cereals, wholegrains (such as
                                Postmenopausal women (50+ years)                    8.7                                      wholemeal bread, brown rice and wholemeal pasta), dried fruits
                                Source: Department of Health, 1991.                                                          (such as raisins, prunes, apricots and figs) black treacle and plain
                                                                                                                             dark chocolate.

                               Supplements
                               Supplementing the diet with too much iron can lead to constipation,                             T h e I r o n C o n t e n t o f S e l e c t e d P l a n t Fo o d s
                               nausea, vomiting and stomach pain and very high doses can be fatal,                             Food (medium portions)                   mg iron Percentage of daily RNI
                               particularly in children (FSA, 2003). Furthermore, not all                                                                                       Men      Women
                               supplements are the same. For example, iron (ferrous) sulphate                                                                                   (8.7 mg) (14.8 mg)
                               (which many GPs prescribe) can cause nausea and constipation and                                Baked beans (135g)                       1.9     22       13
                               may interfere with vitamin E absorption. However, other forms are                               Bran flakes (40g)                        9.7     111      66
                               much better-tolerated such as iron picolinate, iron citrate and iron                            Tofu (100g)                              3.5     40       24
                               bisglycinate. Plant forms of iron supplements such as Floradix and                              Kidney beans (90g)                       1.8     16       12
                               Floravital, sold in health food shops, are gentle on the system. The                            Red lentils (120g)                       2.9     33       20
                               VVF recommends that you seek the advice of a nutritional therapist                              Spaghetti (220g)                         3.1     36       21
                               before taking supplements. Most people can get all the iron they                                Brown rice (180g)                        0.9     10       6
                               need by eating a varied and balanced diet.                                                      Curly kale (95g)                         1.9     22       13
Chari ty numb er : 1 037 486




                                                                                                                               Broccoli (85g)                           0.9     10       6
                               Type s o f Ir o n                                                                               Sesame seeds (12g)                       1.3     15       9
                               There are two types of iron in food:                                                            Pumpkin seeds (12g)                      1.8     21       12
                                                                                                                               Prunes (six dried fruits 48g)            1.2     14       8
                               Haem Iron is found in animal tissue. It is a component of                                       Figs (three dried fruits 60g)            2.5     29       17
                               haemoglobin (an oxygen-carrying protein in the blood) and                                       Source: FSA, 2002.


                               VVF, Top Suite, 8 York Cou rt, W i l d e r S t r ee t , B r i s t o l B S2 8QH. Tel: 0117 970 5190. Email: info@vegetarian.org.uk Web: www.vegetarian.org. uk           FS7 1
Iron Absorption                                                          compounds in red wine is unlikely to affect iron balance
Both haem and non-haem iron are absorbed in the small intestine,         significantly (Cook et al., 1995).
but by different mechanisms. It is thought that haem iron is
transported across the intestinal membrane (gut wall) into the           There has been conflicting evidence on the effect of tea-drinking
blood intact where the iron component is removed to enter a              on iron status. However, the research appears to show that tea
common pool of iron along with non-haem iron (Geissler and               consumption does not influence iron status in healthy people who
Powers, 2005). This process occurs regardless of how much iron           eat a well-balanced diet and have adequate iron stores (Temme
there already is in the body (iron status) and what else is in the       and Hoydonck, 2002; Nelson and Poulter, 2004). If you are
diet. This is why haem iron is more easily absorbed than non-haem        concerned about your iron levels and are used to drinking tea
iron; estimates vary from 15-35 per cent for haem iron and two-          with meals (or just breakfast) try switching to freshly squeezed
20 per cent for non-haem iron (Monsen, 1988).                            orange juice instead (because its vitamin C content increases the
                                                                         absorption of iron) and wait at least one hour after eating before
The amount of non-haem iron absorbed in the gut varies widely as         drinking tea.
it is subject to a range of influences including iron status and other
foods present in the diet. A range of dietary factors influence non-     Calcium
haem iron absorption.                                                    Some studies show that serving cow’s milk with a meal can reduce
                                                                         iron absorption. This inhibitory effect is thought to be related to
A high absorption rate is not necessarily a good thing as the body has   the milk protein casein (Hurrell et al., 1989) and calcium
no mechanism for disposing of excess iron. In other words, iron from     (Hallberg et al., 1991). Unlike phytate and tannin, calcium reduces
plant foods is more beneficial to the body because its absorption        non-haem and haem iron absorption (Fairweather-Tait, 2004) and
remains safely regulated. Whereas iron from animal sources can           this inhibitory effect is not negated by vitamin C or other acids.
accumulate to levels which could be harmful (see below).
                                                                         Calcium is thought to inhibit iron absorption by reducing phytate
Fac t o r s t h a t D e cr e a se I r o n A b s o r p t i o n            breakdown. In one study as little as 40 mg of calcium added to 80
Phytate                                                                  grams of flour reduced phytate degradation by 50 per cent
Phytate (inositol hexaphosphate) is found in unrefined grains,           (Hallberg et al., 1991). Calcium also has a direct inhibitory effect
seeds and pulses (which are also a rich source of iron); bran is a       on iron absorption. In the same study, giving 165 mg of calcium
particularly rich source. It is a strong binder of iron and other        (as milk, cheese or calcium chloride) reduced iron absorption by
minerals (including calcium, magnesium and zinc) and can                 50-60 per cent. The authors concluded that the inhibitory effect of
contribute to mineral deficiencies in people whose intake of these       calcium in amounts frequently encountered in normal meals has
nutrients is low. For example, low iron absorption from porridge         important nutritional implications. This doesn’t mean you should
made from rice, maize, wheat, oat or sorghum, contributes to the         limit your calcium intake; calcium is a very important mineral.
high prevalence of iron deficiency in infants from Third World           However, to limit the negative effects of calcium on iron
countries (Hurrell et al., 2003).                                        absorption avoid drinking cow’s milk and taking calcium
                                                                         supplements with food.
There are various ways you can combat the effects of phytate.
Eating foods rich in vitamin C with iron-rich food can help (see         Oxalic Acid
below). Also, cooking can increase the amount of iron available          Oxalic acid is a compound found in many plants such as spinach,
(Viadel et al., 2006; Bishnoi et al., 1994). One study showed that       Swiss chard and beetroot leaves. It also occurs in tea, chocolate
37 out of 48 different vegetables provided more iron after being         and other cocoa products. It can bind with calcium and
cooked (Yang et al., 2002). The available iron in broccoli increased     magnesium to form insoluble salts which reduce the absorption of
five-fold and in cabbage, three-fold.                                    these important minerals. Some work suggests that oxalic acid may
                                                                         also compromise iron absorption. However, recent evidence
Increasing the amount of time bread is fermented also lowers the         suggests that oxalic acid in fruits and vegetables is of minor
phytate content (Nävert et al., 1985). Sprouting grains, seeds and       relevance in iron nutrition (Bonsmann et al., 2008).
pulses is another effective way of reducing phytate as it is released
on germination. Studies show that germinating and dehusking can          Fa c t o r s t h a t I n c r e a s e I r o n A b s o r pt i o n
reduce phytate in rice and mung beans by 92 per cent (Marero et          Vi t a m i n C
al., 1991), and increase iron absorption from various grains and         Vitamin C (ascorbic acid) found in abundance in fruit and
pulses by between 20 and 62 per cent (Hemalatha et al., 2007).           vegetables, can increase the amount of iron absorbed considerably
                                                                         (Hunt et al., 1990; Sharma and Mathur, 1995). It does this by two
Remember though, wholemeal bread and brown rice contain                  mechanisms: converting iron into a soluble, more readily
around two to three times the amount of iron found in white bread        absorbable form and by binding to it, preventing it from forming
and rice (Craig et al., 1994). So even though the percentage of iron     complexes with phytate or tannin (Fairweather-Tait, 2004). The
absorbed from wholegrain foods may be lower, the total amount of         amount of vitamin C in eight strawberries or 200 ml of orange
iron absorbed is similar, making wholegrain foods the healthier          juice (75 mg) can increase iron absorption three- to four-fold
option as they also contain more vitamins, minerals and fibre.           (Craig, 1994). To increase your iron absorption substitute your
                                                                         morning cup of tea or coffee with a glass of freshly squeezed
Polyphenols and Ta n n i n s                                             orange juice. If you are concerned about low iron levels, try to
Polyphenols are a group of chemical substances found in plants           combine vitamin C-containing foods with your iron-rich meal. See
that possess antioxidant properties that may offer potential             suggestions below.
health benefits such as a reduced risk of cardiovascular disease
(CVD) and cancer. Tannins are a type of polyphenol found in              Meat
tea and red wine that bind with non-haem iron to form                    Small amounts of meat (around 50 grams) have been shown to
complexes that may reduce iron absorption (Brune et al., 1989).          increase non-haem iron absorption from meals that contain high
The effect of tannins may be a concern for those who regularly           levels of phytate and are low in vitamin C (Baech et al., 2003).
consume wine with food. However, alcohol may enhance iron                Several groups have tried to identify the elusive ‘meat factor.’
absorption (by stimulating gastric acid secretion) and some              Potential candidates include certain amino acids (the building
researchers conclude that the inhibitory effect of phenolic              blocks of protein) found in meat, which may convert non-haem


                                                                                                                                            2
iron into a more absorbable form. Alternatively, it may be a              Veggie Diets and Iron
component of muscle tissue called L-alpha-glycerophosphocholine           Vegetarian diets have been described as being deficient in iron,
that helps (Armah et al., 2008). However, vitamin C seems to be a         although numerous studies show that when this occurs, it is usually
stronger enhancer of non-haem iron absorption than meat (Baech            due to poor meal planning (Leitzmann, 2005). A well-balanced
et al., 2003) and if vitamin C intake is adequate then meat may           vegetarian or vegan diet provides plenty of iron. In fact, in
have little effect.                                                       Western countries, vegetarian diets can contain as much or more
                                                                          iron than mixed diets containing meat (Harvey et al., 2005; Hunt,
Measuring Iron Status                                                     2003). Vegetarians and vegans, even with a high dietary fibre (and
There are several different ways of assessing the body’s iron status.     hence phytate) intake, have been found to have a similar amount
Two of the most common methods involve measuring haemoglobin              of iron in their diets compared to meat-eaters (Craig, 1994). A
and serum ferritin. Ferric is a term that means containing or             recent study compared iron intake among 33,000 meat-eaters,
having to do with iron, derived from the Latin word ferrum,               10,000 fish-eaters, 18,000 vegetarians and 2,500 vegans and found
meaning ‘iron’. Ferritin is a protein that stores iron for later use by   that the vegans had the highest intake, followed by the fish-eaters
your body. So the amount of ferritin in your blood reflects the           and the vegetarians; the meat-eaters had the lowest intake (Davey,
amount of iron you have tucked away for future use. You can have          et al., 2003).
normal haemoglobin levels, yet low ferritin. Ferritin levels are low
in long-term iron deficiency, or if your body’s protein levels are        Vegetarians tend to have lower iron stores (serum ferritin) than
very low, as in some cases of malnutrition. Conversely, ferritin          meat-eaters. This may be because haem iron is more readily
levels are high in states of long-term iron overload.                     absorbed than non-haem iron, because meat enhances non-haem
                                                                          iron absorption or because vegetarian diets may contain higher
If you think that you might have too little (or too much) iron in         levels of inhibitors of iron absorption such as phytate, tannins and
your blood you can ask for a blood test. In the West, low iron            calcium (Harvey et al., 2005). However, vegetarians have no
levels and anaemia are usually due to long-term or heavy bleeding         greater incidence of iron deficiency anaemia. The British Medical
(in menstruation for example), pregnancy or rapid growth in               Association and the American Dietetic Association agree that
children rather than a poor diet. High iron levels can be due to a        vegetarians are no more likely to suffer from iron deficiency than
genetic condition, extensive blood transfusions or an overdose of         meat eaters (BMA, 1986; American Dietetic Association, 2003).
iron supplements.
                                                                          Although vegetarians have lower iron stores, adverse health effects
 Status indicator    Normal range (per litre of blood)                    have not been demonstrated with varied vegetarian diets in
 Serum ferritin      30-300 micrograms                                    developed countries. In fact, moderately lower iron stores reduce
 Haemoglobin         120-180 grams                                        the risk of some chronic diseases (Hunt, 2003). It is well known
 Source: Sharp, P. 2005.                                                  that many meat eaters are oversupplied with iron, increasing the
                                                                          risk of cardiovascular disease (CVD) and certain cancers
                                                                          (Leitzmann, 2005).
Iron Deficiency
A lack of iron in the body is the most common nutritional problem         Too Much of a Good Thing?
worldwide (Sharp, 2005). In fact a quarter of the world’s                 Excessive iron in the body is toxic. Despite this, there exists a
population may be iron deficient and approximately 500 million            widespread conviction that the more iron in the diet the better. This
people suffer from iron deficiency anaemia (Cook et al., 1994).           is what is still written in some nutrition and dietetic textbooks.
Symptoms include fatigue, pale skin and a weakened immune                 Numerous studies now show that people with high iron stores suffer
system. A reduced ability to concentrate can also lead to problems                                        a higher incidence of cardiovascular
at school for children with iron deficiency anaemia (Grantham-                                               disease (CVD), certain cancers and
McGregor and Ani, 2001).                                                                                     other health problems.

The FSA states that groups that are vulnerable                                                            Iron overload can be caused by an
to iron deficiency include: infants over                                                                 inherited genetic condition
six months, toddlers, adolescents                                                                       (hereditary haemochromatosis),
and pregnant women because of                                                                          which affects one in 250 people (of
their increased requirements                                                                             Northern European descent) (Burke
(FSA, 2003). Older                                                                                          et al., 2000). Normally the liver
people and those                                                                                                stores a small amount of iron
consuming foods                                                                                                   to provide new red blood
that inhibit iron                                                                                                 cells with it. If you absorb
absorption may                                                                                                    excessive amounts of iron (as
suffer due to poor                                                                                                  some people with this
absorption.                                                                                                         condition do) it builds up in
Menstruating                                                                                                       the liver and is deposited in
women and                                                                                                         other tissues and organs. Iron
individuals with                                                                                              overload may cause
pathological blood loss                                                                                 uncomfortable symptoms such as
may also be at risk due to high blood                                                                  nausea, abdominal pain, constipation
losses. For example, one study looking at                                                              and joint pain. It can also lead to liver
menstrual blood loss and diet among                                                                    damage, heart failure and diabetes
women in the UK concluded that menstrual                                                              (NHS Direct, 2008). Men are more at
blood loss was the most significant factor                                                           risk from haemochromatosis because
affecting iron status, although the type of diet                                                     women regularly lose blood (and
did affect iron stores (Harvey et al., 2005). The                                                   therefore iron), during menstruation.
FSA does not identify vegetarians and vegans as                                                    This condition illustrates how you can
a vulnerable group.                                                                               have too much of a good thing.


                                                                                                                                               3
the evidence may even be strong enough to recommend ending iron

 Iron-Rich Recipes                                                        fortification and supplementation and to start advising people to
                                                                          donate blood to reduce their stores of iron. However, others caution
                                                                          that, given the extent of iron deficiency, any decision to reverse iron
 Iron-Rich Recipes                                                        fortification and supplementation policy should be based on
 The following meals will help to boost your iron intake as they          extremely sound science (Sempos, 2002). Clearly more research is
 combine iron-rich foods with foods that help increase iron               needed. The sensible approach is to eat a well-balanced vegetarian
 absorption.                                                              or vegan diet containing plenty of iron-rich plant-based foods.

 Breakfast                                                                Iron and Diabetes
 •   Baked beans and/or scrambled tofu on wholemeal toast                 Up to 65 per cent of patients with haemochromatosis develop
 •   Porridge oats with rice, soya or oat milk and topped with            diabetes (Adams et al., 1991). As people with this condition
     dried fruit (such as figs or prunes) and ground flaxseeds            accumulate iron stores in the body, this has led to speculation that
 •   Freshly squeezed orange or grapefruit juice with the above           iron overload may cause diabetes. An investigation into iron intake
                                                                          and diabetes revealed that while total iron intake was not related to
 Lunch                                                                    diabetes, haem-iron intake from red meat was (Jiang et al., 2004).
 •   Watercress salad with dates, toasted pumpkin seeds and
     slices of orange                                                     Haem-iron is absorbed in an unregulated way and so accumulates
 •   Bean salad (canned mixed beans, celery, olive oil, garlic,           in the body over time. As stated above, iron can catalyse the
     lemon juice, parsley and thyme) with a green salad, cherry           formation of free radicals. These harmful molecules are implicated
     tomatoes and a wholemeal roll                                        in the development of diabetes (Oberley, 1988; Wolff, 1993) and
 •   Wholemeal pitta bread stuffed with houmous, red onion                other diseases. New research also indicates an association between
     and red pepper slices                                                high iron status in pregnant women and gestational diabetes. The
 •   Fruit juice and/or fruit                                             authors of this study conclude that the role of iron excess from
                                                                          iron supplementation in the development of gestational diabetes
 Dinner                                                                   needs to be examined (Afkhami-Ardekani and Rashidi, 2008).
 •   Vegetable stir-fry (broccoli, green pepper, pak-choy, sugar-         Taken together, the research indicates that insulin resistance and
     snap peas, sesame, sunflower and pumpkin seeds and                   diabetes is directly related to excessive iron stores.
     cashew nuts served on a bed of quinoa
 •   Wholemeal spaghetti Bolognese made with soya mince,                  The good news is that vegetarians and vegans have less insulin
     kidney beans, courgettes, onions, tomatoes, peppers,                 resistance and diabetes than meat-eaters (Kuo et al., 2004).
     mushrooms, basil and oregano                                         Remember, a vegan diet provides iron in its non-haem form, which
 •   Spinach and chick pea curry with lentil dhal and a                   is absorbed in a more regulated way than haem-iron. A study
     wholemeal chapatti                                                   comparing 30 vegetarians and 30 meat-eaters showed that
 •   Fruit juice and/or fruit                                             vegetarians had adequate but lower body iron stores compared
                                                                          with meat-eaters. The vegetarians also had less insulin resistance
                                                                          (Hua et al., 2001).
Iron and Heart Disease
The idea that high iron stores can increase the risk of heart disease     In summary, vegetarians and vegans tend to have lower iron stores
was first proposed in the Lancet in 1981 (Sullivan, 1981). Sullivan       than meat-eaters, but have no greater incidence of iron deficiency
proposed that menstrual blood loss could be responsible for the lower     anaemia. Conversely, it is well known that many meat-eaters are
risk of heart disease observed among pre-menstrual women compared         oversupplied with iron, increasing the risk of CVD and cancer
to men of the same age. Since then, other studies have confirmed that     (Leitzmann, 2005).
high iron stores are a risk factor for CVD (Salonen et al., 1992).
                                                                          Baby Blues
As well as menstruation in women, voluntary blood donation is an          For the first six months of life, infants require only breast milk,
important cause of blood loss that can affect iron stores. In 1997,       which contains appropriate amounts of iron (or specially
three different studies showed that regular blood donation reduced        formulated milk). At around six months of age their nutritional
the risk of heart disease and strokes (Tuomainen et al., 1997;            requirements increase and they need more than milk alone. For
Meyers et al., 1997; Kiechl et al., 1997). The loss of iron               example, the daily iron requirement of an infant rises from 4.3mg
associated with giving blood could be the reason for the observed         at four to six months, to 7.8mg at six months. A primary cause of
reduction in risk. More recently another study showed that high-          anaemia in infants is therefore inappropriate weaning – too early,
frequency blood donation was associated with lower iron stores,           too late or an unbalanced diet.
improved vascular function and reduced oxidative stress in blood
donors (Zheng et al., 2005). The theory is that iron promotes the         To make matters worse, cow’s milk allergy can lead to
production of harmful molecules called free radicals that can cause       gastrointestinal bleeding and is a well-recognised cause of rectal
(oxidative) damage to the lining of the arteries. This, in turn,          bleeding in infancy (Willetts et al., 1999). Gastrointestinal bleeding
increases the risk of CVD. These findings lend further support to         from milk allergy often occurs in such small quantities that the
the hypothesis linking high iron stores to CVD.                           blood loss is not noticed, but over time these losses can cause iron
                                                                          deficiency anaemia in infants. In a trial of 52 infants (31 of whom
However, some studies have concluded that there is no association         had been breast fed and 21 fed formula milk), the introduction of
between iron status and CVD. In a letter to the British Medical           cow’s milk rather than formula milk was associated with an
Journal, researchers from Finland countered this argument by              increased blood loss from the intestinal tract and a nutritionally
asserting that all of the negative studies used unreliable measurements   important loss of iron (Ziegler et al., 1990). Frank Oski, former
of iron status (such as serum iron concentration, transferrin iron        paediatrics director at Johns Hopkins School of Medicine, estimates
saturation) or other design problem (Hemilä and Paunio, 1997).            that half the iron deficiency in infants in the US results from cow’s
                                                                          milk-induced gastrointestinal bleeding (Oski, 1996). This represents
So convinced of the link are some researchers that they have              a staggering figure since more than 15 per cent of US infants under
suggested reducing iron stores to reduce the risk of CVD. Some say        the age of two suffer from iron deficiency anaemia.


                                                                                                                                                4
Summary
•    Iron is an essential part of the haemoglobin in red blood cells                     •    In the West, low iron levels and anaemia are usually due to
     which helps carry oxygen to all parts of the body.                                       long-term or heavy bleeding (in menstruation for example),
•    The UK recommended nutrient intake for iron in adult males is                            pregnancy or rapid growth in children rather than a poor diet.
     8.7 mg per day and for women up to 50 it is 14.8 mg per day.                        •    High iron levels can be due to a genetic condition,
•    Most people can get all the iron they need by eating a varied                            extensive blood transfusions or (more rarely) an overdose of
     and balanced diet.                                                                       iron supplements.
•    Too much iron can lead to constipation, nausea, vomiting                            •    Low iron in the body is the most common nutritional problem
     and stomach pain and very high doses can be fatal, particularly                          worldwide. Symptoms include fatigue, pale skin, a weakened
     in children.                                                                             immune system and a reduced ability to concentrate.
•    Ferrous sulphate as a supplement can lead to constipation                           •    Vulnerable groups include: infants over six months, toddlers,
     and nausea.                                                                              adolescents and pregnant as well as older people and those
•    There are two types of iron in food: haem iron from meat and                             consuming foods that inhibit iron absorption. Menstruating
     non-haem iron from plant foods.                                                          women and people with pathological blood loss may also be
•    Most iron in the diet (over 75 per cent) comes from plant-                               at risk.
     based foods.                                                                        •    A well-balanced vegetarian or vegan diet provides as much or
•    Good sources of iron include pulses (peas, beans and lentils),                           more iron than mixed diets containing meat.
     soya bean products (soya milk and tofu), dark green leafy                           •    Vegetarians tend to have lower iron stores than meat-eaters but
     vegetables (parsley, broccoli, pak choy and watercress),                                 have no greater incidence of iron deficiency anaemia.
     fortified breakfast cereals, wholegrains (wholemeal bread,                          •    Moderately lower iron stores may reduce the risk of some
     wholemeal pasta), dried fruits (raisins, prunes, apricots and                            chronic diseases.
     figs) black treacle and plain dark chocolate.                                       •    Excessive iron in the body is toxic; symptoms include nausea,
•    Haem iron is absorbed regardless of both iron status and what                            abdominal pain, constipation and joint pain. It can also lead to
     else is in the diet.                                                                     liver damage, heart failure and diabetes.
•    Non-haem iron absorption is subject to a range of influences                        •    High iron stores may be a risk factor for CVD, insulin
     including iron status and other foods in the diet.                                       resistance and diabetes.
•    Iron from animal sources and supplements can accumulate to                          •    Anaemia in infants may be caused by inappropriate weaning or
     harmful levels.                                                                          cow’s milk allergy induced gastrointestinal bleeding.
•    Phytate from unrefined grains, seeds and pulses binds iron and
     can reduce absorption. Phytate can be reduced by fermenting,
     cooking and sprouting.
•    Tannins in tea may reduce iron absorption. Avoid drinking tea
     with meals.
•    Cow’s milk (casein and calcium) can reduce iron absorption.
     Avoid drinking cow’s milk and taking calcium supplements
     with food.
•    Oxalic acid in spinach, Swiss chard and beetroot is of minor
     relevance in iron nutrition.
•    Soya protein may decrease iron absorption although this effect
     can be reduced by lowering the amount of phytate present.
•    Vitamin C in fruit and vegetables can increase iron absorption
     considerably; the amount of vitamin C in 200 ml of orange
     juice can increase iron absorption three- to four-fold.
•    Small amounts of meat may increase non-haem iron absorption
     from high-phytate, low-vitamin C meals that contain high
     levels of phytate, but vitamin C is a stronger enhancer of non-
     haem iron absorption than meat.
•    Iron status is assessed by measuring haemoglobin and
     serum ferritin.




References
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                                                                                                                   .
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70-75.
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                                            .
                                                                                                           Join the VVF
iron stores and the risk of carotid atherosclerosis: prospective results from the                          The Vegetarian & Vegan Foundation can help you and your
Bruneck study. Circulation. 96, 3300-3307.                                                                 family to start eating healthily – giving everyone the chance of a
Kuo, C.S., Lai, N.S., Ho, L.T. and Lin, C.L. 2004. Insulin sensitivity in Chinese                          brighter future.
ovo-lactovegetarians compared with omnivores. European Journal of Clinical
Nutrition. 258 (2) 312-316.                                                                                For just £15 per year, you’ll receive the colourful, easy-to-read
Leitzmann C., 2005. Vegetarian diets: what are the advantages? Forum on                                    Veggiehealth magazine, five fact sheets in a special folder and
Nutrition. (57) 147-156).                                                                                  you’ll be entitled to free health advice from our nutritionists.
Marero, L.M., Payumo, E.M., Aguinaldo, A.R., Matsumoto, I. and Homma, S.
1991. The antinutritional factors in weaning foods prepared from germinated                                To join the VVF either write to us, telephone or join online.
legumes and cereals. Lebensmittelwissenschaft Technol. 24, 177–81.
Meyers, D.G., Strickland, D., Maloley, P.A., Seburg, J.K., Wilson, J.E. and                                VVF, Top Suite, 8 York Court, Wilder Street, Bristol BS2 8QH.
McManus, B.F. 1997. Possible association of a reduction in cardiovascular events                           Tel: 0117 970 5190. Email: info@vegetarian.org.uk
with blood donation. Heart. 78, 188-193.                                                                   Web: www.vegetarian.org.uk
Monsen, E.R. 1988. Iron nutrition and absorption: dietary factors which impact
iron bioavailability. Journal of the American Dietetic Association. 88 (7) 786-90.
                                                                                                                                             VVF – Feeding you the Facts
T h i s i s o n e i n a s e r i e s o f V V F f a c t s h e e t s . Fo r d e t a i l s c o n t a c t :
VVF, Top Suite, 8 Yor k Co urt, W i l d e r S t r e et , B r i s t o l B S2 8QH. Tel: 0117 970 5190. Email: info@vegetarian.org.uk Web: www.vegetarian. org. uk                               6

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Why Plant Iron is Best: The Facts on Iron Deficiency

  • 1. Ironing out the Facts Why Plant Iron is Best By Dr Justine Butler VVF Senior Health Campaigner One of the commonest food myths is that vegetarians and vegans have a higher risk of iron deficiency anaemia because they don’t eat meat. This is simply not the case and many major health organisations a g r e e – t h e B r i t i s h M e d i c a l A s s o c i a t i o n , t h e Wo r l d H e a l t h O r g a n i s a t i o n a n d t h e A m e r i c a n D i e t e t i c A s s o c i a t i o n . H o w e v e r, so m e so - c al l ed ‘ h e al t h ’ o r g an i s a t i o n s, h e a l t h p r o f e ss io n a ls a n d f o o d w r it e r s p e r s is t in promoting red meat as the best source of iron. They invariably fail to mention the health risks associated with the type of iron found in meat as opposed to iron from plants. This fact sheet debunks the We s t e r n m y t h o f p r o m o t i n g m e a t a s a g o o d s o u r c e o f i r o n a n d e x p l a i n s w h y p l a n t i r o n i s b e s t . W h a t i s I r o n a n d W h y D o We N e e d I t ? myoglobin (oxygen-carrying molecules in muscle) and makes up Iron is an essential component of the pigment haemoglobin, found around half the iron found in red meat, poultry and fish. in red blood cells. It helps carry oxygen to all parts of the body and is essential for life. If iron intake is low, the amount of Non-Haem Iron makes up the other half of the iron in animal haemoglobin in the red blood cells can fall leading to iron- tissue and all of the iron found in plant foods, dairy foods (which deficiency anaemia. Symptoms include tiredness, weakness, feeling contain a very small amount) and eggs. Around 90 per cent of cold and an inability to concentrate. the iron in the average British diet is non-haem iron; the other 10 per cent comes mainly from the haemoglobin of meat (Bull H o w M u c h I r o n D o We N e e d ? and Buss, 1980). The UK recommended nutrient intake (RNI) for iron in adult males is 8.7 mg per day and for women up to the age of 50 it is The UK’s Food Standards Agency (FSA) looked at sources of iron 14.8 mg per day (Department of Health, 1991). Women have in their 2003 National Diet and Nutrition Survey and found that higher requirements as they lose iron during menstruation. The 17 per cent of total (haem and non-haem) iron came from meat, RNIs for younger and older groups are given below. three per cent from fish, three from eggs and one per cent from dairy foods. The vast majority (over 75 per cent) of iron in the Recommended daily intakes in the UK diet came from plant-based foods. Cereals (such as wholegrain Age mg iron pasta, brown rice and wholemeal bread) made the single biggest 0-3 months 1.7 contribution at 44 per cent (FSA, 2003a). This demonstrates the 4-6 months 4.3 important contribution plant foods make to iron intake in meat- 7-12 months 7.8 eaters and veggies alike. 1-3 years 6.9 4-6 years 6.1 T h e I r o n C o n t e n t o f P l a n t Fo o d s 7-10 years 8.7 The table below shows that there is no shortage of iron in plant Men aged 11-18 11.3 foods. Pulses (peas, beans and lentils) and soya bean products Men aged 19 and over 8.7 (such as soya milk and tofu) provide an excellent source. As do Women aged 11-50 14.8 dark green leafy vegetables (such as broccoli, pak choy and Pregnant women 27.0 watercress), fortified breakfast cereals, wholegrains (such as Postmenopausal women (50+ years) 8.7 wholemeal bread, brown rice and wholemeal pasta), dried fruits Source: Department of Health, 1991. (such as raisins, prunes, apricots and figs) black treacle and plain dark chocolate. Supplements Supplementing the diet with too much iron can lead to constipation, T h e I r o n C o n t e n t o f S e l e c t e d P l a n t Fo o d s nausea, vomiting and stomach pain and very high doses can be fatal, Food (medium portions) mg iron Percentage of daily RNI particularly in children (FSA, 2003). Furthermore, not all Men Women supplements are the same. For example, iron (ferrous) sulphate (8.7 mg) (14.8 mg) (which many GPs prescribe) can cause nausea and constipation and Baked beans (135g) 1.9 22 13 may interfere with vitamin E absorption. However, other forms are Bran flakes (40g) 9.7 111 66 much better-tolerated such as iron picolinate, iron citrate and iron Tofu (100g) 3.5 40 24 bisglycinate. Plant forms of iron supplements such as Floradix and Kidney beans (90g) 1.8 16 12 Floravital, sold in health food shops, are gentle on the system. The Red lentils (120g) 2.9 33 20 VVF recommends that you seek the advice of a nutritional therapist Spaghetti (220g) 3.1 36 21 before taking supplements. Most people can get all the iron they Brown rice (180g) 0.9 10 6 need by eating a varied and balanced diet. Curly kale (95g) 1.9 22 13 Chari ty numb er : 1 037 486 Broccoli (85g) 0.9 10 6 Type s o f Ir o n Sesame seeds (12g) 1.3 15 9 There are two types of iron in food: Pumpkin seeds (12g) 1.8 21 12 Prunes (six dried fruits 48g) 1.2 14 8 Haem Iron is found in animal tissue. It is a component of Figs (three dried fruits 60g) 2.5 29 17 haemoglobin (an oxygen-carrying protein in the blood) and Source: FSA, 2002. VVF, Top Suite, 8 York Cou rt, W i l d e r S t r ee t , B r i s t o l B S2 8QH. Tel: 0117 970 5190. Email: info@vegetarian.org.uk Web: www.vegetarian.org. uk FS7 1
  • 2. Iron Absorption compounds in red wine is unlikely to affect iron balance Both haem and non-haem iron are absorbed in the small intestine, significantly (Cook et al., 1995). but by different mechanisms. It is thought that haem iron is transported across the intestinal membrane (gut wall) into the There has been conflicting evidence on the effect of tea-drinking blood intact where the iron component is removed to enter a on iron status. However, the research appears to show that tea common pool of iron along with non-haem iron (Geissler and consumption does not influence iron status in healthy people who Powers, 2005). This process occurs regardless of how much iron eat a well-balanced diet and have adequate iron stores (Temme there already is in the body (iron status) and what else is in the and Hoydonck, 2002; Nelson and Poulter, 2004). If you are diet. This is why haem iron is more easily absorbed than non-haem concerned about your iron levels and are used to drinking tea iron; estimates vary from 15-35 per cent for haem iron and two- with meals (or just breakfast) try switching to freshly squeezed 20 per cent for non-haem iron (Monsen, 1988). orange juice instead (because its vitamin C content increases the absorption of iron) and wait at least one hour after eating before The amount of non-haem iron absorbed in the gut varies widely as drinking tea. it is subject to a range of influences including iron status and other foods present in the diet. A range of dietary factors influence non- Calcium haem iron absorption. Some studies show that serving cow’s milk with a meal can reduce iron absorption. This inhibitory effect is thought to be related to A high absorption rate is not necessarily a good thing as the body has the milk protein casein (Hurrell et al., 1989) and calcium no mechanism for disposing of excess iron. In other words, iron from (Hallberg et al., 1991). Unlike phytate and tannin, calcium reduces plant foods is more beneficial to the body because its absorption non-haem and haem iron absorption (Fairweather-Tait, 2004) and remains safely regulated. Whereas iron from animal sources can this inhibitory effect is not negated by vitamin C or other acids. accumulate to levels which could be harmful (see below). Calcium is thought to inhibit iron absorption by reducing phytate Fac t o r s t h a t D e cr e a se I r o n A b s o r p t i o n breakdown. In one study as little as 40 mg of calcium added to 80 Phytate grams of flour reduced phytate degradation by 50 per cent Phytate (inositol hexaphosphate) is found in unrefined grains, (Hallberg et al., 1991). Calcium also has a direct inhibitory effect seeds and pulses (which are also a rich source of iron); bran is a on iron absorption. In the same study, giving 165 mg of calcium particularly rich source. It is a strong binder of iron and other (as milk, cheese or calcium chloride) reduced iron absorption by minerals (including calcium, magnesium and zinc) and can 50-60 per cent. The authors concluded that the inhibitory effect of contribute to mineral deficiencies in people whose intake of these calcium in amounts frequently encountered in normal meals has nutrients is low. For example, low iron absorption from porridge important nutritional implications. This doesn’t mean you should made from rice, maize, wheat, oat or sorghum, contributes to the limit your calcium intake; calcium is a very important mineral. high prevalence of iron deficiency in infants from Third World However, to limit the negative effects of calcium on iron countries (Hurrell et al., 2003). absorption avoid drinking cow’s milk and taking calcium supplements with food. There are various ways you can combat the effects of phytate. Eating foods rich in vitamin C with iron-rich food can help (see Oxalic Acid below). Also, cooking can increase the amount of iron available Oxalic acid is a compound found in many plants such as spinach, (Viadel et al., 2006; Bishnoi et al., 1994). One study showed that Swiss chard and beetroot leaves. It also occurs in tea, chocolate 37 out of 48 different vegetables provided more iron after being and other cocoa products. It can bind with calcium and cooked (Yang et al., 2002). The available iron in broccoli increased magnesium to form insoluble salts which reduce the absorption of five-fold and in cabbage, three-fold. these important minerals. Some work suggests that oxalic acid may also compromise iron absorption. However, recent evidence Increasing the amount of time bread is fermented also lowers the suggests that oxalic acid in fruits and vegetables is of minor phytate content (Nävert et al., 1985). Sprouting grains, seeds and relevance in iron nutrition (Bonsmann et al., 2008). pulses is another effective way of reducing phytate as it is released on germination. Studies show that germinating and dehusking can Fa c t o r s t h a t I n c r e a s e I r o n A b s o r pt i o n reduce phytate in rice and mung beans by 92 per cent (Marero et Vi t a m i n C al., 1991), and increase iron absorption from various grains and Vitamin C (ascorbic acid) found in abundance in fruit and pulses by between 20 and 62 per cent (Hemalatha et al., 2007). vegetables, can increase the amount of iron absorbed considerably (Hunt et al., 1990; Sharma and Mathur, 1995). It does this by two Remember though, wholemeal bread and brown rice contain mechanisms: converting iron into a soluble, more readily around two to three times the amount of iron found in white bread absorbable form and by binding to it, preventing it from forming and rice (Craig et al., 1994). So even though the percentage of iron complexes with phytate or tannin (Fairweather-Tait, 2004). The absorbed from wholegrain foods may be lower, the total amount of amount of vitamin C in eight strawberries or 200 ml of orange iron absorbed is similar, making wholegrain foods the healthier juice (75 mg) can increase iron absorption three- to four-fold option as they also contain more vitamins, minerals and fibre. (Craig, 1994). To increase your iron absorption substitute your morning cup of tea or coffee with a glass of freshly squeezed Polyphenols and Ta n n i n s orange juice. If you are concerned about low iron levels, try to Polyphenols are a group of chemical substances found in plants combine vitamin C-containing foods with your iron-rich meal. See that possess antioxidant properties that may offer potential suggestions below. health benefits such as a reduced risk of cardiovascular disease (CVD) and cancer. Tannins are a type of polyphenol found in Meat tea and red wine that bind with non-haem iron to form Small amounts of meat (around 50 grams) have been shown to complexes that may reduce iron absorption (Brune et al., 1989). increase non-haem iron absorption from meals that contain high The effect of tannins may be a concern for those who regularly levels of phytate and are low in vitamin C (Baech et al., 2003). consume wine with food. However, alcohol may enhance iron Several groups have tried to identify the elusive ‘meat factor.’ absorption (by stimulating gastric acid secretion) and some Potential candidates include certain amino acids (the building researchers conclude that the inhibitory effect of phenolic blocks of protein) found in meat, which may convert non-haem 2
  • 3. iron into a more absorbable form. Alternatively, it may be a Veggie Diets and Iron component of muscle tissue called L-alpha-glycerophosphocholine Vegetarian diets have been described as being deficient in iron, that helps (Armah et al., 2008). However, vitamin C seems to be a although numerous studies show that when this occurs, it is usually stronger enhancer of non-haem iron absorption than meat (Baech due to poor meal planning (Leitzmann, 2005). A well-balanced et al., 2003) and if vitamin C intake is adequate then meat may vegetarian or vegan diet provides plenty of iron. In fact, in have little effect. Western countries, vegetarian diets can contain as much or more iron than mixed diets containing meat (Harvey et al., 2005; Hunt, Measuring Iron Status 2003). Vegetarians and vegans, even with a high dietary fibre (and There are several different ways of assessing the body’s iron status. hence phytate) intake, have been found to have a similar amount Two of the most common methods involve measuring haemoglobin of iron in their diets compared to meat-eaters (Craig, 1994). A and serum ferritin. Ferric is a term that means containing or recent study compared iron intake among 33,000 meat-eaters, having to do with iron, derived from the Latin word ferrum, 10,000 fish-eaters, 18,000 vegetarians and 2,500 vegans and found meaning ‘iron’. Ferritin is a protein that stores iron for later use by that the vegans had the highest intake, followed by the fish-eaters your body. So the amount of ferritin in your blood reflects the and the vegetarians; the meat-eaters had the lowest intake (Davey, amount of iron you have tucked away for future use. You can have et al., 2003). normal haemoglobin levels, yet low ferritin. Ferritin levels are low in long-term iron deficiency, or if your body’s protein levels are Vegetarians tend to have lower iron stores (serum ferritin) than very low, as in some cases of malnutrition. Conversely, ferritin meat-eaters. This may be because haem iron is more readily levels are high in states of long-term iron overload. absorbed than non-haem iron, because meat enhances non-haem iron absorption or because vegetarian diets may contain higher If you think that you might have too little (or too much) iron in levels of inhibitors of iron absorption such as phytate, tannins and your blood you can ask for a blood test. In the West, low iron calcium (Harvey et al., 2005). However, vegetarians have no levels and anaemia are usually due to long-term or heavy bleeding greater incidence of iron deficiency anaemia. The British Medical (in menstruation for example), pregnancy or rapid growth in Association and the American Dietetic Association agree that children rather than a poor diet. High iron levels can be due to a vegetarians are no more likely to suffer from iron deficiency than genetic condition, extensive blood transfusions or an overdose of meat eaters (BMA, 1986; American Dietetic Association, 2003). iron supplements. Although vegetarians have lower iron stores, adverse health effects Status indicator Normal range (per litre of blood) have not been demonstrated with varied vegetarian diets in Serum ferritin 30-300 micrograms developed countries. In fact, moderately lower iron stores reduce Haemoglobin 120-180 grams the risk of some chronic diseases (Hunt, 2003). It is well known Source: Sharp, P. 2005. that many meat eaters are oversupplied with iron, increasing the risk of cardiovascular disease (CVD) and certain cancers (Leitzmann, 2005). Iron Deficiency A lack of iron in the body is the most common nutritional problem Too Much of a Good Thing? worldwide (Sharp, 2005). In fact a quarter of the world’s Excessive iron in the body is toxic. Despite this, there exists a population may be iron deficient and approximately 500 million widespread conviction that the more iron in the diet the better. This people suffer from iron deficiency anaemia (Cook et al., 1994). is what is still written in some nutrition and dietetic textbooks. Symptoms include fatigue, pale skin and a weakened immune Numerous studies now show that people with high iron stores suffer system. A reduced ability to concentrate can also lead to problems a higher incidence of cardiovascular at school for children with iron deficiency anaemia (Grantham- disease (CVD), certain cancers and McGregor and Ani, 2001). other health problems. The FSA states that groups that are vulnerable Iron overload can be caused by an to iron deficiency include: infants over inherited genetic condition six months, toddlers, adolescents (hereditary haemochromatosis), and pregnant women because of which affects one in 250 people (of their increased requirements Northern European descent) (Burke (FSA, 2003). Older et al., 2000). Normally the liver people and those stores a small amount of iron consuming foods to provide new red blood that inhibit iron cells with it. If you absorb absorption may excessive amounts of iron (as suffer due to poor some people with this absorption. condition do) it builds up in Menstruating the liver and is deposited in women and other tissues and organs. Iron individuals with overload may cause pathological blood loss uncomfortable symptoms such as may also be at risk due to high blood nausea, abdominal pain, constipation losses. For example, one study looking at and joint pain. It can also lead to liver menstrual blood loss and diet among damage, heart failure and diabetes women in the UK concluded that menstrual (NHS Direct, 2008). Men are more at blood loss was the most significant factor risk from haemochromatosis because affecting iron status, although the type of diet women regularly lose blood (and did affect iron stores (Harvey et al., 2005). The therefore iron), during menstruation. FSA does not identify vegetarians and vegans as This condition illustrates how you can a vulnerable group. have too much of a good thing. 3
  • 4. the evidence may even be strong enough to recommend ending iron Iron-Rich Recipes fortification and supplementation and to start advising people to donate blood to reduce their stores of iron. However, others caution that, given the extent of iron deficiency, any decision to reverse iron Iron-Rich Recipes fortification and supplementation policy should be based on The following meals will help to boost your iron intake as they extremely sound science (Sempos, 2002). Clearly more research is combine iron-rich foods with foods that help increase iron needed. The sensible approach is to eat a well-balanced vegetarian absorption. or vegan diet containing plenty of iron-rich plant-based foods. Breakfast Iron and Diabetes • Baked beans and/or scrambled tofu on wholemeal toast Up to 65 per cent of patients with haemochromatosis develop • Porridge oats with rice, soya or oat milk and topped with diabetes (Adams et al., 1991). As people with this condition dried fruit (such as figs or prunes) and ground flaxseeds accumulate iron stores in the body, this has led to speculation that • Freshly squeezed orange or grapefruit juice with the above iron overload may cause diabetes. An investigation into iron intake and diabetes revealed that while total iron intake was not related to Lunch diabetes, haem-iron intake from red meat was (Jiang et al., 2004). • Watercress salad with dates, toasted pumpkin seeds and slices of orange Haem-iron is absorbed in an unregulated way and so accumulates • Bean salad (canned mixed beans, celery, olive oil, garlic, in the body over time. As stated above, iron can catalyse the lemon juice, parsley and thyme) with a green salad, cherry formation of free radicals. These harmful molecules are implicated tomatoes and a wholemeal roll in the development of diabetes (Oberley, 1988; Wolff, 1993) and • Wholemeal pitta bread stuffed with houmous, red onion other diseases. New research also indicates an association between and red pepper slices high iron status in pregnant women and gestational diabetes. The • Fruit juice and/or fruit authors of this study conclude that the role of iron excess from iron supplementation in the development of gestational diabetes Dinner needs to be examined (Afkhami-Ardekani and Rashidi, 2008). • Vegetable stir-fry (broccoli, green pepper, pak-choy, sugar- Taken together, the research indicates that insulin resistance and snap peas, sesame, sunflower and pumpkin seeds and diabetes is directly related to excessive iron stores. cashew nuts served on a bed of quinoa • Wholemeal spaghetti Bolognese made with soya mince, The good news is that vegetarians and vegans have less insulin kidney beans, courgettes, onions, tomatoes, peppers, resistance and diabetes than meat-eaters (Kuo et al., 2004). mushrooms, basil and oregano Remember, a vegan diet provides iron in its non-haem form, which • Spinach and chick pea curry with lentil dhal and a is absorbed in a more regulated way than haem-iron. A study wholemeal chapatti comparing 30 vegetarians and 30 meat-eaters showed that • Fruit juice and/or fruit vegetarians had adequate but lower body iron stores compared with meat-eaters. The vegetarians also had less insulin resistance (Hua et al., 2001). Iron and Heart Disease The idea that high iron stores can increase the risk of heart disease In summary, vegetarians and vegans tend to have lower iron stores was first proposed in the Lancet in 1981 (Sullivan, 1981). Sullivan than meat-eaters, but have no greater incidence of iron deficiency proposed that menstrual blood loss could be responsible for the lower anaemia. Conversely, it is well known that many meat-eaters are risk of heart disease observed among pre-menstrual women compared oversupplied with iron, increasing the risk of CVD and cancer to men of the same age. Since then, other studies have confirmed that (Leitzmann, 2005). high iron stores are a risk factor for CVD (Salonen et al., 1992). Baby Blues As well as menstruation in women, voluntary blood donation is an For the first six months of life, infants require only breast milk, important cause of blood loss that can affect iron stores. In 1997, which contains appropriate amounts of iron (or specially three different studies showed that regular blood donation reduced formulated milk). At around six months of age their nutritional the risk of heart disease and strokes (Tuomainen et al., 1997; requirements increase and they need more than milk alone. For Meyers et al., 1997; Kiechl et al., 1997). The loss of iron example, the daily iron requirement of an infant rises from 4.3mg associated with giving blood could be the reason for the observed at four to six months, to 7.8mg at six months. A primary cause of reduction in risk. More recently another study showed that high- anaemia in infants is therefore inappropriate weaning – too early, frequency blood donation was associated with lower iron stores, too late or an unbalanced diet. improved vascular function and reduced oxidative stress in blood donors (Zheng et al., 2005). The theory is that iron promotes the To make matters worse, cow’s milk allergy can lead to production of harmful molecules called free radicals that can cause gastrointestinal bleeding and is a well-recognised cause of rectal (oxidative) damage to the lining of the arteries. This, in turn, bleeding in infancy (Willetts et al., 1999). Gastrointestinal bleeding increases the risk of CVD. These findings lend further support to from milk allergy often occurs in such small quantities that the the hypothesis linking high iron stores to CVD. blood loss is not noticed, but over time these losses can cause iron deficiency anaemia in infants. In a trial of 52 infants (31 of whom However, some studies have concluded that there is no association had been breast fed and 21 fed formula milk), the introduction of between iron status and CVD. In a letter to the British Medical cow’s milk rather than formula milk was associated with an Journal, researchers from Finland countered this argument by increased blood loss from the intestinal tract and a nutritionally asserting that all of the negative studies used unreliable measurements important loss of iron (Ziegler et al., 1990). Frank Oski, former of iron status (such as serum iron concentration, transferrin iron paediatrics director at Johns Hopkins School of Medicine, estimates saturation) or other design problem (Hemilä and Paunio, 1997). that half the iron deficiency in infants in the US results from cow’s milk-induced gastrointestinal bleeding (Oski, 1996). This represents So convinced of the link are some researchers that they have a staggering figure since more than 15 per cent of US infants under suggested reducing iron stores to reduce the risk of CVD. Some say the age of two suffer from iron deficiency anaemia. 4
  • 5. Summary • Iron is an essential part of the haemoglobin in red blood cells • In the West, low iron levels and anaemia are usually due to which helps carry oxygen to all parts of the body. long-term or heavy bleeding (in menstruation for example), • The UK recommended nutrient intake for iron in adult males is pregnancy or rapid growth in children rather than a poor diet. 8.7 mg per day and for women up to 50 it is 14.8 mg per day. • High iron levels can be due to a genetic condition, • Most people can get all the iron they need by eating a varied extensive blood transfusions or (more rarely) an overdose of and balanced diet. iron supplements. • Too much iron can lead to constipation, nausea, vomiting • Low iron in the body is the most common nutritional problem and stomach pain and very high doses can be fatal, particularly worldwide. Symptoms include fatigue, pale skin, a weakened in children. immune system and a reduced ability to concentrate. • Ferrous sulphate as a supplement can lead to constipation • Vulnerable groups include: infants over six months, toddlers, and nausea. adolescents and pregnant as well as older people and those • There are two types of iron in food: haem iron from meat and consuming foods that inhibit iron absorption. Menstruating non-haem iron from plant foods. women and people with pathological blood loss may also be • Most iron in the diet (over 75 per cent) comes from plant- at risk. based foods. • A well-balanced vegetarian or vegan diet provides as much or • Good sources of iron include pulses (peas, beans and lentils), more iron than mixed diets containing meat. soya bean products (soya milk and tofu), dark green leafy • Vegetarians tend to have lower iron stores than meat-eaters but vegetables (parsley, broccoli, pak choy and watercress), have no greater incidence of iron deficiency anaemia. fortified breakfast cereals, wholegrains (wholemeal bread, • Moderately lower iron stores may reduce the risk of some wholemeal pasta), dried fruits (raisins, prunes, apricots and chronic diseases. figs) black treacle and plain dark chocolate. • Excessive iron in the body is toxic; symptoms include nausea, • Haem iron is absorbed regardless of both iron status and what abdominal pain, constipation and joint pain. It can also lead to else is in the diet. liver damage, heart failure and diabetes. • Non-haem iron absorption is subject to a range of influences • High iron stores may be a risk factor for CVD, insulin including iron status and other foods in the diet. resistance and diabetes. • Iron from animal sources and supplements can accumulate to • Anaemia in infants may be caused by inappropriate weaning or harmful levels. cow’s milk allergy induced gastrointestinal bleeding. • Phytate from unrefined grains, seeds and pulses binds iron and can reduce absorption. Phytate can be reduced by fermenting, cooking and sprouting. • Tannins in tea may reduce iron absorption. Avoid drinking tea with meals. • Cow’s milk (casein and calcium) can reduce iron absorption. Avoid drinking cow’s milk and taking calcium supplements with food. • Oxalic acid in spinach, Swiss chard and beetroot is of minor relevance in iron nutrition. • Soya protein may decrease iron absorption although this effect can be reduced by lowering the amount of phytate present. • Vitamin C in fruit and vegetables can increase iron absorption considerably; the amount of vitamin C in 200 ml of orange juice can increase iron absorption three- to four-fold. • Small amounts of meat may increase non-haem iron absorption from high-phytate, low-vitamin C meals that contain high levels of phytate, but vitamin C is a stronger enhancer of non- haem iron absorption than meat. • Iron status is assessed by measuring haemoglobin and serum ferritin. References Adams, P.C., Kertesz, A.E. and Valberg, L.S. 1991. Clinical presentation of Bishnoi, S., Khetarpaul, N. and Yadav, R.K. 1994. Effect of domestic processing hemochromatosis: a changing scene. American Journal of Medicine. 90, 445–9. and cooking methods on phytic acid and polyphenol contents of pea cultivars Afkhami-Ardekani, M. and Rashidi, M. 2008. Iron status in women with and (Pisum sativum). Plant Foods for Human Nutrition. 45 (4) 381-388. without gestational diabetes mellitus. Journal of Diabetes and its Complications. BMA, 1986. Diet, nutrition and health. BMA Report 4.11. 2008 Jan 4. [Epub ahead of print]. Bonsmann (genannt), S.S., Walczyk, T., Renggli, S. and Hurrell, R.F. 2008. American Dietetic Association; Dieticians of Canada. 2003. Position of the Oxalic acid does not influence nonhaem iron absorption in humans: a comparison American Dietetic Association and Dieticians of Canada: Vegetarian diets. Journal of kale and spinach meals. European Journal of Clinical Nutrition. 62 (3) 336-341. of the American Dietetic Association. 103 (6) 748-65. Brune, M., Rossander, L. and Hallberg, L. 1989. 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Upper Levels for Vitamins and Minerals. London: Food Standards Agency. Sempos C.T. 2002. Do body iron stores increase the risk of developing coronary FSA, 2003a. Henderson, L., Irving, K., Gregory, J., Bates, C.J., Prentice, A., Perks, J., heart disease? American Journal of Clinical Nutrition. 76, 3, 501-503. Swan, G. and Farron, M. National Diet and Nutrition Survey: adults aged 19 to 64 Sharma, D.C. and Mathur, R. 1995. Correction of anemia and iron deficiency in years: Vitamin and mineral intake and urinary analytes. London: TSO. Volume 3. vegetarians by administration of ascorbic acid. Indian Journal of Physiology and Geissler, C. and Powers, H. eds. 2005. Human Nutrition. 11th ed. [CD-ROM] Pharmacology. 39 (4) 403-406. London: Elsevier Churchill Livingstone. Figure 12.3. Sharp, P 2005. Minerals and trace elements. In: Geissler, C. and Powers, H. eds. . Grantham-McGregor, S. and Ani, C. 2001. A review of studies on the effect of Human Nutrition. 11th edition. 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(2005). Iron Stores and Hunt, J.R. 2003. Bioavailability of iron, zinc, and other trace minerals from Vascular Function in Voluntary Blood Donors. Arteriosclerosis, Thrombosis, and vegetarian diets. American Journal of Clinical Nutrition. 78 (3) 633S-639S. Vascular Biology. 25: 1577-1583. Hurrell, R.F., Lynch, S.R., Trinidad, T.P Dassenko, S.A. and Cook, J.D. 1989. ., Ziegler, E.E., Fomon, S.J., Nelson, S.E., Rebouche, C.J., Edwards, B.B., Iron absorption in humans as influenced by bovine milk proteins. American Rogers, R.R. and Lehman, L.J. 1990. Cow milk feeding in infancy: further Journal of Clinical Nutrition. 49, 546-552. observations on blood loss from the gastrointestinal tract. The Journal of Hurrell, R.F., Reddy, M.B., Juillerat, M.A. and Cook, J.D. 2003. Degradation of Pediatrics. 116 (1) 11-8. phytic acid in cereal porridges improves iron absorption by human subjects. American Journal of Clinical Nutrition. 77 (5) 1213-1219. Jiang, R., Ma, J., Ascherio, A., Stampfer, M.J., Willett, W and Hu, F.B. 2004. .C. Dietary iron intake and blood donations in relation to risk of type 2 diabetes in men: a prospective cohort study. American Journal of Clinical Nutrition. 79 (1) 70-75. Kiechl, S., Willeit, J., Egger, G., Poewe, W And Oberhollenzer, F. 1997. Body . Join the VVF iron stores and the risk of carotid atherosclerosis: prospective results from the The Vegetarian & Vegan Foundation can help you and your Bruneck study. Circulation. 96, 3300-3307. family to start eating healthily – giving everyone the chance of a Kuo, C.S., Lai, N.S., Ho, L.T. and Lin, C.L. 2004. Insulin sensitivity in Chinese brighter future. ovo-lactovegetarians compared with omnivores. European Journal of Clinical Nutrition. 258 (2) 312-316. For just £15 per year, you’ll receive the colourful, easy-to-read Leitzmann C., 2005. Vegetarian diets: what are the advantages? Forum on Veggiehealth magazine, five fact sheets in a special folder and Nutrition. (57) 147-156). you’ll be entitled to free health advice from our nutritionists. Marero, L.M., Payumo, E.M., Aguinaldo, A.R., Matsumoto, I. and Homma, S. 1991. The antinutritional factors in weaning foods prepared from germinated To join the VVF either write to us, telephone or join online. legumes and cereals. Lebensmittelwissenschaft Technol. 24, 177–81. Meyers, D.G., Strickland, D., Maloley, P.A., Seburg, J.K., Wilson, J.E. and VVF, Top Suite, 8 York Court, Wilder Street, Bristol BS2 8QH. McManus, B.F. 1997. Possible association of a reduction in cardiovascular events Tel: 0117 970 5190. Email: info@vegetarian.org.uk with blood donation. Heart. 78, 188-193. Web: www.vegetarian.org.uk Monsen, E.R. 1988. Iron nutrition and absorption: dietary factors which impact iron bioavailability. Journal of the American Dietetic Association. 88 (7) 786-90. 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