The healthcare decision-making landscape is changing, with insurers, governments, hospitals, and multi-specialists now having more influence in addition to doctors. Pharmaceutical companies must develop new skillsets and strategies like key account management, health economics, and real-world evidence generation in order to effectively engage and build relationships with these diverse set of players. Additionally, the rise of chronic diseases requires a shift from treatment to disease management, utilizing integrated approaches and uncommon partnerships with more patient-centricity.