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PowerPoint Presentation Materials to accompany Genetics: Analysis and Principles Robert J. Brooker Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display CHAPTER 8 VARIATION IN CHROMOSOME STRUCTURE AND NUMBER
INTRODUCTION ,[object Object],[object Object],[object Object],[object Object],[object Object],8-2 Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display
[object Object],[object Object],[object Object],[object Object],8.1 Variation in Chromosome Structure 8-3 Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display
Cytogenetics 8-4 Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
8-5 Figure 8.1 Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display Short arm;  For the French,  petite Long arm
Cytogenetics 8-6 Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
8-7 Figure 8.1 Banding pattern during  metaphase Banding pattern during  prophase
Cytogenetics Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display ,[object Object],[object Object],[object Object],[object Object],8-8
Mutations Can Alter Chromosome Structure Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],8-9
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],8-10 Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display
Figure 8.2 8-11 Human chromosome 1 Human chromosome 21
Deficiencies 8-12 Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display ,[object Object],Figure 8.3
Deficiencies 8-13 Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Duplications 8-17 Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display ,[object Object],Figure 8.5
Duplications 8-15 Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Duplications can provide additional genes, forming gene families 8-16 Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display
8-28 Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display Figure 8.6 Genes derived from a single ancestral gene
8-18 Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
8-30 Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display Figure 8.7 Duplication Better at binding and storing oxygen in muscle cells Better at binding and transporting oxygen via red blood cells Expressed very early in embryonic life Expressed maximally during the second and third trimesters Expressed after birth
Duplications and Gene Families 8-27 Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display ,[object Object],[object Object],[object Object],[object Object]
Experiment : Comparative Genomic Hybridization to detect deletions and duplications 8-21 Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display ,[object Object],[object Object],[object Object],[object Object],[object Object]
8-21 Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display
Inversions 8-22 ,[object Object],Figure 8.9 Centromere lies within inverted region Centromere lies outside inverted region
8-23 Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Inversion Heterozygotes 8-24 Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Figure 8.10 8-25
Translocations 8-26 Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
8-27 Figure 8.11 Telomeres prevent chromosomal DNA from sticking to each other
Translocations 8-28 Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display ,[object Object],[object Object],[object Object],[object Object]
8-29 Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
8-30 Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Balanced Translocations and Gamete Production 8-31 Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display ,[object Object],[object Object],[object Object],[object Object],[object Object]
8-41 Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Figure 8.13 8-33
8-34  Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],8.2  VARIATION IN CHROMOSOME NUMBER Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display 8-35
Figure 8.14 8-36 Polyploid organisms have three or more sets of chromosomes Individual is said to be  trisomic Individual is said to be  monosomic
Aneuploidy 8-37 Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
8-38 Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display Figure 8.15 In most cases, these effects are detrimental They produce individuals that are less likely to survive than a euploid individual
Aneuploidy 8-39 Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
8-49 Figure 8.16 Blakeslee noted that this plants is “weak and lopping with the leaves narrow and twisted.”
Aneuploidy 8-41 Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display ,[object Object],[object Object],[object Object],[object Object],[object Object]
8-42
8-43 Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display ,[object Object],[object Object],[object Object],[object Object],[object Object]
8-44 ,[object Object],[object Object],[object Object],[object Object],Figure 8.17
8-45 Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Euploidy 8-46 Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Euploidy 8-47 Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display ,[object Object],[object Object],[object Object],[object Object],[object Object]
Euploidy 8-51 Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display ,[object Object],[object Object],[object Object],[object Object],[object Object]
8-52 ,[object Object],[object Object],[object Object],Figure 8.21 Each cell receives  one copy of some chromosomes  and two copies of other chromosomes
8-53 Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],8.3  NATURAL AND EXPERIMENTAL WAYS TO PRODUCE VARIATIONS IN CHROMOSOME NUMBER Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display 8-54
Meiotic Nondisjunction Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display ,[object Object],[object Object],[object Object],[object Object],[object Object],8-55
Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display 8-56 Figure 8.22 All four gametes are abnormal During fertilization, these gametes produce an individual that is  trisomic   for the missing chromosome During fertilization, these gametes produce an individual that is  monosomic  for the missing chromosome
Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display 8-57 Figure 8.22 50 %  Abnormal gametes 50 % Normal gametes
Meiotic Nondisjunction Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],8-58
Mitotic Abnormalities Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],8-59
8-60 Figure 8.23 This cell will be  monosomic This cell will be  trisomic Will be degraded if left outside of the nucleus when nuclear envelope reforms This cell will be  monosomic This cell will be  normal
Mitotic Abnormalities Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display ,[object Object],[object Object],[object Object],[object Object],[object Object],8-61
Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display ,[object Object],[object Object],[object Object],8-62 The XX cell is the precursor for this side of the fly, which developed as a  female The X0 cell is the precursor for this side of the fly, which developed as a  male ,[object Object],Figure 8.24

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Variation in chromosome structure and number chapter 8

  • 1. PowerPoint Presentation Materials to accompany Genetics: Analysis and Principles Robert J. Brooker Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display CHAPTER 8 VARIATION IN CHROMOSOME STRUCTURE AND NUMBER
  • 2.
  • 3.
  • 4.
  • 5. 8-5 Figure 8.1 Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display Short arm; For the French, petite Long arm
  • 6.
  • 7. 8-7 Figure 8.1 Banding pattern during metaphase Banding pattern during prophase
  • 8.
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  • 11. Figure 8.2 8-11 Human chromosome 1 Human chromosome 21
  • 12.
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  • 17. 8-28 Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display Figure 8.6 Genes derived from a single ancestral gene
  • 18.
  • 19. 8-30 Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display Figure 8.7 Duplication Better at binding and storing oxygen in muscle cells Better at binding and transporting oxygen via red blood cells Expressed very early in embryonic life Expressed maximally during the second and third trimesters Expressed after birth
  • 20.
  • 21.
  • 22. 8-21 Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display
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  • 28. 8-27 Figure 8.11 Telomeres prevent chromosomal DNA from sticking to each other
  • 29.
  • 30.
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  • 36.
  • 37. Figure 8.14 8-36 Polyploid organisms have three or more sets of chromosomes Individual is said to be trisomic Individual is said to be monosomic
  • 38.
  • 39. 8-38 Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display Figure 8.15 In most cases, these effects are detrimental They produce individuals that are less likely to survive than a euploid individual
  • 40.
  • 41. 8-49 Figure 8.16 Blakeslee noted that this plants is “weak and lopping with the leaves narrow and twisted.”
  • 42.
  • 43. 8-42
  • 44.
  • 45.
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  • 47.
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  • 49.
  • 50.
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  • 53.
  • 54. Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display 8-56 Figure 8.22 All four gametes are abnormal During fertilization, these gametes produce an individual that is trisomic for the missing chromosome During fertilization, these gametes produce an individual that is monosomic for the missing chromosome
  • 55. Copyright ©The McGraw-Hill Companies, Inc. Permission required for reproduction or display 8-57 Figure 8.22 50 % Abnormal gametes 50 % Normal gametes
  • 56.
  • 57.
  • 58. 8-60 Figure 8.23 This cell will be monosomic This cell will be trisomic Will be degraded if left outside of the nucleus when nuclear envelope reforms This cell will be monosomic This cell will be normal
  • 59.
  • 60.