Heavy metal toxicity and it\'s harmful effexts to your body

1. Lead Toxicity ACAM April 21, 2010 Dorothy Merritt, MD This lecture is dedicated to Clair Patterson, whose inadvertant discovery of severe lead contamination in the US while trying to date the age of the Earth, lead to the Clean Air Act of 1970 and the removal of lead from gasoline for sale in the US in 1986 despite attempts of the ETHYL Corporation to get him fired from his position at Cal Tech. His persistance paid off for the betterment of society . This lecture also recognizes Thomas Midgley, an engineer whose dabbling in chemistry resulted in lead being introduced into gasoline, CFCS (chlorofluorocarbons) being unleashed on the atmosphere. His untimely death was from being strangled in a bed of pulleys he had himself invented for turning polio victims, which he himself contracted after his construction of his device. He may deserve the 20 th century’s top “Darwin Award” for removing his DNA from the pool in a most unusual way caused by his own invention.

2. Lead –Who Is Affected The Most Blood-brain barrier is not complete until 6 months of age so lead can be absorbed by CNS of fetus and young child ( lead crosses placenta). Absorption of lead is estimated to be as much as FIVE TO TEN TIMES GREATER in infants and young children than in adults. Needleman H. Ann Rev Med 2004;55:209-222

7. Lead glaze used on plate imported from Portugal and sold at American Home Furnishings

11. Distribution of workers with BLLs greater than or equal to 25 µg/dL, by industry, 2003-2004 Total = 12,712 Section 44 of The Construction Chart Book, Fourth Edition, December 2007 -

12. Number of workers with BLLs greater than or equal to 25 or 40 µg/dL , by detailed construction sector, 2003-2004 1,051 406 412 92 70 41 41 39 14 Section 44 of The Construction Chart Book, Fourth Edition, December 2007

24. CDC NHANES Blood Lead

36. Lead Exposure and Cardiovascular Disease A Systematic Review Ana Navas-Acien, Eliseo Guallar, Ellen K. Silbergeld and Stephen J. Rothenberg doi:10.1289/ehp.9785 (available at http://dx.doi.org/) Online 22 December 2006

41. Heart rate variability as defined as autonomic dysfunction is more pronounced on high air pollution days in patients with increased bone lead Epidemiology 2008; 19; 111-120 More Lead Effects

43. Methylation Pathways and Lead Heartfixer.com

45. Methylation cycle

50. Progression to renal failure

56. Check list for heavy metal symptoms used in our clinic

57. 9,100 ug Pb/gm  Herbman/DMSA