Taxoids, also known as paclitaxel, are derivatives from taxol, an early potent anticancer compound extracted from Pacific yew (Taxus brevifolia Nutt).

1. Taxoids
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2. Taxoids
• Taxoids, also known as paclitaxel, are derivatives from taxol,
an early potent anticancer compound extracted from Pacific
yew (Taxus brevifolia Nutt). Taxiods was first discovered and
named by Wall et al. in 1966 and their cytotoxcicity was later
demonstrated in 9 KB cancer cell and tissue culture. Since then,
taxiods have been documented to show anti-cancer activity
against leukemia and murine melanoma cell cultures, as well
as various xenograft mouse models bearing MX1 (breast), CX1
(colon) and LX1 (lung) carcinomas.

3. • Taxiods were shown to
function as microtubule-
stabilizing agents to expedit
tubulin polymerization. They
have generated a remarkable
impact on current cancer
chemotherapy against breast,
ovary, and lung cancers.
• Additionally, taxoids have
also been used in the form of
conjugates with different
tumor-targeting modules
including polyunsaturated
fatty acids (PUFAs) and
monoclonal antibodies, etc.
to further enhance their anti-
cancer activities and to
increase their theraputic
windows.

4. The structure of taxol (paclitaxel), a powerful anti-cancer agent (J Med
Chem, 2010).

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6. Content
2 Ta x o i d s - b a s e d a n t i b o d y - d r u g
c o n j u g a t e s
1 Taxoids mode of action (MOA)

7. At clinically interrelated concentrations (1–10 nM), taxoids (paclitaxel)
reveal their efficacy by inhibiting microtubule dynamics. Taxoids bind to
the tubulin heterodimer at its β-tubulin subunit, and they have been
shown to change microtubule morphology, resulting in a decreased
number of protofilaments in microtubules. Taxoids (paclitaxel) mainly bind
to microtubules rather than individual tubulin dimers and cause
protofilament reduction within second in preformed microtubules.
Taxoids mode of action (MOA)

8. Clinical analysis have revealed taxoids’ significant efficacy against advanced solid
tumors, such as breast and ovarian cancer. However, taxoids are still highly toxic
and they often present with poor solubility. A novel strategy of the taxoids delivering,
taxoid-antibody conjugates, has arisen to circumvent these limitations. The
antibody’s targeting function is usually not compromized by the chemical coupling of
a taxoid-linker complex and the antibody deliver the drug into the tumor cells via
receptor mediated endocytosis upon target receptor binding.
Taxoids-based antibody-drug conjugates

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