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First 1,000 days’ care of life
         determines the Health Prospects for future




                 Dr Kuntal Biswas
                      Registrar
        Medical College & Hospitals, Kolkata
2
Rationale
The 1,000 days between a woman’s pregnancy and her child’s 2nd
birthday offer a unique window of opportunity to shape healthier and
more prosperous futures.
Children who do not get adequate nutrition during the 1,000 days
between their mother’s pregnancy and their second birthday can suffer
from stunted physical and cognitive development.
Impaired cognitive function means a child can have a diminished
capacity to learn, leading to lower educational performance and
ultimately, lower economic productivity.
This in turn can hinder a nation’s economic development.
Evidence shows that in countries where childhood undernutrition is
pervasive, the loss to GDP can be as high as 2 to 3%, not including
the indirect costs of malnutrition such as health care and lost wages
due to illness.
In the adult life they are greater risk of the NCDs such as
diabetes, heart disease, hypertension, Osteoporosis, Neuro
-Psychiatric Disorder, Cancer etc, resulting life long medical
expenses
4
5
Back Ground
• On an average, more than 22,000 children < 5 yrs

   of age still die every day from preventable causes.
• Hunger starts in the womb. Malnutrition in the first
  1,000 days can lead to irreversible damage to minds and
  bodies.
• According to UNICEF’s State of the World’s Children
  2010, undernutrition contributes to more than one-
  third of these deaths.
• Undernutrition, particularly in children < 2 Yrs of age,
                      prevents them from reaching their
  full development potential.
                                                         6
Back Ground
•World over 136 million babies are born annually, around
  250babies every minute.
•WHO’s recommendation of optimal infant feeding
  includes: beginning breastfeeding within an hour of birth
   and exclusive breastfeeding for the first 6 mos, followed
   by timely and appropriate complementary feeding after
   6 mos along with continued breastfeeding for 2 years or
    beyond.
• Every minute more than 250 women need support to
   practice the first standard of health care for their babies.
•According to the UNICEF’s State of World Children
  Report only 32.6 % (about 44.5 million) of the babies
  born worldwide are able to practice exclusive
  breastfeeding for the first six months, i.e. about
                                                                  7
Breastfeeding in the First Hour:
                           Why it Matters

All newborn mammals stay close to their mothers and start to suckle
shortly after delivery.
Breastfeeding immediately after birth is a natural behaviour.
                                        Human babies are no
different.
Step 4 of the ‘UNICEF/WHO Ten Steps to Successful Breastfeeding’
is “Help mothers initiate breastfeeding within a half-hour of birth.”

The uninterrupted journey of a newborn baby to the mother’s breast is
guided by the sensory stimulation of touch and smell.

Finding the mother’s nipple for the first time outside the sheltered
environment of the womb, baby and mother’s first encounter is not
only full of wonder but also full of nourishment & benefit for both.   8
Colostrum – First Food
■ Colostrum is the first rich, yellow milk -.contains large amounts of
   leukocytes – living cells that engulf and defend against viruses and
    infectious micro-organisms.
■ It has large quantities of the antibody, secretory immunoglobulin
    IgA which protects the vulnerable mucous membranes of the
    throat, lungs and the intestinal tract.
■ It has a laxative effect that helps the newborn baby pass early stools
  and excrete excess bilirubin and prevent jaundice.
■ A newborn baby’s stomach holds about 5 to 7 mL, the amount of
   one teaspoon. Newborn babies need frequent feeds to gain the
    maximum benefit from colostrum and to stimulate milk production.
■ By day 3 the baby’s stomach capacity

  has grown to nearly 30 mL
■ Stomach capacity of newborn to 1 yr increases 10 times
                                                           9
•Stomach Volume of adult is: 20.4ml/KG of BW& 30gm/KG of BW
Intelligence quotient by type of feeding
                                             BF 12.9 points
    BF 2 points                              higher than FF
   higher than FF                             Study in 9.5
                                              year-olds
    Study in 3-7
                                                 1996
     year-olds
       1982
                                              BF 8.3 points
                                              higher than FF
                                              Study in 7.5-8
     BF 2.1 points                            year-olds
    higher than FF                               1992
  Study in 6 months
    to 2 year- olds                          References:
         1988             BM 7.5 points
                                             •Fergusson DM et al. Soc
                         higher than no BM      SciMed 1982
                          Study in 7.5-8     •Morrow- Tlucak M et al.
BF = breastfed              year-olds           SocSci Med 1988
FF = formula fed                             •Lucas A et al. Lancet 1992
BM = breast milk             1992            •Riva Eet al. Acta Paediatr 1996

                                                                        10
Nutrition during pregnancy
Conception to 2nd week              The total cost of supplying
•Umbilical cord not formed          & maintainaning the Foetus
•Mother’s food intake does not      •Calorie: 40,000KCal
have an effect on the embryo up to •Protein: 910 gm
2 wks                               •Calcium: 30 gm
From 2 wks mother need extra       •Iron: 540 mg
Energy, extra Protein, extra EFA,   •Vitamin A: Retinol
extra Iron, Calcium & other              5400-7200 micro gram
Micronutrients.
•Lactating mother need more than Fetal growth & development
                                   increases the BMR by 5%
in Antenatal Period.               during 1st trimester and 12%
                                   during 2nd & 3rd trimester.
                                                            11
Growth Faltering by Age




                          12
                          12
13
14
Let's make malnutrition visible
Malnutrition is an "invisible crisis" - ignored by governments and
development agencies. Most malnourished children may appear healthy
- there is no obvious “distress”
Most people think malnutrition is all about not having enough food or
enough of the right kind of food to eat. But there are many other links
in the chain Dealing with malnutrition means fixing all the links in the
chain - food, health, sanitation, water and care... If children are
drinking dirty water or are playing in areas where people are defecating
in the open, diarrhea will ensure that the nutrients are not absorbed
and that appetite will be depressed.
                                                           If children do
not receive enough attention from parents and care givers, they will fail
to receive the stimulation and interaction that helps convert food
                                                                          15
intake into growth.
Six key nutrition solutions
• Iron, vitamin A and zinc – are typically packaged as
  capsules costing pennies per dose, or about $1 to $2 per
   person, per year.
• The other three solutions – breastfeeding,
   complementary feeding and good hygiene – are
   behaviour-change solutions, which are implemented
   through outreach, education and community support.

 These can be delivered through community nutrition
 programs at a cost of $15 / household or
 $7.50/child.
• All combined, the entire lifesaving package costs less   16
WHO child growth standards
       • WHO standards for MUAC-for-age,
                       115 mm is recommended as
         it will identify more infants and
         children as having severe acute
         malnutrition and have a high
         specificity of more than 99% over the
         age range 6–60 mos.
                           mos
         5 Types of Undernutrition
Stunting         Under weight
Wasting           Micro nutrient deficiency
   Over Weight/ Obesity

                                              17
Need of Nutrition
 Not only proper food ,but
 proper feeding technique is
 required for proper growth
 & development.




Babies feed themselves,
caregivers’ role is to provide &
help them in age appropriate
manner                         18
Human Brain Development
        Synapse Formation Dependent on Early Experiences
   Required
3 Components
1. Nutrition
2. Prevention of infection
3. Psycho Social Stimulation




                                         Synaptic Connections
                                                                19
                                                                19
Emerging Brain Structures
•At 3 week after conception, the neural plate forms .
•At 6 week Spinal Synapse occurs.
•50,000 neurons/ sec are developed.
•There can be 15,000 synaptic connections for each cell.
•In the 4th month , axons begin to form myelin, which helps to speed transmission
&baby can show liking / disliking.
Nerve cell generation complete.
Cortex beginning to wrinkle.
•By 28 weeks after conception, the brain has 100 billion neurons &
  1 trillion synaptic beads.
By 2 yrs age baby’s brain has double & by 3 yrs triple synaptic connections than adult
brain, but in later life the brain mapping decreases due to inappropriate handling.
Nurture is equally important as Nature.
•Myelinization completes by 30 yrs
             6 Week Fetus           7 Weeks           14 Weeks      6 Months




                                                                                   20
                                                                                   20
Eight Phases in Embryonic and Fetal
        Development at a Cellular Level
1. Mitosi s 2. Migration 3. Aggregation 4.
Differentiation




5. Synaptogenesis 6. Death                     8. Myelination
7.Rearrangement
                                             Between
                                                         40
                                             and 75 %
                                                   of all
                                             neurons born in
                                             embryonic and
                                             fetal development
                                                             21
                                             do not survive.
Brain Cell Connections in the Early Months




 newborn       1 month         3 months            6
months




             14
6 Years     Years
                                                       22
                                                       22
Parenting as Primary Prevention of Ill Health
Promoting Parenting Skills in the first 1000 days
– Parenting is personal – makes pediatricians NERVOUS!
– “Positive/Nurturing/Supportive” Parenting
– Are parenting skills “teachable?” YES !
                        teachable
   •Early maternal support
exerts a positive influence on
hippocampal development
   •The positive effect of
maternal support on
hippocampal volumes was
                    greater in
nondepressed children




                                 Lusby et al., 2012. Available at: www.pnas.org/cgi/doi/10.1073/pnas.1118003109
                                                                                                               23
Altered Immunity                    Human rights
   in PEM & IDA         The International Convention on
Children                Human Rights, to which nearly all
                        countries of the world adhere,
                        includes the right to access to food.
                        Hunger and malnutrition are a
                        violation of human rights.
                        Nutrition is now so much a part of the
                        consciousness of today’s political leaders,
                        that the current political and economic
                        crisis will not in the long run jeopardize the
                        remarkable progress that has been achieved
                        in overcoming or reducing the burden of
      IDA children
      PEM children
                        malnutrition on the population of the
      Normal children   country.                                   24
Proper Food Handling
•Wash caregivers’ and children’s    •Encourage families to continue
   hands before food preparation     breastfeeding for ill baby.
   and eating                       •Avoid medications or birth
•Use clean utensils, cups, and        control methods that can
  bowls to prepare, serve, and         affect breastfeeding
  store food.                       •Encourage the use of spoons
•Avoid the use of feeding bottles    and cups for feeding in
•Serve foods immediately after        responsive method with
   preparation.                       complementary foods,
•Store foods safely                   expressed breast milk,
• Use safe water.                     or breast milk substitutes




                                                                  25
Food Pyramid




               26
               26
Broad Objective
Every birth should be safe, supervised & with scientific facilities, target
• reducing child mortality by two-thirds (MDG 4),
• maternal mortality by three-quarters (MDG 5),
• improving child nutrition (MDG 1).
                           Success Stories
Vietnam, the success in reducing malnutrition was fuelled by
economic growth by reducing inequality and this led to
important investments for the poorest.

Mexico, a successful cash transfer programme made the receipt
of money conditional on visits to health centers.       .
Brazil's Zero Hunger programme was driven by the values of
that country's labour movement, by electoral politics, and by the
personal conviction of then President Lula.
India is undertaking ‘Janani Suraksha Yojona’ , JSK & NSSK with these
We can eradicate malnutrition in 20 years
It is a movement of individuals and organisations who are
determined to make nutrition more visible, to raise
resources for it, to support governments which do
something about it.
There are about 170 million young children who are
malnourished, and there are many more adults who are
suffering from the terrible legacy of malnutrition early in
their own lives.
Good nutrition and education may be not just the best way, but 
the ONLY way to reach ALL of the MDGs. 
                                                                  28
Thanks
           Nation’s
           prospect
          depends on
              the
          Nutritional
           Status of
           Mother &
          Children of
         that Country.

                   29

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1000 days

  • 1. First 1,000 days’ care of life determines the Health Prospects for future Dr Kuntal Biswas Registrar Medical College & Hospitals, Kolkata
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  • 3. Rationale The 1,000 days between a woman’s pregnancy and her child’s 2nd birthday offer a unique window of opportunity to shape healthier and more prosperous futures. Children who do not get adequate nutrition during the 1,000 days between their mother’s pregnancy and their second birthday can suffer from stunted physical and cognitive development. Impaired cognitive function means a child can have a diminished capacity to learn, leading to lower educational performance and ultimately, lower economic productivity. This in turn can hinder a nation’s economic development. Evidence shows that in countries where childhood undernutrition is pervasive, the loss to GDP can be as high as 2 to 3%, not including the indirect costs of malnutrition such as health care and lost wages due to illness. In the adult life they are greater risk of the NCDs such as diabetes, heart disease, hypertension, Osteoporosis, Neuro -Psychiatric Disorder, Cancer etc, resulting life long medical expenses
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  • 6. Back Ground • On an average, more than 22,000 children < 5 yrs of age still die every day from preventable causes. • Hunger starts in the womb. Malnutrition in the first 1,000 days can lead to irreversible damage to minds and bodies. • According to UNICEF’s State of the World’s Children 2010, undernutrition contributes to more than one- third of these deaths. • Undernutrition, particularly in children < 2 Yrs of age, prevents them from reaching their full development potential. 6
  • 7. Back Ground •World over 136 million babies are born annually, around 250babies every minute. •WHO’s recommendation of optimal infant feeding includes: beginning breastfeeding within an hour of birth and exclusive breastfeeding for the first 6 mos, followed by timely and appropriate complementary feeding after 6 mos along with continued breastfeeding for 2 years or beyond. • Every minute more than 250 women need support to practice the first standard of health care for their babies. •According to the UNICEF’s State of World Children Report only 32.6 % (about 44.5 million) of the babies born worldwide are able to practice exclusive breastfeeding for the first six months, i.e. about 7
  • 8. Breastfeeding in the First Hour: Why it Matters All newborn mammals stay close to their mothers and start to suckle shortly after delivery. Breastfeeding immediately after birth is a natural behaviour. Human babies are no different. Step 4 of the ‘UNICEF/WHO Ten Steps to Successful Breastfeeding’ is “Help mothers initiate breastfeeding within a half-hour of birth.” The uninterrupted journey of a newborn baby to the mother’s breast is guided by the sensory stimulation of touch and smell. Finding the mother’s nipple for the first time outside the sheltered environment of the womb, baby and mother’s first encounter is not only full of wonder but also full of nourishment & benefit for both. 8
  • 9. Colostrum – First Food ■ Colostrum is the first rich, yellow milk -.contains large amounts of leukocytes – living cells that engulf and defend against viruses and infectious micro-organisms. ■ It has large quantities of the antibody, secretory immunoglobulin IgA which protects the vulnerable mucous membranes of the throat, lungs and the intestinal tract. ■ It has a laxative effect that helps the newborn baby pass early stools and excrete excess bilirubin and prevent jaundice. ■ A newborn baby’s stomach holds about 5 to 7 mL, the amount of one teaspoon. Newborn babies need frequent feeds to gain the maximum benefit from colostrum and to stimulate milk production. ■ By day 3 the baby’s stomach capacity has grown to nearly 30 mL ■ Stomach capacity of newborn to 1 yr increases 10 times 9 •Stomach Volume of adult is: 20.4ml/KG of BW& 30gm/KG of BW
  • 10. Intelligence quotient by type of feeding BF 12.9 points BF 2 points higher than FF higher than FF Study in 9.5 year-olds Study in 3-7 1996 year-olds 1982 BF 8.3 points higher than FF Study in 7.5-8 BF 2.1 points year-olds higher than FF 1992 Study in 6 months to 2 year- olds References: 1988 BM 7.5 points •Fergusson DM et al. Soc higher than no BM SciMed 1982 Study in 7.5-8 •Morrow- Tlucak M et al. BF = breastfed year-olds SocSci Med 1988 FF = formula fed •Lucas A et al. Lancet 1992 BM = breast milk 1992 •Riva Eet al. Acta Paediatr 1996 10
  • 11. Nutrition during pregnancy Conception to 2nd week The total cost of supplying •Umbilical cord not formed & maintainaning the Foetus •Mother’s food intake does not •Calorie: 40,000KCal have an effect on the embryo up to •Protein: 910 gm 2 wks •Calcium: 30 gm From 2 wks mother need extra •Iron: 540 mg Energy, extra Protein, extra EFA, •Vitamin A: Retinol extra Iron, Calcium & other 5400-7200 micro gram Micronutrients. •Lactating mother need more than Fetal growth & development increases the BMR by 5% in Antenatal Period. during 1st trimester and 12% during 2nd & 3rd trimester. 11
  • 12. Growth Faltering by Age 12 12
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  • 15. Let's make malnutrition visible Malnutrition is an "invisible crisis" - ignored by governments and development agencies. Most malnourished children may appear healthy - there is no obvious “distress” Most people think malnutrition is all about not having enough food or enough of the right kind of food to eat. But there are many other links in the chain Dealing with malnutrition means fixing all the links in the chain - food, health, sanitation, water and care... If children are drinking dirty water or are playing in areas where people are defecating in the open, diarrhea will ensure that the nutrients are not absorbed and that appetite will be depressed. If children do not receive enough attention from parents and care givers, they will fail to receive the stimulation and interaction that helps convert food 15 intake into growth.
  • 16. Six key nutrition solutions • Iron, vitamin A and zinc – are typically packaged as capsules costing pennies per dose, or about $1 to $2 per person, per year. • The other three solutions – breastfeeding, complementary feeding and good hygiene – are behaviour-change solutions, which are implemented through outreach, education and community support. These can be delivered through community nutrition programs at a cost of $15 / household or $7.50/child. • All combined, the entire lifesaving package costs less 16
  • 17. WHO child growth standards • WHO standards for MUAC-for-age, 115 mm is recommended as it will identify more infants and children as having severe acute malnutrition and have a high specificity of more than 99% over the age range 6–60 mos. mos 5 Types of Undernutrition Stunting Under weight Wasting Micro nutrient deficiency Over Weight/ Obesity 17
  • 18. Need of Nutrition Not only proper food ,but proper feeding technique is required for proper growth & development. Babies feed themselves, caregivers’ role is to provide & help them in age appropriate manner 18
  • 19. Human Brain Development Synapse Formation Dependent on Early Experiences Required 3 Components 1. Nutrition 2. Prevention of infection 3. Psycho Social Stimulation Synaptic Connections 19 19
  • 20. Emerging Brain Structures •At 3 week after conception, the neural plate forms . •At 6 week Spinal Synapse occurs. •50,000 neurons/ sec are developed. •There can be 15,000 synaptic connections for each cell. •In the 4th month , axons begin to form myelin, which helps to speed transmission &baby can show liking / disliking. Nerve cell generation complete. Cortex beginning to wrinkle. •By 28 weeks after conception, the brain has 100 billion neurons & 1 trillion synaptic beads. By 2 yrs age baby’s brain has double & by 3 yrs triple synaptic connections than adult brain, but in later life the brain mapping decreases due to inappropriate handling. Nurture is equally important as Nature. •Myelinization completes by 30 yrs 6 Week Fetus 7 Weeks 14 Weeks 6 Months 20 20
  • 21. Eight Phases in Embryonic and Fetal Development at a Cellular Level 1. Mitosi s 2. Migration 3. Aggregation 4. Differentiation 5. Synaptogenesis 6. Death 8. Myelination 7.Rearrangement Between 40 and 75 % of all neurons born in embryonic and fetal development 21 do not survive.
  • 22. Brain Cell Connections in the Early Months newborn 1 month 3 months 6 months 14 6 Years Years 22 22
  • 23. Parenting as Primary Prevention of Ill Health Promoting Parenting Skills in the first 1000 days – Parenting is personal – makes pediatricians NERVOUS! – “Positive/Nurturing/Supportive” Parenting – Are parenting skills “teachable?” YES ! teachable •Early maternal support exerts a positive influence on hippocampal development •The positive effect of maternal support on hippocampal volumes was greater in nondepressed children Lusby et al., 2012. Available at: www.pnas.org/cgi/doi/10.1073/pnas.1118003109 23
  • 24. Altered Immunity Human rights in PEM & IDA The International Convention on Children Human Rights, to which nearly all countries of the world adhere, includes the right to access to food. Hunger and malnutrition are a violation of human rights. Nutrition is now so much a part of the consciousness of today’s political leaders, that the current political and economic crisis will not in the long run jeopardize the remarkable progress that has been achieved in overcoming or reducing the burden of IDA children PEM children malnutrition on the population of the Normal children country. 24
  • 25. Proper Food Handling •Wash caregivers’ and children’s •Encourage families to continue hands before food preparation breastfeeding for ill baby. and eating •Avoid medications or birth •Use clean utensils, cups, and control methods that can bowls to prepare, serve, and affect breastfeeding store food. •Encourage the use of spoons •Avoid the use of feeding bottles and cups for feeding in •Serve foods immediately after responsive method with preparation. complementary foods, •Store foods safely expressed breast milk, • Use safe water. or breast milk substitutes 25
  • 26. Food Pyramid 26 26
  • 27. Broad Objective Every birth should be safe, supervised & with scientific facilities, target • reducing child mortality by two-thirds (MDG 4), • maternal mortality by three-quarters (MDG 5), • improving child nutrition (MDG 1). Success Stories Vietnam, the success in reducing malnutrition was fuelled by economic growth by reducing inequality and this led to important investments for the poorest. Mexico, a successful cash transfer programme made the receipt of money conditional on visits to health centers. . Brazil's Zero Hunger programme was driven by the values of that country's labour movement, by electoral politics, and by the personal conviction of then President Lula. India is undertaking ‘Janani Suraksha Yojona’ , JSK & NSSK with these
  • 28. We can eradicate malnutrition in 20 years It is a movement of individuals and organisations who are determined to make nutrition more visible, to raise resources for it, to support governments which do something about it. There are about 170 million young children who are malnourished, and there are many more adults who are suffering from the terrible legacy of malnutrition early in their own lives. Good nutrition and education may be not just the best way, but  the ONLY way to reach ALL of the MDGs.  28
  • 29. Thanks Nation’s prospect depends on the Nutritional Status of Mother & Children of that Country. 29