![Background Information mtDNA is in close proximity to the mitochondrial respiratory chain, which causes oxidative damage by the production of reactive oxygen species (ROS). Accumulation of somatic mtDNA mutations were claimed to have a role in aging. The number of cytochrome c oxidase (COX) deficient cells progressively increases in postmitotic tissues. ,[object Object]](data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7)
Recommandé
Contenu connexe
Tendances
Tendances (20)
En vedette
En vedette (15)
Similaire à Bmb 411 presentation open
Similaire à Bmb 411 presentation open (20)
Bmb 411 presentation open
- 1. Premature ageing in mice expressing defective mitochondrial DNA polymeraseAleksandra Trifunovic, Anna Wredenberg, Maria Falkenberg, Johannes N. Spelbrink, Anja T. Rovio, Carl E. Bruder, Mohammad Bohlooly-Y, Sebastian Gidlöf, Anders Oldfors, Rolf Wibom, Jan Tornell, Howard T. Jacobs & Nils- Göran Larsson Presentation by BerilKumcuoglu 04/20/2010
- 4. Exon 3 ( yellow box) of the targeting vector encodes alanine instead of aspartate.
- 6. The median lifespan was 48 weeks.
- 7. All of them died before the age of 61 weeks.
- 8. Aging Related Phenotypes were first observed at the age of 25 weeks.
- 9. Weight loss
- 12. Kyphosis ( curvature of the spine)
- 13. Osteoporosis
- 14. Anaemia
- 17. Body weight gain started to decelerate from 15 weeks and weight loss was noted in 24 weeks for both male and female mice.
- 19. X-ray densitometry revealed a reduction in bone mineral density ( BMD) and bone mineral content (BMC)/ length observed at the age of 40 weeks. Body composition of dissected femur bones Body composition of the whole mouse
- 21. Cytochrome c oxidase (COX) activity deficiency was observed in some cardiomyocytes ( shown in blue).
- 23. Spleen enlergement and extramedullaryhaematopoiesis in the liver were present.
- 27. Mutations were evenly distributed along the cytochrome b gene.