This document discusses the role of epigenetics in obesity. It defines epigenetics as heritable changes in gene expression that occur without alterations to the DNA sequence, such as DNA methylation and histone modifications. Certain nutritional conditions can dynamically change DNA methylation patterns and histone modifications. The conclusions suggest identifying early in life individuals who may have methylation and acetylation profiles in specific genes linked to metabolic disease risk. A personalized supplemented diet or epigenetic drugs could potentially counter these profiles and help with preconception counseling.

1. DR. ARNOLDO GUZMAN SANCHEZ
JEFE DEL SERVICIO DE OBSTETRICIA
HCFAA
DR. CARLOS VICTOR PIÑUELAS MERCADO
MEDICO INTERNO DE PREGRADO – HCFAA
UNIVERSIDAD GUADALAJARA LAMAR

2. ASPECTOS BÁSICOS
METILACION O NO DEL DNA
ACETILACION O NO DE HISTONAS
GRUPO DE GENES EPIOBESIOGENICOS
CONCLUSIONES

3. Introduction
 The aetiology of obesity is multifactorial,
involving complex interactions among
the genetic background, hormones and
different unhealthy environmental
factors such as sedentarism or
inadequate dietary habits.

4. Epigenetics:
 The study of heritable (from cell to
daughter cell, parents to off spring, or
both) changes in genome function by
chemical modifications of DNA and
DNA-associated proteins that occur
without a change in the DNA nucleotide
sequence.

5. Epigenetics
 These changes include DNA methylation,
covalent modifications to histones,
packaging of DNA around nucleosomes,
chromatin folding and chromatin
attachment to the nuclear matrix.
 More recently, the involvement of
epigenetic mechanisms such as poly comb
group (PcG) complexes and microRNAs
(miRNAs) has been reported in mammals.

9. Some examples of dynamical changes in DNA methylation pattern and
histone modifications because different nutritional conditions.

12. CONCLUSIONES
 Identificar en edades tempranas a
individuos que pudieran presentar perfiles
de metilación y acetilación en genes
específicos que sugieran suceptibilidad a
diferentes enfermedades
metabolicas(ganancia de peso y DM2).
 Uso de dieta suplementaria que
contrarresten los perfiles epigenomicos de
manera individualizada, similares a la
administracion de inhibidores DNMTs e
inhibidores de deacetilasa.
 Consultoría preconcepcional.

13. GRACIAS!