The document discusses several topics related to DNA replication and repair: 1) A study found that faulty proteins involved in DNA repair may be linked to ovarian cancer recurrence and response to PARP inhibitor drugs. 2) PARP inhibitors are being tested for ovarian cancer patients with BRCA1/BRCA2 mutations or other damaged DNA repair proteins. 3) Research is exploring an earlier genetic molecule called TNA that may have preceded DNA and RNA due to its simpler structure and ability to self-replicate, providing insights into the origins of life. 4) Understanding DNA repair mechanisms and how they relate to disease could help develop new treatments, such as genomic therapies that insert missing genes.

1. Carolina Madrid Cardona Medicine student Universidad pontificia bolivariana Medellín Febrero 13, 2012

5. “ A constellation of defective proteins suspected in causing a malfunction in the body's ability to repair its own DNA could be the link scientists need to prove a new class of drugs will be effective in treating a broad range of ovarian cancer patients, an Oregon Health & Science University Knight Cancer Institute study found” ScienceDaily (Jan. 13, 2012)

8. there is evidence that these proteins influence a patient's ability to respond to drugs and their survival rates after treatment "If we are able to identify the proteins that differentiate these patients at risk for early recurrence, this would open up a new direction in ovarian cancer treatment" Pe jovic the study focused on proteins that are supposed to assist cells in repairing harmful breaks in DNA strands, a process called homologous recombination (HR)

10. I n the chemistry of the living world, a pair of nucleic acids -- DNA and RNA -- reign supreme. As carrier molecules of the genetic code, they provide all organisms with a mechanism for faithfully reproducing themselves as well as generating the myriad proteins vital to living systems. Science Daily (Jan. 9, 2012)

12. Could a simpler, self-replicating molecule have existed as a precursor to RNA, perhaps providing genetic material for earth's earliest organisms? TNA uses tetrose sugars that are simpler than the pentose sugars found in both DNA and RNA could assemble more easily in a prebiotic world, from two identical two-carbon fragments. a single strand of TNA can bind with both DNA and RNA by Watson-Crick base pairing . molecular evolution to explore TNA's potential as a genetic biomolecule Extending this technique to TNA requires polymerase enzymes that are capable of translating a library of random DNA sequences into TNA

15. Life has been going on during lots and lots of time. It started ever since prokaryots and evolved to eukaryots . There one of the most important molecules took place, RNA. And then the appearance of DNA. the eukaryot was formed when the chloroplast and a mitochondria where endocytosed by a bacteria. Even from this far ago a disease placed on a mitochindria could have it’s explanation. For example, diabetes milletus, leigh sindrome and others are causesd by alterations in the protiens of mitochondria. This as indication of the relevance of understanding where we come from, to go from there to the future.