La Dra. Begoña Benito Villabriga explica el diseño y conclusiones clave del análisis sobre el efecto combinado, presentado en ESC Congress 2019.

1. Begoña Benito VillabrigaCombined effect of lower LDL-C and lower SBPCombined effect of lower LDL-C and lower SBP

2. Begoña Benito VillabrigaCombined effect of lower LDL-C and lower SBP
Background

3. Begoña Benito VillabrigaCombined effect of lower LDL-C and lower SBP
Objectives

4. Begoña Benito VillabrigaCombined effect of lower LDL-C and lower SBP
Study design
Mendelian randomization
1. By LDL-C score
(built from 100 genetic variants associated with low
LDL-C: number of variants + strenght of association)
2. By SBP score
(built from 61 genetic variants associated with low
SBP: number of variants + strenght of association)
(40-79y)

5. Begoña Benito VillabrigaCombined effect of lower LDL-C and lower SBP
Study design
1. By LDL-C score
2. By
SBP score

6. Begoña Benito VillabrigaCombined effect of lower LDL-C and lower SBP
Study end-points
Major coronary events (MCE)
Major cardiovascular events (MCVE)
individual components

7. Begoña Benito VillabrigaCombined effect of lower LDL-C and lower SBP
Population characteristics and total events

8. Begoña Benito VillabrigaCombined effect of lower LDL-C and lower SBP
Effect of lower LDL-C and lower SBP on lifetime
risk of CV disease

9. Begoña Benito VillabrigaCombined effect of lower LDL-C and lower SBP
Effect on lifetime risk of various CV outcomes

10. Begoña Benito VillabrigaCombined effect of lower LDL-C and lower SBP
Dose-response of combined low LDL-C and SBP

11. Begoña Benito VillabrigaCombined effect of lower LDL-C and lower SBP
Conclusions

12. Begoña Benito VillabrigaCombined effect of lower LDL-C and lower SBP