2. what is green chemistry?
It is the utilization of a set of principles that
reduces or eliminates the use or generation of
hazardous substances in design, manufacture
and application of chemical products.
It is also called sustainable chemistry which is a
chemical philosophy encouraging design of
products and processes that reduce or eliminate
use of hazardous substances.
3. Principles of green chemistry
1.Prevent waste.
2.Design safer chemicals and products.
3.Design less hazardous chemical syntheses.
4.Use renewable feed stocks.
5.Use catalysts non stoichiometric reagent.
6.Avoid chemical derivatives.
7.Minimize atom economy.
8.Use safer solvents and reaction conditions.
9.Increase energy efficiency.
10.Design chemicals and products to degrade after use.
11.Analyse in real time to prevent pollution.
12.Minimize potentials for accidents.
4. Need for green drug
Incidentsof mass death of animals.
eg:Diclofenac used in cattles killed
vultures.
Side effects of certain drugs-decrease the
ability to provide milk, renal failure.
Effect food chain.
5.
6. Advantages of green pharma
practices
Reduces ecological impact of drugs.
It is less toxic.
Reduced dosing frequency.
It is environment friendly.
Benefit millions of patients.
Maximum usage of raw materials to
produce active drugs.
7. Green chemistry in pharmaceutical
industries
our quality of life depend upon on products of
pharmaceutical industries.
‘YIELD’-main concern of industries.
Amount of waste produced in synthesizing and purifying
drugs produced-secondary concern.
In past decade pharma companies started designing
green chemical drugs to reduce E-factor (measure of
waste produced).
For bulk chemicals - < 1.5 kg,For pharmaceutic-25-100kg
8. Green chemist perspective on pharmaceutical life
cycle
Petroleum based Regulatory starting
chemicals. materials to API.
Bulk chemicals .
Fine chemicals.
Dosage form to patient . API to dosage form.
Patient to Dosage form to packaged
the environment. product.
9. Achievements of green chemistry in
pharmaceutical industries
A drug slidenafil citrate (viagra) manufactured has very
low E-factor about 6.
In reveloutionary drug delivery methods-to deliver
cutting edge drugs.
In coating drugs-plastic design-patient need less no:of
injections.
In making polymers-biodegradable plastics from lactic
acid-dissolvable stiches.
Discovery of regio and enantiospecific microbial
hydroxylation of progesterone to 11alpha –hydroxy
progesterone.
10.
11. Researches
Development in making greener cymene
which is currently sourced from
petrochemicals.
Development of pencillin antibiotics.
12. Perceived green chemistry of phRMA
member companies
Over 10,000 different drugs
are sold in world wide today.
1% ARE MADE BY PROCESS THAT COULD
BE CONSIDERED ‘GREEN’.
The graph shows the activity of
phRMA companies.
13.
14. CONCLUSION
Green chemistry in pharmaceutical
industries seems developing day by day. As our
population is increasing year after year, amount
of wastes produced will also increase, which will
adversely effect our environment. With different
life styles, there is a great chance of people
subjected to diseases. So our principles must be
the principle of green chemistry which in turn
promises as to make chemical industry cleaner
and safer ,while producing better , purer
product in process.
