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- 1. Osteoporosis Shelley B. Bhattacharya, D.O., M.P.H. MS-3 Geriatrics Clerkship University of Kansas School of Medicine
- 7. Prevalence 2000 (in millions) 2015 (in millions) Osteoporosis 10 41 Osteopenia 14 80
- 9. Ten-Year Probability of Fracturing the Hip, Spine, Forearm, or Shoulder in Postmenopausal Women (Relative Risk Attributable to Prior Fracture, 1.74) 3,9 Kanis JA et al. Ten year probabilities of osteoporotic fractures according to BMD and diagnostic thresholds. Osteoporos Int 2001 Dec; 12:989-95 Example Age BMD T-score in Femoral Neck Prior Fragility Fracture 10-year8232;Fracture Probability A 55 – 1.2 No 7.3% B 65 – 1.5 No 12.6% C 65 – 2.5 No 19.3% D 65 – 1.5 Yes 21.9% E 75 – 1.5 No 15.2% F 75 – 1.5 Yes 26.4% G 75 – 2.4 Yes 40.9%
- 15. 10-Year Probability of Fracture in Women by Age and T-Score Data from Kanis JA, et al. Osteoporos Int. 2001;12:989-995. 30.8 24.5 19.4 15.2 11.8 9.1 7.0 28.4 22.8 18.3 14.6 11.5 9.0 7.1 23.9 19.3 15.6 12.6 10.0 8.0 6.3 20.2 16.2 13.0 10.4 8.2 6.5 5.1 16.8 13.4 10.7 8.5 6.7 5.3 4.1 14.1 11.3 9.2 7.4 5.9 4.7 3.8 75 70 65 60 55 50 T-Score – 3.0 T-Score – 2.5 T-Score – 2.0 T-Score – 1.5 T-Score – 1.0 T-Score – 0.5 T-Score 0 Age (years) 30.8 24.5 19.4 15.2 11.8 9.1 7.0 28.4 22.8 18.3 14.6 11.5 9.0 7.1 23.9 19.3 15.6 12.6 10.0 8.0 6.3 20.2 16.2 13.0 10.4 8.2 6.5 5.1 16.8 13.4 10.7 8.5 6.7 5.3 4.1 14.1 11.3 9.2 7.4 5.9 4.7 3.8 75 70 65 60 55 50 T-Score – 3.0 T-Score – 2.5 T-Score – 2.0 T-Score – 1.5 T-Score – 1.0 T-Score – 0.5 T-Score 0 Age (years) 30.8 24.5 19.4 15.2 11.8 9.1 7.0 28.4 22.8 18.3 14.6 11.5 9.0 7.1 23.9 19.3 15.6 10.0 8.0 6.3 20.2 16.2 10.4 8.2 6.5 5.1 16.8 13.4 10.7 8.5 6.7 5.3 4.1 14.1 9.2 7.4 5.9 4.7 3.8 75 70 65 60 55 50 T-Score – 3.0 T-Score – 2.5 T-Score – 2.0 T-Score – 1.5 T-Score – 1.0 T-Score – 0.5 T-Score 0 Age (years) 12.6 13.0 11.3
- 24. X-ray finding of mild deformity Source: schoolscience.co.uk
- 25. X-ray findings of classic wedge fracture Source: schoolscience.co.uk
- 37. PTH Efficacy
- 43. The information requested can be easily obtained from simple questioning; I includes age, sex, weight, height, personal and family history of fracture, current tobacco and alcohol consumption, corticosteroid usage, previous conditions associated with secondary osteoporosis, and history of rheumatoid arthritis FRAX
- 45. The American SOF STUDY OSTEOPOROSIS FRACTURE Research Group has also created another assessment tool for fracture risk. The SOF model, unlike FRAX. And QFRAX. Is based only on BMD and age. However, it predicts the 10-year risk of hip and major osteoporotic fracture as well as the FRAX tool in a group of postmenopausal females, 65 years and old. These findings highlight the importance of age as a risk factor for fragility fractures .
Notes de l'éditeur
- Kanis and colleagues reported 10-year probabilities of osteoporotic fracture in Swedish women according to age and BMD at the femoral neck. 1 These findings demonstrate that there is no specific point at which intervention is recommended. The green, amber, and red coloration is an arbitrary way of demonstrating the increased risk of fracture as patient age increases and T-score declines. The osteopenic group exhibits a wide range of 10-year fracture rate probabilities. Decisions must be made patient by patient on the basis of individual risk. Because the osteopenic group is a large population with wide variations in fracture risk, it is important to understand which patients in a given BMD range would benefit from therapeutic intervention. 1 Of note, the 10-year probability of fracture is also dependent on the patient’s age: A 50-year-old woman with a T-score of –2.5 has a 10-year probability of fracture of 11.3%. A 60-year-old woman with a T-score of –2.0 has a 10-year probability of fracture of 13%. A 65-year-old woman with a T-score of –1.5 has a 10-year probability of fracture of 12.6%. Reference 1. Kanis JA, Johnell O, Oden A, Dawson A, De Laet C, Jonsson B. Ten year probabilities of osteoporotic fractures according to BMD and diagnostic thresholds. Osteoporos Int . 2001;12:989-995.