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General Principles in Pharmacology
- 25. RECEPTORS Agonist Antagonist Beta adrenoreceptor Norepi- nephrine Propranolol Opiate (mu) Morphine Naloxone Dopamine (D2) Dopamine Bromocrip- tine Chlorpro- mazine Insulin insulin None known Estrogen receptors Ethinyl- estradiol Tamoxifen
- 26. ENZYMES INHIBITORS FALSE SUBSTRATE Cyclooxy- genase Aspirin Carbonic Anhydrase Acetazola- Mide Dihydrofolate reductase trimetoprin Monoamine oxidase B Selegiline Angiotensin convering enzymes Captopril
- 27. ION CHANNELS BLOCKERS MODULATORS Renal tubule Sodium channels Amiloride Aldosterone ATP sensitive K + channels ATP Cromokalin sulfonylureas GABA gated chloride channels Picrotoxin Benzodiazepines Voltage gated Ca ++ channels Divalent cations Beta-adrenoreceptor agonists
- 28. CARRIERS INHIBITORS FALSE SUBSTRATE Na + K + Cl co transporter Loop diuretics Na + K + pump Cardiac glycosides Proton pump Omeprazole Weak acid carrier(renal tubule) Probenecid
- 29. OVERVIEW OF PRODUCT DEVELOPMENT Lead Compound Efficacy Selectivity Mechanism Phase 1 Phase 2 Phase 3 Drug metabolism, safety assessment Phase 4 In vitro studies Animal Studies Clinical Testing Marketing 0 2 4 8 – 9 20 YEARS