8. Signs and Symptoms Thyroid Storm Uncomplicated Thyrotoxicosis Confusion, agitation, delirium, frank psychosis, seizures, stupor or coma Anxiety, restlessness Nausea, vomiting, severe diarrhea, abdominal pain, hepatocellular dysfunction-jaundice Diarrhea, increased appetite with loss of weight Heart rate faster than 140 beats/min, hypotension, atrial dysrhythmias, congestive heart failure Sinus tachycardia, heart rate 100-140 Hyperpyrexia, temperature in excess of 106 o C, dehydration Heat intolerance, diaphoresis
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11. Pathophysiology Hyperthyroid state Precipitating factor Increase in thyroid hormone (shift from protein bound to free hormone) Sudden increase in metabolism End organ damage Exaggerated SSx of hyperthyroidism
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